• 대한전자공학회논문지
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• 제23권5호
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• pp.591-596
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• 1986

A binary continuous phase frequency shift keying (CPFSK), whose phase is a continuous function of time and instantaneous frequency is constant, is a bandwidth efficient constant envelope signalling scheme. A transmitting signal is formed by combined coding of a convolutional encoder and a binary CPFSK modulator. The signal is transmitted throuth additive white Gaussian noise(AWGN) channel. If the received signal is detected by a coherent maximum likelihood(ML) receiver, error probability can be expressed approximately in terms of minimum Euclidean distance. We propose rate 2/4 codes for the improvement of error performance without increating the data rate per bandwidth and the receiver complexity. Its minimum Euclidean distances are compared with those of rate \ulcornercodes as a function of modulation index and observation interval.

• Journal of Acupuncture Research
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• 제25권3호
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• pp.115-125
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• 2008

Diabetes mellitus is a worldwide epidemic. Global projections suggest that most nations will have a doubling of the incidence of Diabetes mellitus(DM) within 20years. The Herb-Combined Remedy(HCR) of DM was known as one of anti-hyperglycaemic agents. But it is unclear whether HCR can be used to treat patients with Diabetic nephropathy or not. The present study was designed to investigate the anti-hyperglycaemic and preventive effects from diabetic nephropathy of HCR in STZ-induced diabetic rats. Treatment with HCR regulated blood glucose levels, but did not affect body weights. In addition, HCR was able to decrease blood glucose levels after 120min. Serum BUN levels were not effective but, serum Creatinine levels were lowered by treatment with HCR or MF. In histopathological observation of renal tissue, both HCR and MF groups showed decreased tendency of inflammation and renal injury. In conclusion, these results demonstrate that HCR is effective to treat patients with DM and also has preventive activity on diabetic nephropathy.

• 약학회지
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• 제55권1호
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• pp.49-55
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• 2011

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is one of the promising anti-cancer agent because of its ability to selectively induce apoptosis in tumor cell lines but not in normal cells. However, TRAIL resistance has been reported in some cancer cells including hepatocarcinoma cells. Therefore, studies of agents that sensitize TRAIL-resistant cancer cells could be a effective therapeutic approach in cancer management. In our study, we examined the effect of combination of TRAIL with apigenin in human hepatocellular carcinoma cells. As a result, the combined use of TRAIL and apigenin significantly enhanced the cytotoxicity in PLC-PRF5 cells. Flow cytometry analysis after annexin V-FITC/PI dual staining showed that this increase of cell cytotoxicity was related to enhanced apoptosis in combined treatment of TRAIL with apigenin. Furthermore, synergistic induction of apoptosis was also confirmed by observation of morphological changes and annexin V-FITC/PI fluorescence. Our findings suggests that apigenin has the potential to improve the efficiency of TRAIL-based therapies in human hepatocellular carcinoma cells. Further study is needed to reveal the molecular mechanisms of this combined therapy.

• 천문학회보
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• 제37권2호
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• pp.238.1-238.1
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• 2012

We present the results of simultaneous observations of SiO v=1 and 2, J=1-0 maser lines which were carried out with the combined network of the KVN and VERA in 2012 April. The observations were performed toward a long period OH/IR star, WX Psc in order to test the technical and scientific feasibilities of the KVN+VERA combination. The resultant (u, v) coverage of the KVN+VERA combined array enhances the image quality. We confirmed that the distribution and intensity of individual maser spots using the combined network are more reliable compared with the images using the KVN or VERA only. This observation also provides a chance to find a high sensitivity and imaging quality which are comparable to those of VLBA. In addition, the simultaneous observations of two SiO v=1 and 2, J=1-0 maser lines enable us to trace the detail physical environments close to the central star due to different high excitation conditions between two lines at a time.

• 생약학회지
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• 제42권3호
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• pp.265-270
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• 2011

Acute toxicity of a combined preparation of the standardized extracts Scutellaria baicalensis GEORGI and Salvia miltiorrhiza BUNGE in a ratio of 3:1 was examined in male and female ICR mice. Mice were treated with the test substance intragastrically at a dose of 0 mg/kg, 5 mg/kg, 50 mg/kg, 500 mg/kg or 2,000 mg/kg and observed for two weeks. No death or abnormal clinical sign was shown during the observation period. Also there were no difference in net body weight gain, organ weight, and gross pathological findings at the terminal sacrifice. The results suggested that acute oral toxicity of a combined preparation of the standardized extracts is very low at the conditions employed in this study.

• Journal of Yeungnam Medical Science
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• 제39권2호
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• pp.161-167
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• 2022

Congenital web formations are extremely rare anomalies of the extrahepatic biliary tree. We herein report a case of common bile duct septum combined with multiple intrahepatic bile duct strictures in a 74-year-old female patient who was successfully treated with radiological intervention. The patient initially visited the hospital because of upper abdominal pain. Imaging studies revealed multifocal strictures with dilatation in both intra- and extrahepatic ducts; the final clinical diagnosis was congenital common bile duct web combined with multiple intrahepatic duct strictures. Surgical treatment was not indicated because multiple biliary strictures were untreatable, and the disease was clinically diagnosed as benign. The multiple strictures were extensively dilated twice through bilateral percutaneous transhepatic biliary drainage (PTBD) for 2 months. After 1 month of observation, PTBD catheters were successfully removed. The patient is doing well at 6 months after completion of the radiological intervention, with the maintenance of normal liver function. Congenital web of the bile duct is very rare, and its treatment may vary depending on the patterns of biliary stenosis. In cases where surgical intervention is not indicated for congenital web and its associated disease, radiological intervention with balloon dilatation can be a viable therapeutic option.

• Nuclear Engineering and Technology
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• 제55권9호
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• pp.3472-3484
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• 2023

The objective of this research is to assess the seismic performance of different types of electrical cabinets in nuclear power plants. The cabinets under investigation are: (a) Case 1: a short single cabinet; (b) Case 2: a tall single cabinet; (c) Case 3: separated cabinets; and (d) Case 4: a combined cabinet with coupling effects. To accurately capture the real behavior of the cabinet, three-dimensional finite element models are developed using ANSYS with connection non-linearity. Frequency domain decomposition (FDD) is used to determine the dynamic properties of the cabinets from shaking table testing data, and these results are utilized to validate the numerical model. The close match between the experimental and numerical results obtained from the modal analysis demonstrates the accuracy of the numerical model. Subsequently, transient structural analysis is performed on the validated models to explore seismic performance. The results show that the acceleration response of the combined cabinet is lower than the single cabinet and the separated cabinet. This observation suggests that top anchors used to combine two different types of cabinets play a crucial role in assessing the efficiency and seismic resistance of electrical cabinets in a nuclear power plant.

• Journal of the Korean Data and Information Science Society
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• 제17권4호
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• pp.1053-1065
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• 2006

This paper proposes a method in one-way layouts for longitudinal data with informative drop-out. When dropouts are informative, that is, correlated with unobserved data and/or the previous observed data, the simple imputation methods such as 'last observation carried forward' (LOCF) methods would arise the bias of the testing models. The maximum likelihood procedure combined with a logit model for the drop-out process is proposed to test treatment effects for one factorial designs and compared with LOCF method in two examples.

• International Journal of Human Ecology
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• 제3권1호
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• pp.21-36
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• 2002

Recently, early childhood education in England has experienced a significant level of government intervention including reforms for improving it. This study examines to what extent new Labour government initiatives impact preschool education in England and how effectively the English government implements its preschool education policies. This empirical study uses a combination of methods, including documentary analysis, questionnaire, and observation. Findings show that recent English government policy, especially the introduction of a national preschool curriculum framework combined with an inspection process and funding mechanism, appears to have had a strong influence on preschool practices.

• Journal of the Korean Data and Information Science Society
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• 제15권2호
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• pp.307-316
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• 2004

Principal Component Regression(PCR) and Partial Least Squares Regression(PLSR) are the two most popular regression techniques in chemometrics. In the field of chemometrics usually the number of regressor variables greatly exceeds the number of observation. So we have to reduce the number of regressors to avoid the identifiability problem. In this paper we compare PCR and PLSR techniques combined with various robust regression methods including regression depth estimation. We compare the efficiency, goodness-of-fit and robustness of each estimators under several contamination schemes.