• 한국콘텐츠학회논문지
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• 제21권1호
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• pp.311-320
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• 2021

현재 국내 국·공립 중등교사가 되기 위한 유일한 등용문은 중등교원 임용시험이며 2014학년도 개정 이후 임용시험의 모든 문항이 서답형으로 전환되었기 때문에 더 완성도 높고 정확하고 견고한 답안 작성이 요구된다. 재인기억을 측정하는 선택형 문항과 비교하면 회상기억을 측정하는 서답형 문항의 경우 정보 인출을 위해 더 많은 인지적 노력이 요구된다. 이 때문에 지속적인 암기 및 인출 연습이 필요하지만 이를 수행할 수 있는 학습 도구가 충분하지 않다. 이러한 맥락에서 본고는 중등영어교사 임용시험 준비용 모바일 어플인 ONE PASS를 구현하였다. 본 어플에서는 특히 인지작용의 근간이 되는 뇌의 작용기제를 반영하여 학습용 콘텐츠를 구현하였으며 학습계획 설정 및 동기측정, 마인드맵, 브레인스토밍, 기출문제 등 다양한 기능을 구안하였다. 본 연구는 학습용 어플 콘텐츠 개발 관련 연구에 이바지함과 동시에 임용시험 수험자들에게 조금이나마 도움이 될 수 있기를 기대한다.

• 한국노년학
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• 제28권4호
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• pp.1213-1225
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• 2008

본 연구는 고령자들의 운동지속 행동에 영향을 미치는 사회심리적 결정요인들을 분석하는데 목적을 두었다. 계획된 행동이론을 바탕으로 본 연구는 고령자들의 건강에 대한 위험지각, 역경의 상황에서도 운동을 실천할 수 있다는 믿음(자기효능감), 운동결과에 대한 기대와 평가(태도), 운동에 대한 주위 사람들의 의사를 따르려는 생각(집단동조)과 같은 사회인지적 요인들이 고령자들의 운동지속 행동(의도성, 실행력, 지속성)에 영향을 미치는 결정요인이라고 예상했다. 연구 대상자들은 서울시에 위치한 노인복지관과 노인대학 등에서 선정된 65세 이상의 남녀 노인 453명(남: 171명, 여: 282명)이었다. 이들의 사회인지적 요인들과 운동지속 행동 요인들은 일련의 질문지를 사용하여 측정됐다. 위계적 중다회귀분석 결과는 본 연구에서 제안된 사회인지적 요인들(자기효능감, 운동태도, 집단동조, 건강위험지각)이 운동의도에 영향을 미치는 결정요인이라는 사실을 제시해 주고 있다. 그러나 운동의도에 대한 집단동조와 건강위험지각의 예측력은 매우 미약하게 나타났다. 또한 운동의도는 초기 운동실행의 가장 강력한 결정요인으로 나타났으며, 초기 운동실행은 지속적인 운동행동을 가장 강력하게 예측해 주었다. 이러한 결과들은 고령자 운동지속 행동에 영향을 미치는 사회심리적 결정요인들이 시간의 경과에 따라 역동적으로 변화할 수 있다는 가능성을 시사해 주고 있다.

• Journal of Applied Biological Chemistry
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• 제64권2호
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• pp.105-112
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• 2021

Excessive accumulation of the amyloid beta (Aβ) peptide has been implicated in the pathogenesis of Alzheimer's disease (AD). Paeonia lactiflora (PL) has been used in treatments of several conditions such as inflammation, arthritis, and cognitive impairment. The purpose of this study was to investigate the neuroprotective effect and mechanisms of PL and its active compound, paeoniflorin (PF), on Aβ_25-35-induced neurotoxicity in SH-SY5Y cells. We evaluated cell viability, lactate dehydrogenase (LDH) release and reactive oxygen species (ROS) production. Furthermore, underlying mechanism of PL and PF on the regulation of amyloidogenic pathway was analyzed by Western blotting. In our results, Aβ_25-35-induced neuronal cell loss was observed, whereas treatment with PL (10, 50, and 100 ㎍/mL) and PF (1, 5, and 10 ㎍/mL) significantly elevated the cell viability, and decreased LDH release and ROS production. In addition, exposure of SH-SY5Y cells to Aβ_25-35 significantly increased the protein levels of amyloid precursor protein (APP)-C-terminal fragment β, β-site APP-cleaving enzyme, and presenilin-1 and -2. However, treatment with PL and PF inhibited the amyloidogenic pathway via the down-regulation of those protein expressions. Taken together, our results indicate that PL, and its active compound PF, could protect SH-SY5Y cells against Aβ_25-35-induced cell neurotoxicity by attenuating LDH release and ROS production, and these effects may be attributed to regulation of amyloidogenic pathway-related protein expression. In conclusion, PL and PF could be a potential to prevent neurodegenerative disorders such as AD.

• 산업융합연구
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• 제20권10호
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• pp.61-69
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• 2022

외상 후 성장 개념은 다양한 분야에서 사용되고 있다. 연구의 목적은 네트워크 분석을 활용하여 외상 후 성장의 지식구조를 확인하기 위함이다. 1996년에서 2018년 사이에 출판된 국외논문 중 외상 후 성장 키워드를 사용한 논문을 Web of Science에서 검색하여 1,780편의 논문에 1,659개의 키워드가 6,343회 등장하는 것을 확인할 수 있었으며, 최종 분석을 위한 총 322개의 키워드를 선택하였다. 가장 많이 등장한 키워드는 '외상 후 성장', '외상 후 스트레스 장애', '암', '트라우마' 순이었다. 총 322개의 노드 중 175개의 노드로 정리하여 '암, 만성/중증 질환 및 장애에서 외상 후 성장', '외상 후 성장 관련 심리적 변수 및 심리 치료', '죽음의 맥락에서 외상 후 성장', '외상 후 성장의 인지 메커니즘' 및 '대리 외상 후 성장'의 5개 그룹으로 나눌 수 있었다. 본 연구는 정량적 네트워크 분석을 통해 외상 후 성장의 지식 구조에 대한 체계적인 개요를 제공 하였다는데 의의가 있다.

• 디지털융복합연구
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• 제20권5호
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• pp.253-260
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• 2022

21세기의 핵심역량 중 하나인 창의성은 사회구성원의 필수 항목으로 요구되다. 원하는 방향으로 사용할 수 있도록 하는 개성적인 측면에서 그 능력을 강조한다. 그러나 창의성은 새로운 아이디어나 제품을 만들어내는 것뿐만 아니라 변화하는 환경에 적응하고 문제를 해결하는 등 조직의 긍정적인 변화에 기여하는 것으로 간주되다. 이에 따라 선행연구를 검토하여 보상이 창의성을 촉진하거나 방해할 수 있다는 결론을 내렸으며, 이는 보상의 성격과 연구자가 보유한 창의성 개념, 개인차 및 외부 환경에 따라 달라질 수 있다. 우리는 또한 보상이 동기, 인지 및 합성 기능을 통하여 창의성에 영향을 미칠 수 있다고 제안하였다. 분석을 바탕으로 보상이 창의성에 미치는 영향을 구체적으로 모델을 제안하였다. 본 연구는 기존의 연구를 기반으로 하며, 어떠한 외적 동기와 내적 동기가 어떠한 관계를 가지고 있는지 비교를 바탕으로 창의성에 영향을 미치는 과정에서 작용하는 다양한 요소와 메커니즘을 분석하였다. 다음으로, 보상은 사람마다 환경적 상황에서 주어지는 방식에 따라 다른 것으로 나타났다. 마지막으로 다양한 유형의 창작과제를 보상함으로써 적극적인 보상의 역할을 확보할 수 있다.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.285-297
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• 2023

Alzheimer's disease (AD) is a neurodegenerative disease with progressive memory loss and the cognitive decline. AD is mainly caused by abnormal accumulation of misfolded amyloid β (Aβ), which leads to neurodegeneration via a number of possible mechanisms such as down-regulation of brain-derived neurotrophic factor-tropomyosin-related kinase B (BDNF-TRKB) signaling pathway. 7,8-Dihydroxyflavone (7,8-DHF), a TRKB agonist, has demonstrated potential to enhance BDNF-TRKB pathway in various neurodegenerative diseases. To expand the capacity of flavones as TRKB agonists, two natural flavones quercetin and apigenin, were evaluated. With tryptophan fluorescence quenching assay, we illustrated the direct interaction between quercetin/apigenin and TRKB extracellular domain. Employing Aβ folding reporter SH-SY5Y cells, we showed that quercetin and apigenin reduced Aβ-aggregation, oxidative stress, caspase-1 and acetylcholinesterase activities, as well as improved the neurite outgrowth. Treatments with quercetin and apigenin increased TRKB Tyr516 and Tyr817 and downstream cAMP-response-element binding protein (CREB) Ser133 to activate transcription of BDNF and BCL2 apoptosis regulator (BCL2), as well as reduced the expression of pro-apoptotic BCL2 associated X protein (BAX). Knockdown of TRKB counteracted the improvement of neurite outgrowth by quercetin and apigenin. Our results demonstrate that quercetin and apigenin are to work likely as a direct agonist on TRKB for their neuroprotective action, strengthening the therapeutic potential of quercetin and apigenin in treating AD.

• 농업과학연구
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• 제49권1호
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• pp.137-149
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• 2022

We investigated the effects of Cirsium japonicum var. maackii (CJM) against oxidative stress-induced C6 glial cells and cognitive impairment in mice. To evaluate the anti-oxidative effect of the extract and fractions from CJM, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), reactive oxygen species (ROS), and nitric oxide (NO) assays were conducted in H₂O₂-treated C6 glial cells. Furthermore, we identified the protective mechanisms of CJM with a scopolamine-treated mice model. The results revealed that H₂O₂ decreased the cell viability in C6 glial cells, indicating that H₂O₂ induced oxidative stress in glial cells. However, CJM fractions significantly increased cell viability in H₂O₂-treated C6 glial cells, which suggested that CJM protected against oxidative stress. CJM extract and fractions also reduced ROS and NO production, which were increased by H₂O₂ in C6 glial cells. In particular, the EtOAc fraction from CJM (EACJM) effectively protected against oxidative stress by increasing the cell viability and decreasing ROS and NO. Therefore, we carried out further in vivo experiments with EACJM. Scopolamine caused increases of ROS, thiobarbituric acid reactive substances (TBARS), and NO production. However, EACJM effectively alleviated ROS, TBARS, and NO levels compared to scopolamine-injected mice. In addition, EACJM up-regulated protein expressions of superoxide dismutase and glutathione peroxidase, indicating that EACJM enhanced the antioxidative system. Our results demonstrated that CJM had protective effects against oxidative stress in glial cells and memory dysfunction in mice. Based on these results, we propose that CJM could be a potential AD preventive and therapeutic agent.

• Asia Marketing Journal
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• 제17권4호
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• pp.21-42
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• 2016

Purpose: Social influence has a decisive role in shaping a person's cognition and behavior. Chinese face consciousness, including moral component, is an important part of Chinese traditional culture, which influences people to implement moral behavior. With both eye-tracking technology and traditional questionnaire, this research aims to explore people's moral psychology and the psychological processing mechanisms of Chinese face consciousness, as well as the impact of Chinese face consciousness on the preference for the ecological product. Method and Data: 75 college and MBA students' eye movement data were collected when they read different kinds of moral materials, as well as data from the subsequent questionnaires. To test the hypothesis, ANOVA analysis and Heat Map analysis were performed. Besides, the PROCESS of bootstrap was used to test mediation effect. Findings: The results reveal that: 1. Compared to the moral-situation reading, when subjects read immoral situations, they need more processing time due to the moral dissonance and cognitive load. 2. Compared to the control condition, when threatened moral self is primed, subjects prefer to choose ecological product. 3. Protective face orientation is the mediator between threatened moral self and preference to ecological product. Key Contributions: First, this study broadens the use of eye-tracking technology in marketing and demonstrates a better understanding of the relationship between morality and consumer behavior in a more scientific way. Second, this study not only distinguishes the meanings between "protective face orientation" and "acquisitive face orientation", but also innovatively validates that when moral self is threatened, consumers tend to choose ecological product as moral compensation in order to protect their face. It can shed light on the promotion of ecological product in practical applications.

• Journal of Ginseng Research
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• 제47권4호
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• pp.552-560
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• 2023

Background: Ginseng Radix (Panax ginseng Meyer, Araliaceae) has been used medicinally to treat the brain and nervous system problems worldwide. Recent studies have revealed physiological effects that could potentially benefit cognitive performance or mood. The present study aimed to investigate the antidepressant effects of Korean red ginseng water extract (KGE) and its active component in an unpredictable chronic mild stress (UCMS)-induced animal model and elucidate the underlying mechanisms. Methods: The antidepressant potential of the UCMS model was evaluated using the sucrose preference test and open field tests. The behavioral findings were further corroborated by the assessment of neurotransmitters and their metabolites from the prefrontal cortex and hippocampus of rats. Three doses of KGE (50, 100, and 200 mg/kg) were orally administered during the experiment. Furthermore, the mechanism underlying the antidepressant-like action of KGE was examined by measuring the levels of brain-derived neurotrophic factor (BDNF)/CREB, nuclear factor erythroid 2-related factor 2 (Nrf2), and Kelch-like ECH-associated protein 1 (Keap1) proteins in the prefrontal cortex of UCMS-exposed rats. Results: KGE treatment normalized UCMS-induced depression-related behaviors. Neurotransmitter studies conducted after completing behavioral experiments demonstrated that KGE caused a reduction in the ratio of serotonin and dopamine, indicating a decrease in serotonin and dopamine turnover. Moreover, the expression of BDNF, Nrf2, Keap1 and AKT were markedly increased by KGE in the prefrontal cortex of depressed rats. Conclusion: Our results provide evidence that KGE and its constituents exert antidepressant effects that mediate the dopaminergic and serotonergic systems and expression of BDNF protein in an animal model.

• Journal of Ginseng Research
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• 제47권4호
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• pp.583-592
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• 2023

Background: Alcohol is one of the most commonly used psychoactive drugs. Due to its addictive characteristics, many people struggle with the side effects of alcohol. Korean Red Ginseng (KRG) is a traditional herbal medicine that is widely used to treat various health problems. However, the effects and mechanisms of KRG in alcohol-induced responses remain unclear. Therefore, the purpose of this study was to investigate the effects of KRG in alcohol-induced responses. Methods: We investigated two aspects: alcohol-induced addictive responses and spatial working memory impairments. To determine the effects of KRG in alcohol-induced addictive responses, we performed conditioned place preference tests and withdrawal symptom observations. To assess the effects of KRG in alcohol-induced spatial working memory impairment, Y-maze, Barnes maze, and novel object recognition tests were performed using mice after repeated alcohol and KRG exposure. To investigate the potential mechanism of KRG activity, gas chromatography-mass spectrometry and western blot analysis were performed. Results: KRG-treated mice showed dose-dependent restoration of impaired spatial working memory following repeated alcohol exposure. Furthermore, withdrawal symptoms to alcohol were reduced in mice treated with KRG and alcohol. The PKA-CREB signaling pathway was activated after alcohol administration, which was reduced by KRG. However, the levels of inflammatory cytokines were increased by alcohol and decreased by KRG. Conclusion: Taken together, KRG may alleviate alcohol-induced spatial working memory impairments and addictive responses through anti-neuroinflammatory activity rather than through the PKA-CREB signaling pathway.