• Korean Journal of Radiology
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• 제21권4호
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• pp.431-441
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• 2020

Objective: To compare the diagnostic performance and interobserver variability of strain ratio obtained from one or two regions of interest (ROI) on breast elastography. Materials and Methods: From April to May 2016, 140 breast masses in 140 patients who underwent conventional ultrasonography (US) with strain elastography followed by US-guided biopsy were evaluated. Three experienced breast radiologists reviewed recorded US and elastography images, measured strain ratios, and categorized them according to the American College of Radiology breast imaging reporting and data system lexicon. Strain ratio was obtained using the 1-ROI method (one ROI drawn on the target mass), and the 2-ROI method (one ROI in the target mass and another in reference fat tissue). The diagnostic performance of the three radiologists among datasets and optimal cut-off values for strain ratios were evaluated. Interobserver variability of strain ratio for each ROI method was assessed using intraclass correlation coefficient values, Bland-Altman plots, and coefficients of variation. Results: Compared to US alone, US combined with the strain ratio measured using either ROI method significantly improved specificity, positive predictive value, accuracy, and area under the receiver operating characteristic curve (AUC) (all p values < 0.05). Strain ratio obtained using the 1-ROI method showed higher interobserver agreement between the three radiologists without a significant difference in AUC for differentiating breast cancer when the optimal strain ratio cut-off value was used, compared with the 2-ROI method (AUC: 0.788 vs. 0.783, 0.693 vs. 0.715, and 0.691 vs. 0.686, respectively, all p values > 0.05). Conclusion: Strain ratios obtained using the 1-ROI method showed higher interobserver agreement without a significant difference in AUC, compared to those obtained using the 2-ROI method. Considering that the 1-ROI method can reduce performers' efforts, it could have an important role in improving the diagnostic performance of breast US by enabling consistent management of breast lesions.

• 한국지리정보학회지
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• 제27권2호
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• pp.34-44
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• 2024

최근 기후변화로 인한 이상기후로 인해 홍수, 산사태, 토사 유출과 같은 자연재난의 피해가 급증하고 있다. 우리나라는 국토의 63% 이상이 산지라는 지형적 특성 때문에 사면 재해에 취약하며, 특히, 토석채취지는 소단형성 과정에서 흙과 암석을 채굴하기 때문에 산사태가 발생할 확률이 높으며, 사업장 내부 뿐만 아니라, 외부까지 재해발생 위험이 높은 지역이다. 이에 따라, 본 연구는 토석채취지의 모니터링을 위해 UAV와 항공LiDAR를 활용하여 DEM을 구축하고 시계열 변화 분석을 수행하였으며, 토석채취지 모니터링을 위한 최적의 DEM 구축방법을 제안하였다. DEM 구축을 위해 UAV와 LiDAR 기반 Point Cloud 구축하고 Aggressive Classification(AC), Conservative Classification(CC), Standard Classification(SC) 등 세가지 알고리즘을 활용하여 지면부를 추출하였다. 알고리즘에 따라 구축한 UAV 및 LiDAR기반 DEM은 수치지형도 기반 DEM과의 비교를 통해 정확도를 평가하였다. 정확도 평가 결과, 알고리즘 방법간의 높이 차는 최대 1 m 내외로 차이가 거의 없었다. 또한, 음영기복도를 활용한 지면부의 질감을 시각적 비교해보았을 때 CC 알고리즘의 성능이 가장 우수하였으며, 산림지역에서 LiDAR 기반 DEM이 높은 정확도를 보였다. 구축한 최적의 DEM을 통해 토석채취지의 시계열 변화량을 비교한 결과, 토석채취지역, 소단 형성지역 등 시계열 변화에 따른 토석채취지의 변화지역 탐지가 가능하였다.

• Korean Journal of Radiology
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• 제22권5호
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• pp.829-839
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• 2021

Objective: To compare the diagnostic performance of contrast-enhanced radial T1-weighted gradient-echo 3-tesla (3T) magnetic resonance imaging (MRI) and computed tomography (CT) for the detection of visceral pleural surface invasion (VPSI). Visceral pleural invasion by non-small-cell lung cancer (NSCLC) can be classified into two types: PL1 (without VPSI), invasion of the elastic layer of the visceral pleura without reaching the visceral pleural surface, and PL2 (with VPSI), full invasion of the visceral pleura. Materials and Methods: Thirty-three patients with pathologically confirmed VPSI by NSCLC were retrospectively reviewed. Multidetector CT and contrast-enhanced 3T MRI with a free-breathing radial three-dimensional fat-suppressed volumetric interpolated breath-hold examination (VIBE) pulse sequence were compared in terms of the length of contact, angle of mass margin, and arch distance-to-maximum tumor diameter ratio. Supplemental evaluation of the tumor-pleura interface (smooth versus irregular) could only be performed with MRI (not discernible on CT). Results: At the tumor-pleura interface, radial VIBE MRI revealed a smooth margin in 20 of 21 patients without VPSI and an irregular margin in 10 of 12 patients with VPSI, yielding an accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and F-score for VPSI detection of 91%, 83%, 95%, 91%, 91%, and 87%, respectively. The McNemar test and receiver operating characteristics curve analysis revealed no significant differences between the diagnostic accuracies of CT and MRI for evaluating the contact length, angle of mass margin, or arch distance-to-maximum tumor diameter ratio as predictors of VPSI. Conclusion: The diagnostic performance of contrast-enhanced radial T1-weighted gradient-echo 3T MRI and CT were equal in terms of the contact length, angle of mass margin, and arch distance-to-maximum tumor diameter ratio. The advantage of MRI is its clear depiction of the tumor-pleura interface margin, facilitating VPSI detection.

• 한국해양학회지:바다
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• 제13권2호
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• pp.156-163
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• 2008

해양 기원의 발광박테리아 Vibrio fischeri를 이용한 발광박테리아 독성시험법은 1980년대 초반에 소개된 이후 많은 연구자들에 의해 이용되어오다 1998년 국제공인시험법으로 등재되어 지금은 전 세계적으로 이용되고 있다. 이 시험법은 테스트하고자하는 화학물질이나 환경시료에 발광박테리아를 30분간 노출시킨 후 나타나는 발광량 감소의 정도로서 독성 유무나 강도를 평가하는 방법으로서 신속성, 정밀성, 민감성, 경제성이 뛰어나다는 평가를 받고 있으며, 시험생물의 유지/배양없이 상용화된 키트 제품을 이용하여 독성 시험을 수행할 수 있다. 본 연구에서는 해양성 발광 박테리아 독성평가 키트로 판매되는 상용화제품(N-Tox)을 이용하여 수행된 결과를 제시하였다. 시험법 개발 및 표준화를 위한 시험항목으로는 시료 주입량, 발광량과 같은 기본 항목 테스트와 표준독성물질을 이용한 정도관리 테스트, 화학물질 및 현장시료에 대한 테스트가 포함되었다. 이 시험법은 자동화되어 누구나 쉽게 수행이 가능하면서도, 시험 결과 독성물질에 대한 용량-반응 관계가 확실하게 평가되고, 정밀도가 뛰어나며, 현장시료 독성평가에 이용할 수 있을 정도의 민감성을 지닌 것으로 입증되었다. 따라서 아직 생물검정이 보편화되지 않은 국내에서 편리하게 이용할 수 있는 표준독성시험방법의 하나로서 활용 가능하다고 사료된다.

• 환경영향평가
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• 제33권2호
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• pp.53-63
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• 2024

생물다양성은 환경영향평가 제도의 목표에 중요한 부문으로, 개발대상지 입지 선정, 주변 환경 파악 및 교란으로 인한 생물종 영향 등에서 활용되고 있다. 환경영향평가 분야에서 새로운 기술과 모델을 활용하여 생물다양성을 보다 정확하게 평가하고 예측하는 방안에 대한 연구가 많이 진행되고 있다. 비록 현장, 문헌조사를 통한 데이터를 바탕으로 종 풍부도 지수를 평가하고 있으나, 현장 데이터는 시·공간적으로 미흡하므로 고해상도의 종 풍부도 매핑을 통한 기초자료를 활용함으로서, 모니터링 실효성 문제 해결이 필요하다. 따라서 본 연구에서는 제4차 전국자연환경조사 데이터와 환경변수를 바탕으로 Random forest 모델을 활용하여 종 분포모형을 개발하였다. 해당 모델은 24종의 포유류 종 분포 매핑 결과를 species richness index를 활용하여 100m 해상도의 종 풍부도 매핑 결과를 도출하였다. 연구 결과, 종 분포모형은 평균 0.82의 AUC값으로 우수한 예측 정확도를 보였다. 또한, 전국자연환경조사 데이터와 비교결과, 고 해상도의 종 풍부도 매핑 결과의 종 풍부도 분포는 정규분포의 형태를 가지고 있어 환경영향평가에서의 기초자료로 사용함에 있어 신뢰성이 높다. 본 연구의 분석결과는 추후 도시개발과 사업을 함에 있어 생물다양성 평가, 서식지 보전 등에 새로운 참고자료로 활용될 수 있을 것으로 사료된다.

• 한국전산구조공학회논문집
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• 제37권3호
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• pp.173-178
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• 2024

본 논문에서는 스테레오 비전 센서를 이용한 프리팹 강구조물(PSS: Prefabricated Steel Structures)의 조립부 형상 품질 평가 기법을 소개한다. 스테레오 비전 센서를 통해 모형의 조립부 영상과 포인트 클라우드 데이터를 수집하였으며, 퍼지 기반 엣지 검출, 허프 변환 기반 원형의 볼트 홀 검출 등의 영상처리 알고리즘을 적용하여 조립부 영역의 볼트홀을 검출하였다. 영상 내 추출된 볼트홀 외곽선 위 세 점의 위치 정보에 대응되는 3차원 실세계 위치 정보를 깊이 영상으로부터 획득하였으며, 이를 기반으로 각 볼트홀의 3차원 중심 위치를 계산하였다. 통계적 기법 중 하나인 주성분 분석 알고리즘(PCA: Principal component analysis) 알고리즘을 적용함으로써 3차원 위치 정보를 대표하는 최적의 좌표축을 계산하였다. 이를 통해 센서의 설치 방향 및 위치에 따라 센서와 부재 간 평행이 아니더라도 안정적으로 볼트홀 간의 거리를 계측하도록 하였다. 각 볼트홀의 2차원 위치 정보를 기반으로 볼트홀의 순서를 정렬하였으며, 정렬된 볼트홀의 위치 정보를 바탕으로 인접한 볼트홀 간의 각 축의 거리 정보를 계산하여 조립부 볼트홀 위치 중심의 형상 품질을 분석하였다. 측정된 볼트홀 간의 거리 정보는 실제 도면의 거리 정보와의 절대오차와 상대오차를 계산하여 성능 비교를 진행하였으며, 중앙값 기준 1mm 내의 절대오차와 4% 이내의 상대오차의 계측 성능을 확인하였다.

• 한국군사과학기술학회지
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• 제27권4호
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• pp.507-515
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• 2024

Microbial forensics is a scientific discipline for analyzing evidence related to biological crimes by identifying the origin of microorganisms. Multiple locus variable number tandem repeat analysis(MLVA) is one of the microbiological analysis methods used to specify subtypes within a species based on the number of tandem repeat in the genome, and advances in next generation sequencing(NGS) technology have enabled in silico anlysis of full-length whole genome sequences. In this paper, we analyzed unknown samples provided by Robert Koch Institute(RKI) through The United Nations Secretary-General's Mechanism(UNSGM)'s external quality assessment exercise(EQAE) project, which we officially participated in 2023. We confirmed that the 3 unknown samples were B. anthracis through nucleic acid isolation and genetic sequence analysis studies. MLVA results on 32 loci of B. anthracis were analysed by using genome sequences obtained from NGS(NextSeq and MinION) and Sanger sequencing. The MLVA typing using short-reads based NGS platform(NextSeq) showed a high probability of causing assembly error when a size of the tandem repeats was grater than 200 bp, while long-reads based NGS platform(MinION) showed higher accuracy than NextSeq, although insertion and deletion was observed. We also showed hybrid assembly can correct most indel error caused by MinION. Based on the MLVA results, genetic identification was performed compared to the 2,975 published MLVA databases of B. anthracis, and MLVA results of 10 strains were identical with 3 unkonwn samples. As a result of whole genome alignment of the 10 strains and 3 unknown samples, all samples were identified as B. anthracis strain A4564 which is associated with injectional anthrax isolates in heroin users.

• Korean Journal of Radiology
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• 제24권6호
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• pp.553-563
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• 2023

Objective: Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging-derived tractography (DTI-t) contribute to the localization of language areas, but their accuracy remains controversial. This study aimed to investigate the diagnostic performance of preoperative fMRI and DTI-t obtained with a simultaneous multi-slice technique using intraoperative direct cortical stimulation (DCS) or corticocortical evoked potential (CCEP) as reference standards. Materials and Methods: This prospective study included 26 patients (23-74 years; male:female, 13:13) with tumors in the vicinity of Broca's area who underwent preoperative fMRI and DTI-t. A site-by-site comparison between preoperative (fMRI and DTI-t) and intraoperative language mapping (DCS or CCEP) was performed for 226 cortical sites to calculate the sensitivity and specificity of fMRI and DTI-t for mapping Broca's areas. For sites with positive signals on fMRI or DTI-t, the true-positive rate (TPR) was calculated based on the concordance and discordance between fMRI and DTI-t. Results: Among 226 cortical sites, DCS was performed in 100 sites and CCEP was performed in 166 sites. The specificities of fMRI and DTI-t ranged from 72.4% (63/87) to 96.8% (122/126), respectively. The sensitivities of fMRI (except for verb generation) and DTI-t were 69.2% (9/13) to 92.3% (12/13) with DCS as the reference standard, and 40.0% (16/40) or lower with CCEP as the reference standard. For sites with preoperative fMRI or DTI-t positivity (n = 82), the TPR was high when fMRI and DTI-t were concordant (81.2% and 100% using DCS and CCEP, respectively, as the reference standards) and low when fMRI and DTI-t were discordant (≤ 24.2%). Conclusion: fMRI and DTI-t are sensitive and specific for mapping Broca's area compared with DCS and specific but insensitive compared with CCEP. A site with a positive signal on both fMRI and DTI-t represents a high probability of being an essential language area.

• Korean Journal of Radiology
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• 제24권11호
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• pp.1151-1163
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• 2023

Objective: To develop a deep-learning-based bone age prediction model optimized for Korean children and adolescents and evaluate its feasibility by comparing it with a Greulich-Pyle-based deep-learning model. Materials and Methods: A convolutional neural network was trained to predict age according to the bone development shown on a hand radiograph (bone age) using 21036 hand radiographs of Korean children and adolescents without known bone development-affecting diseases/conditions obtained between 1998 and 2019 (median age [interquartile range {IQR}], 9 [7-12] years; male:female, 11794:9242) and their chronological ages as labels (Korean model). We constructed 2 separate external datasets consisting of Korean children and adolescents with healthy bone development (Institution 1: n = 343; median age [IQR], 10 [4-15] years; male: female, 183:160; Institution 2: n = 321; median age [IQR], 9 [5-14] years; male: female, 164:157) to test the model performance. The mean absolute error (MAE), root mean square error (RMSE), and proportions of bone age predictions within 6, 12, 18, and 24 months of the reference age (chronological age) were compared between the Korean model and a commercial model (VUNO Med-BoneAge version 1.1; VUNO) trained with Greulich-Pyle-based age as the label (GP-based model). Results: Compared with the GP-based model, the Korean model showed a lower RMSE (11.2 vs. 13.8 months; P = 0.004) and MAE (8.2 vs. 10.5 months; P = 0.002), a higher proportion of bone age predictions within 18 months of chronological age (88.3% vs. 82.2%; P = 0.031) for Institution 1, and a lower MAE (9.5 vs. 11.0 months; P = 0.022) and higher proportion of bone age predictions within 6 months (44.5% vs. 36.4%; P = 0.044) for Institution 2. Conclusion: The Korean model trained using the chronological ages of Korean children and adolescents without known bone development-affecting diseases/conditions as labels performed better in bone age assessment than the GP-based model in the Korean pediatric population. Further validation is required to confirm its accuracy.

• Korean Journal of Radiology
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• 제23권4호
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• pp.466-478
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• 2022

Objective: ¹⁸F-fluorodeoxyglucose (FDG) PET/CT is often used for detecting malignancy in patients with newly diagnosed hemophagocytic lymphohistiocytosis (HLH), with acceptable sensitivity but relatively low specificity. The aim of this study was to improve the diagnostic ability of ¹⁸F-FDG PET/CT in identifying malignancy in patients with HLH by combining ¹⁸F-FDG PET/CT and clinical parameters. Materials and Methods: Ninety-seven patients (age ≥ 14 years) with secondary HLH were retrospectively reviewed and divided into the derivation (n = 71) and validation (n = 26) cohorts according to admission time. In the derivation cohort, 22 patients had malignancy-associated HLH (M-HLH) and 49 patients had non-malignancy-associated HLH (NM-HLH). Data on pretreatment ¹⁸F-FDG PET/CT and laboratory results were collected. The variables were analyzed using the Mann-Whitney U test or Pearson's chi-square test, and a nomogram for predicting M-HLH was constructed using multivariable binary logistic regression. The predictors were also ranked using decision-tree analysis. The nomogram and decision tree were validated in the validation cohort (10 patients with M-HLH and 16 patients with NM-HLH). Results: The ratio of the maximal standardized uptake value (SUVmax) of the lymph nodes to that of the mediastinum, the ratio of the SUVmax of bone lesions or bone marrow to that of the mediastinum, and age were selected for constructing the model. The nomogram showed good performance in predicting M-HLH in the validation cohort, with an area under the receiver operating characteristic curve of 0.875 (95% confidence interval, 0.686-0.971). At an appropriate cutoff value, the sensitivity and specificity for identifying M-HLH were 90% (9/10) and 68.8% (11/16), respectively. The decision tree integrating the same variables showed 70% (7/10) sensitivity and 93.8% (15/16) specificity for identifying M-HLH. In comparison, visual analysis of ¹⁸F-FDG PET/CT images demonstrated 100% (10/10) sensitivity and 12.5% (2/16) specificity. Conclusion: ¹⁸F-FDG PET/CT may be a practical technique for identifying M-HLH. The model constructed using ¹⁸F-FDG PET/CT features and age was able to detect malignancy with better accuracy than visual analysis of ¹⁸F-FDG PET/CT images.