• Title/Summary/Keyword: colloidal

Search Result 1,005, Processing Time 0.036 seconds

Measurement of Normal Spring Constant of Colloidal Probes for Atomic Force Microscope (원자 현미경용 콜로이드 탐침 수직 스프링 상수 측정)

  • Kim, Dae-Hyun;Kim, Min-Seok;Hahn, Junhee;Ahn, Hyo-Sok
    • Tribology and Lubricants
    • /
    • v.28 no.5
    • /
    • pp.212-217
    • /
    • 2012
  • A modified thermal noise method was proposed to measure the normal spring constants of the colloidal probes for an atomic force microscope. We used commercial tipless cantilevers (length 150, width 30, nominal k 7.4 N/m) and borosilicate spheres with a diameter of 20 to fabricate colloidal probes. The inverse optical lever sensitivity of both the tipless cantilever and colloidal probes were used to measure the normal spring constant of the colloidal probes. We confirmed the accuracy and usefulness of our method by comparing the measurement results with those obtained using the nanoforce calibrator (NFC), which reportedly has an uncertainty of 1.00%. The modified thermal method showed a good agreement (~10% difference) with the NFC, allowing us to conclude that the modified thermal method could be employed for the effective measurement of the normal spring constants of colloidal probes.

Fabrication and Evaluation of Colloidal Silica Containing Powders for Solid Self-emulsifying Drug Delivery System of Poorly Water Soluble Rivaroxaban (난용성 리바록사반 약물의 자가 유화 시스템 분말 제조를 위한 콜로이드 실리카 함유 분말의 제조 및 평가)

  • Sung Giu Jin
    • Journal of Powder Materials
    • /
    • v.30 no.4
    • /
    • pp.305-309
    • /
    • 2023
  • This study aims to prepare a colloidal silica-containing powder to enhance the solubility and dissolution rate of rivaroxaban using a self-nanoemulsifying drug delivery system (SNEDDS). We investigate the impact of colloidal silica on a nanoemulsion system for preparing powdered SNEDDS. The liquid SNEDDS comprises 30/20/50 (w/w/w) Peceol/Cremophor RH40/Tween 80, which results in the formation of the smallest droplets. Three powdered SNEDDS formulations are prepared by suspending the liquid SNEDDS formulation using colloidal silica and spray drying. The powdered SNEDDS prepared with liquid SNEDDS and colloidal silica at a ratio of 1/0.5 (w/w) exhibits the highest water solubility (0.94 ± 0.62 vs. 26.70 ± 1.81 ㎍/mL) and dissolution rate (38.4 ± 3.6 vs. 85.5 ± 3.4%, 45 min) when compared to the drug alone. Morphologically, the liquid SNEDDS is adsorbed onto colloidal silica and forms smaller particles. In conclusion, an SNEDDS containing rivaroxaban, prepared using colloidal silica, facilitates the creation of a nanoemulsion and enhances the water solubility of rivaroxaban. Accordingly, this technology holds significant potential for commercialization.

Colloidal Crystallization in Microgravity

  • Okubo, Tsuneo
    • Proceedings of the Korean Fiber Society Conference
    • /
    • 2003.10a
    • /
    • pp.5-6
    • /
    • 2003
  • Kinetic study on the colloidal crystallization of single component and mixture of different sizes or densities of spheres was made in the exhaustively deionized suspensions and in microgravity, and compared with the results in normal gravity. Colloidal crystallization rates were retarded in microgravity for single component of spheres, whereas rates of alloy crystallization were enhanced substantially in microgravity. The rotational diffusion coefficients of colloids and the formation reaction rates of colloidal silica spheres were also studied in microgravity.

  • PDF

Characteristics Evaluation of Thin Films Formed on Mg-Al Alloy in Various Chemical Conversion Solution Conditions (다양한 화성처리 용액 조건에서 마그네슘-알루미늄 합금위에 형성된 박막의 특성 평가)

  • Jang Seok-Ki;Kim Seong-Jong;Kim Jeong-Il
    • Journal of Advanced Marine Engineering and Technology
    • /
    • v.29 no.1
    • /
    • pp.98-106
    • /
    • 2005
  • The chemical conversion film formed on magnesium alloy was investigated by using the colloidal silica with some parameters such as solution pH. temperature, solution conditions, and treatment time. Moreover. the solutions consisted of colloidal silica titanium sulfate, and cobalt ions were used for the colloidal silica film to having a good corrosion resistance and adhesion properties. It was thought that the film at 298K was made with combination of Si-O. The quantity of film formed at high temperature such as 333K and 353K is smaller than dissolved quantity during chemical conversion treatment. Adding $CoSO_4$ to the colloidal silica solution enhanced the adhesion force between the silica film and magnesium substrate, The optimum conditions for the chemical conversion treatment solution were PH 2.90 s treatment, and 298K.

The Control of Anti-slip Characteristics of Packaging Paper Using Nano-colloidal Silica (나노 콜로이달 실리카를 이용한 포장용지의 미끄럼특성 제어)

  • Lee, Won-No;Kim, Hyoung-Jin
    • Journal of Korea Technical Association of The Pulp and Paper Industry
    • /
    • v.37 no.3
    • /
    • pp.33-40
    • /
    • 2005
  • In this study, a nano-colloidal silica sol was applied to control the anti-slip property by spraying on kraft paper. Two kinds of nano-colloidal silica sol which have cationic and anionic charge were applied in kraft paper, and the friction and physical strength properties of kraft paper were investigated. The application of colloidal silica sol on wet web in wet-end process by spraying method was tried to improve the friction property and to avoid the general problems of machine contaminations caused by the scattering of sprayed silica particles in dryer part. The physical properties of sheet were also improved by the application of wet web spraying method, and the optimum conditions of wet web spraying operation were closely related with the conditions of pH and electrical charge of wet web and silica sol.

Retention and Drainage Characteristics of Compozil System and Impact of Cationic Corn Starch for its Improvement (콤포질 시스템의 보류 및 탈수특성과 양성 옥수수전분을 이용한 성능 개선)

  • 이학래;김태영;윤혜정
    • Journal of Korea Technical Association of The Pulp and Paper Industry
    • /
    • v.30 no.2
    • /
    • pp.30-39
    • /
    • 1998
  • Effect of cationic starches and anionic colloidal silica on retention and drainage characteristics of Compozil system was investigated. Depending upon the degree of substitution and molecular weight of cationic starches and morphological characteristics of anionic colloidal silica, retention and drainage properties of Compozil system were significantly influenced. When cationic starch addition level increased above a certain limit retention and stock freeness were decreased. To elucidate this an electrostatic coagulation mechanism occurring between unadsorbed starch molecules and anionic colloidal silica was proposed. Unstructured colloidal silica showed greater improvement in retention than structured colloidal silica. Cationic corn starches with different degree of substitution and molecular weights were prepared and their effect as a constituent of Compozil system was also evaluated. By controlling the molecular weight and degree of substitution of cationic corn starch it was possible to achieve significant improvement in fines retention. Cationic corn starch with higher degree of substitution maintained its retention efficiency even when the stock conductivity was increased. Turbidity measurement technique was found to be a simple and useful method to measure the retention characteristics.

  • PDF

Cellular Immune Responses of Lucilia illustris Hemocvte to Protein A- Gold and Colloidal Gold Particles (Proiein A-gold와 colloidal gold 입자에 대한 연두금파리 (Lucilia illustris) 혈구의 세포성 면역반응)

  • 노미전;김우갑
    • The Korean Journal of Zoology
    • /
    • v.36 no.2
    • /
    • pp.200-208
    • /
    • 1993
  • 연두금파리 종령유충의 복강내에 이물질로서 protein-A gold 용액(20 nm 크기) colloidal gold 용액(15 nm 크기), 그리고 이들의 혼합액을 주입하여 혈구가 이들을 처리하는 양상을 전자현미경을 이용하여 관찰하였다. Gold 입자에 대한 혈구의 세포성 면역작용 방식은 식세포작용이었고 이러한 식세포 작용은 연두금파리에서 확인한 prohemocyte, plasmatocyte. granulocyte type I, II, III, 그리고 oneocvtoid 등의 6가지 혈구 중 type 11 granulocyte에 의해서 수행되었다. Gold 입자는 주로 판상의 원형질 돌기를 통하여 혈구 속으로 들어갔으며 coated-pit로 보이는 구조에 의해서도 받아들이는 것으로 나타났다. 식세포 작용은 gold 용액 주입후 10분 이내에 빠른 속도로 일어났으며 시간이 경과함에 따라 gold 입자를 함유한 phagosome은 리소소음과 융합하여 phagolysosome을 형성하면서 세포질내에 축적되어 있었다. Gold 용액을 주입한 후 type II granulocyte에서는 세포질 돌기와 전자 밀도가 높은 과립, 그리고 세포 소기관이 소실되는 등의 변화가 일어났다. protein A-gold 및 colloidal gold 용액에 대한 기본적인 식세포 과정은 별다른 차이점이 없었으나 gold 입자 섭취 초기 과정과 양, 그리고 multivesicular body의 모습등에서는 차이점을 보여 주었다.

  • PDF

Development & Characteristics of the Permanent Grout based on Colloidal Silica (실리카 콜로이드를 기재(基材)로 한 항구그라우트(PSG)의 개발과 공학적 특성)

  • Ryu, Dong-Sung;Jeong, Gyung-Hwan;Lee, Sng-Kook;Lee, Jun-Seok
    • Proceedings of the Korean Geotechical Society Conference
    • /
    • 2004.03b
    • /
    • pp.189-196
    • /
    • 2004
  • In this study, the colloidal silica grouts (PSG) with novel chemical compositions for permanent reinforcement and water cut-off of the ground were prepared and their engineering charateristics were investigated. The optimum mixing recipes for both homogeneous solution grouts and heterogeneous suspension grouts were investigated and established through many repeated lab tests. The various physical properties(such as compressive strength, durability and syneresis) of the grout gels derived from the colloidal silica were investigated and compared with those of the well-known existing watergalss grouts. The all experimental results showed that the novel colloidal silica grouts(PSG) had greatly excellent performances as permanent grouts, especially in comparison with the existing watergalss grouts.

  • PDF

A STUDY ON THE STABILITY, EFFICACY, AND EFFECT OF COLLOIDAL SILVER EMULSION

  • Yun, Kyung-Rho;Ji, Hong-Geun;Seo, Bong-Seok
    • Journal of the Society of Cosmetic Scientists of Korea
    • /
    • v.25 no.4 s.34
    • /
    • pp.75-95
    • /
    • 1999
  • A colloid refers to dispersed particles of a solid or liquid having the diameter of about $10^{-5}-10^{-7}cm$. Such colloidal silver is produced by electrolysis. In this paper, colloidal silvers of various concentrations according to charge amount and time are produced, and their anti-microbial activities are measured. And optimum conditions for emulsion are measured by varying the concentration of colloidal silvers. Further, stability of the emulsion is measured with a Zeta potential, chrome meter by applying colloidal silvers to creams (W/Si, O/W, MLV).

  • PDF

A STUDY ON THE STABILITY, EFFICACY, AND EFFECT OF COLLOIDAL SILVER EMULSION

  • Yun, Kyung-Rho;Ji, Hong-Geun;Seo, Bong-Seok
    • Proceedings of the SCSK Conference
    • /
    • 1999.10a
    • /
    • pp.75-95
    • /
    • 1999
  • A colloid refers to dispersed particles of a solid or liquid having the diameter of about $10^{-5}$ - $10^{-7}$. Such colloidal silver is produced by electrolysis. In this paper. colloidal silvers of various concentrations according to charge amount and time are produced, and their anti-microbial activities are measured. And optimum conditions for emulsion are measured by varying the concentration of colloidal silvers. Further, stability of the emulsion is measured with a Zeta potential. chrome meter by applying colloidal silvers to creams (W/Si. O/W, MLV).

  • PDF