• 한국임상약학회지
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• 제15권2호
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• pp.75-81
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• 2005

Community acquired pneumonia (CAP) remains a prevalent and potentially life threatening illness. American Thoracic Society and Infectious Disease Society America recommend combination therapies with ${\beta}-lactam$ plus a macrolide or a fluoroquinolone monotherapy for the empirical treatment of CAP. The aim of this study was to compare moxifloxacin monotherapy with cephalosporin plus azithromycin combination therapies. From January 2004 to March 2005, 18 patients in the moxifloxacin group(MG) and 21 patients in the cefuroxime or ceftriaxone plus azithromycin group(CAG) with CAP were retrospectively reviewed with regard to clinical, laboratory and microbiological data. Each patient was stratified into mild (risk class I-II), moderate (risk class III) and severe (risk class VI, V) group according to and PSI (Pneumonia Severity Index) score. Each group was compared for microbiological eradication, clinical assessment, the length of hospital stay. As results, Total 39 patients with CAP were reviewed. The appropriateness of admission was 83.3% in MC vs. 76.2% in CAC. The mean length of the hospital day was for 8.31 days vs. 7.39 days, days switching parenteral to oral antibiotics in 5.19 days vs. 5.28 days, clinical improvement in 2.43 days vs. 2.61 days in MG vs. CAC. Radiological improvement required 3.75 days vs 3.63 days in MG vs. CAG and bacteriological eradication rate at discharge was the same in the both groups. Mortality rate was 11.1% (2 of 18) vs 14.3% (3 of 21) in MG vs. CAG (p=0.77). Drug cost of the mean 5 hospital days requiring parenteral antibiotics was the most inexpensive in moxifloxacin group for the 147,045 won, and ceftriaxone 1g-azithromycin group for the 170,285 won, cefuroxime bid-azithromycin group for the 207,800 won, ceftriaxone 2g-azithromycin group far the 220,570 won, cefuroxime tid-azithromycin group for the 251,700 won. There was no significant statistical difference in clinical, bacterial, radiological cure and hospital days, and switch to oral days. In conclusion, that i.v. moxifloxacin monotherapy was as effective as azithromycin plus cefuroxime or ceftriaxone combination therapies fur the treatment of CAP. In drug cost analysis, moxifloxacin is less expensive than CAG.

• 한국환경교육학회지:환경교육
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• 제17권2호
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• pp.94-105
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• 2004

The purpose of this study is to understand what kind of effects a local residents’ participation on a local environmental problem has on the Environmental consciousness of the resident, and on the local community. I (researcher) employed qualitative research methods on the residents' environmental movement, which claimed to preserve the Sung Mi Mountain from the Seoul City Hall's plan of the water reservoir construction. I tried to understand the participation motivation and participating actions, and also the changes and effects the participation brought at both a personal, and community level. The data were gathered by means of in-depth interview with the local residents and unstructured questionnaire. At first, through the residents' environmental movement, the participants acquired a growth in environmental consciousness. For example, they obtained better understanding of the environment, change of attitude to environment, and participation function. Secondly, it is meaningful that a local tie intervened by the environment, enforced self-governing, and shows how community sentiment plays an important role for local community organization. Moreover, the environmental movement contributed to developing a ‘culture for participation’. In conclusion, participating in a local environmental problem can be an integration of learning and practice and also leads to reflective thinking about the relationship not only between human beings and nature, but also among human beings. In addition, it can buildup a systemic cooperation for local problem-solving and the ability to make an alternative culture in the community. These are the significances of the local environmental problem-participation on the environmental education.

• Childhood Kidney Diseases
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• 제8권2호
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• pp.214-222
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• 2004

목적: 소아 요로감염은 적절한 항생제 치료가 중요하며 항생제의 선택에는 E. coli에 대한 항생제 감수성이 기준이 된다. Extended-spectrum ${\beta}-lactamase(ESBL)$은 E. coli 등 그람음성균에서 분비되어 광범위 항생제 내성을 초래하는 효소로서 주로 병원 감염에서 발생하여 치료를 어렵게 하는 요인으로 알려져 있다 저자들은 지역사회 획득 소아 요로감염에서도 ESBL(+) E. coli가 분리되었기에 ESBL(+) E. coli 요로감염의 특성을 후향적으로 조사하고자 하였다. 방법: 2001년 3월부터 2003년 2월까지 이대목동병원 소아과에 입원한 지역사회 획득 E. coli 요로감염 소아(288명)를 대상으로 ESBL을 검사하였다. 검사 방법은 미량 액체배지 희석법을 이용한 자동화 기계(Vitek GNS 433 card)에서 ESBL이 의심되는 균주에 한해 National Committee for Clinical Laboratory Standard (NCCLS)의 기준에 따라 ESBL을 확인하였다. ESBL의 결과에 따라 ESBL(+) E. coli 요로감염의 발생률을 조사하였고 임상적 특징, 위험요인, 항생제 내성률 및 치료효과 등을 ESBL(-) E. coli 요로감염과 비교 분석하였다. 결과:지역사회 획득 소아 요로감염에서 ESBL(+) E. coli의 발생률은 10.8%(31명)이였고 93.5%(29/31)가 6개월 미만의 영아에서 발생하였다(P<0.01). 임상소견은 ESBL 양성군과 음성군 사이에 유의한 차이가 없었다. ESBL 밭생의 위험인자로 잘 알려진 항생제 사용력, 입원병력 및 요로계 기형과도 무관하였다. ESBL(+) E. coli의 항생제 내성률은 ESBL(-) E. coli 에 비하여 유의하게 높았다(P<0.05). Ceftriaxone 투여 48시간 후의 멸균률은 ceftriaxone에 대한 높은 내성률에도 불구하고 96.8%(30/31)로 높았다. 그러나 6개월 이내의 재발률이 25.8%(9/31)나 되었고 이는 ESBL 음성군의 재발률 6.6%(17/227)에 비하여 유의하게 높았다(P<0.05). 결론: 지역사회 획득 소아 요로감염에서 6개월 미만의 어린 영아는 ESBL(+) E. coli 발생의 새로운 위험요인이므로 이에 대한 역학적 연구가 요구된다. 소아 요로감염에서 경험적으로 사용하는 항생제의 선택에 대한 변화가 필요할 것으로 생각된다.

• 한국임상약학회지
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• 제30권2호
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• pp.120-126
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• 2020

Objective: The rising number of carbapenemase-resistant Enterobacteriaceae (CRE) cases has become a concern worldwidely. This study investigated patient characteristics with CRE and analyzed the risk factors associated with its acquisition. Methods: A retrospective review of the electronic medical records of the Kangbuk Samsung Medical Center from May 2016 to April 2019 was performed. The inclusion criterion was hospitalized patients aged ≥18 years with confirmed CRE acquisition. Patients were divided by CRE acquired and non-required patients. CRE acquired patients were those with CRE confirmed by their active surveillance cultures, while non-acquired patients were those with carbapenemase-sensitive Enterobacteriaceae (CSE). If CRE was isolated more than once during hospitalization, only the first isolation was used for data analysis. Patient characteristics, antibiotic used, and the duration of use were compared between two groups using univariate analysis, and the risk factors associated with CRE were analyzed using multiple logistic regression analysis. Results: Among the 73 CRE acquired patients, 44 (60.3%) were positive for carbapenemase-producing Enterobacteriaceae (CPE). Infection from Klebsiella pneumonia (42 cases, 57.5%), Escherichia coli (17 cases, 23.3%), and Enterobacter cloacae (5 cases, 6.8%). The risk of CRE acquisition was significantly increased by 4.99 times [confidence interval (CI), 1.40-17.78; p=0.013] with mechanical ventilation, 3.86 times (CI, 1.59-9.36; p=0.003) with penicillin administration, and 21.19 times (CI, 6.53-68.70; p<0.001) with carbapenem administration. Conclusions: Proper antibiotic use including the selection, frequency, and duration, and patients on mechanical ventilators need close monitoring.

• Tuberculosis and Respiratory Diseases
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• 제76권4호
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• pp.160-162
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• 2014

Increasing incidence of pleural infection has been reported worldwide in recent decades. The pathogens responsible for pleural infection are changing and differ from those in community acquired pneumonia. The main treatments for pleural infection are antibiotics and drainage of infected pleural fluid. The efficacy of intrapleural fibrinolytics remains unclear, although a recent randomized control study showed that the novel combination of tissue plasminogen activator and deoxyribonuclease had improved clinical outcomes. Surgical drainage is a critical treatment in patient with progression of sepsis and failure in tube drainage.

• 한국물환경학회지
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• 제24권2호
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• pp.195-200
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• 2008

To analyze the riverine microbial community structure, genetic fingerprints and ecological indexes such as species abundances, diversity, evenness, dominance of targeted rivers in Gyeonggi Province were acquired and evaluated using terminal restriction fragment length polymorphism (T-RFLP) technique. Genetic fingerprinting technique such as T-RFLP, which is able to show the microbial community clearly unlike traditional culture-dependent techniques, was thought to be useful to analyse the riverine microbial ecosystem under various factors. Riverine ecosystem evaluation using visible organisms would give biased results with time, targeted organism and researcher. But, T-RFLP, which can exclude the subjected biases such as culture condition and identification, would be an option to understand natural ecosystem by including the microorganisms that defy culture but perform important functions.

• 한국주거학회논문집
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• 제12권2호
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• pp.13-23
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• 2001

These data were acquired by 630 residents at Changwon city and Masan city in Kyungsang-namdo. 66.7% of them were positive or strongly positive on collaborative housings. This is presented the emerging housing needs because they were fed up with the present supply system of housings. They wanted that collaborative housings is low rising buildings and under 20 dwelling units, but rather to protect their own private spaces than to actualize community or common spaces. Sport facilities and parking spaces were the favourite spaces, but common dining room and laundry etc were disfavor spaces of community spaces. Now, to actualize the collaborative housings will be need the coordinate groups to have the special knowledge and experience.

• 환경생물
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• 제22권1호
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• pp.1-11
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• 2004

Ecological methods were reviewed through reports such as environmental impact assessment and damage effect of fishery in the Korean watershed. Survey items in marine ecological field were included: phytoplankton, zooplankton, benthic animal, algae, adult fish, egg and juvenile of fish. A standardization of survey method in the field of community ecology was suggested to consider the convenience, Sequency in Use of device, accuracy of data collected from that. It is necessary that spatial data should be sufficiently acquired toy statistical analysis of biodiversity and spatial comparison. Quantitative sampling method must be inevitably adopted based nature of biota and geographical type of the survey area. The same sampling method can make the data compared spatially but can't be applicable in all area. Standardizing survey method should be by no means under certain restriction of study and would become different according to survey environments. The first thing is minutely understanding about ecological character of biota inhabiting in certain area, and then determining survey method.

• 한국농공학회논문집
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• 제46권2호
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• pp.29-37
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• 2004

An areal elderly migration model (AEMM) was developed to assess the demand of rural development projects targeted towards elderly people. The AEMM was developed with adaptation of the gravity model to represent spatial interaction regarding amenities. Areal characteristics were classified for estimating the amenities from the perspective of net migration. From 1990 to 2000, data were acquired from USCB, PASDA, PAHEALTH, PADCNR, PFBC, and NCDC in 67 Pennsylvania counties for analysis and application. The results revealed that elderly migration can be explained not only by areal characteristics but also by spatial interaction considering the population, distances, and amenities of surrounding areas.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2008년도 추계 학술발표회
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• pp.930-937
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• 2008

From the result of precise field investigation and stability analysis for the cut slope, following results were acquired. 1. The cause of the collapse of cut slope came from circle sliding collapse by fault zone which remained inner weathering zone. 2. The existing destructed soil and rock can be removed by reinforcement. And to prevent the additional destruction, it is judged that applying the method after relaxing the slope would be reasonable. 3. To make cut slope stable, soft rock layer should be done cutting 1:1.5 and 1:2.0 ~ 1:2.5 for weathered rock and soil layer. 4. Heavy water leakage section should be applied horizontal drain method so that water pressure should not act to the cut slope.