• Communications for Statistical Applications and Methods
• /
• v.4 no.2
• /
• pp.565-579
• /
• 1997

A robust test is proposed for the problem of testing the parallelism of several regression lines against ordered alternatives. The proposed test statistic is based on a linear combination of one-step pairwise GM-estimators. We compare the performance of the proposed test with that of the other tests through a Monte Carlo simulation. The results of the simulation study show that the proposed test has stable levels, good empirical powers in various circumstances, and particularly higher empirical powers under the presence of extreme outliers or leverage points.

• Journal of Periodontal and Implant Science
• /
• v.30 no.2
• /
• pp.375-390
• /
• 2000

The purpose of this study is to evaluate the expression ofIGF-I, considered as the mediator of action of estrogen, and IGF-IA and IGF-IB, alternative slicing form of IGF-I, using $17{\beta}-estradiol$ in MC3T3-E1 cells. We observed the effect on type I collagen and osteopontin gene expression and DNA synthetic activity of MC3T3-E1 cells, added by estrogen, IGF-I and combination and the interactionon proliferation and differentiation of MC3T3-E1 cells. The results were as follows :RT-PCR experiment for observing timedependantIGF-I gene expression patternshowed IGF-IA and IB gene expression in both of control and test group. In these IGF-IA gene expression was appeared predominantly. In control, IGF-I geneexpression level was maintained until 24hr and then decreased gradually. In testgroup, IGF-I gene expression level increased as time goes by. Experiment measuring DNA synthetic activity, as it is added by $17{\beta}-estradiol$, IGF-I and combination, showed that first day , there was the tendency of more increase of synthetic activity in all test group than control but no statical significance(P>0.05), and third day, there was more increase of DNA synthetic activity in $17{\beta}-estradiol$ group and combination group and it was statically significant. (P<0.005) Experiment for observing type I collagen gene expression pattern showed more increase of expression in $17{\beta}-estradiol$ group than control and no significant difference in IGF-I group and combination group. Experiment for observing osteopontin gene expression pattern showed no significant difference in control and test group. In conclusion, $17{\beta}-estradiol$ in MC3T3- E1 cells increased IGF-I gene and DNA synthetic activity simultaneously, therefore it appeared that IGF-I is related to the action of estrogen. Combination treatment of IGF-I and $17{\beta}-estradiol$ has effect on cell proliferation but this effect is lower than IGF-I or $17{\beta}-estradiol$ alone. However, combination treatment has not great effect on type I collagen or osteopontin gene expression thus little effect of cell differentiation.

• The Korean Journal of Pain
• /
• v.27 no.3
• /
• pp.278-284
• /
• 2014

Background: Establishment of laparoscopic cholecystectomy as an outpatient procedure has accentuated the clinical importance of reducing early postoperative pain, as well as postoperative nausea and vomiting (PONV). We therefore planned to evaluate the role of a multimodal approach in attenuating these problems. Methods: One hundred and twenty adult patients of ASA physical status I and II and undergoing elective laparoscopic cholecystectomy were included in this prospective, randomized, placebo-controlled study. Patients were divided into four groups of 30 each to receive methylprednisolone 125 mg intravenously or etoricoxib 120 mg orally or a combination of methylprednisolone 125 mg intravenously and etoricoxib 120 mg orally or a placebo 1 hr prior to surgery. Patients were observed for postoperative pain, fentanyl consumption, PONV, fatigue and sedation, and respiratory depression. Results were analyzed by the ANOVA, a Chi square test, the Mann Whitney U test and by Fisher's exact test. P values of less than 0.05 were considered to be significant. Results: Postoperative pain and fentanyl consumption were significantly reduced by methylprednisolone, etoricoxib and their combination when compared with placebo (P<0.05). The methylprednisolone + etoricoxib combination caused a significant reduction in postoperative pain and fentanyl consumption as compared to methylprednisolone or etoricoxib alone (P<0.05); however, there was no significant difference between the methylprednisolone and etoricoxib groups (P>0.05). The methylprednisolone and methylprednisolone + etoricoxib combination significantly reduced the incidence and severity of PONV and fatigue as well as the total number of patients requiring an antiemetic treatment compared to the placebo and etoricoxib (P<0.05). Conclusions: A preoperative single-dose administration of a combination of methylprednisolone and etoricoxib reduces postoperative pain along with fentanyl consumption, PONV, antiemetic requirements and fatigue more effectively than methylprednisolone or etoricoxib alone or a placebo.

• Korean Journal of Microbiology
• /
• v.44 no.4
• /
• pp.339-345
• /
• 2008

This study was to detect MBL (metallo-${\beta}$-lactamase) among glucose non-fermenting Gram-negative bacilli isolated from clinical specimen and to search antimicrobial combination therapy against MBL producing Pseudomonas aeruginosa. Among fifty one isolates of Gram-negative bacilli with reduced imipenem susceptibility ($MIC{\ge}8{\mu}g/ml$), nine isolates have shown positive results in MBL detection test. They were seven Achromobacter xylosoxidans subsp. xylosoxidans and two P. aeruginosa. The results from EDTA-DDST coin-cided with those of PCR and nucleotide sequence analysis which showed the presence of $bla_{VIM-2}$. The combination of aztreonam (AZT) and piperacillin-tazobactarn (TZP) or AZT and amikacin (AN) screened by one disk synergy test showed no synergistic effect. Triple antibiotic combination therapy with AZT, TZP and AN, however, was shown to be effective and the most synergistic after 8 hrs of exposure. This result strongly suggest that the triple combination therapy of AZT, TZP, and AN could be useful for the treatment of infection caused by MBL producing Gram-negative bacilli.

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2003.10b
• /
• pp.95-95
• /
• 2003

The comet assay has been recently validated as a sensitive and specific test system for the quantification of DNA damage. with 11 substances that demonstrated positive results in at least one test among 4 standard short-term genotoxicity tests, and to evaluate its ability to predict rodent carcinogenicity.(omitted)

• Steel and Composite Structures
• /
• v.50 no.6
• /
• pp.659-674
• /
• 2024

Casting Ultra High-Performance Concrete (UHPC) on an orthotropic steel deck and forming a composite action by connectors could improve the steel deck fatigue performance. This study presents the mechanical performance of a proposed post-combination connection between UHPC and steel, which had a low constraint effect on UHPC shrinkage. A total of 10 push-out tests were conducted for static and fatigue performance investigations. And the test results were compared with evaluation methods in codes to verify the latter's applicability. Meanwhile, nonlinear simulation and parametric works with material damage plasticity models were also conducted for the static and fatigue failure mechanism understanding. The static and fatigue test results both showed that fractures at stud roots and surrounding local UHPC crushes were the main failure appearances. Compared with normally arranged studs, group arrangement could result in reductions of static stud shear stiffness, strength, and fatigue lives, which were about 18%, 12%, and 27%, respectively. Compared with the test results, stud shear capacity and fatigue lives evaluations based on the codes of AASHTO, Eurocode 4, JSCE and JTG D64 could be applicable in general while the safety redundancies tended to be smaller or even insufficient for group studs. The analysis results showed that arranging studs in groups caused obviously uneven strain distributions. The severer stress concentration and larger strain ranges caused the static and fatigue performance degradations of group studs. The research outcome provides a very important basis for establishing a design method of connections in the novel post-combination steel-UHPC composite deck.

• Journal of the Korean Society for information Management
• /
• v.27 no.3
• /
• pp.227-239
• /
• 2010

Opinion retrieval is to retrieve items which are relevant to the user information need topically and include opinion about the topic. This paper aims to find a method to represent user information need for effective opinion retrieval and to analyze the combination methods for opinion features through various experiments. The experiments are carried out in the inference network framework using the Blogs06 collection and 100 TREC test topics. The results show that our suggested representation method based on hidden 'opinion' concept is effective, and the compact model with very small opinion lexicon shows the comparable performance to the previous model on the same test data set.

• Proceedings of the KSME Conference
• /
• 2001.06a
• /
• pp.211-216
• /
• 2001

The components with the circular cross section have the symmetric combination parts for rotating balance and the crack emanates from the symmetric combination parts. The symmetric cracks from symmetric combination parts make a decrease in the component fatigue life more than single crack. In this study, to estimate the behavior of symmetric cracks, the fatigue test was performed using rotary bending tester on the specimen with a symmetric defects in circular cross section. The material used in this study is Ni-Cr-Mo steel alloy. Under the same stress, the result from the rotary bending fatigue test turned out that the symmetric cracks made a decrease in the fatigue life by 35% more than single crack and the relation between log a and cycle ratio $N/N_f$ obtained linearly.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.12 no.6
• /
• pp.36-50
• /
• 2009

To suggest the native plants combination for restoration of the dissected sloping area, the plant communities of thirty seven quadrats from five localities of mid-southern part of Korean peninsula were surveyed from 2007 to 2008. Their flora, vegetation structure, and dominant species based on the importance value were investigated. And the soil characters (pH, moisture content, water holding capacity, and organic matter) of each dominant species were analyzed. Also, germination tests were performed to check the stability of restored native plants using seed chips. As a result, 79 native plants were suggested for the dissected sloping area : 20 trees and subtrees for the upper layer, 18 shrubs and vines for the middle layer, and 41 herbs for the lower layer, taken together their flora, dominant species, vegetation structure, soil condition, germination test, flowering period.

• Journal of Korean Society for Atmospheric Environment
• /
• v.22 no.E1
• /
• pp.27-34
• /
• 2006

Although the importance of size-resolved raindrops study has been known, it has not been popularized up to the present. In the present study, an attempt was made to generalize the size-resolved raindrops study by a combination of the frozen raindrop collection method and a commercially available high-performance capillary electrophoresis (HPCE). Samplings were carried out at Kyoto, Japan in October 2002. The inorganic ions (chloride, nitrate, sulphate, calcium, ammonium, sodium, magnesium, potassium) in size classified raindrop samples were successfully analyzed by HPCE with good repeatability. To assure the accuracy and precision of HPCE data, t-test was conducted with paired analytical data, which were experimentally constructed by analyzing standard solutions with HPCE and IC, respectively. T-test showed that there is no notable difference between the concentrations determined by the two analytical methods. Every ionic concentration in both cation and anion was found to be strong raindrop size dependence. Though there was slight increase of sodium and sulphate concentrations between 0.85 mm and 1.15 mm raindrop radius, it showed a strong decrease for every ionic component with increasing droplet radius. The combination of the frozen raindrop collection method and a commercially available HPCE can meet the need of size-resolved raindrops study.