• Title/Summary/Keyword: competing risk

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Survival of Colorectal Cancer Patients in the Presence of Competing-Risk

  • Baghestani, Ahmad Reza;Daneshvar, Tahoura;Pourhoseingholi, Mohamad Amin;Asadzade, Hamid
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.15
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    • pp.6253-6255
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    • 2014
  • Background: Colorectal cancer (CRC) is considered to be a main cause of malignancy-related death in the world, being commonly diagnosed in both men and women. It is the third leading cause of cancer dependent death in the world and there are one million new cases diagnosed per year. In Iran the incidence of colorectal cancer has increased during the last 25 years and it is the fifth cause of cancer in men and the third in women. Materials and Methods: In this article we analyzed the survival of 475 colorectal patients of Taleghani hospital in Tehran with the semi-parametric competing-risks model. Results: There were 55% male cases and at the time of the diagnosis most of the patients were between 48 and 67years old. The probability of a patient death from colorectal cancer with survival of more than 25 years was about 0.4. Body mass index, height, tumour site and gender had no influence. Conclusions: According to these data and by using semi-parametric competing-risks method, we found out that only age at diagnosis has a significant effect on these patient survival time.

Bayes estimation of entropy of exponential distribution based on multiply Type II censored competing risks data

  • Lee, Kyeongjun;Cho, Youngseuk
    • Journal of the Korean Data and Information Science Society
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    • v.26 no.6
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    • pp.1573-1582
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    • 2015
  • In lifetime data analysis, it is generally known that the lifetimes of test items may not be recorded exactly. There are also situations wherein the withdrawal of items prior to failure is prearranged in order to decrease the time or cost associated with experience. Moreover, it is generally known that more than one cause or risk factor may be present at the same time. Therefore, analysis of censored competing risks data are needed. In this article, we derive the Bayes estimators for the entropy function under the exponential distribution with an unknown scale parameter based on multiply Type II censored competing risks data. The Bayes estimators of entropy function for the exponential distribution with multiply Type II censored competing risks data under the squared error loss function (SELF), precautionary loss function (PLF) and DeGroot loss function (DLF) are provided. Lindley's approximate method is used to compute these estimators.We compare the proposed Bayes estimators in the sense of the mean squared error (MSE) for various multiply Type II censored competing risks data. Finally, a real data set has been analyzed for illustrative purposes.

Joint model of longitudinal data with informative observation time and competing risk (결시적 자료에서 관측 중단을 모형화하기 위해 사용되는 경쟁 위험의 적용과 결합 모형)

  • Kim, Yang-Jin
    • The Korean Journal of Applied Statistics
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    • v.29 no.1
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    • pp.113-122
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    • 2016
  • Longitudinal data often occur in prospective follow-up studies. Joint model for longitudinal data and failure time has been applied on several works. In this paper, we extend it to the case where longitudinal data involve informative observation time process as well as competing risks survival times. We use a likelihood approach and derive an EM algorithm to obtain maximum likelihood estimate of parameters. A suggested joint model allows us to make inferences for three components: longitudinal outcome, observation time process and competing risk failure time. In addition, we can test the association among these components. In this paper, liver cirrhosis patients' data is analyzed. The relationship between prothrombin times measured at irregular visiting times and drop outs is investigated with a joint model.

A two-sample test with interval censored competing risk data using multiple imputation (다중대체방법을 이용한 구간 중도 경쟁 위험 모형에서의 이표본 검정)

  • Kim, Yuwon;Kim, Yang-Jin
    • The Korean Journal of Applied Statistics
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    • v.30 no.2
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    • pp.233-241
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    • 2017
  • Interval censored data frequently occur in observation studies where the subject is followed periodically. In this paper, our interest is to suggest a test statistic to compare the CIF of two groups with interval censored failure time data in the presence of competing risks. Gray (1988) suggested a test statistic for right censored data that motivated a well-known Fine and Gray's subdistribution hazard model. A multiple imputation technique is adopted to adopt Gray's test statistic to interval censored data. The powers and sizes of the suggested method are investigated through diverse simulation schemes. The main merit of the suggested method is its simplicity to implement with existing software for right censored data. The method is illustrated by analyzing Bangkok's HIV cohort dataset.

A Study on Determinants of the Elderly's Self-employment Exits - Focusing on why they exit from their owned business (중고령층 자영업 이탈 요인 분석: 자영업 이탈 이유를 중심으로)

  • Moon, Sanggyun;Park, Sae Jung
    • Journal of Labour Economics
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    • v.43 no.3
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    • pp.1-31
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    • 2020
  • This study analyzed the determinants of self-employment exits among the middle-aged and senior adults. For the analysis, we used KLoSA(Korean Longitudinal Study of Ageing) data from the first(2006) to the sixth(2016) and vocational data, which is a retrospective data surveyed in 2007. Among the reasons for exiting the self-employment, we find that the group that went out of their businesses due to management difficulties were more likely to have economic difficulties after the exit. Therefore, we analyzed the determinants of self-employment exits considering the exit reason due to management difficulties. The analysis model used a competing risk regression model that defined the only exit due to management difficulties as failures. As a result, the significance of gender, age, and education variables, which were well known as determinants of exiting the self-employment, disappeared. On the other hand, we find that the prior experience in the same industry tended to lower the risk of exiting the self-employment. To summarize the results, we suggest that we need some ways to help the middle-aged and senior adults who start their own businesses without any experience in the same industry to prevent them from failures.

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Analyzing the Dysfunction of Fully Shared Stock Information in a Supply Chain with Competiting Retailers (경쟁적 소매상으로 구성된 공급사슬에서 정보공유의 역효과에 관한 연구)

  • Seo, Yong-Won
    • Journal of the Korean Operations Research and Management Science Society
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    • v.37 no.3
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    • pp.95-116
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    • 2012
  • The purpose of this paper is to show the effect of information sharing strategy on the supply chain performances. While traditional information sharing models assumed centralized stock information, recent supply chain practices often implement fully shared stock information, where real-time stock information is accessible on retailers. When retailers are competing with each other, this fully shared stock information may incur retailers' strategic order behaviors. Thus, this paper analyzes a simple two-level supply chain consisting of one warehouse and two identical competing retailers where the real time stock information is fully shared. The warehouse uses the traditional echelon stock policy. Under this environment the retailers' reorder decisions are derived using the order risk concept and the retailer competition mechanism is analyzed. Computational results show that the supply chain performace degradation in the fully shared stock information is quite significant, implying the importance of designing information sharing strategies in the supply chain design phase.

Resistance to Mobile Commerce Services (모바일상거래 서비스의 저항요인)

  • Song, Hee-Seok;Kim, Kyeong-Cheol
    • The Journal of Society for e-Business Studies
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    • v.11 no.2
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    • pp.111-134
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    • 2006
  • This paper analyzes the resistance to mobile commerce services in consumer adoption process. Relative advantage, compatibility, perceived risk, complexity, self-efficacy, innovativeness and attitude for competing service have been chosen as independent variables. This paper also investigates on the significant factors which resist against adoption of mobile commerce service according to adoption phase. The results show that relative advantage, self-efficacy, perceived risk, attitude for competing service are significant factors to affect resistance to mobile commerce services. Relative advantage, perceived risk, attitude for competing service are significant resistance to mobile commerce services for consumers in before-adoption group and compatibility, complexity, self-efficacy are significant factors for consumers in after-adoption group. This study can be extended to new communication services such as Wibro and DMB to reduce resistances in early adoption phase.

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Modeling Survival in Patients With Brain Stroke in the Presence of Competing Risks

  • Norouzi, Solmaz;Jafarabadi, Mohammad Asghari;Shamshirgaran, Seyed Morteza;Farzipoor, Farshid;Fallah, Ramazan
    • Journal of Preventive Medicine and Public Health
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    • v.54 no.1
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    • pp.55-62
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    • 2021
  • Objectives: After heart disease, brain stroke (BS) is the second most common cause of death worldwide, underscoring the importance of understanding preventable and treatable risk factors for the outcomes of BS. This study aimed to model the survival of patients with BS in the presence of competing risks. Methods: This longitudinal study was conducted on 332 patients with a definitive diagnosis of BS. Demographic characteristics and risk factors were collected by a validated checklist. Patients' mortality status was investigated by telephone follow-up to identify deaths that may be have been caused by stroke or other factors (heart disease, diabetes, high cholesterol, etc.). Data were analyzed by the Lunn-McNeil approach at alpha=0.1. Results: Older age at diagnosis (59-68 years: adjusted hazard ratio [aHR], 2.19; 90% confidence interval [CI], 1.38 to 3.48; 69-75 years: aHR, 5.04; 90% CI, 3.25 to 7.80; ≥76 years: aHR, 5.30; 90% CI, 3.40 to 8.44), having heart disease (aHR, 1.65; 90% CI, 1.23 to 2.23), oral contraceptive pill use (women only) (aHR, 0.44; 90% CI, 0.24 to 0.78) and ischemic stroke (aHR, 0.52; 90% CI, 0.36 to 0.74) were directly related to death from BS. Older age at diagnosis (59-68 years: aHR, 21.42; 90% CI, 3.52 to 130.39; 75-69 years: aHR, 16.48; 90% CI, 2.75 to 98.69; ≥76 years: aHR, 26.03; 90% CI, 4.06 to 166.93) and rural residence (aHR, 2.30; 90% CI, 1.15 to 4.60) were directly related to death from other causes. Significant risk factors were found for both causes of death. Conclusions: BS-specific and non-BS-specific mortality had different risk factors. These findings could be utilized to prescribe optimal and specific treatment.

Constructing a Competing Risks Model for the Combined Structure with Dependent Relations (종속적 관계를 갖는 혼합구조에 대한 경쟁적 위험모형의 구축)

  • Park, Seonghwan;Park, Jihyun;Bae, Kiho;Ahn, Suneung
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.40 no.3
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    • pp.92-98
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    • 2017
  • The rapid growth of engineering technology and the emergence of systemized and large-scale engineering systems have resulted in complexity and uncertainty throughout the lifecycle activities of engineering systems. This complex and large-scale engineering system consists of numerous components, but system failure can be caused by failure of any one of a number of components. There is a real difficulty in managing such a complex and large-scale system as a part. In order to efficiently manage the system and have high reliability, it is necessary to structure a system with a complex structure as a sub-system. Also, in the case of a system in which cause of failures exist at the same time, it is required to identify the correlation of the components lifetime and utilize it for the design policy or maintenance activities of the system. Competitive risk theory has been used as a theory based on this concept. In this study, we apply the competitive risk theory to the models with combined structure of series and parallel which is the basic structure of most complex engineering systems. We construct a competing risks model and propose a mathematical model of net lifetime and crude lifetime for each cause of failure, assuming that the components consisting a parallel system are mutually dependent. In addition, based on the constructed model, the correlation of cause of failure is mathematically analyzed and the hazard function is derived by dividing into net lifetime and crude lifetime.

Risk of Death and Occurrence of Secondary Disease of Cancer and Cardiovascular Disease Patient by Income Level in Korea (암, 심뇌혈관 질환자의 소득수준에 따른 사망 및 이차 질환 발생 위험)

  • Kang, Minjin;Son, Kangju
    • The Journal of the Korea Contents Association
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    • v.18 no.10
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    • pp.145-157
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    • 2018
  • In this study, we analyzed the effect of the income level of cancer, stroke, and myocardial infarction on mortality by using National Health Insurance Service(NHIS) Cohort 2.0 DB. Patients who newly developed the disease in 2007 were observed till 2015. The analysis used the Cox probability proportional risk model and the competing risk model. The income level used information at the time of the onset of the disease in 2007, categorized into low / mid / high. The results showed that there were differences in the risks of death and secondary disease in patients with cancer, stroke, or myocardial infarction according to the income level. In addition to the need for a social safety net to lower the incidence of early deaths in low-income families, it seems necessary to continue to strengthen universal protection for serious diseases similar to the current policy.