• 대한유전성대사질환학회지
• /
• 제14권1호
• /
• pp.10-18
• /
• 2014

Recent advances in the diagnosis and treatment of inborn errors of metabolism have improved substantially the prognosis of many of these diseases, if diagnosed early enough before irreversible damage occurs. This makes it essential that the practicing pediatrician, especially neonatologists be familliar with the clinical presentations and systematic approaches of these disorders. Characteristic clinical presentations, methods of systematic approach and typing of various disorders is discussed in this review. The signs of neurological dysfunctions of many IEMs manifesting in the neonatal period is very nonspecific, such as poor feeding, poor sucking, apnea or tachypnea, vomiting, hypertonia, hypotonia, seizure, letharginess, consciousness change and coma. Many other non-metabolic severe disorders of neonatal period such as neonatal sepsis and intracerebral hemorrhage share these nonspecific symptoms. Hyperammonemia, metabolic acidosis, ketosis and hyperlatic acidemia are observed in many of these conditions but there are exceptions in which conditions all basal laboratory tests are normal, such as NKH, sulfite oxidase deficiency and peroxisomal disorders. According to the results of basal laboratory tests, IEMs in the neonatal period can be categorized in to 6 types. Grouping of IEMs into 6 types will make confirmatory tests and early emergency treatment more efficient.

• 한국광학회지
• /
• 제4권3호
• /
• pp.243-251
• /
• 1993

두개의 모듈(module)로서 이루어진 telephoto형 망원경 대물렌즈의 각각의 모듈에 대해 Seidel 1차 수차중 구면수차계수와 코마계수를 영으로 하고, 또 종색수차계수를 영으로 하는 조건을 Gauss괄호를 써서 표현하고, 이어서 이들 연립방정식의 해를 구함으로서 눈으로 직접 관찰하는데 쓰이는 조준용광학계의 최초설계가 유도되었다. 이어서 눈의 분해능에 걸맞게 최적화 수치계산을 수행하여서 최종설계를 얻었다. Aplanat조건을 만족하고 색수차가 제거된 이 telephoto 형 망원경 대물렌즈의 f/${\sharp} 와 half field angle은 각각 8.5, 0.$3^{\circ}$이고 초점거리와 telephoto ratios 는 각각 30cm, 0.839이었다.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제20권1호
• /
• pp.61-64
• /
• 2017

Recurrent acute pancreatic attacks is a rare clinical condition (2-5% of all acute pancreatis) in children and is mainly idiopathic in most cases. Sometimes it may be associated with congenital anomalies, metabolic diseases or hereditary conditions. Isovaleric acidemia (IVA) is a rare autosomal recessive amino acid metabolism disorder associated with isovaleryl coenzyme A dehydrogenase deficiency presenting the clinical findings such metabolic acidosis with increased anion gap, hyperammonemia, ketonemia, hypoglycemia, "the odor of sweaty feet," abdominal pain, vomiting, feeding intolerance, shock and coma. Recurrent acute pancreatitis associated with IVA have been rarely reported. Herein; we report a child who admitted with recurrent acute pancreatic attacks and had the final diagnosis of IVA. Mutation analysis revealed a novel homozygous mutation of (p.E117K [c.349G>A]) in the IVA gene. Organic acidemias must kept in mind in the differential diagnosis of recurrent acute pancreatic attacks in children.

• 대한수의학회지
• /
• 제34권2호
• /
• pp.339-347
• /
• 1994

This study was carried out to investigate the pathological changes with paraquat(1.1'-dimethyl-4.4'-dipyrildiylium dichloride) administered by intraperitoneally, orally, skin applied in mice, rats and rabbits. Results were obtained as follows; In 2 days after paraquat administration clinical signs anorexia, depression, tachypnea, and tachycardia, respiratory failure, coma and death were observed in mice, rats and rabbits. Compared toxicity of paraquat with mouse were observed toward to paraquat that resistance was strong than rats and rabbits. Also, mortality of skin application were found the low than intraperitoneal and high than oral administration. In the case of gross observation were appear lips moisture in orally administered rats and rabbits by skin application. Lung of all laboratory animals were observed congestion and haemorrhage, swelling or atrophy. In the case of microscopic findings were severe congestion and haemorrhage, interstitial pneumonia of lung. Congestion and haemorrhage of liver, congestion and haemorrhage, renal tubule epithelium necrosis of kidney were observed in mice, rats and rabbits. Skin application group of mice, rats and rabbits showed infiltration of inflammatory cells and folliculitis of epidermis and dermis. Also, in oral administration group showed congestion and haemorrhage, tachment, necrosis of alimentary tract mucosa.

• 한국치위생학회지
• /
• 제15권1호
• /
• pp.147-152
• /
• 2015

Objectives: The purpose of this study was to investigate the oral health and hygiene in the neurosurgical patients in intensive care unit(ICU). Methods: The subjects were 92 neurosurgical patients in intensive care unit(ICU) from March, 2011 to December, 2012. The oral examination consisted of number of residual teeth, DMFT index, clinical attachment loss, gingival index, plague index, and Candida species colony of tongue and saliva. Plaque was inoculated from tongue and saliva and incubated in 36.5C incubator for 48 hours using $Dentocult^{(R)}$ CA(Orion Diagnostica, Espoo, Finland). Glasgow coma scale(GCS) was measured to evaluate the consciousness of the patients on the basis of medical record. Results: Oral health was poor in clinical attachment loss and gingival index. Oral hygiene in neurosurgical patients in ICU was very poor due to high plaque index and Candida colonization of tongue and saliva. Plague index was closely related to Candida colonization of tongue and saliva(p<0.05). Conclusions: Oral health and hygiene of patients in neurosurgical ICU were very poor. More careful oral hygiene care is very important and necessary to enhance the oral health improvement of the neurosurgical patients in ICU.

• 한국통신학회논문지
• /
• 제29권3A호
• /
• pp.248-256
• /
• 2004

Woerner는 비동기 트레리스 부호화 DS/COMA (asynchronous treilis-coded DS/CDMA systems, A-TC-CDMA) 시스템에 낮은 상관도의 다중 시퀀스 시그날링인 배직교 시퀀스 (biorthogonal sequence)를 이용함으로써 단일 시퀀스 시그날링인 M-ary PSK에 비해 보다 개선된 시스템 성능을 얻을 수 있음을 보여주었다. 본 논문에서는 최근 기 제안된 다중 시퀀스 시그날링 방식인 OPSM (orthogonal plane sequence modulation)과 배직교 시퀀스를 이용한 비동기 트레리스 부호화 CDMA 시스템 성능을 상호 비교 분석한다. 가입자 수신신호의 상호간섭 랜덤변수의 모멘트를 유도하고 그 결과 배직교 시퀀스 시그날링 방식에 비해 적은 수의 심볼당 시퀀스를 갖는 OPSM(orthogonal plane sequence modulation)이 시퀀스간 낮은 상호상관도 특성을 가짐을 보여준다. 또한 컴퓨터 시뮬레이션을 통하여 다중 시퀀스 시그날링 비동기 트레리스 시스템의 전력 효율 및 스펙트럼 효율을 비교 검증한다.

• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 2002년도 춘계공동학술발표회요약집
• /
• pp.242-242
• /
• 2002

Two MIMAS MaX fuel rods base-irradiated in a commercial PWR have been reinstrumented and irradiated at a test reactor. The fabrication data for two MOX roda are characterized together with base irradiation information. Both Rods were reinstrumented to be fitted with thermocouple to measure centerline temperature of fuel. One rod was equipped with pressure transducer for rod internal pressure whereas the other with cladding elongation detector. The post irradiation examinations for various items were performed to determine fuel and cladding in-pile behavior after base irradiation. By using well characterized fabrication and re-instrumentation data and power history, the fuel performance code, COSMOS, is verified with measured in-pile and PIE information. The COMaS code shows good agreement for the cladding oxidation and creep, and fission gas release when compared with PIE dad a after base irradiaton. Based on the re-instrumention information and power history measured in-pile, the COSMOS predicts re-instrumented in-pile thermal behaviour during power up-ramp and steady operation with acceptable accuracy. The rod internal pressure is also well simulated by COSMOS code. Therfore, with all the other verification by COSMOS code up to now, it can be concluded that COSMOS fuel performance code is applicable for the design and license for MaX fuel rods up to high burnup.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
• /
• 한국우주과학회 2009년도 한국우주과학회보 제18권2호
• /
• pp.35.2-35.2
• /
• 2009

One possible channel for the formation of dwarf galaxies involves birth in the tidal tails of interacting galaxies. We report the detection of a bright UV tidal tail and several young tidal dwarf galaxy candidates in the post-merger galaxy NGC 4922 in the Coma cluster. Based on a two-component population model (combining young and old stellar populations), we find that its light predominantly comes from young stars (a few Myr old). The Galaxy Evolution Explorer (GALEX) ultraviolet data played a critical role in the parameter (age and mass) estimation. Our stellar mass estimates of the tidal dwarf galaxy candidates are ~10^{6-7} M_sun, typical for dwarf galaxies.

• 한국동물위생학회지
• /
• 제31권1호
• /
• pp.37-42
• /
• 2008

Riemerellosis, contagious disease of domestic ducks in Korea, occurred in December of 2007 in a farm located in Eumsung, Chungbuk province. The affected ducks were 22 days old and the owner reported that almost one hundred of ducks had died everyday for a few days after infection. Clinical signs were listlessness, ocular and nasal discharge, greenish diarrhea, ataxia, tremor of head and legs, and coma. On necropsy we found fibrinous exudate, which involved serosal surfaces in general, but most evidences were in the pericardial cavity and over the surface of the liver. The causative agent was isolated from the liver of the affected ducks and identified as Riemerella anatipestifer using biochemical tests. Also, the isolate was susceptible to ampicillin, cephalothin, sulfamethazole/trimethoprim, Florfenicol among the 23 species antibiotics (AST Discs, OXOID) used in our laboratory. Further studies should be needed for the more effective control and better epidemiological information such as pathogenicity, serotype, genotype and treatment.

• 혜화의학회지
• /
• 제8권1호
• /
• pp.425-449
• /
• 1999

For the evaluation of the effect on SWS, experiments were made on hyperlipidemia induced by hypercholesterol diet, inhibitory reaction to human platelet aggregation, Pulmonary thrombosis induced by collagen and epinephrine, global cerebral ischemia induced by KCN, brain ischemia induced by MCA occlusion, cytotoxicity of PC12 cells induced by amyloid ${\beta}$ protein(25-35), and NO production in RAW cells stimulated by lipopolysaccharide. The results were obtained as follows : 1. In the experiment on hyperlipidemia, the level of serum total cholesterol, phospholipid, and LDL-cholesterol were significantly decreased while the level of triglyceride, VLDL-cholesterol, and HDL-cholesterol had no significant change. 2. In the experiment on inhibitory reaction to platelet aggregation, SWS inhibited platelet aggregation induced by ADP(36.05%), by collagen(20.4%), and by thrombin(0.6%). 3. In the experiment on pulmonary thrombosis induced by collagen and epinephrine, the protective effect was found(37%). 4. In the experiment on global cerebral ischemia, coma duration induced by KCN changed insignificantly. 5. In the experiment on MCA occlusion, the change of neurologic grades on hind limb was significant only after the operation. Besides brain ischemic area and edema ratio were significantly decreased. 6. In the experiment on cytotoxicity of PC 12 cells induced by amyloid ${\beta}$ protein, the significant protective effect was found as concentration increases. 7. In the experiment on NO production in RAW cells stimulated by lipopolysaccharide, NO was significantly decreased. According to the results, it is expected that SWS might be effective on hyperlipidemia and brain damage.