• Korean Journal of Biological Psychiatry
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• v.8 no.1
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• pp.62-70
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• 2001

Alzheimer's disease(AD) is associated with a characteristic neuropathology. The major hallmarks of AD are senile plaques (SPs) and neurofibrillary tangles(NFTs). ${\beta}$-amyloid protein($A{\beta}$) is derived from the proteolysis of amyloid precursor protein(APP) and then converted to SPs. Mature SPs produce cytotoxicity through direct toxic effects and activation of microglia and complement. NFTs are composed of paired helical filaments(PHFs) including abnormally phosphorylated form of the microtubule-associated protein(MAP) tau and increased tau level in cerebrospinal fluid may be observed in most AD. The aggregation of $A{\beta}$ and tau formation are thought to be a final common pathway of AD. Acetylcholine, dopamine, serotonin, GABA and their receptors are associated with AD. Especially, decreased nicotinic acetylcholine receptors(nAChRs) in AD are reported. Genetic lesions associated with AD are mutations in the structural genes for the APP located on chromosome 21, presenilin(PSN)1 located on chromosome 14 and PSN2 located on chromosome 1. Also, trisomy 21, Apo-E gene located on chromosome 19, PMF locus, low density lipoprotein receptor-related protein and ${\alpha}$-macroglobulin increase risk of AD. In this article, we will review about the neurobiology of AD and some newly developed research areas.

• The KIPS Transactions:PartD
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• v.11D no.7 s.96
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• pp.1417-1426
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• 2004

As Ubiquitous commerce is coming personalization service is getting interested. And also the recommendation method which offers useful information to customer becomes more important. However, most of them depend on specific method and are restricted to the E-commerce. For applying these recommendation methods into U-commerce, first it is necessary that the extended context modeling and systematic connection of the methods to complement strength and weakness of recommendation methods in each commercial transaction. Therefore, we propose a mod-eling technique of context information related to personal activation in commercial transaction and show incremental preference analysis method, using preference tree which is closely connected to recommendation method in each step. And also, we use an XML indexing technique to effi-ciently extract the recommendation information from a preference tree.

• Journal of Haehwa Medicine
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• v.20 no.1
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• pp.11-23
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• 2011

Systemic Lupus Erythematosus(SLE) is an autoimmune disease invading the skin, joint, kidney, intestinal membrane, neurosystem and other organs. SLE is an autoimmune disease characterized by immune dysregulation resulting in the production of antinuclear antibodies(ANA), generation of circulating immune complexes, and activation of the complement system. In Korean medicine, lupus can be classified as acute arthritis, reddish butterfly erythema, asthenic disease, edema and so on. The cause and procedure of the diseases are flourishing noxious heat, excessive fire due to deficiency of yin, blood stasis due to stagnation of qi, internal movement of the liver-wind, congenital deficiency, exhausted vital-qi, which are treated by clearing away heat and cooling the blood, nourshing yin and extinguishing fire, treating flatulence and activating blood circulation, nourishing the blood to expel wind, invigorating the liver and kidney, invigorating qi and replenishing the blood. To experimentally examine the influence of Insam-Buja-Tang (Ginseng & Aconiti Extract, IBT) on the outbreak and development of lupus, lupus induce MRL/MpJ-Faslpr lupus-prone mice model was used. As IBT was orally administrated to a lupus model mouse, various tests such as the weight, urine protein, renal function, Lymph cell test of the spleen, Cytokine expression, histopathological analysis of kideny were performed to see the influence on the kidney and whether it work effectively on the immune function. The main purpose of this study is to evaluate the effect of IBT on MRL/MpJ-Faslpr lupus-prone mice model. The effect of IBT on MRL/MpJ-Faslpr lupus-prone mice that can have autoimmune disease similar to SLE in human was evaluated after IBT per oral in the present study.

• Journal of Chest Surgery
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• v.43 no.1
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• pp.96-99
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• 2010

Artificial lung support may be necessary in various conditions during the performance of bilateral lung transplantation, and cardiopulmonary bypass (CPB) has usually been used. Yet using the conventional CPB techniques may increase risk of bleeding and early allograft dysfunction due to the large dosages of heparin and the complement activation. Extracorporeal membrane oxygenation (ECMO) is able to support gas exchange and maintain the hemodynamics without administering high-dose heparin for anticoagulation. We performed sequential bilateral lung transplantation with ECMO support. ECMO is a valuable tool when performing lung transplantation and it has the potential to replace CPB.

• Journal of the Korean Society for Library and Information Science
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• v.45 no.4
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• pp.157-178
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• 2011

In the field of science and technology, influential international journals can easily be found in SCIE. A total number of journals published by societies or institutes in Korea are only 82 of the 8,300 SCIE titles. In this study, in light of the SCI criteria the detailed analysis, of these journals was performed for Korean SCIE journals. The results show that in general domestic journals were not actively cited, had a low level of internationality, and user services through the website was insufficient. Korean SCIE journals should continue to complement these points and elevate its reputation. Candidate journals should concentrate on recruiting more excellent papers, promoting communication with foreign researchers, enhancing domestic and international public relations, and the like. To actively support the domestic publication of excellent journals, long-term and short-term measures should be established and consistently practiced at the national level.

• Fire Science and Engineering
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• v.30 no.5
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• pp.26-35
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• 2016

Sprinkler installations shall be operated at normal operating temperature of the atmosphere as a fire sprinkler head in any facility to control and extinguish the fire when the fire initially. Recently, however, some flush type quick response automatic sprinkler heads in slow fire place is a problem that can not be normal operation are raised. In this paper, by using the experimental model of the Apartment house of Commons and Cabinet burner size bedrooms fire conditions to form a slow growth rate and can supply more than 0.2 MPa pressure is the minimum pressure that can be applied inside the pipe in the field experiment was conducted. In the majority of experiments lush type quick response automatic sprinkler heads which is used in the country it was confirmed to be incompletely opened as the Cold Soldering occur. This phenomenon is likely to fail early fire suppression and control because they can cause the spread of fire and casualties needed to complement domestic product testing and type approval standards through additional research.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.9 no.2
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• pp.153-160
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• 2015

With the development of recent IT fusion technology, IT fusion technology of medical equipment has been dramatically development. The need to most basic preferential implementation of emergency is the respiration of the patient, it is necessary to first aid is maintained in emergency patients airway simultaneously. However, to the endotracheal intubation is a procedure to secure the airway, it requires experience and first aid, Inc. good career, very that may lead to sequelae in patients who otherwise have failed to procedures It is a sensitive and important procedure. For these reasons, the success rate of current endotracheal intubation technique is not at a high level and about 50 percent. In an attempt to complement these problems, in this paper, in the process of endotracheal intubation, intubated by inserting an endoscopic camera to Into Activation tube, the streaming is a real-time monitoring and wireless video transmission method using, there is a purpose of enabling the monitoring in smart devices increase the success rate of endotracheal intubation of first aid purchases.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.10
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• pp.189-198
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• 2016

In recent years, the global financial crisis has worsened the economic environment for small and medium-sized businesses. A great number of South Korean enterprises are having various managerial difficulties, such as insufficient funds, shortage of manpower and lack of market information. To overcome these difficulties, many experts have suggested plans to encourage cooperation among small businesses, and such cooperation has provided diverse services to complement the insufficient capabilities of the individual companies. In spite of the efforts made by government to incite cooperation, however, the businesses themselves have displayed a lack of willingness to such cooperation. Cooperation requires a series of complicated and interdependent processes and, thus, governmental support alone cannot guarantee the necessary willingness to cooperate among small businesses. This research empirically analyzed how cooperative and creative leaderships influence the willingness to cooperate among corporate members. We also empirically studied how relationships among corporate members vary in accordance with their absorptive capacity.

• The Korea Journal of Herbology
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• v.32 no.2
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• pp.1-16
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• 2017

Objective : The study was for researching the activation methods about Korean overall medical crops business from 2010 to 2016. In addition, it was to be given to examining complement points and improving methods to the changeable domestic market of medical crops caused by a considerable export-import amount of them. Methods : By examining and analyzing data for the trend of medical crops production and their export-import trend from 2010 to 2015, I found it valuable to use it as the basic resources for researching the urgent problem of medical crops' business and its improvement. Results : 1. As surveying the trend of the domestic medical crops over the recent six years, I found that the export amount of them has drastically decreased, while the import amount has increased. And so, the prices of the domestic medical crops and their production are unstable. 2. By developing standardized medical crops which a trading counterpart country could prefer, we have to promote the export competitiveness. 3. We should reinforce an origin mark and geographical mark practice for domestic herbal materials and expand GMP. 4. We should prepare a standardization of herbal medicines by setting up an independent governmental department. Conclusion : 1. The government should present an appropriate supply-demand amount of the medical crops depending on the domestic needs and the export-import transactions. 2. There should be an institutional supportive system which is able to guarantee stable incomes of farmers through contract cultivation. 3. We should develop high value standardized medical crops.

• The Journal of Information Systems
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• v.33 no.1
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• pp.45-68
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• 2024

Purpose This paper examines the role of local market-based communities in driving regional revitalization, using detailed analysis of online networks. We aim to dissect a local community's communication network, highlighting members with high engagement levels and exploring their characteristics. Our goal is to identify the conditions that allow local community networks to grow independently and to demonstrate how the activation of these networks contributes to regional revitalization. Design/methodology/approach We employ a mixed-methods approach, combining social network analysis with statistical techniques to investigate the structure of online communication networks. Specifically, we use ANOVA to determine the statistical significance of our findings, ensuring their reliability. To complement our quantitative data, we include qualitative insights from interviews, adding depth and context to our analysis. Findings Our results show that individuals with high centrality in the online network are crucial for maintaining active local communities. We find that leveraging local resources to create a supportive and adaptable environment is essential for the communities' sustainability and expansion. Importantly, our research draws a direct connection between the vitality of local community networks and the broader process of regional revitalization. We argue that energizing local communities is an effective way to address the risk of regional decline. By integrating quantitative analysis with qualitative feedback, this study contributes to the understanding of local market-based communities as key drivers of regional development. It emphasizes the importance of building vibrant, resourceful community networks to revitalize areas experiencing socio-economic challenges.