• Experimental and Molecular Medicine
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• 제50권12호
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• pp.3.1-3.14
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• 2018

Type 1 diabetes mellitus (T1DM) is a pathological condition associated with osteopenia. $WNT/{\beta}$-catenin signaling is implicated in this process. Trabecular and cortical bone respond differently to $WNT/{\beta}$-catenin signaling in healthy mice. We investigated whether this signaling has different effects on trabecular and cortical bone in T1DM. We first established a streptozotocin-induced T1DM mouse model and then constitutively activated ${\beta}$-catenin in osteoblasts in the setting of T1DM (T1-CA). The extent of bone loss was greater in trabecular bone than that in cortical bone in T1DM mice, and this difference was consistent with the reduction in the expression of ${\beta}$-catenin signaling in the two bone compartments. Further experiments demonstrated that in T1DM mice, trabecular bone showed lower levels of insulin-like growth factor-1 receptor (IGF-1R) than the levels in cortical bone, leading to lower $WNT/{\beta}$-catenin signaling activity through the inhibition of the IGF-1R/Akt/glycogen synthase kinase $3{\beta}$ ($GSK3{\beta}$) pathway. After ${\beta}$-catenin was activated in T1-CA mice, the bone mass and bone strength increased to substantially greater extents in trabecular bone than those in cortical bone. In addition, the cortical bone of the T1-CA mice displayed an unexpected increase in bone porosity, with increased bone resorption. The downregulated expression of WNT16 might be responsible for these cortical bone changes. In conclusion, we found that although the activation of $WNT/{\beta}$-catenin signaling increased the trabecular bone mass and bone strength in T1DM mice, it also increased the cortical bone porosity, impairing the bone strength. These findings should be considered in the future treatment of T1DM-related osteopenia.

• 한국융합학회논문지
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• 제11권7호
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• pp.193-206
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• 2020

최근 라이프 스타일의 변화에도 불구하고 서점이라는 콘텐츠는 그 양태를 바꾸면서 꾸준히 우리 곁을 지키고 있다. 본고는 이런 환경에서 개인의 혁신성이 복합서점의 서비스 디자인 요인과 구전 의도에 미치는 영향을 정량적으로 실증한 연구이다. 연구자들은 개인의 혁신성이 복합서점의 서비스 디자인 요인에 영향을 줄 것으로 보았다. 또한 선행연구를 통하여 추론한 복합서점의 서비스 디자인 요인 상호간에도 상당한 인과관계가 있을 것으로 가정하였다. 나아가 매개변인으로서 이들이 내부변인인 지각된 용이성과 지각된 유용성 및 만족, 구전 의도에 영향을 줄 것이라는 가설을 제시하였고, 확장된 기술수용모델과 후기수용모델의 통합모델을 이용하여 검증하였다. 연구자들은 본 연구가 대형 유통시설 내 주요 테넌트로 주목받는 복합서점에 대하여 개발자의 입장으로 접근한 연구라는 점에서 상당한 기여가 있을 것으로 기대한다.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2009년도 공동학술대회
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• pp.171-172
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• 2009

일반적으로 컨테이너 공로 운송은 근거리 운송, 장거리 운송, 셔틀 운송으로 구분되고, 컨테이너 차량은 chassis 형태에 따라 20' 컨테이너 전용, 40' 컨테이너 전용, combined chassis 차량으로 나눌 수 있다. 본 논문에서는 셔틀 운송을 고려한 컨테이너 차량 경로 문제를 다루고자 한다. 셔틀 서비스는 O/D pairs가 같은 물량이 여러 개 발생할 수 있다. 문제 정의는 기존의 연구된 combined chassis 트레일러를 이용한 컨테이너 차량 경로 문제와 유사하지만 셔틀 서비스의 특징을 고려해야 한다. 이에 각 노드를 한 번 이상 방문할 수 있는 pick-up and delivery 제약을 가진 차량경로문제를 근간으로 하여 combined chassis 트레일러를 이용한 컨테이너 셔틀 운송계획 문제를 정의하고, 적합하고 효율적인 해법을 제안하고자 한다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1989년도 한국자동제어학술회의논문집; Seoul, Korea; 27-28 Oct. 1989
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• pp.524-529
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• 1989

In this paper, an approximate sojourn time distribution is obtained for cyclic service systems. We consider symmetric and limited service systems in which each queue has an infinite capacity. The combined service time is defined which consists of the frame service time and server waiting time that is approximated by two cases of the uniform and exponential distributions. The approximate sojourn time distribution is obtained from the Pollaczek-Khinchine formula where the combined service time is used for the service time in the M/G/I model. And some numerical examples are given to validate the suggested approximate analysis.

• 반도체디스플레이기술학회지
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• 제17권1호
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• pp.12-20
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• 2018

Recently, web-based service software has been used as to combine various information or to share information according to the needs of users and the convergence of specialized fields and individual dependent systems. According to the necessity of the user, the proper service environment and the selective service environment according to the purpose and the needs of the user have been studied in a variety of specialized and combined professional research fields and industries. Software based on cloud systems and web services is being used as a tool for appropriate group and user groups and roles. A service system combined dynamically needs a module to manage a user through internal logic and grant a service access authentication. Therefore, it has been considered various approaches that a user who accesses the system is given a service access authority for a certain period of time. Also, when the deadline is over, the authority that you are given to access system will go through the process of expire the right. In this paper, we define the roles of users who access web services, manage user rights according to each role, and provide appropriate service resources to users according to their rights and session information. We analyzed the procedure of constructing the algorithm for the service according to the procedure of each user accessing the web service, granting the service resource and constructing a new role.

• 한국항해항만학회지
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• 제37권3호
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• pp.321-327
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• 2013

As the market of express delivery services expands rapidly, delivery service companies are exposed to severe competition. As a result of the surplus of delivery companies, they are struggling with remaining competitive at a reasonable price with appropriate level of customer satisfaction. To cope with competition pressures, a strategic alliance is suggested as an effective solution to the challenges faced by small and medium enterprises (SMEs) in express delivery services. Therefore, this study suggests a combined optimization and simulation approach to the reconfiguration of an express delivery service network for strategic alliance with respect to strategy partnership of closing/keeping service centers among companies involved and adjustments of their cutoff times. An illustrative numerical example is presented to demonstrate the practicality and efficiency of the approach.

• Journal of information and communication convergence engineering
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• 제8권3호
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• pp.245-250
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• 2010

To support various bandwidth requirements for many kinds of devices such as PC, notebook, PDA, cellular phone, a transcoding proxy is usually necessary to provide not only adapting multimedia streams to the client by transcoding, but also caching them for later use. Due to huge size of streaming media, we proposed the 3 kinds of segmentation - PT-2, uniform, bitrate-based segmentation. And to reduce the CPU cost of transcoding video, we proposed the DQS service policy. In this paper, we simulate the combined our previous two researches that are bitrate-based segmentation and DQS(Degraded Quality Service) policy. Experimental results show that the combined policy outperforms companion schemes in terms of the byte-hit ratios and delay saving ratios.

• 한국식생활문화학회지
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• 제35권2호
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• pp.181-192
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• 2020

This study aimed to identify whether or not four service situations varying according to positive and negative combinations of physical evidence and functional service influence store image and purchase behavioral intentions of customers at bulgogi restaurants. The video-scenario technique was used for the study. Data were analyzed with the SPSS (Window 19.0) package using frequency analysis, one-way ANOVA, 2 by 2 factorial ANOVA, exploratory factor analysis, and multiple regression analysis to confirm the hypotheses. The combined effect of functional service and physical evidence influenced store image and purchase intention. In terms of seperate effect of physical evidence and functional service, the effect of employee service on store image was more powerful than that of physical evidence, even though the effect differed depending on the situation. Purchase intention was only influenced by functional service quality from employees under the four different scenarios. Thus, when opening a Korean restaurant, proper management of tangible evidence suitable to service, and the prices expected from local customers should be determined. Additionally, extremely high or low levels of physical evidence management should be avoided.

• 대한수의학회지
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• 제47권2호
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• pp.139-145
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• 2007

Measurement uncertainty could play an important role in the assessment of test results in laboratories and industries. We investigated measurement uncertainties possibly included in determination of flubendazole, a benzimidazole anthelmintic, in pork by HPLC. The concentration of flubendazole was 62.69 ng/g in a sample of pork. Uncertainty was estimated in the analytical procedure of flubendazole. A model equation was made for determination of flubendazole in pork. The four uncertainty components such as weight of sample, volume of sample, calibration curve, and recovery were selected to estimate measurement uncertainties. Standard uncertainty was calculated for each component and all the standard uncertainties were combined. The combined standard uncertainty was expanded to a sample population as an expanded uncertainty. The expanded uncertainty was calculated using k value on Student's t-table and effective degrees of freedom from Welch-Satterthwaite formula. The expanded uncertainty was calculated as 3.45 with the combined standard uncertainty, 1.584 6 and the k value, 2.18. The final expression can be ($62.69{\pm}3.45$) ng/g (confidence level 95%, k = 2.18). The uncertainty value might be estimated differently depending on the selection of the uncertainty components. It is difficult to estimate all the uncertainty factors. Therefore, it is better to take several big effecting components instead of many small effecting components.

• 한국인터넷방송통신학회논문지
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• 제13권2호
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• pp.269-273
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• 2013

본 논문은 대표적인 전파응용기기로 알려진 PDP(Plasma Display Panel) TV와 RF(Radio Frequency) 전구가 30MHz 이하 무선 서비스에 대한 전자기기의 잠재적 간섭 영향을 분석한 것이다. PDP TV와 RF 전구의 방사 크기를 전자파무반사실에서 측정하였고 이를 바탕으로 다수의 간섭 신호가 존재하는 경우에 결합된 간섭신호의 크기를 계산하였다. 분석 결과, 간섭원의 수에 따라 결합된 간섭 신호의 크기가 증가되는 경향을 확인하였다. 실험을 통해 얻어진 전자기기의 방사 측정값과 CISPR(International Special Committee on Radio Interference) 11의 제한치를 비교함으로 30MHz 이하의 무선 서비스에 대한 전자기기 간섭 잠재성을 확인하였다.