• YAKHAK HOEJI
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• v.43 no.1
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• pp.77-84
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• 1999

To search for less toxic antiherpetic agents, the inhibitory effects of natural naringenin on the plaque formation of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in Vero cells were examined by the plaque reduction assay in vitro. Naringenin inhibited plaque formations of HSV-l and HSV-2 in a dose dependent manner. It also exhibited more potent antiherpetic activity on HSV-l with selectivity index (SI) of 19.1 than on HSV-2 with SI of 5.7 The combined antiherpetic effects of naringenin with nucleoside antiherpetic agents, acyclovir and vidarabine, were examined on the multiplication of these two strains of herpesviruses in Vero cells by the combination assay. The results of combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combinations of naringenin with acyclovir on HSV-l and HSV-2 showed more potent synergism with CI values of 0.28∼0.81 for 50%, 70%, 90% effective levels than those with vidarabine with CI values of 0.86-3.28.

• Journal of the Korea Fashion and Costume Design Association
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• v.16 no.2
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• pp.71-80
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• 2014

The purpose of this study was to investigate consumer evaluation on visual sensibility of stripe pattern shirts for separation coloration. The experimental materials developed for this study were a set of clothing stimuli and response scales. The clothing stimuli were 27 color pictures, in which separation color(white: W, gray: G, black: B), separation width(small: S, medium: M, large: L), and combination color(magenta and yellow: MY, magenta and cyan: MC, yellow and cyan: YC) were manipulated. The subjects of this research were female in their 20s to 30s living in Seoul, Gwangju, Daegu, Busan, and Changwon. The investigation was carried out at December 2013. The data were analyzed by using SPSS program. Analysis methods were factor analysis, ANOVA, and Duncan-test. Results of this study were as follow.; The factors of visual sensibility according to separation color, separation width, and combination color consisted of four dimensions of attractiveness, appeal, individuality freshness, and grace. Separation color showed an independent effect on appeal and individuality freshness. Combination color showed an independent effect on individuality freshness. Interaction effects of separation color and separation width on appeal were found. Interaction effects of separation color and combination color on individuality freshness and grace were found. The study results are highly expected to be used as useful sources in a fashion product.

• Journal of Animal Environmental Science
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• v.7 no.2
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• pp.119-126
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• 2001

For the odor test, it was chosen the conventional spreader, the hose spreader, and its combination with disk harrow and spring harrow as a slurry spreader. By the odor tester (Kalmor-$\sum$) with dairy slurry, the conventional spreader has the average $\sum$ value of 270, which means that one fells substantial odor and torment. In the cases of hose spreader and its combination with disk harrow, $\sum$ value was 217 and 182 respectively, which means a normal person does not smell any odor. Spreading the swine slurry with a conventional spreader shows $\sum$ value of 440, which means one feels unpleasant. The hose spreader shows $\sum$ value of 258, which lies in the limit one feels some odor and torment. Its combination with disk harrow has $\sum$ value 184, which means that a normal person can not smell any more. For the conventional spreader, the odor intensity indices from air dilution sensual test and 3 point odor bag as a sensual test were 66.9 and 35.4 respectively. On the other hand, the indices were 9.65 and 11.10 by hose spreader and its combination with disk harrow, which were lower than that of the regulation for industry. Therefore, the developed hose spreader showed an excellent effect on decreasing odor. The correlation between the results from odor tester and 3 point odor bag has shown 0.997 by swine slurry.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.3
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• pp.221-230
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• 2023

Diabetic kidney disease is one of the most serious complications of diabetes. Although diabetic kidney disease can be effectively controlled through strict blood glucose management and corresponding symptomatic treatment, these therapies cannot reduce its incidence in diabetic patients. The sodium-glucose cotransporter 2 (SGLT2) inhibitors and the traditional Chinese herb "Gegen" have been widely used in diabetes-related therapy. However, it remains unclear whether the combined use of these two kinds of medicines contributes to an increased curative effect on diabetic kidney disease. In this study, we examined this issue by evaluating the efficacy of the combination of puerarin, an active ingredient of Gegen, and canagliflozin, an SGLT2 inhibitor for a 12-week intervention using a mouse model of diabetes. The results indicated that the combination of puerarin and canagliflozin was superior to canagliflozin alone in improving the metabolic and renal function parameters of diabetic mice. Our findings suggested that the renoprotective effect of combined puerarin and canagliflozin in diabetic mice was achieved by reducing renal lipid accumulation. This study provides a new strategy for the clinical prevention and treatment of diabetic kidney disease. The puerarin and SGLT2 inhibitor combination therapy at the initial stage of diabetes may effectively delay the occurrence of diabetic kidney injury, and significantly alleviate the burden of renal lipotoxicity.

• Journal of the Korean Society of Physical Medicine
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• v.3 no.2
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• pp.103-112
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• 2008

Purpose : The Purpose of this study was to investigate the effects of taping and AMCT(activator methods chiropractic technique) on the pain and grip strength in patients with lateral epicondylitis. Methods : To study divided of three groups. Taping groups were apply to taping was attached from wrist joint to elbow joint lateral epicondly after maximun flexion. AMCT application was contact the posterior aspect of the proximal head of the radius. The line of drive is anterior and inferior. Next, contact the anterior aspect of the lunate by positioning the instrument on the volar aspect of the wrist. The line of drive is straight posterior. combination groups was treated using the taping and AMCT application. Result : 1. The pain was decreased on taping groups, AMCT groups and combination groups of all(p<.05). 2. Power grip was enhanced in taping groups, AMCT and combination groups(p<.05). but taping, AMCT, combination groups was no difference compared with after 1 week therapy(p>.05). 3. Compared with AMCT and taping therapy about pain decreased was AMCT groups better than taping groups(p<.05). 4. Compared with AMCT and taping therapy about power grip was AMCT groups better than taping groups(p<.05). 5. AMCT and combination groups was no difference compared with pain release and power grip after therapy(p>.05). Conclusion : AMCT groups therapy are more effect able than taping therapy for grip strength and pain reduction. Hence, AMCT groups therapy is most effect able for pain reduction with lateral epicondylitis patients.

• The Journal of Industrial Distribution & Business
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• v.11 no.10
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• pp.75-89
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• 2020

Purpose: The container terminal is an area that plays an important role in the country's import and export. As the volume of containers increased worldwide, competition between terminals became fiercer, and increasing the productivity of terminals became more important. Re-handling is a serious obstacle that lowers the productivity of terminal. There are two ways to reduce re-handling in the terminal yard. The first method is to load containers in terminal yards using effective carry-in algorithms that reduce re-handling. The second method is to carry out effective remarshalling. In this paper, the performance of various carry-in algorithms and various remarshalling algorithms are reviewed. Next, we try to find the most effective combination of carry-in algorithm and remarshalling algorithm. Research design, data and methodology: In this paper, we analyze the performance of the four carry-in algorithms, AP, MDF, LVF, RP and the four remarshalling algorithms, ASI, ASI+, ASO, ASO+. And after making all the combinations of carry-in algorithms and remarshalling algorithms, we compare their performance to find the best combination. To that end, many experiments are conducted with eight types of 100 bays through simulation. Results: The results of experiments showed that AP was effective among the carry-in algorithms and ASO+ was effective among remarshalling algorithms. In the case of the LVF algorithm, the effect of carrying in was bad, but it was found to be effective in finding remarshalling solution. And we could see that ASI+ and ASO+, algorithms that carry out remarshalling even if they fail to find remarshalling solution, are also more effective than ASI and ASO. And among the combinations of carry-in algorithms and remarshalling algorithms, we could see that the combination of AP algorithm and ASO+ algorithm was the most effective combination. Conclusion: We compared the performance of the carry-in algorithms and the remarshalling algorithms and the performance of their combination. Since the performance of the container yard has a significant effect on the performance of the entire container terminal, it is believed that the results of this experiment will be effective in improving the performance of the container terminal when carrying-in or when remarshalling.

• Fashion & Textile Research Journal
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• v.10 no.6
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• pp.1051-1057
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• 2008

Safflower red and Amur Cork Tree dyes have used for dyeing on cotton fabrics largely. But they have low degree of lightfastness, So this study investigated the effect of BTCA pre-treatment on lightfastness of cotton fabrics dyed with Safflower red and Amur Cork Tree. The result is as the following; By FT-IR spectra, crosslingking was proved in cotton fabric pre treated with BTCA. K/S value of Safflower red dyed cotton fabric pretreated with BTCA was much more decreased than untreated cotton fabric with BTCA. It showed that the hue of the Safflower red dyed cotton fabric changed from reddish purple to red. However, K/S value of Amur Cork Tree dyed cotton fabric pre treated with BTCA was much more increased than untreated cotton fabric with BTCA. It showed that the hue of the Amur Cork Tree dyed cotton fabric changed from green yellow to yellow. For K/S value of Combination dyed cotton fabric pre treated with BTCA, Safflower red color was much more decreased than untreated cotton fabric. But Amur Cork Tree color was much more increased than untreated cotton fabric. It changed from reddish purple, red, yellowe red, to yellow in hue. ${{\Delta}E^*}_{ab}$ of Combination dyed cotton fabric in 40 hours irradiation was 15.7, however ${{\Delta}E^*}_{ab}$ of Combination dyed cotton fabric treated with 2% BTCA was 8.0, and that treated with 3% BTCA was 9.8. So, pre-treatment with BTCA to combination dyed cotton fabric with Safflower red and Amur Cork Tree showed more effective improvement of Lightfastness than untreated cotton fabric with BTCA.

• Journal of Pharmacopuncture
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• v.26 no.4
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• pp.298-306
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• 2023

Objectives: Cucumis sativus L. (C. sativus) is vegetable commonly used for managing blood pressure and often consumed in combination with standard antihypertensive therapy, despite lack of scientific evidence supporting their use. Combination of herbs and standard medication could have positive or negative effects. Therefore, this study aimed to evaluate the antihypertensive activity of C. sativus and the combined effect with losartan in the hypertensive rat model induced by angiotensin II. Angiotensin II is a component of the renin-angiotensin-aldosterone system that, upon binding to its receptor, constricts blood vessels leading to elevation of blood pressure. Methods: In an antihypertensive study, rats received C. sativus orally at doses of 9, 18, 27, and 36 mg/kg (full dose); while in a combination study, animals received losartan 2.25 mg/kg combined by either with C. sativus 9 or 18 mg/kg. The standards group received losartan 2.25 mg/kg or 4.5 mg/kg (full dose). Results: Blood pressure was measured using the tail-cuff method. C. sativus significantly attenuated angiotensin II-induced hypertension as observed in groups receiving C. sativus at 9, 18, 27, and 36 mg/kg at 30 minutes after induction showed the average change (Δ) of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with respect to time zero were 28.8/18.3, 24.8/15.8, 22.8/15.5, and 11.5/9.0 mmHg, respectively. Whereas the average change (Δ) of SBP and DBP in the rats receiving the combination of half doses of C. sativus and losartan were 8.8/9.0 mmHg, respectively. These diminished effects were better than a full dose of C. sativus and comparable with a full dose of losartan (6.5/7.8 mmHg). Conclusion: The present findings indicate that C. sativus dose-dependently blocks blood pressure elevation induced by angiotensin II. The combination of half dose of C. sativus and losartan has an additive effect in lowering blood pressure.

• Journal of Periodontal and Implant Science
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• v.24 no.3
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• pp.572-580
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• 1994

The purpose of the present study was to evaluate the effect of platelet - derived growth factor(PDGF) - BB and insulin - like growth factor(IGF) - 1, Centella Asiatica, and Zea Mays L. on the mitogenic activity of PDL cells from healthy and RPP patients. Combination of PDGF - BB and IGF - 1, Centella Asiatica, and Zea Mays L. were treated on PDL cells and the mitogenic effects were meaured by quantitative assay of methyl - $^3H$ - thymidine incorporation during DNA synthesis. Combination of PDGF - BB and IGF - 1 enhenced the mitogenic effects of both healthy and RPP PDL cells, however, the effect was less pronounced on RPP PDL cells. In cases of Centella Asiatica and Zea Mays L., no mitogenic effect on healthy PDL cells could be noticed.

• International Journal of Concrete Structures and Materials
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• v.10 no.1
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• pp.113-124
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• 2016

This paper presents the effect of silica fume and nano silica, used individually and in combination with the set accelerator and/or hydrated lime, on the properties of class F high volume ultra fine fly ash (HV-UFFA) cement composites, replacing 80 % of cement (OPC). Compressive strength test along with thermogravimetric analysis, X-ray diffraction and scanning electron microscopy were undertaken to study the effect of various elements on the physico-chemical behaviour of the blended composites. The results show that silica fume when used in combination with the set accelerator and hydrated lime in HV-UFFA cement mortar, improves its 7 and 28 day strength by 273 and 413 %, respectively, compared to the binary blended cement fly ash mortar. On the contrary, when nano silica is used in combination with set accelerator and hydrated lime in HV-UFFA cement mortar, the disjoining pressure in conjunction with the self-desiccation effect induces high early age micro cracking, resulting in hindering the development of compressive strength. However, when nano silica is used without the additives, it improves the 7 and 28 day strengths of HV-UFFA cement mortar by 918 and 567 %, respectively and the compressive strengths are comparable to that of OPC.