• 대한한방소아과학회지
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• 제19권1호
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• pp.83-102
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• 2005

Objectives : This study aimed to investigate acupuncture trend of childhood nocturnal enuresis in current Traditional Chinese Medical Journals. Methods : During the period from January 2000 to August 2004, we searched all Traditional Chinese Medical Journals in oriental medical library in dongguk university. We selected 28 literatures on acupuncture treatment for nocturnal enuresis in children Results : 28 studies are included and classified by diagnosis criteria and outcome criteria. And reclassified into two large groups, case report and comparison study. Totally 2324 cases, complete cures are 1701, significant improvements 2239, complete cure rate 73.2%, total improvement rate 97.3% 33 acupuncture points are used and main meridians are bladder, conception vessel and governor vessel. Conclusion : There remains a debate about diagnosis and outcome criteria. But Acupuncture is very effective and safe in the treatment of enuretic children.

• 대한한의정보학회지
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• 제11권2호
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• pp.65-82
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• 2005

The findings from this study are summarized as follows: 1. Hangul 2004 has 16,023 Chinese Character codes. Among them, 15,231 Chinese Character codes are searched by DB, the others are unsearchable codes. 2. Among 15,231 Chinese Character codes of Hangul 2004, 2,471 Chinese Character codes are converted into 2,232 Simplified Chinese Character codes by Traditional and Simplified Chinese Character Converting program in Hangul 2004. 3. The 5th edition TCM-MeSH has 6,385 thesauruses and 2,142 kinds of Chinese Characters. 4. If we use Simplified Chinese Character of Hangul 2004 to search for TCM-MeSH, we will find 94.3% of TCM-MeSH. But If we use Traditional Chinese Character of Hangul 2004 to search for TCM-MeSH, we will find only 34.2% of TCM-MeSH.

• 동의신경정신과학회지
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• 제27권3호
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• pp.197-206
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• 2016

Objectives: This study was performed to review the research trends in the treatment of posttraumatic stress disorder in traditional Chinese medicine.Methods: We searched articles in the China National Knowledge Infrastructure (CNKI) using keywords, “ Posttraumatic stress disorder” , and “ PTSD” in Traditional Chinese Medicine, Traditional Chinese Medicinal Herbs and Combination of Traditional Chinese Medicine and the Western Medicine field. We selected 16 studies after excluding non-clinical or unrelated studies.Results: Four pre-post comparison studies and 12 controlled clinical trials were performed in patients with PTSD in China. Herbal medicine, acupuncture, and moxibustion therapy were used for the treatment of PTSD. Most of the studies showed positive results, and they reported that the treatment groups had fewer side effects than the control group. However, the quality of these clinical studies was low.Conclusions: According to this study, TCM for PTSD would be an effective and safe intervention. Therefore, based on this study, more clinical research on the treatment of PTSD should be performed in Korean medicine in the near future.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7335-7338
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• 2013

There is increasing evidence that natural killer (NK) cells play an important role in antitumor immunity following dendritic cell (DC) vaccination. Little is known, however, about the optimal stimulation of DCs by epitopes and NK interactions for cytotoxicity in tumors. In this study, DC cells activated by the HPV16E7.49-57 epitope and LPS were co-cultured with NK cells in vitro, and then used ot immunize mice to study CTL activity of TC-1, which constitutively expresses HPV16E6E7, with an LDH release assay. Cytotoxicity in mice immunized with DC loaded with epitope HPVE7.49-57 vaccine co-cultured with NK was enhanced significantly (p<0.01). In conclusion, talk-across between DC and NK cells enhances their functions, also improving cytotoxicity againsttumor cells, suggesting that activated DC-NK by epitopes has potential application for cancer-specific immuno-cellular therapy.

• 대한암한의학회지
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• 제22권1호
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• pp.37-48
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• 2017

Objectives: The purpose of this study was to suggest the direction for the development of a clinical practice guideline (CPG) for esophageal cancer (EC). Methods: We collected and analyzed CPGs and related data about esophageal cancer by searching the database of domestic and foreign articles. Results: There were little contents or proposals related to Korean Medicine (KM) or Traditional Chinese Medicine (TCM), those related to KM or TCM can be found only in "Guidelines of Diagnosis and Therapy in Oncology with Traditional Chinese Medicine (惡性腫瘤中醫診療指南)". They were symptom factors, syndrome differentiation (SD) and 'treatment process of esophageal cancer by combination of western medicine and Korean medicine'. Conclusions: The topics of the development Korean medicine CPG for EC are (1) the method and procedure about combination of western medicine and Korean medicine (2) the process of SD and diagnosis (3) safety and efficacy of the herbal medicine and preparation (4) availability and timing of the tools related to KM or TCM like acupuncture, moxibustion, massage, etc.

• 동의생리병리학회지
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• 제30권4호
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• pp.209-218
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• 2016

The objective of this study was to investigate the diagnosis and treatment of Retinal vein occlusion such as syndrome differentiation and herbal medicine by reviewing Chinese traditional medicine`s journals. The journal search was carried out using China National Knowledge Infrastructure and Pubmed from January 2000 to December 2014. Searching key words were the various combination of "Retinal vein occlusion", "traditional chinese medicine", "syndrome differentiation". The final selection of 11 studies were selected and summarized by researchers. The effective rate was significantly higher than control but, methodological quality of the trials was generally low questioning their liability. The syndrome differentiation was classified as hyperactivity of liver yang and blood stasis. The most frequently prescribed herbal medication was Hyulbuchookeotang, Boyanghwanotang and Cheomagudeungum. This finding could be widely utilized in future clinical practice and form the basis for the development of clinical practice guidelines in advance.

• 동의신경정신과학회지
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• 제31권4호
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• pp.315-327
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• 2020

Objectives: The aim of this study was to review the research trends in the treatment of pharmacopuncture for vascular dementia in Traditional Chinese medicine. Methods: We searched for articles in the China National Knowledge Infrastructure (CNKI) database from January 2000 to August 2020. Results: Among the total 63 articles, 9 articles were selected. All studies were randomized controlled trial studies. The Diagnostic and Statistical Manual of Mental Disorders (DSM) was most frequently used as diagnostic criteria. Effective rate and Activity of Daily Living (ADL) were most commonly used as outcome measurements. Angelica gigantis Radix (當歸), Salvia miltiorrhiza Bunge (丹蔘), and Astragali Radix (黃芪) were the most commonly used ingredients in pharmacopuncture. Joksamni (ST36) and Sinsu (BL23) were the most commonly used acupoints for pharmacopuncture treatment. Based on the Risk of Bias (RoB) of these 9 articles, the overall quality of studies was low. Conclusions: Pharmacopuncture could be considered for the treatment of vascular dementia. In the future, various systematic studies on dementia are needed.

• 동의신경정신과학회지
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• 제31권1호
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• pp.39-47
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• 2020

Objectives: The purpose of this study was to review the research trends in the treatment on narcolepsy in traditional Chinese medicine. Methods: We searched articles in the China National Knowledge Infrastructure (CNKI) October 2009-September 2019. Keywords were 发作性睡病, 嗜睡病, and 嗜睡症. Results: Among a total of 81 articles, 12 articles were selected. The International Classification of Sleep Disorders was most frequently used as a diagnostic criteria. Feng Chi (GB20) and Baek Hoi (GV20) are the most commonly used acupoints in acupuncture treatment. Glycyrrhizae Radix (甘草), Atractylodis Rhizoma Alba (白朮), and Poria (Hoelen) (茯苓) are the most commonly used preparations in herbal medicine. The effective rate is most commonly used as an outcome measurement. Conclusions: Acupuncture and herbal medicine could be considered to improve the symptoms of narcolepsy. In the future, this study could be primary data for the development of more clinical research on the treatment on narcolepsy in Korean medicine.

• Journal of Ginseng Research
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• 제41권3호
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• pp.411-418
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• 2017

Background: Recently, protein from ginseng was studied and used for the treatment of several kinds of diseases. However, the effect of ginseng total protein (GTP) on proliferation and wound healing in fibroblast cells remains unclear. Methods: In this study, cell viability was analyzed using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. Cell cycle distribution was analyzed by flow cytometer. The levels of transforming growth factor ${\beta}1$, vascular endothelial growth factor, and collagens were analyzed by enzyme-linked immunosorbent assay and immunofluorescence staining. The expressions of cyclin A, phosphorylation of extracellular signal-related kinase (p-ERK1/2), and ERK1/2 were analyzed by Western blotting. Results: Our results showed that GTP promoted cell proliferation and increased the percentage of cells in S phase through the upregulation of cyclin A in NIH/3T3 cells. We also found that GTP induced the secretion of type I collagen, and promoted the expression of other factors that regulate the synthesis of collagen such as transforming growth factor ${\beta}1$ and vascular endothelial growth factor. In addition, the phosphorylation of ERK1/2 at Thr202/Tyr204 was also increased by GTP. Conclusion: Our studies suggest that GTP promoted proliferation and secretion of collagen in NIH/3T3 cells by activating the ERK signal pathway, which shed light on a potential function of GTP in promoting wound healing.

• 대한한의학원전학회지
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• 제24권5호
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• pp.147-158
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• 2011

There has been a need for an operational curriculum for teaching Chinese characters used by traditional Korean medicine (TKM), but the it was not thoroughly reviewed so far. We analysed the frequency of unicode Chinese characters with five textbooks of traditional Korean medicine used as a national standard. We found that 氣, 經, 陽, 陰, 不, 熱, 血, 脈, 病, 證, 寒, 中, 心, 痛, 虛, 大, 生, 治, 本, 之 are the 20 most frequently used Chinese characters, and also showed 100 frequently used characters for each textbook. We used a cumulative frequency analysis method to suggest a list of 1,000 prerequisite Chinese characters for the TKM education (TKM 1000). which represents the current usage of Chinese characters in TKM and covers 99% of all textbook use if combined with MEST 1800. This study showed prerequisite and essential Chinese characters for the implementation of evidence-based teaching in TKM. The TKM 1000, a prerequisite characters by this study based on the TKM textbooks can be used for the development of Korean Medicine Education Eligibility Test (KEET), entrance exam to the Colleges of Oriental Medicine or textbooks, and educational curriculum for premed students.