• The Journal of Internal Korean Medicine
• /
• v.22 no.4
• /
• pp.567-571
• /
• 2001

Objective : Cold hypersensitivity is excessive sensitivity of each body part. particularly limbs and low backs, but sometimes it affects upper abdomen region in G-I trouble patients. Methods : We conducted this research on 69 patients who came and took the both exam of gastroscopy and D.I.T.I. in kangnam korean hospital kyung hee university. So, we researched the significance of temperature deviations on upper abdomen which was studied separately by gastritis group, digestive function group and H. pylori group. Results and Conclusion : The temperature deviation of Zhongwan(Ren12)-Danzhong(Ren17) of gastritis group and indigestive patients was significant, it means that patients who have severe gastritis and indigestion have more significant cold hypersensitivity in upper abdomen. The temperature deviation of Zhongwan(Ren12)-Danzhong(Ren17) of H.pylori positive patients in H.pylori group was not significant. The clinical relationship or tendency was not found both between H.pylori group and gastritis group and between H.pylori group and digestive function group.

• Fisheries and Aquatic Sciences
• /
• v.26 no.10
• /
• pp.593-604
• /
• 2023

Post-harvest handling and hygienic level of aquatic products significantly affect the quality and level of safety. Cold chain control is one of the determining factors for the quality of fish and the bacterial community that grows on the fish. Identification of spoilage bacteria and pathogens in aquatic products must be made because it will determine the physical and chemical quality. A molecular identification method with high sensitivity is the solution. This study aims to identify the quality of fish and bacterial communities that grow. The research procedures included sample collection, pH measurement, drip loss measurement, transportation and cold storage treatment, DNA extraction, DNA sequencing, sequence analysis, and bioinformatics analysis. The conclusion obtained from this study is that the simulation of the cold chain system applied to eastern little tuna does not significantly affect changes in the water activity value, pH, and drip loss. The insignificant change indicates that the eastern little tuna samples are still in good quality. The bioinformatics analysis showed the highest diversity and abundance of the bacterial community came from the Gammaproteobacterial class.

• International Journal of Oral Biology
• /
• v.42 no.4
• /
• pp.169-174
• /
• 2017

Transient receptor potential melastatin 8 (TRPM8) plays a crucial role in innocuous cool sensation, acute cold pain and cold-induced hyperalgesia during pathologic conditions. To help understand TRPM8-mediated cold perception in the dental pulp and periodontal tissues, we examined the distribution of TRPM8-immunopositive (+) axons in molar and incisor pulp and periodontal tissues using transgenic mice expressing a genetically encoded axonal tracer in TRPM8+ neurons. In the radicular pulp of the molar teeth, a small number of TRPM8+ axons were observed. TRPM8+ axons branched frequently and extensively in the core of coronal pulp, forming a network in the peripheral pulp. Some TRPM8+ axons ascended between odontoblasts and were observed in the dentinal tubule. TRPM8+ axons were linear-shaped in the radicular pulp, whereas many TRPM8+ axons showed portions shaped like beads connected with thin axonal stands at the peripheral pulp. TRPM8 was densely expressed in the bead portions. In the incisor pulp, TRPM8+ axons were occasionally observed in the core of the coronal pulp and rarely observed at the peripheral pulp. TRPM8+ axons were occasionally observed and showed a linear shape rather than a bead-like appearance in the periodontal ligament and lamina propria of the gingival tissue. These findings, showing differential distribution of TRPM8+ axons between radicular and coronal portions of the molar pulp, between incisor and molar pulp, and between dental pulp and periodontal tissues, may reflect differential cold sensitivity in these regions.

• Proceedings of the KSME Conference
• /
• 2004.11a
• /
• pp.1219-1224
• /
• 2004

The objective of this study is to propose an experimental calibration facility in which a heat flux sensor can be calibrated under conductive condition by using helium gas. The heat flux calibration facility was designed, simulated and manufactured for use in a high heat transfer condition. It delivers heat fluxes up to a maximum of 35 KW $m^{-2}$. A copper block heated electrically with 3.5 KW power is designed to produce uniform temperature up to 600 K across its face. High heat fluxes are provided between hot plate and cold plate by 1 mm height helium filled gap. A cold plate is maintained around 300 K through pool boiling using a refrigerant and water-cooled heat exchanger. A simulation was conducted to verify the design of the main test section. To verify the performance of calibration facility, a heat flux sensor was examined. The measured heat fluxes were compared to the calculated one.

• Nuclear Engineering and Technology
• /
• v.50 no.6
• /
• pp.981-988
• /
• 2018

An experiment was performed for the OECD/NEA ROSA-2 Project with the large-scale test facility (LSTF), which simulated a steam generator tube rupture (SGTR) accident due to a double-ended guillotine break of one of steam generator (SG) U-tubes with operator recovery actions in a pressurized water reactor. The relief valve of broken SG opened three times after the start of intact SG secondary-side depressurization as the recovery action. Multi-dimensional phenomena specific to the SGTR accident appeared such as significant thermal stratification in a cold leg in broken loop especially during the operation of high-pressure injection (HPI) system. The RELAP5/MOD3.3 code overpredicted the broken SG secondary-side pressure after the start of the intact SG secondary-side depressurization, and failed to calculate the cold leg fluid temperature in broken loop. The combination of the number of the ruptured SG tubes and the HPI system operation difference was found to significantly affect the primary and SG secondary-side pressures through sensitivity analyses with the RELAP5 code.

• Journal of Sasang Constitutional Medicine
• /
• v.32 no.4
• /
• pp.65-85
• /
• 2020

Objectives The aim of study was to suggest diagnostic indicator according to Exterior-Interior disease for the Sasang Constitution based on original symptom. Methods We investigated the literature(『Dongeuisusebowon sinchukbon』) and another study(Clinical Practice Guideline for Disease of Sasang Constitutional Medicine: Diagnosis and Algorithm). As a result, we developed diagnostic indicator of original symptom for Exterior-Interior disease in Sasang Constitutional Medicine. Results and Conclusions Diagnosis of Exterior-Interior disease in Sasang Constitution was decided by heat and cold of original symptom. Detailed indicators of diagnosis in Exterior-Interior disease were heat/cold sensitivity, the degree of sweating, the amount of drinking water, thirst, face color and somatalgia.

• The Korean Journal of Physiology
• /
• v.8 no.2
• /
• pp.67-74
• /
• 1974

The object of this research is aimed to determine the activity of adenyl cyclase in both skeletal muscle sarcolemma and fat cell ghost of epididymal adipose tissue isolated from rats exposed to cold for various length of time in an attempt to evaluate whether the tissue sensitivity to catecholamine is increased when rats are exposed to cold for long periods of time Methods: a)Animals: Albino rats ranging in weight from 150 to 200 gm were used throughout this study. For experimental purposes, the rats are divided into two groups: experimental animals were place4 in a cold room at $4^{\circ}C$, controls being kept at $25^{\circ}C$. At the end of 2, 4, 6, 12, and 16 weeks. exposure to cold the rats were used to measure the adenyl cyclase activity. b) Isolation of plasma membrane from skeletal muscle and adipose tissue: The Plasma membrane of skeletal muscle from hind limbs of rats are prepared by the method employed by Rosenthal et at. and fat cell ghost of epididymal adipose tissue of rats by the method employed by Rodbell. c) Adenyl cyclase assay: Adenyl cyclase activity were measured by the method employed by Marinetti et al. Briefly, plasma membrane was incubated with $3^H-ATP$, various amount of noradrenaline and other incubation mixture at $37^{\circ}C$ for 20 minutes. After stopping the enzyme reaction by immersion in boiling water, carrier 3',5'-AMP was added to the system as a marker and $100\;{\mu}1$ aliquots of incubation mixture were pipetted on $20{\time}20$ Whatman No. 3 MM filter paper for one dimensional chromatography. The cyclic AMP spots were cut off and placed in counting vials containing 10ml of Bray's scintillation cocktail. Radioactivity was determined with a Packard Tri-Carb liquid scintillation counter. The enzyme activity is expressed as nanomoles of cyclic AMP produced per mg of membrane per hour. Result: 1. Average adenyl cyclase activity in the plasma membrane of skeletal muscle before and after noradrenaline administration was significantly higher in the cold-exposed rats as compared to the control. Continuous exposure to cold Produced an increased adenyl cyclase activity before and after noradrenaline administration. Adenyl cyclase activity reached peak levels at the 6 weeks exposure to told and level of adenyl cyclase activity remained high. Noradrenaline administration to the incubation medium induced a significant increase in adenyl cyclase activity and the degree of stimulation were proportional to the hormonal concentration But the rate of inclement in adenyl cyclase activity by noradreasline was the same in both groups. 2. Adenyl cyclase activity in fat cell ghost between cold exposed and control rats showed no significant differences before and after noradreualine administration. In summary, it can be concluded that cold adaptation give rise an increased activity of adenyl cyclase in plasma membrane of skeletal muscle in rats.

• International Journal of Reliability and Applications
• /
• v.16 no.2
• /
• pp.99-111
• /
• 2015

In this paper, we study the reliability analysis of a repairable system with two types of failure in which switching failures and reboot delay are considered. Let units in this system be cold standby, and failure rate and repair rate of [type1, type2] components be exponentially distributed. The expressions of reliability characteristics - such as the system reliability and the mean time to system failure MTTF - are derived. We use several cases to graphically analyze the effect of various system parameters on the system reliability and MTTF. We also perform a sensitivity analysis of the reliability characteristics with changes in specific values of the system's parameters.

• 한국전산유체공학회:학술대회논문집
• /
• 2004.10a
• /
• pp.131-136
• /
• 2004

Thermal control of satellite propellant tank is achieved by patch heaters enabled by thermostat's behavior. It is important to attach the thermostat on the appropriate position of the propellant tank. However its position cannot be given with exact numerics because tank is spherical. Actually the position for thermostat is designated in relevant drawing approximately, therby, the engineer practices depending on his own experience and intuition. The sensitivity analysis for the position of thermostat is performed such that the influence on the thermal behavior and control of tank is examined quantatively. When assembling tank module, the reasonable performance on the thermal control is believed with possible human errors if the uncertainty in the position of thermostat is not quite large.

• Journal of radiological science and technology
• /
• v.43 no.6
• /
• pp.461-467
• /
• 2020

In the field of nuclear medicine, errors are sometimes generated because the assessment of the uniformity of gamma cameras relies on the naked eye of the evaluator. To minimize these errors, we created an artificial intelligence model based on CNN algorithm and wanted to assess its usefulness. We produced 20,000 normal images and partial cold region images using Python, and conducted artificial intelligence training with Resnet18 models. The training results showed that accuracy, specificity and sensitivity were 95.01%, 92.30%, and 97.73%, respectively. According to the results of the evaluation of the confusion matrix of artificial intelligence and expert groups, artificial intelligence was accuracy, specificity and sensitivity of 94.00%, 91.50%, and 96.80%, respectively, and expert groups was accuracy, specificity and sensitivity of 69.00%, 64.00%, and 74.00%, respectively. The results showed that artificial intelligence was better than expert groups. In addition, by checking together with the radiological technologist and AI, errors that may occur during the quality control process can be reduced, providing a better examination environment for patients, providing convenience to radiologists, and improving work efficiency.