• Journal of Life Science
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• v.33 no.9
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• pp.736-745
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• 2023

Aging is a complex biological process characterized by a gradual decline in cellular and physiological functions. This natural process is associated with age-related diseases, including Alzheimer's disease, atherosclerosis, and hypogonadism, which are significant health concerns among older individuals and can significantly impact their quality of life. Researchers have found that epigenetic markers play a crucial role in regulating aging and age-related diseases. Epigenetic markers are heritable gene expression alterations that do not change in the DNA sequence. This review focuses on the involvement of various epigenetic marks, such as RNA methylation, DNA methylation, and microRNAs (miRNAs), in regulating gene expression patterns associated with age-related diseases, such as Alzheimer's disease, atherosclerosis, and hypogonadism. These epigenetic alterations can lead to the dysregulation of specific genes and signaling pathways, contributing to the development and progression of Alzheimer's disease, atherosclerosis, and hypogonadism. Understanding the molecular mechanisms behind these epigenetic modifications is essential for both the aging population and individuals seeking ways to promote overall well-being. By gaining deeper insights into how epigenetic marker alteration occurs during aging and age-related diseases, researchers can potentially develop targeted therapeutic strategies to alleviate the impact of these conditions and improve the quality of life for older individuals.

• Journal of People, Plants, and Environment
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• v.22 no.6
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• pp.629-639
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• 2019

This study was conducted to analyze the characteristics of visitors to Hadong Bukcheon Iceland Poppy (BIP) Festival in order to sustain and enhance local flower festivals as a garden tourism. A questionnaire was distributed to BIP Festival visitors from May 18 to 27, 2018. A total of 167 responses were subject to be analyzed. Descriptive statistics analysis was mainly used and focused on describing the results in direct to explain the BIP Festival as a garden tourism. The number of female visitors and those in their 40s and 50s was high. Most of the visitors were found to live in other cities or counties near the area where BIP Festival was held and to prefer festivals held on the theme of nature and local features. The revisit rate and awareness of BIP Festival were 52.1% and 72.5% respectively. They mainly obtained the information on BIP Festival from people around them including family members, friends and colleagues, or from the Internet. Most answered that BIP festival was the most important destination on their trip. The major motives of BIP Festival visit included "spending quality time with family or friends (34.1%)", "appreciating Iceland poppy and gardens (25.6%)", and "enjoying oneself (tranquility, mental rest, etc.; 21.3%). As a companion, family and friends/colleagues accounted for 62.3% and 26.3% respectively. Most were found to spend 1-2 hours on visiting BIP festival and stay in Hadong county for a quarter of a day. In satisfaction of BIP Festival itself, "display and maintenance of Iceland poppy (3.76)" and "easiness of viewing (places arrangement, path, etc.) (3.57)" were high. In satisfaction of public relation and information, "service and hospitality of guides and desk clerks (3.66)" was high. The intention to revisit BIP Festival was nearly affirmative (3.73-3.80).

• Tunnel and Underground Space
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• v.33 no.2
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• pp.83-94
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• 2023

Unlike the conventional triaxial test cells for cylindrical specimens, which impose uniform lateral confining pressures, the GREAT (Geo-Reservoir Experimental Analogue Technology) cell can exert differential radial stresses using eight independently-controlled pairs of lateral loading elements and thereby generate horizontal stress fields with various magnitudes and orientations. In the preceding companion paper, GREAT cell tests were numerically simulated under different mechanical loading conditions and the validity of the numerical model was investigated by comparing experimental and numerical results for circumferential strain. In the present study, we simulated GREAT cell tests for an artificial sample containing a fracture under both mechanical loading and fluid flow conditions. The numerical simulation was carried out by varying the mechanical properties of the fracture surface, which were unknown. The numerical responses (circumferential strains) of the sample were compared with experimental data and a good match was found between the numerical and experimental results under certain mechanical conditions of the fracture surface. Additionally, the effect of fluid flow conditions on the mechanical behavior of the sample was investigated and discussed.

• Journal of the Korean Geotechnical Society
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• v.22 no.2
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• pp.29-39
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• 2006

In the companion paper (Paik 2006), a new formulation for calculating the nonlinearly distributed active earth pressure acting on a caisson backfilled with crushed rock and sand is proposed, and it takes into account arching effects as well as difference in internal friction angles and unit weights between sand and crushed rock. In this study, in order to partially check the accuracy of the proposed equation, the results of the proposed equation are compared with the equation proposed by Paik (2003a) for caissons with rough surface and homogeneous backfill, and are compared with results of Rankine's theory for caissons with smooth surface and homogeneous backfill. In addition, a parametric study is performed to investigate the effect of $phi_{r}$, $phi_{s}$, $\delta_{r}$, $\gamma_{r}$, $\gamma_{s}$ and $\beta$ on the magnitude of active earth pressure acting on the caisson, and construction methods for minimizing active earth pressure on the caisson are also provided based on the results of a parametric study.

• Journal of the Korean Geotechnical Society
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• v.26 no.2
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• pp.33-43
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• 2010

Geothermal energy is gaining wide attention as a highly efficient renewable energy and being increasingly used for heating/cooling systems of buildings. The standing column well (SCW) is especially efficient, cost-effective, and suitable for Korean geological and hydrological conditions. However, a numerical model that simulates the SCW has not yet been developed and applied in Korea. This paper describes the development of the SCW numerical model using a finite-volume analysis program. The model, through hydro-thermal coupled analyses, simulates heat transfer through advection, convection, and conduction. The accuracy of the model was verified through comparisons with field data measured at SCWs in the U.S. and Korea. Comparisons indicated that the SCW numerical model can closely predict the performance of a SCW. The numerical model was used to perform a comprehensive parametric study in the companion paper.

• Journal of the Korean Geotechnical Society
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• v.23 no.3
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• pp.89-100
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• 2007

In the companion paper, we provided the novel elastic-plastic constitutive model based on the micromechanics theory. Herein, the elastic and elastic-plastic deformation of granular soils is meticulously analyzed. To guarantee high accuracy of the microscopic parameter, the systematic procedure to evaluate the parameters is provided. The analysis of the elastic response during the isotropic and triaxial compression shows that the stress-level dependency of cross-anisotropic elastic moduli is induced by the power relationship of the contact force in the normal contact stiffness, while the evolution of fabric anisotropy is more pronounced during triaxial compression. The micromechanical analysis indicates that the plastic strains are likely to occur at very small strains. The plastic deformation of tangential contacts has an important role in the reduction of soil stiffness during axial loading.

• Korean Journal of Veterinary Service
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• v.46 no.1
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• pp.67-74
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• 2023

In the present study, the incidence of bovine tubeculosis (bTB) and brucellosis in Hanwoo (Korean native cattle) and dairy cow in Gyeongsangnam-do was investigated for three years from 2020 to 2022. The incidence bTB tested by tuberculin skin test with purified protein derivative (PPD) and gamma interferon (γ-INF) test with a commercial enzyme-linked immunosorbent assay. From 2020 to 2022, the incidence of bTB showed a decreasing trend in Hanwoo, while an increasing trend in dairy cow. In the case of Brucellosis, the positive rates for Hanwooe gradually increased. However, no brucellosis was found in dairy cow from 2020 to 2022. The increase in the incidence of these diseases is presumed to be related the small scale and poor sanitation facilities of livestock farms in Gyeongsangnam-do, and easy access of wild animals. Therefore, in order to suppress the incidence of the diseases, it is necessary to the farm scale from small to large and to strengthen sanitary facilities on farms.

• Korean Journal of Veterinary Service
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• v.46 no.1
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• pp.87-92
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• 2023

A 7-year-old dog weighing 3.9 kg visited the hospital with symptoms of inability to stand and quadriparesis. There were seizure symptoms 2 months before admission to the hospital, and the symptoms of stiffness and rigidity appeared. Radiographs showed normal vertebrae in cervical vertebral column. Magnetic resonance imaging (MRI) and computed tomography (CT) were performed immediately to diagnose vertebral lameness. As a result of the CT, it was possible to observe the fracture of the odontoid process of the axis, and the exact location of the damage was identified. The odontoid process was fractured and separated from the body of the 2^nd cervical vertebra (axis), and fragment of the process was observed inside the vertebral arch of the first cervical vertebra (atlas), and the body of the axis was lifted to the dorsal side. The MRI examination reflected the CT findings and confirmed severe spinal cord compression due to the fracture of the odontoid process. The patient was applied by neck brace and medical management including Mycophenolate mofetil administration was performed. The patient was able to move legs and tail after 2 weeks, and was able to voluntarily defecate, urinate and stand up after 4 weeks of administration.

• Journal of Veterinary Clinics
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• v.39 no.1
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• pp.9-15
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• 2022

As more veterinary clinics become specialized with the growth of the companion animal market, an increasing number of veterinary clinics perform orthopedic surgery and use orthopedic products, some of which are defective and have side effects. Thus, the present study aimed to prepare fundamental data for the revision and development of manufacturing standards for these products in order to prevent their side effects. We conducted a survey targeting veterinary clinics as consumers and medical device companies as suppliers. Veterinary clinics were surveyed via offline and online methods; 320 clinics that offered orthopedic surgery and approximately 4,000 veterinary clinics that were registered in the Korean Veterinary Medical Association were targeted, and 153 veterinary clinics responded to the survey. The survey for medical device companies, was performed online, targeting 29 companies; 14 companies responded. The number of side effects of orthopedic products was higher in animal orthopedic products than in those for human use. Many consumers tended to suspect that side effects were caused by product defects. To resolve side effects after using orthopedic products, consumers mostly underwent reoperation. Meanwhile, some severe cases proceeded to legal disputes. Similarly, medical device companies, or the suppliers, responded that most side effects occurred in veterinary orthopedic products and that product defects and mistakes in use were the causes. As for most of the follow-up actions for side effects, these companies either reported the issue to those in charge or analyzed and resolved the issues themselves. Therefore, to develop quality products, suppliers should be provided with clear standards for the production, and information disclosure and a report system for side effects should be particularly established to gain consumers' trust regarding the safety of these products.

• Journal of Environmental Science International
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• v.31 no.2
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• pp.215-218
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• 2022

This study investigated the effect of adding poultry litter additive containing probiotics and amino acids to the litter on weight gain in ducks and ammonia content in poultry litter. Nine hundred 1-day-old ducks (Pekin) were randomly distributed into three groups (300 birds per treatment divided into three replicates) using a randomized block design. Treatments were top-dressed on the litter surface at rates of 2 kg poultry litter additives (T1) and 2 kg macsumsuk (T2) per m², and untreated poultry litter was used as the control. Overall, a significant difference (p<0.05) in weight gains was observed at 3 and 4 weeks, but not at 5 and 6 weeks. After 4 weeks, when compared to other treatments, the addition of poultry litter additive tended to increase the average body weight gain (90-130 g). The ammonia content was affected by all treatments (p<0.05) over time except at 3 weeks, however, compared to other treatments, the poultry litter additive decreased the ammonia content. In particular, the rate of ammonia reduction by the poultry litter additives over time was approximately 20.2%-49.2%. Regarding temperature, a significant difference was observed in all treatment groups (p<0.05), except at 3 weeks. In conclusion, considering poultry litter additives and temperature, the increase in duck weight gain was associated with a decrease in ammonia content in the poultry litter.