• The Korean Journal of Pain
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• v.30 no.2
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• pp.86-92
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• 2017

Osteoblasts, originating from mesenchymal cells, make the receptor activator of the nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in order to control differentiation of activated osteoclasts, originating from hematopoietic stem cells. When the RANKL binds to the RANK of the pre-osteoclasts or mature osteoclasts, bone resorption increases. On the contrary, when OPG binds to the RANK, bone resorption decreases. Denosumab (AMG 162), like OPG (a decoy receptor), binds to the RANKL, and reduces binding between the RANK and the RANKL resulting in inhibition of osteoclastogenesis and reduction of bone resorption. Bisphosphonates (BPs), which bind to the bone mineral and occupy the site of resorption performed by activated osteoclasts, are still the drugs of choice to prevent and treat osteoporosis. The merits of denosumab are reversibility targeting the RANKL, lack of adverse gastrointestinal events, improved adherence due to convenient biannual subcutaneous administration, and potential use with impaired renal function. The known adverse reactions are musculoskeletal pain, increased infections with adverse dermatologic reactions, osteonecrosis of the jaw, hypersensitivity reaction, and hypocalcemia. Treatment with 60 mg of denosumab reduces the bone resorption marker, serum type 1 C-telopeptide, by 3 days, with maximum reduction occurring by 1 month. The mean time to maximum denosumab concentration is 10 days with a mean half-life of 25.4 days. In conclusion, the convenient biannual subcutaneous administration of 60 mg of denosumab can be considered as a first-line treatment for osteoporosis in cases of low compliance with BPs due to gastrointestinal trouble and impaired renal function.

• Journal of Digital Convergence
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• v.12 no.5
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• pp.115-123
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• 2014

Patent information analysis has been carried out for technological capability analysis of competitors relating to next generation mobile communication. Various analysis methods, such as applicant analysis, technology classification analysis, indicator analysis and the like have been utilized as a method of analyzing patent information. As a first step for the technological capability analysis of competitors, applicants having high patent activity(PA) were selected, and as a second step therefor, technology classifications showing high technological independence (TI) were selected. Furthermore, portfolios for technology classifications showing high technological independence in the patents of main applicants having high patent activity by matching results the first and second steps together were prepared. Through such a process, portfolios for important technologies which have been concentrically researched by competitors could be analyzed. Accordingly, the present analysis results will help to carry out strategic R&D management, such as the establishment of company R&D plans and patent strategies.

• Journal of the Korea Convergence Society
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• v.8 no.3
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• pp.31-40
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• 2017

The rise of eco-friendly personal electric mobility is a worldwide trend and the first Korean-made IT convergence electric skateboard, Youth Board, is developed to lead the trend. Youth Board is remotely controllable using either Youth Wearable Controller or Youth App through Bluetooth v4.0 communication, can speed up to 25 km/hr, and operating time is approximately 1.5 hr. A LED display located in the front side of Youth Board deck shows three different states to a rider for user convenience: remaining battery SOC, current driving speed, and braking amount. Indoor EMC test results between Youth Board and Youth Wearable Controller and outdoor Youth Board driving test results are analyzed. In particular, driving test results show the maximum current output is about 15% lowered compared to the other competitor electric skateboard and it lessens the power burden of the motor ESC. These results show Youth Board's usefulness as a personal mobility in the sense of small, light, and inexpensive aspects.

• Journal of Digital Convergence
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• v.11 no.11
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• pp.491-498
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• 2013

The purpose of this study was to evaluate the economy and efficiency of two trained athlete groups of different training status. The subjects were 20 elite athletes composed of the cyclists group (n=10) and triathlon group (n=10). All subjects performed steady state testing at 50, 100, and 150 watts, with ample time to reach resting $VO_2$ and ventilation values between stages. The efficiency of two groups appears to be quite different, with triathlon competitors displaying superior efficiency values for the transitions from 0 to 50 and 100 watts. This same principle likely explains the economy of the groups, as triathlon competitor was again more economic at 50 and 100 watts. As though this matching of oxygen consumption and workload they can reduce the amount of oxygen deficit that must be repaid post exercise.

• Korean Journal of Environment and Ecology
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• v.15 no.4
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• pp.344-353
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• 2002

To investigate the forest structure and to suggest the basic data of forest in the Cheongoksan and near the ridge area, the Baekdudaegan, thirty-five plots were set up and surveyed. According to the analysis of classification by TWINSPAN, the community was divined by four groups of Quercus mongolica-Fraxinus rhynchophylla(I). Q. mongolica-Acer pseudosieboldianum(II). Q. mongolica-Tripterygium regelii(III), and Q. mongolica-Rhododendron schlippenbachii community(IV). The structure of communities were investigated using importance value by layer. The survey results were summarized as follows:1) the results of annual ring analysis revealed that the age of forest in the Cheongoksan was about 30~150 years old, 2) number of the average species was 6.5$\pm$1.8 and number of average individuals was 68.3$\pm$39.9 per a plot(100$m^2$). From the above results, it was anticipated that Q. mongolica stand will be old-growth forest because they do not have competitor species and a specific ridge environment.

• Journal of Global Scholars of Marketing Science
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• v.11
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• pp.103-128
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• 2003

As the service market is increasingly competitive, internal marketing, marketing orientation, and customer satisfaction are becoming a crucial issue to the survival and growth of the service firms. This Study examined the structure modeling of internal marketing, market orientation, and customer satisfaction to verify the relationship among construct variables. Conslusively, the higher degree of internal marketing and market orientation, the higher degree of customer satisfaction. Specifically, The positive impact of internal marketing, customer orientation and competitor orientation on customer satisfaction is verified respectively. But, the impact of interfunctional coordination on customer satisfaction is rejected. The company is required to intensify interfunctional coordination in company operation process to boost sustainable competative advantage.

• Korean Journal of Childcare and Education
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• v.9 no.3
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• pp.95-119
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• 2013

The study uses a qualitative research method for an in-depth study on child care practice for preliminary child care teachers. The study shows firstly that prior to practice, a preliminary child care teacher expects to perform a dual role. The preliminary child care teacher conceives an unequal, vertical relationship with a practice guidance teacher and serves as someone between a teacher and a friend to children, while perceiving the facility head as a mediator and practice colleagues as companions. Secondly, the preliminary child care teacher performed a triple role, while the practice guidance teacher played the role of a preliminary child care teacher. A preliminary child care teacher has mutually supportive interaction with a practice guidance teacher and serves as someone between a teacher and a friend, while acting as an important supporter to the facility head and as an uncomfortable competitor to a practice colleague. Thirdly, when a practice is completed, a preliminary child care teacher feels satisfied and sorry, while emphasizing a balance between theory and practice in a curriculum. The purpose of the current study lies in figuring out the needs for child care practice for a preliminary child care teacher who is the subject in child care practice to suggest improvements for a qualitative enhancement of child care practice.

• Journal of Navigation and Port Research
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• v.33 no.1
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• pp.91-98
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• 2009

Busan port, which had ranked at 3rd busiest port following Singapore and Hong Kong in 2002, has been nudged out of 5th place. Growth of China ports threatens Korea ports to be a hub port in Far East Asia. Therefore, Korea ports are needed to establish competitive strategies to overcome a crisis of local ports. In this paper, the question, 'Who is my competitor?' is examined There is a different aspect between this work and many studies that has been done before, because the fore studies focused on the competitive factors or port efficiencies. Above all, the meaning of competition among ports has been summarized through existing literatures. Next. the competition structure among ports is researched, based 0/1 import-export traffic of five local ports including Busan.

• Journal of Life Science
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• v.7 no.3
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• pp.161-166
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• 1997

HIV-1 Rev protein plays an important role in regulating the expression of viral structural proteins. It allows the nuclear export and accumulation of unspliced and partially spliced viral mRNA in the cytoplasm. The Rev-responsive element RNA, present in the env gene, forms a higly ordered RNA secondary structure and is required for the Rev-mediated mRNA export. For this process to complete factor(s) are strongly suggested. From our experiments of electrophoretic mobility shift, UV-crosslinking and SDS/PAGE, RRE RNA was found to be recognized to several nuclear factors such as 36/37, 56, 41. 76, 150 kD proteins in the order of reactivity. Among them, 36/37 and 56 kD proteins are more reactive upon a brief UV treatment (5 min) and more persistent in the presence of high amount of nonspecific competitor, heparin. Certain nuclear protein9s) seemed to recognize the RRE RNA structure in competition with Rev to gel mobility shift assay.

• The Journal of the Korea Contents Association
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• v.9 no.6
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• pp.390-398
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• 2009

This study researches on the two types. First, Researched into important perception, relationship maintenance perception, relationship improvement, relationship recognition between franchisor and franchisee, Seconds, Researched into correlation between franchisor and franchisee at function achievement and relationship maintenance, conflict resolve and relationship maintenance, function achievement and compare with competitor. If franchisor with to experience the benefits of a strong franchise partnership, they must be willing to work on behalf of the partnership, perform roles that may extend beyond their traditional boundaries, and resolve their disagreement to the benefit of the partnership rather than to their own benefit. Strong partnerships require sacrifices on the part of both the franchisees and franchisors. However, These sacrifices have substantial payoffs in terms of franchisor performance as well as the performance of the relationship as a whole.