Acute Toxicity of a Combined Preparation of the Standardized Extracts of Scutellaria baicalensis GEORGI and Salvia miltiorrhiza BUNGE
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Chang, Bo-Yoon
(Unstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University)
Malla, Bindu (Unstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) Sohn, Dong-Hwan (Unstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) Kim, Yoon-Chul (Unstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) Kim, Sung-Yeon (Unstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) |
1 | Chan, T. Y. (2001) Interaction between warfarin and danshen (Salvia miltiorrhiza). Ann Pharmacother. 35: 501-504. DOI |
2 | Yuan, S. L., Wei, Y, Q,, Wang, X, J., Xiao, F., Li, S. F. and Zhang, J. (2004) Growth inhibition and apoptosis induction of tanshinone IIA on human hepatocelluar carcinoma cells. World J. Gastroenterol. 10: 2024-2028. DOI |
3 | Ueng, Y. F., Kuo, Y. H., Peng, H. C., Chen, T. L., Jan, W. C., Peter, G. F. and Lin, Y. L. (2001) Diterpene quinone tanshinone IIA selectivity inhibits mouse and human cytochrome P4501A2. Xenobiotica 33: 603-613. |
4 | Chang, B. Y., Oh, B. R., Sohn, D. H. and Kim, S.Y. (2008) Single oral toxicity study in the standardozed extract of salvia miltiorrhiza. Kor. J. Pharmacogn. 39: 352-356. |
5 | Liu, Y., Wang, X. and Liu, Y. (2003) Protective effect of tan shinone IIA on injured primary cultured rat hepatocytes induced by CCL4. Zhong Yao Cai 26: 415-417. |
6 | Liu, Y., Chen, H. and Jiang, Y. (2002) Effect of tanshinone IIA on CCL4-induced liver fibrosis in rats. Zhong Yao Cai 25: 31-33. |
7 | 노정구, 한상섭, 김용화, 김영구, 김성훈 (1986) 화학물질의 독성 평가 및 방법 개발보고서 86-10-0227-00-00, 한국화학연구원. |
8 | Kim, J. Y., Kim, K. M., Nan, J. X., Zhao, Y. Z., Park, P. H., Lee, S. J. and Sohn, D. H. (2003) Introduction of apoptosis by tanshinone I via cytochrome c release in activated hepatic stellate cells. Pharmacol. Toxicol. 92: 195-200. DOI ScienceOn |
9 | 김수현, 이혜영, 김선희, 박석희, 정미숙, 문설희, 이미영, 심용희, 서민수, 문제민, 강대혁, 서형석, 나재범 (2005) 생약(한약) 등의 90일 반복투여독성실험(황금). 독성물질국가관리사업연구보고서 4: 256-280, 식품의약품안전평가원. |
10 | 이종권, 신지순, 이근영, 김형수, 김진호, 엄주호, 조수미, 조연옥, 길정현, 김정래, 전영진, 박귀례 (2004) 생약제제의 in vitro 면역독성연구보고서, 04-N-10, 식품의약품안전평가원. |
11 | 노정구, 한상섭, 김용화, 김성훈, 이현걸 (1987) 화학물질의 독성 평가 및 방법 개발 보고서 87-10-0319-00-00, 한국화학연구원. |
12 | 정보섭, 신민교 (1990) 도해향약(생약)대사전(식물편), 860-862, 도서출판 영림사, 서울. |
13 | Chen, F., Chan, K. H., Jiang, Y., Kao, R. Y., Lu, H. T., Fan, K. W., Cheng, V. C., Tsui, W. H., Hung, I. F., Lee, T. S., Guan, Y., Peiris, J. S. and Yuen, K. Y. (2004) In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds. J. Clin. Virol. 31: 69-75. |
14 | Chen, Y., Yang, L. and Lee, T. J. (2000) Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. Biochem. Pharmacol. 59: 1445-1457. DOI ScienceOn |
15 | Hara, H., Sukamoto, T., Ohtaka, H., Abe, K., Tatumi, Y., Saito, Y., Suzuki, A. and Tsukamoto, G. (1992) Effects of baicalein and alpha-tocopherol on lipid peroxidation, free radical scavenging activity and 12-O-tetradecanoylphorbol acetate-induced ear edema. Eur. J. Pharmacol. 221: 193-198. DOI |
16 | Wakabayashi, I. (1999) Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages. Pharmacol. Toxicol. 84: 288-291. DOI ScienceOn |
17 | Ikemoto, S., Sugimura, K., Yoshida, N., Yasumoto, R., Wada, S., Yamamoto, K. and Kishimoto, T. (2000) Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Urology 55: 951-955. DOI ScienceOn |
18 | Sohn, D.H., Kim, Y.C. and Park E.J. (2007) A purified extract isolated from Salvia miltiorrhiza, amethod for preparing them and the compositioncomprising the same having hepato-protecting activityand protecting or treating activity from liver fibrosisand liver cirrhos. Korea Patent, 10-2007-0113561. |
19 | 식품의약품안전청 (1999) 의약품등의 독성시험기준, 식품의약품안전청고시, 1999-61, 식품의약품안전청. |
20 | Organization for Economic Cooperation and Development (OECD) (2001) OECD Guideline for the Testing of Chemicals revised draft guideline 420. |
21 | 정보섭, 신민교 (1990) 도해향약(생약)대사전(식물편), 5001-5009, 도서출판 영림사, 서울. |
22 | Sohn, D.H., Kim, Y.C., Park, E. J., and Zhao, Y.-Z. (2006) A purified extract isolated from Scutellaria baicalensis GEORGI, a method for preparing them and the composition comprising the same having hepato-protecting activity and protecting or treating activity from liver fibrosis and liver cirrhosis. Korea Patent, 10-2006-0048798 |
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