• 대한한방내과학회지
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• 제45권1호
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• pp.1-10
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• 2024

Objectives: This study investigated the pattern identification (PI) and clinical index of Parkinson's disease (PD) for personalized diagnosis and treatment. Methods: This prospective observational multi-center study recruited 100 patients diagnosed with PD from two Korean medicine hospitals. To cluster new subtypes of PD, items on a PI questionnaire (heat and cold, deficiency and excess, visceral PI) were evaluated along with pulse and tongue analysis. Gait analysis was performed and blood and feces molecular signature changes were assessed to explore biomarkers for new subtypes. In addition, unified PD rating scale II and III scores and the European quality of life 5-dimension questionnaire were assessed. Results: The clinical index obtained in this study analyzed the frequency statistics and hierarchical clustering analysis to classify new subtypes based on PI. Moreover, the biomarkers and current status of herbal medicine treatment were analyzed using the new subtypes. The results provide comprehensive data to investigate new subtypes and subtype-based biomarkers for the personalized diagnosis and treatment of PD patients. Ethical approval was obtained from the medical ethics committees of the two Korean medicine hospitals. All amendments to the research protocol were submitted and approved. Conclusions: An objective and standardized diagnostic tool is needed for the personalized treatment of PD by traditional Korean medicine. Therefore, we developed a clinical index as the basis for the PI clinical evaluation of PD. Trial Registration: This trial is registered with the Clinical Research Information Service (CRIS) (KCT0008677)

• 사상체질의학회지
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• 제23권4호
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• pp.429-444
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• 2011

1. Objective This study is aimed to present the effective classification of Soeumin symptomatology and the standardized signs for classification which can be applied for KCD, ICD and the insurance codification system. 2. Methods 1) Differentiate Soeumin symptomatology based on exterior-interior patterns, favorable-unfavorable patterns, and mild-severe-dangerous-urgent patterns. 2) Investigate the standard signs and symptoms to claasify Soeumin symptomatology based on exterior-interior patterns, favorable-unfavorable patterns, and mild-severe-dangerous-urgent patterns. 3. Results and Conclusions 1) The diagnosis criteria for Soeumin exterior-interior disease is based upon signs & symptoms of cold/heat, condition of stool, state of digestive system(such as digestion and appetite)among others. 2) The diagnosis criteria for Soeumin favorable-unfavorable disease is generally based upon whether the vital force of the spleen is damaged or not. More specifically, for the exterior disease, whether or not sweating is present. For the interior disease, whether or not dry mouth, body ache(a main symptom of the exterior state), and anxiousness are present. 3) For the Soeumin Wool-gwang disease, the diagnosis criteria of mild-severe disease is whether or not chills is present and the degree of body fever. 4) For Soeumin Mang-yang disease, the diagnosis criteria of dangerous-urgent disease is whether or not chills is, the degree of sweating and urine condition. 5) For the Soeumin Greater-Yin disease, Abdominal-pain bowel irritability pattern and Epigastric discomfort pattern are early state signs, Jaundice pattern is mild-state sign, edema & Greater-Yang disease Yin-toxin pattern are terminal state signs. 6) For the Soeumin interior disease, Abdominal-pain bowel irritability pattern and Epigastric discomfort pattern are of the dangerous state pattern, Jang-gual and Exuberant-Yin-repelling-Yang pattern are of the urgent state patterns.

• 한국건축시공학회지
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• 제20권1호
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• pp.53-60
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• 2020

본 논문은 동절기 콘크리트 보양 시 투입되는 에너지(전력) 소비량과 콘크리트 발열량 변화를 통해 단열갱폼의 단열성능을 검토하고자 하였다. 실험결과에 따르면, 일반갱폼은 콘크리트 타설 이후 12시간동안 에너지(전력) 소비가 3회 발생하게 된다. 반면 단열갱폼은 콘크리트 타설 후 21시간 동안 에너지(전력) 소비가 발생되지 않았다. 최종 전력 소비량은 일반갱폼이 단열갱폼보다 3.7배 높게 나타나 에너지(전력) 소비에서 단열갱폼의 우수한 성능을 확인할 수 있었다. 발열량 검토결과는 일반갱폼에서 콘크리트 타설 후 외기 온도변화에 따라 발열량이 크게 변하는 것을 알 수 있었다. 하지만 단열갱폼의 경우 프레임 일부에서 미비한 열손실이 발생했을 뿐 콘크리트 타설 직후부터 거푸집 탈형까지 일정한 발열패턴을 보여주고 있었다.

• 대한한의학원전학회지
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• 제37권2호
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• pp.49-76
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• 2024

Objectives : The purpose of this paper is to examine the mechanism and treatment of the Zangfu warm disease in the Beijiqianjinyaofang. Methods : This study examined the Zangfu warm disease content in the Beijiqianjinyaofang, Shanghanzongbinglun, Saninfang, based on the Neijing explanation of the pathological mechanism. Treatment was analyzed among the three texts in terms of their similarity and difference. Results & Conclusions : 1. Zangfu warm disease is caused by seasonally inappropriate qi, which is infectious, epidemic, and seasonal. 2. While the Qingjinqian disease pattern was explained in terms of the relationship between Shaoyin and Shaoyang, the actual disease pattern happened more in the Taiyang channel, and partly in the Shaoyang channel. For treatment of Fu deficiency pattern, the Chaihudihuangtang was listed in the Qianjinyaofang and the Shanghanzongbinglun, while in the Sanyinfang, the formula was modified to extinguish heat and thin phlegm, while reinforcing healthy qi. 3. The Chimaifei disease pattern was explained in terms of the relationship between Shaoyin and Taiyang that is deeply associated with Wei qi. For treatment of Fu deficiency the Qianjinyaofang and Shanghanzongbinglun used the Shigaodihuangtang, while the Sanyinfang reinforced healthy qi and eliminated pathogenic qi. 4. The Huangrousui disease pattern was explained as being caused by problems in the Taiyin and Yangming, in which the Triple Burner fails to control and manage cold dampness. In treating Zang excessiveness, the Qianjinyaofang and Shanghanzongbinglun used the Xuanshenhanshuishitang, while the Sanyinfang instructed to reinforce healthy qi and eliminate pathogenic qi. In treating Fu deficiency, the Sanyinfang instructed to warm the center and dry dampness, tonifying the Spleen and reinforcing qi. 5. The Baiqili disease pattern was explained within the relationship between Taiyin and Taiyang. In treating Fu deficiency, the Qianjinyaofang and Shanghanzongbinglun used the Shigaoxingrentang, while the Sanyinfang instructed to reinforce healthy qi and eliminate pathogenic qi. In treating Zang excessiveness, the Qianjinyaofang and Shanghanzongbinglun used the Shigaocongbaitang, while the Sanyinfang instructed to reinforce healthy qi and eliminate pathogenic qi. 6. The Heiguwen disease pattern was explained as being caused by stagnation and obstruction in the Triple Burner due to clash between Taiyang and Shaoyin. In treating Zang excessiveness, the Qianjinyaofang and Shanghanzongbinglun used the Kushenshigaotang, while the Sanyinfang instructed to reinforce healthy qi and eliminate pathogenic qi. The Zangfu Warm Disease is a infectious disease concept which is based on the Five Zang that integrates the meridian aspect together with the Six Fu with which there is an external/internal relationship. This concept and treatment could be considered in dealing with COVID-19.

• The Journal of Korean Physical Therapy
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• 제9권1호
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• pp.185-193
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• 1997

The purpose of this study was to investigate the neurophysiological mechanisms, assessment of muscle spasm and treatments that could apply to clinical field. Spasm is a painful pattern of contraction of muscle caused by chronic or acute trauma, excessive tension, or organic disorders. Aside from pain, muscle spasm creates shortenning of muscles and limits motion. Untreated spasm and protective immobility due to pain lead to decreased local blood flow in the muscles and result in a vicious cycle of muscle spasm and paul. The assessment of muscle spasm involve muscle tone assessment, tissue compliance, and joint ROM. Each of these aessessments utilize as a part of the patient's condition Clinical managements involve drug management and physical therapy. Expecially, physical therapy is one of the most important techniques to reduce muscle spasm. Physical therapy includes applying heat and cold, electrical stimulation, massage, and traction. This investigation should entourage phisical therapists to experiment further with various techniques to reduce muscle spasm.

• 사상체질의학회지
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• 제30권1호
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• pp.66-73
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• 2018

Objectives The purpose of this study was to develop mobile a application that evaluate the Mibyeong(deterioration of the health) in daily life and provide optimal Yangseng(養生) interventions according to the Korean medicine types. Methods The evaluation of Mibyeong utilized questionnaire or objective informations including Facial photographs and hemodynamic information. The Korean medicine type classification was reconstructed based on the concept of Sasang constitution and cold-heat pattern identification. Yangseng interventions were recommended based on Mibyeong symptoms, Korean medicine types, and demographic information. And we have developed tracking and ranking functions for user motivations. We used a Korean medicine database that focused on healthy people as a reference data, and used Yangseng interventions database that reinterpreted classical Yangseng in a modern way. Results and Conclusions We have developed a mobile application that evaluates the user's Mibyeong state and provides optimal Yangseng interventions based on Korean medicine types. This study are expected to improve the quality of health and contribute to the prevention of diseases.

• 대한수의학회지
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• 제26권2호
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• pp.265-276
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• 1986

The bovine serum factor influencing the growth of swine testicle (ST) cell and the END effect of hog cholera SN test was studied. Throughout the experimental studies. following results were obtained and summarized. 1. Bovine whole serum of 16(76.2%) and 4(19.0%) samples out of 21 have shown a positive ST cell growth and the END effect, respectively. However, all of 21(100%) and 8(38.1%) samples out of 21 serum supernatant fractions, prepared from the bovine whole serum, have shown positive ST cell growth and END effect, respectively. 2. In the SDS-polyacrylamide gel electrophoretic analysis of the bovine whole serum and the supernatant fractions, ST cell growth inhibiting factor was proved present in globulin fraction and in whole gel plate as a diffusible component. 3. The END ineffective component present in the whole serum and its supernatant fraction was proved to be BVDV neutralizing antibody. 4. The difference of osmolarity, optical density, pH, degree of precipitant formation following heat cold treatment, A/G ratio as we11 as electrophoretic pattern and NDV SN index of the samples were not correlated to the degree of 57 cell growth and to the END effectiveness.

• 대한기계학회논문집B
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• 제23권7호
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• pp.841-855
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• 1999

In the present work, the effect of a flow maldistribution on the thermal and conversion response of 8 monolith catalytic converter is Investigated. To achieve this goal, a combined chemical reaction and multi-dimensional fluid dynamic mathematical model has been developed. The present results show that flow uniformity within the monolith brick has 8 great impact on light-off performance of the catalytic converter. In the case of lower flow uniformity, large portions of the monolith remain cold due to locally concentrated high velocities and CO, HC are unconverted during warm-up period, which loads to retardation of light-off. It has been also found that the heat-up pattern of the monolith ill similar to the flow distribution profile, In the early stage of the reaction. It may be concluded that flow maldistribution can cause a significant retardation of the light-off and hence can eventually worsen tho conversion efficiency of automotive catalytic converter.

• 해양환경안전학회지
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• 제25권6호
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• pp.678-686
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• 2019

본 연구에서는 인공위성 해수면온도 편차(Sea Surface Temperature Anomaly, SSTA)를 이용하여 한반도 연안해역의 고수온 해역을 추출하고, 국립수산과학원의 고수온속보 발령 문서와 비교하였다. 일일 SSTA 이미지를 이용하여 임계값을 적용하는 고수온 탐지 알고리즘을 제안하였으며, 고수온 주의보는 2℃ 이상, 경보는 3℃ 이상인 것으로 가정하였다. 2017~2018년 7~9월의 일평균 SST를 기반으로 한 편차자료를 사용하였으며, 고수온속보에 사용되는 지역을 대상으로 위성기반 탐지 결과를 9개 영역으로 구분하고 비교하였다. 해역별 고수온 발생 횟수 비교 결과, 수온 관측 부이가 고르게 분포한 남해 연안은 고수온속보와 위성 탐지 횟수가 유사하게 나타났다. 반면에 다른 해역은 위성 탐지 횟수가 약 2배 이상 많았으며, 이는 고수온속보 발령이 해역의 일부 위치 수온만을 고려하기 때문인 것으로 판단된다. 본 연구 결과는 향후 위성기반 연안해역 고·저수온 모니터링 체계 개발에 활용하고자 한다.

• 대한한방부인과학회지
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• 제32권1호
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• pp.48-72
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• 2019

Objectives: This study was conducted to comprehend the syndrome differentiations of dysmenorrhea and find out their clinical symptoms, tongue images and pulse patterns by analyzing previous studies. Methods: The following researches were collected by searching the medical journals published from November, 2007 to October, 2017, from KISS, OASIS, CNKI. : researches on the syndrome differentiation of dysmenorrhea, researches on the criteria of diagnosis of syndrome differentiation of dysmenorrhea, randomized controlled trials (RCT) used syndrome differentiation for treating dysmenorrhea. Results: By investigating the frequency of syndrome differentiations used in RCT studies, the frequent ones were chosen. They were qi stagnation and blood stasis (氣滯血瘀), qi-blood deficiency (氣血虛弱), congealing cold with blood stasis (寒凝血瘀), liver-kidney depletion (肝腎虧損), blood stasis with dampness-heat (濕熱瘀阻). Conclusion: 4 syndrome differentiations were frequently used in RCT studies. And the frequency of clinical symptoms on each syndrome differentiations from each RCT study was analyzed and compared. Clinical symptoms chosen as chief symptoms in more than one reference, appeared in more than half of the references, most frequent tongue images and pulse conditions were organized. The most frequent clinical symptoms included the period and pattern of pain, the accompanying symptoms of whole-body and the pattern of menstrual bleeding.