• Journal of the Korean Society of Clothing and Textiles
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• v.38 no.3
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• pp.415-426
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• 2014

This study investigated the color change, enhancement of dye uptake, washing fastness, and light fastness of cotton and silk when dyed with Juniperus chinensis and Terminalia chebula (combination dyeing) using various methods. The dyeing methods were 1) dyeing Juniperus chinensis extract and Terminalia chebula Retzius extract sequentially (J-T), 2) dyeing Terminalia chebula Retzius extract and Juniperus chinensis extract sequentially (T-J), 3) dyeing Juniperus chinensis extract and Terminalia chebula Retzius extract simultaneously (J+T), and 4) dyeing Juniperus chinensis extract 4 times repeatedly and followed by a dyeing Terminalia chebula Retzius extract in sequence. In terms of increased dyeing uptake, combination dyeing (dyeing 2 times like method 1, 2, 3) had the same impact as the repeated dyeing (method 4). The color of J, T combination dyeing showed wide range of mixed YR series, Y series resulting from Terminalia chebula Retzius, and R series resulting from Juniperus chinensis. In cotton, J-T dyeing method showed superior enhancement of dye uptake, and T-J method in silk. In both of the cases, Y series color from Terminalia chebula Retzius extract was mainly shown (Y series color was superior to R series color after dyeing). Therefore, it is recommended for cotton to implement T-J method and for silk to implement J-T method in order to enhance both dyeing uptake and emphasize the color of R series. The K/S value of combination dyed fabrics was decreased by increasing washing time; however, the K/S value of combination dyed fabrics was increased by increasing UV irradiation time. But after repeated washing and longer UV irradiation, ${\Delta}E$ value of combination dyed fabric became smaller compared to fabric dyed with Juniperus chinensis only. Thus, it was found that after J, T combination dyeing, fabric became less prone to fading by washing and UV than after Juniperus chinensis single dyeing was done.

• Korean Journal of Acupuncture
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• v.35 no.1
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• pp.27-35
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• 2018

Objectives : The purpose of this study was to investigate the analgesic effect of electroacupuncture(EA) and radio-frequency warm needling(RFWN) stimulation in acupoint combination on ankle sprained pain in rats. Methods : The lateral ligaments of the Sprague-Dawley rats ankle were injured surgically resulting in sprain, of which was divided into EA, RFWN treatment groups and control group without treatment. The level of pain was measured through foot weight bearing force ratio followed by calculating pain relief. To stimulate proximal or distal area in ankle sprain, combination of proximal acupoints(GB34-GB39) and distal acupoints(GB39-GB42) from sprain area were applied, respectively, to either EA or RFWN stimulation. In addition, naltrexone or phentolamine was injected intraperitoneally before the stimulation to observe the pathway of analgesic effects. Results : In the proximal combination of GB34-GB39, EA and RFWN significantly increased pain relief compared to the control group (p<0.05). However, in distal combination with GB39-GB42, both EA and RFWN stimulation did not relieve pain due to ankle sprains. In the combination of GB34-GB39, the analgesia of EA was inhibited by blockade of the ${\alpha}$-adrenoceptor receptor. The analgesia of RFWN was inhibited by blockade of the ${\alpha}$-adrenoceptor receptor as well as ${\mu}$-opioid receptor. Conclusions : We observed that the proximal combination was effective in relieving pain when the treatment by acupoint combination was applied to the ankle sprain pain. Also, it was confirmed that this analgesia was also related to the pathways of ${\mu}$-opioid receptors and/or ${\alpha}$-adrenoceptors.

• Journal of Korea Water Resources Association
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• v.42 no.3
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• pp.201-212
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• 2009

The Tank model and the PRMS(Precipitation Runoff Modeling-modular System) model have been adopted to simulate runoff data from 1981 to 2001 year in the Seomgin-dam basin. However, the simulated runoff by each single model showed some deviations compared with the observed runoff, respectively. In this study a genetic algorithm combination runoff model has been proposed to minimize deviations between simulated runoff and observed runoff that should yield from single model such as Tank model or PRMS model. The proposed combination runoff model combining the simulated respective output of the Tank model and the PRMS model is to produce the optimum combination ratio of each single model applying to the genetic algorithm which may yield the minimum deviations between simulated runoff and observed one. The proposed combination runoff model has been applied to the Seomgin-dam basin. It has also been shown that the combination model by introducing optimal combination ratio should yield less deviations than single model such as the Tank model or the PRMS model.

• Biomolecules & Therapeutics
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• v.28 no.5
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• pp.473-481
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• 2020

Axl receptor tyrosine kinase has been implicated in cancer progression, invasion, and metastasis in various cancer types. Axl overexpression has been observed in many cancers, and selective inhibitors of Axl, including R428, may be promising therapeutic agents for several human cancers, such as breast, lung, and pancreatic cancers. Here, we examined the cell growth inhibition mediated by R428 and auranofin individually as well as in combination in the human breast cancer cell lines MCF-7 and MDA-MB-231 to identify new advanced combination treatments for human breast cancer. Our data showed that combination therapy with R428 and auranofin markedly inhibited cancer cell proliferation. Isobologram analyses of these cells indicated a clear synergism between R428 and auranofin with a combination index value of 0.73. The combination treatment promoted apoptosis as indicated by caspase 3 activation and poly (ADP-ribose) polymerase cleavage. Cancer cell migration was also significantly inhibited by this combination treatment. Moreover, we found that combination therapy significantly increased the expression level of Bax, a mitochondrial proapoptotic factor, but decreased that of the X-linked inhibitor of apoptosis protein. Furthermore, the suppression of cell viability and induction of Bax expression by the combination treatment were recovered by treatment with N-acetylcysteine. In conclusion, our data demonstrated that combined treatment with R428 and auranofin synergistically induced apoptosis in human breast cancer cells and may thus serve as a novel and valuable approach for cancer therapy.

• Korean Journal of Clinical Pharmacy
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• v.32 no.1
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• pp.13-19
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• 2022

Background: The use of combination therapy and fixed-dose combination therapy is increasing for the treatment of type 2 diabetes. Sodium glucose cotransporter-2 inhibitor (SGLT2i) is a drug class used in combination with metformin. Methods: Type 2 diabetes patients on SGLT2i/metformin combination therapy were extracted from the 2019 Health Insurance Review & Assessment Service-National Patients Sample. On July 1, 2019, SGLT2i and metformin fixed-dose combination (SGLT2i/metformin FDC) and two-pill combination (TPC) groups were identified, and a chi-square test and multiple logistic regression were performed. Results: Of total 2,992 patients, 1,077 (36%) were prescribed SGLT2i/metformin FDC and 1,915 (64%) were prescribed TPC. We found that the most common comorbidities were in the order of dyslipidemia, gastrointestinal disease, and hypertension. Multiple logistic regression analysis showed that the use of SGLT2i/metformin FDC was lower than TPC in patients with diabetic neuropathy (OR=0.76, p=0.008). Clinic (OR=2.09, p<0.001) and general hospital (OR=1.40, p=0.019) showed higher tendency to prescribe SGLT2i/metformin FDC compared to tertiary hospital. The tendency of prescribing SGLT2i/metformin FDC was lower in Kyeonggi (OR=0.79, p=0.037), Gyeongsang (OR=0.77, p=0.025) and Chungcheong (OR=0.68, p=0.007) than Seoul. Conclusion: Factors related to the use of SGLT2i/metformin FDC in patients with type 2 diabetes were complication, medical institution and region. The tendency to prescribe SGLT2i/metformin FDC was relatively higher in clinics than in tertiary general hospitals and in Seoul than in other regions.

• Journal of the Korean Society of Safety
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• v.20 no.2 s.70
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• pp.38-43
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• 2005

Several nuclear power plants reported that they often found the combination cracks, which consist of longitudinal and circumferential cracks in the tubes. For the burst pressure of a tube with a single longitudinal or circumferential crack several experimental equations have been proposed in published literatures. But for the combination crack appropriate fracture criterion has not been proposed yet. In this study the burst pressures of a tube with a longitudinal crack or a T-type combination crack consisting of longitudinal and circumferential cracks were obtained experimentally and analytically. Fracture parameters such as crack opening angle (COA) were investigated by using elastic plastic analysis. Also the burst pressure far a T-type combination crack located near a tubesheet was considered to develop a length-based criterion. Because most of the axial, circumferential or combination cracks initiate in roll transition zone near the tubesheet.

• Korean Institute of Interior Design Journal
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• no.34
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• pp.114-123
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• 2002

Koreans have regarded the red as a major color from old times. The red is a traditional color to have symbols of high position, national foundation and especially royalty. So, we can see the reds in the palace for kings very much.The purpose of this study is to draw out the features of color red in the Kyungbok palace. The color was analyzed by two categories-architectural buildings${\cdot}$structures and ornamental painted patterns. The major findings from this research are summarized as follows:1. Seokganju(similar to terra rossa) and toyugsaek(light seokganju) are found main colors in architectural space, while seokganju has a linear effect and toyuk has a facial effect. 2. Yugsaek(similar to light vermillion) and Jangdan(similar to orange) are found main colors in ornamental painted patterns. These colors are more vivid and brighter than those for architectural space.3. As for two-color combination, reds and blues(including greens) are found major combination both of architectural space and ornamental patterns. And reds and white are the following combination, which gives an bright image by white. 4. As for three-color combination, red-white-black combination of pediment and red-blue-white combination of openings are found very popular in architectural space, while red-blue-yellow combination is most popular in ornamental patterns.The reds are found dominant color of both architectural space and ornamental patterns in the Kyungbok palace. The color design as shown in the Kyungbok palace can be considered as the feature of traditional color design.

• Journal of the Korean Society of Physical Medicine
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• v.7 no.1
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• pp.1-9
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• 2012

Purpose : This study aimed to compare the effect of two modes (proprioceptive neuromuscular facilitation combination patterns and ball exercise) of low back stability for chronic low back patients. Methods : The subjects were recruited fourty patients who had low back pain. All subjects were randomly assigned to PNF combination patterns group, ball exercise group. Measurements were performed fourtimes: pre test, 2weeks, 4weeks, and 6weeks. Main outcome measures comprised the visual analogue scale(VAS), balance performance monitor(BPM). Results : The results were as follows. In the comparison of VAS score, sway area, sway path, and sway velocity according treatment period, score was significantly reduced in both PNF combination pattern group and ball exercise group. In the comparison of the both VAS and sway area between groups, there were significant. PNF combination pattern group significantly more decrease than ball exercise group at 6 weeks. However, both sway path and sway max velocity between group, there were not significantly. Conclusion : These results of this study indicated that PNF combination pattern which performed for six weeks had a significant influence than ball exercise group on low back pain.

• Korean Management Science Review
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• v.25 no.3
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• pp.101-122
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• 2008

A wide variety of convergent digital products are emerging through the combination of multiple independent digital technologies. Digital convergence provides new revenue sources for businesses and new ways of satisfying individual needs of consumers. Despite its business and consumer implications, little research has addressed how people perceive or evaluate convergent products. This study aims at understanding how consumers interpret and evaluate convergent digital products by conducting two consecutive studies. Firstly, a survey was conducted to understand how people interpret convergent products in three ways suggested by the conceptual combination theory based in cognitive science. Secondly, an experiment was conducted to investigate the impact of combination strategies and product similarities on user evaluation of convergent products. Study results indicate that similarity of constituent products has a substantial effect on the interpretation of concept combination strategies. Moreover, combination strategy and product similarity were found to have substantial effects on user comprehension, perceived newness, and preferences for convergent products. This paper ends with an examination of the implications and limitations of the study results.

• Biomolecules & Therapeutics
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• v.10 no.4
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• pp.236-239
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• 2002

The goal of this study was to evaluate the antidiarrheal efficacy of $Lacteol^{TM}$-loperamide combination against the mouse model of secretory diarrhea. Secretory dirrhea was induced in mice by p.o. administration of castor oil (0.3 ml). Antidirrheal effects of $Lacteol^{TM}$-loperamide combination were compared with each individual component. $Lacteol^{TM}$-loperamide combination was the most potent among these agents, eliminating diarrhea in 100% of mice at a dose 1360/4 mg/kg (Lacteol/loperamide, respectively). In this study, we also measured changes of bodyweight as another indicator of the dirrhea, based on the assumption that lower bodyweight loss represented reduced fecal passage. The bodyweight loss of $Lacteol^{TM}$-loperamide combination administered group was 4 times lower than that of vehicle control. These findings indicate that $Lacteol^{TM}$-loperamide combination may be more potent than individual component in its antidiarrheal action, so we are going to challenge this combination for further study and clinical evaluation.