• 한국식품과학회지
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• 제54권1호
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• pp.52-58
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• 2022

Phosphatidylserine (PS) is an essential component of the cerebral cortex and is associated with cognitive function. In this systematic review, the effects of PS on cognitive function in the elderly population are examined. The literature search included PubMed, EMBASE, Cochrane, and Web of Science databases. Subsequently, nine studies, including five randomized controlled trials and four pre-post studies, were selected. There were 961 participants in the selected studies; PS dosage varied from 100 to 300 mg/d, and the experimental period ranged from 6 weeks to 6 months. Five out of the nine selected studies were assessed to have a 'low' risk of bias, whereas the other four studies were assessed to have 'some concerns' regarding the risk of bias. The results of the meta-analysis concluded that PS had a positive effect on the memory of older adults with cognitive decline. Thus, PS appears to improve age-associated cognitive decline, especially memory, with no adverse effects.

• 대한치매학회지
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• 제17권3호
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• pp.120-129
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• 2018

Background and Purpose: Prospective memory (PM) has a known relationship with frontal function, and PM decline has been observed in amnestic mild cognitive impairment (aMCI). Cerebral small vessel disease, as evidenced by white matter hyperintensities (WMHs), is linked to frontal dysfunction. This study was undertaken to evaluate the relationship between PM decline and WMHs in patients with aMCI. Methods: Of 74 enrollees with aMCI, 69 completed this prospective study. We compared total scores and sub-scores of the Prospective and Retrospective Memory Questionnaire (PRMQ) administered at baseline and 3 months later, stratifying patients by degree of WMHs. Results: A significant decline was seen in PRMQ total scores and PM scores at the 3-month mark in patients with moderate (vs. mild) degrees of WMHs ($-2.8{\pm}7.2$ vs. $0.2{\pm}7.1$; p=0.032). In addition, patients with moderate (vs. mild) degrees of deep WMHs (DWMHs) showed greater PM decline, whereas PM loss in patients with mild, moderate, or severe degrees of periventricular WMHs (PVWMHs) did not differ significantly. Conclusions: Findings of this study indicate that the burden of WMHs is consistently implicated in PM deterioration experienced by patients with aMCI, and signifies greater PM decline, especially in instances of extensive DWMHs. Greater attention to the change of PM is therefore needed in aMCI patients with WMHs.

• 한방재활의학과학회지
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• 제23권3호
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• pp.211-217
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• 2013

2013년 3월 9일부터 6월 11일까지 대전대학교 부속 대전한방병원 한방재활의학과에 부동(immobility)으로 노쇠가 진행되어 보행장애 및 인지 기능 저하가 발생한 노인 입원환자 1명을 대상으로, 운동요법을 병행한 한방치료가 증상 호전에 미치는 영향에 대해 다음과 같은 결론을 얻었다. 1. 치료 후 양하지 도수근력검사는 4등급으로 근력이 향상되었다. 2. 슬관절 신전 수동운동범위는 -30/-30에서 0/-5도로 호전되었다. 3. 한국형 간이 정신상태 검사는 7점에서 25점으로 호전되었다.

• 한국산학기술학회논문지
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• 제21권9호
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• pp.358-372
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• 2020

본 연구는 성인의 인지예비능, 주관적 기억감퇴, 우울 및 삶의 질 등과 같은 요인들이 인지기능에 미치는 직·간접 효과를 규명하고자 하였다. 연구 대상자는 만 40세 이상 80세 미만의 성인 남녀 253명을 대상으로 설문 조사하였고, 본 연구에 사용된 도구는 인지기능 척도, 우울 척도, 삶의 질, 주관적 기억감퇴, 인지예비능 척도를 사용하였다. 데이터 결과는 SPSS 25.0를 이용하여 분석하였고, PROCESS macro for SPSS Version 3.3과 부트스트래핑 방법을 활용하였다. 연구결과, 성인의 인지예비능은 우울과 삶의 질에 영향을 미치는 것으로 나타났으며, 인지예비능과 인지기능의 다중 매개 결과는 우울 및 주관적 기억감퇴에서 매개효과가 나타나지 않았다. 그러나 삶의 질은 성인의 인지예비능과 주관적 인지기능 간의 관계에서 완전매개효과를 나타냈다. 본 연구결과를 토대로 성인들은 다양한 활동과 지속적인 훈련을 통해 인지예비능을 꾸준히 축적하여 인지기능이 긍정적인 방향으로 이어지도록 하는 것이 필요하다. 또한 건강한 성인들을 대상으로 한 인지예비능과 인지기능을 위한 많은 연구들이 실행되기를 제언한다.

• 대한통합의학회지
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• 제8권4호
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• pp.59-66
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• 2020

Purpose : This study aimed to present normative data for older Korean adults completing the Yonsei dual task cognitive screening test (Y-DuCog) and identify changes in cognitive function on the Montreal Cognitive Assessment - Korean (MoCA-K) with age. Methods : From May 2019 to August 2019, 195 healthy adults aged ≥60 years participated in this study. All participants completed the Y-DuCog to assess their dual-task performance and the MoCA-K to assess their cognitive function. Participants were divided into three groups based on their age: 60~69 years, 70~79 years, and ≥80 years. Results : The results of the Y-DuCog showed that dual-task performance time, effect, and correct response rate decreased significantly with age (p<.001). Scores from the three groups showed differences on all items (p<.001). Cognitive function on the MoCA-K also decreased significantly with age (mean score ± standard deviation [SD]; 27.33 ± 2.61 in subjects aged 60~69 years; 24.82 ± 3.20 in subjects aged 70~79 years; and 22.10 ± 4.91 in subjects aged ≥80 years; p<.001). Conclusions : Occupational therapists should be aware of the decline in cognitive function and dual-task performance time, effect, and correct response rate in older adults and consider interventions to treat this decline. Further studies are needed with larger groups of participants to examine factors, such as sex and education, that may impact dual-task performance and cognitive function.

• 한국임상약학회지
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• 제29권4호
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• pp.238-246
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• 2019

Background: In South Korea, as an aged society, an understanding of dementia and its risk factors is important from clinical and healthcare policy perspectives. Relationship between cognitive impairment and body weight or weight changes have been reported, but these were contradictory. We have evaluated the association between weight changes and cognitive decline using national level longitudinal data. Methods: Data from the Korean Longitudinal Study of Ageing from 2006 to 2012 were used. Association between weight changes and decline in cognitive function as measured by K-MMSE (the Korean version of the Mini-mental state examination) score was assessed by multivariate logistic regression. Weight changes were calculated from 1st wave and 3rd wave survey data, and classified into five groups as stable, increases, decreases of >10%, or 5%-10%. Results: About 37% of the total participants (n=4,512) were 65 years or older. These participants made up the largest proportion of the groups with weight change exceeding 10%. Multivariate logistic regression analyses revealed that weight changes exceeding 10% (10% increase vs stable, adjusted OR [aOR] 1.47, 95% confidence interval (CI) 1.11-1.95; 10% decrease vs stable, aOR 1.44, 95% CI 1.11-1.88) were significant predictive factors for decline in cognitive function. In subgroup analyses, the association between weight changes and cognitive decline was significant in males aged over 65 years and in normal BMI groups. Conclusion: Weight changes, both increases and decreases exceeding 10% of baseline, were significantly associated with declines in cognitive function among older adults in South Korea.

• 보건의료산업학회지
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• 제13권1호
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• pp.67-78
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• 2019

Objectives: To identify the factors affecting the cognitive function according to the education level of people aged 65 or older. Methods: This study used the data from the 2014 survey of living conditions and welfare needs of Korean older adults. A total of 10,248 people were analyzed in the final analysis, not including those who responded by proxy and those who did not participate in cognitive function tests. Cognitive function was measured by Mini Mental State Examination -Dementia Screening(MMSE-DS), and logistic regression was performed using the SPSS/WIN 24.0 program. Results: There were differences in factors affecting cognitive function depending on the education level. Overall, regular exercise had a positive effect on maintaining cognitive function, and the higher the education level, the more important it was to maintain the Instrumental Activities of Daily Living(IADL). In addition, for lower education levels, improving the life satisfaction was important to prevent the decline of cognitive function. Conclusions: Based on the results of this research, it is suggested that customized approaches shoud be taken according to education level when developing and implementing programs to prevent the decline of cognitive function.

• 디지털융복합연구
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• 제17권2호
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• pp.283-292
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• 2019

초기의 인지 감퇴를 판단하는 요소로 의미지식 및 의미 연관관계의 범주별 손상 유무가 주목을 받고 있다. 본 연구에서는 정상 및 주관적 기억장애, 경도인지장애 노인을 대상으로 의미연상과제를 사용하여 인지 감퇴의 정도에 따라 관찰되는 의미 하위범주별 수행과 오류유형의 차이를 살펴보고자 하였다. 연구 결과, 의미연상과제 범주별 정반응 점수와 반응시간에서 세 군 간 유의한 차이를 보였으며, 하위범주 중, '기능'에서 가장 높은 수행력을, '상위'와 '부분/전체'에서 가장 낮은 수행력을 보였다. 또한, 오류유형별 산출 횟수는 정상에서 경도인지장애 노인으로 갈수록 유의하게 높아졌으며, 무반응은 주관적 기억장애 노인부터 유의하게 증가하였다. 결론적으로, 인지 감퇴가 진행될수록 의미연결망에서 범주별 손상의 정도와 과정이 다르므로, 기억장애 노인의 인지적 감퇴를 확인하고 추적 관찰하기 위한 지표로 의미연상과제 수행력을 활용할 수 있을 것이다.

• 대한물리의학회지
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• 제5권3호
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• pp.313-322
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• 2010

Purpose : This study was to evaluate the effects of cognitive rehabilitation training on the cognitive decline of dementia patients. Therefore the purpose of this study was to examine the influence of brain activation according to bio-feedback training in dementia. Methods : Ten dementia patients were recruited this study. Experiment was performed for 30min per session, five times a week through 4 week and two measurements before and after bio-feedback training. Brain activity was measured by Korea Electroencephalogram(EEG) system. Statistical analysis was used Wilcoxon signed rank test to know difference of EEG between pre and post-test in each group and Mann-Whitney U test was to know difference between experimental and control group. Results : Significant improvement of slow-alpha wave was observed following bio-feedback in experiment group. There was no significant change in experiment and control group. Conclusion : In this study, the bio-feedback training was effective in improving slow-alpha wave in dementia patients. It is suggested that bio-feedback training with dementia patients can be useful to ameliorate the cognitive decline. And it will be effective for prevention of cognitive function decline.

• 한국보건간호학회지
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• 제31권2호
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• pp.209-219
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• 2017

Purpose: The purpose of this study was to identify the gender differences in the cognitive function and nutritional status among elderly people living in the community. Methods: This study used data from the 2014 National Survey on the Elderly and focused on 10,054 respondents who answered that they did not have dementia. The Korean version of Mini-Mental State Examination for Dementia Screening and the Nutrition Screening Initiative were used. IBM SPSS Statistics 23.0 was used to conduct statistical analyses. Results: The cognitive function score was 25.30 for men, which was higher than for women. The percentage of subjects who showed cognitive decline was 25.5% for males and 50.2% for females, which was statistically significant (p<.001). There were statistically significant differences in the nutritional status between males and females (p<.001). There was a statistically significant negative correlation between the cognitive function and nutritional status in both men and women (p<.001, p<.001). Conclusion: These results showed that the intervention to maintain cognitive functioning should be provided to elderly women with a low education level or high number of chronic diseases and medication, and an intervention to prevent the cognitive decline of the elderly should include nutritional management for health and function maintenance.