• 대한한방소아과학회지
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• 제21권3호
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• pp.85-95
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• 2007

Objectives Attention Deficit Hyperactivity Disorder(ADHD) is a type of psychiatric disorder characterized with the primary symptoms of inattention and/or impulsivity and hyperactivity. The purpose of this study is to examine ADHD children who were treated with neurofeedback therapy. Methods We analyzed clinical report of 3 ADHD children who treated with neurofeedback therapy from January 2006 to June 2006. Results 1. All 3 children were diagnosed with predominantly inattention type of ADHD. 2. After treatment, cognitive strength, response, concentration, workload, left / right brain activity score were all different from each children. 3. After treatment, left and right brain activities were balanced. 4. After treatment, learning ability level was increased. 5. After treatment, the childrenwere in a better state referred to conner's scale and H.S.Q. score. Conclusions Further studies will be needed to get more clinical cases about the benefits of neurofeedback therapy with herbal medicine and acupuncture treatment.

• Journal of Interdisciplinary Genomics
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• 제1권1호
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• pp.10-13
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• 2019

A 10-year and 5 month-old girl with developmental delay, intellectual disability, attention deficit hyperactivity disorder, poor weight gain, and microcephaly was transferred to our pediatric clinic for genetic evaluation. Her height was within the 5-10th percentile, and her weight was under the 3rd percentile. On the social maturity scale, her developmental status was scored as 3 years 9 months for social age, and the social quotient was 35.98. A chromosomal microarray analysis was performed and the microduplication at chromosome 16p was observed: arr[GRCh37] 16p11.2 (29580020_30190029)${\times}3$. Currently, the patient is diagnosed with Grade 2 intellectual disability and is attending a computerized cognitive rehabilitation class twice weekly. In addition, nutritional support and growth follow up are also ensured in the Pediatric Gastrointestinal and Endocrinology clinic.

• 한국노년학
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• 제28권4호
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• pp.925-940
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• 2008

현대 사회에서 노인 인구의 비율이 꾸준하게 증가하면서, 정상적 및 병리적 노화와 관련된 기억 결함을 다루는 인지적 재활 전략의 영향력도 차차 커지고 있다. 본 논문에서는 현재 이루어지고 있는 노인을 위한 기억 재활 기법을 개관하였다. 먼저, 기억의 노화를 이해하기 위한 이해의 틀로서 인간의 기억 체계를 고찰하였고, 정상적 노화와 알츠하이머병과 같은 병리적 노화에 따른 기억 수행에 관하여 이루어진 연구결과들을 개관한 다음, 그 효과가 입증된 기억 재활 기법들을 소개하였다. 현재까지의 기억 재활 기법들은 아직 남아있는 외현 기억 촉진, 상대적으로 손상되지 않은 암묵 기억 이용, 외부 기억보조 도구 사용에 초점을 맞춘 것이었으나, 새로운 접근으로 뇌 가소성에 기반을 둔 기억 훈련 방법의 가능성을 제안하였다.

• 생물정신의학
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• 제5권1호
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• pp.83-94
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• 1998

Objectives : Phencyclidine(PCP) or PCP-like substances such as ketamine have been known to rekindle the cognitive dysfunction in schizophrenia. The aims of this study were to identify whether PCP-like substances can produce cognitive deficit in schizophrenia, to discuss relation with aging process, and finally to speculate underlying neurochemical mecha-nisms by various drug responses. Methods : In experiment I, radial maze tests were done in 24 Sprague-Dawley rats for 3 days to get baseline data. Being divided into 4 groups(6 rats respectively) of normal aged, normal adult controls, atropine-treated and ketamine-treated, the radial maze tests were repeated on every week for 6 weeks, and then the rats were sacrificed by intracardiac perfusion with phosphate-buffered 10% formaldehyde solution for histology. The brain specimen was stained with hematoxylin-eosin to count cells in the prefrontal cortex and hippocampus. In experiment II, radial maze tests were done for 48 rats before any drug treatment and only after ketamine administration. Thereafter, haloperidol, bromocriptine, clonidine, nimodipine, tacrine, valproic acid, naloxone and fluoxetine were intramuscularly injected on every other day in addition to ketamine. Radial maze tests were repeated on every week for 6 weeks, and then rats were prepared by the same procedure for histology. Results : 1) Reaction times of radial maze tests of atropine-treated rats were significantly prolonged than those of normal aged(p<0.05) or normal adult controls(p<0.05). Cell numbers of prefrontal cortex & hippocampus in ketamine-treated rats were significantly reduced than those in normal aged (p<0.05) or normal adult controls(p<0.005). 2) Reduced cell numbers by ketamine became significantly raised by tacrine administration in prefrontal cortex & hippocampus(p<0.05), while there were no significant changes on radial maze tests. Cell numbers also tended to be raised by nimodipine, fluoxetine and haloperidol administration. Conclusions : In conclusion, the visuospatial memory disorders in ketamine-induced psychotic rats might be partly asso-ciated with aging process. Furthermore, the responses to the various drugs suggested cholinergic system might have an important role in the neurochemical mechanism of the cognitive dysfunction in ketamine-induced psychosis. Otherwise, calcium metabolism as well as serotonergic and dopaminergic systems seemed to be possibly related.

• 한국식품영양과학회지
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• 제43권6호
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• pp.799-806
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• 2014

본 연구는 scopolamine으로 유도한 기억력 및 인지기능 감퇴 동물모델에서 비파엽 추출물의 기억력 및 인지기능 개선효과를 평가하기 위해 수행되어졌다. 6주령의 SD-rat(male)을 총 5개 군으로 분리하였으며, 양성대조군으로 donepezil(1 mg/kg b.w.)을 처리하였다. 15일간 24시간 간격으로 EJE를 50, 200 mg/kg b.w. 농도로 전처리(경구투여) 하였으며, 16일째에 농도별로 EJE 및 양성대조군으로서 donepezil을 투여하고 scopolamine을 복강투여(1 mg/kg b.w.) 하였다. Water maze test와 passive avoidance test를 통해 scopolamine으로 유도한 동물모델에서 EJE의 기억력 및 인지능력 개선 효과를 확인한 결과, scopolamine에 의해 감소된 기억력 및 학습능력이 EJE를 투여함으로써 유의적으로 회복 및 증가한 것을 확인할 수 있었다. Scopolamine에 의해 인지능력과 함께 감소된 운동능력의 평가를 위해 수행한 rotarod test 및 vertical pole test에서는 scopolamine의 투여로 감소된 균형감각, 협응력 그리고 grip strength와 같은 운동능력들이 EJE의 투여로 유의적으로 회복된 것을 확인하였다. 또한 scopolamine에 의해 증가한 AchE의 활성과 감소한 Ach의 함량이 EJE의 투여로 각각 개선되었다. 본 연구에서는 이와 같은 결과를 바탕으로 EJE의 scopolamine으로 유도한 동물모델에서 인지능력 개선과 감퇴한 운동능력의 향상 및 cholinergic neurotransmission system의 강화 효과를 확인할 수 있었으며, 이러한 연구 성과들로 비파엽 추출물이 퇴행성뇌질환인 AD 치료와 학습 및 기억력 개선에 있어 효과적인 대안으로서 보다 더 많은 분야에서 연구되기를 바라는 바이다.

• Journal of Microbiology and Biotechnology
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• 제32권9호
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• pp.1154-1167
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• 2022

In this study, we investigated the anti-amnesic effect of Korean red pine (Pinus densiflora) bark extract (KRPBE) against amyloid beta_1-42 (Aβ_1-42)-induced neurotoxicity. We found that treatment with KRPBE improved the behavioral function in Aβ-induced mice, and also boosted the antioxidant system in mice by decreasing malondialdehyde (MDA) content, increasing superoxide dismutase (SOD) activities, and reducing glutathione (GSH) levels. In addition, KRPBE improved the cholinergic system by suppressing reduced acetylcholine (ACh) content while also activating acetylcholinesterase (AChE), regulating the expression of choline acetyltransferase (ChAT), postsynaptic density protein-95 (PSD-95), and synaptophysin. KRPBE also showed an ameliorating effect on cerebral mitochondrial deficit by regulating reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and ATP levels. Moreover, KRPBE modulated the expression levels of neurotoxicity indicators Aβ and phosphorylated tau (p-tau) and inflammatory cytokines TNF-α, p-IκB-α, and IL-1β. Furthermore, we found that KRPBE improved the expression levels of neuronal apoptosis-related markers BAX and BCl-2 and increased the expression levels of BDNF and p-CREB. Therefore, this study suggests that KRPBE treatment has an anti-amnestic effect by modulating cholinergic system dysfunction and neuroinflammation in Aβ_1-42-induced cognitive impairment in mice.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제14권2호
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• pp.197-208
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• 2003

목 적：본 연구에서는 읽기 장애 아동들(Reading Disability)은 빠르게 제시되는 언어 자극을 처리하는데 핵심적인 문제를 갖고 있으며, 주의력 결핍/과잉 운동 장애 아동들(ADHD)은 반응의 억제에 어려움을 보인다고 가정하였다. 읽기 장애와 주의력 결핍/과잉 운동 장애 그리고 공존 장애 아동 집단을 대상으로 핵심적인 인지 특성을 밝혀보고자 시각/청각 주의력과 음소 변별 검사에서 세 집단의 수행 차이를 비교하였다. 방 법：1차 연구에서는 ADHD 아동 28명과 RD+ADHD 아동 16명에게 주의력의 차이를 평가하기 위해 개별적으로 전산화된 주의력 장애 진단 검사(ADS)를 실시한 후 시각적 주의력과 청각적 주의력의 집단 간 수행 차이를 전체 지능의 영향을 통제하고 비교하였다. 2차 연구에서는 RD+ADHD/RD 아동 13명과 ADHD 아동 13명, 정상 아동 12명에게 전산화된 음소 변별 검사를 실시한 후 지능의 영향을 통제하고 세 집단의 수행 차이를 비교하였다. 결 과：시각적 주의력에서는 유의한 차이가 나타나지 않았으나, 청각적 주의력에서는 RD+ADHD 집단이 유의하게 어려움을 보였으며, 반응시간의 변산성이 증대되는 경향성이 나타났다. 음소 변별 검사에서는 RD 수반 집단과 ADHD 집단이 모두 정상 통제 집단에 비해 오류를 더 많이 보였고, RD 수반 집단과 ADHD 집단간에 다른 수행 패턴을 보였다. 논 의：ADHD들은 RD의 수반여부에 상관없이 반응 억제와 일관적인 주의력 유지에 어려움을 보였고 RD가 공존하는 경우 청각적 주의력의 문제가 증폭되었다. 음소 변별 검사에서 RD가 목표반응에 정확하게 반응하는데 어려움은 나타났으나, ADHD와는 유의한 수행 차이를 나타내지 않았다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제17권2호
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• pp.131-140
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• 2006

Objectives : This study was conducted to investigate the deficits of executive function in children with ADHD, Asperger's Disorder(AD), and teaming disorder (LD), and to identify the differential characteristics of executive function deficits among three groups. Methods : The clinical group consisted of 46 children between the ages of 7 and 15 (16 ADHD, 16 LD, 14 AD). Neuropsychological tests for measuring cognitive function, attention and executive function were individually administered to children, and their performance scores were calculated based on the age norm for each test. Results : There was no significant difference in FSIQ, VIQ, and PIQ among the three groups. However, the AD group tended to show higher scores on the subtests of Information, Vocabulary and Digit Span, and lower score on Comprehension subtest than the ADHD and LD groups, while the LD group tended to show the lowest scores on the Information and Vocabulary subtests. On ADS, the ADHD group showed the highest omission and commission errors. All groups showed poor performances belonging to below 25 percentile ranks on executive function tests when compared to the age norms of normative group. The number of completed category on WCST was the smallest in the ADHD group, while the working memory score was the lowest in the LD group. Conclusion : These results suggest that ADHD, LD, and AD children have executive function deficit in common. However, the specific deficit areas in executive function are different for each group.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제18권1호
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• pp.10-15
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• 2007

Probably the three most important components to a comprehensive evaluation of patients with attention-deficit hyperactivity disorder (ADHD) are the clinical interview, the medical examination, and the completion and scoring or behavior rating scales. Teachers and other school personnel are often the first to recognize that a child or adolescent might have ADHD, and often play an important role in the help-seeking/referral process. A diagnostic evaluation for ADHD should include questions about ADHD symptoms, other problems including alcohol and drug use, family history of ADHD, prior evaluation and treatment for ADHD. Screening interview or rating scales as well as interviews should be used. When it is feasible, clinicians may wish to supplement these components of the evaluation with objective assessments of the ADHD symptoms, such as psychological tests. These tests are not essential to reaching a diagnosis, however, or to treatment planning, but they may yield further information about the presence and severity of cognitive impairments that could be associated with some cases of ADHD. Screening for intellectual ability and academic achievement skills is also important in determining the presence of comorbid developmental delay or loaming disabilities. The number and type of symptoms required for a diagnosis of ADHD vary depending on the specific subtype. To receive a diagnosis of ADHD, the person must be experiencing significant distress or impairment in daily functioning, and must not meet criteria for other mental disorders which might better account for the observed symptoms such as mental retardation, autism or other pervasive developmental disorders, mood disorders, anxiety disorders. This report aims to suggest a practice guideline of assessment and diagnosis for children and adolescents with ADHD in Korea.

• 재활치료과학
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• 제4권2호
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• pp.33-50
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• 2015

목적: 본 연구의 목적은 뇌졸중 환자의 집행 기능 향상을 위해 회복기 및 인지 과정에 따른 중재법을 알아보고, 이를 집행기능 장애의 사례별 특성에 따라 정리하여 임상현장의 작업치료사에게 시행방법과 근거를 제시하고자 하는 것이다. 연구방법: 주요검색 용어'Stroke', 'Executive function', 'Executive function deficit', 'Occupational therapy', 'Rehabilitation', 'Remedial', 'Compensatory' and 'Education'를 사용하여 1996년부터 2015년 4월까지 20년 간의 문헌을 검색하였다. 전자 테이터 베이스인 MEDLINE, SCOPUS, RISS을 사용하였으며 최종적으로 13개의 논문이 본 연구의 분석 대상으로 사용되었다. 결과: 선정된 13편의 연구는 질적 수준(level of evidence)에 따라 전체 연구 중 수준I에 포함하는 무작위 할당 실험설계는 6개(46.2%)이었고, 수준II가 1개(7.7%), 수준III이 2개(15.4%), 수준IV가 4개(30.8%)이었다. 각 중재 방법에 따른 결과로 실행 기능의 향상을 보이나 일상생활의 일반화는 각 실험에 따라 차이가 있었다. 결론: 뇌졸중 환자의 집행 기능 향상을 위해 다양한 중재 방법이 적용되고 있으며, 중재 방법에 따라 효과의 차이가 나타났다. 본 연구는 뇌졸중 환자의 집행 기능 향상을 위한 중재 방법의 임상적 적용에 대한 근거를 제시하였다. 향후 연구에서는 다양한 중재 방법의 적용과 급성기 뇌졸중 환자에 대한 적용이 필요하다.