• 대한조현병학회지
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• 제21권2호
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• pp.74-80
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• 2018

Objectives : This study investigated whether long-acting injectable (LAI) paliperidone is different from its oral form in terms of the effect on cognitive function in schizophrenia spectrum and other psychotic disorders. Methods : We reviewed the medical records of patients in Seoul National University Bundang Hospital who were diagnosed as having schizophrenia and/or other psychotic disorders based on DSM-5 from 2016 to 2017. Seven patients were treated with oral paliperidone and 11 were treated with paliperidone palmitate. All patients underwent clinical and neuropsychological assessment, including the Korean version of the MATRICS Consensus Cognitive Battery (MCCB) at their first visit or within one month of their initial treatment. MCCB was repeated within three to 12 months after the initial assessment. Results : There was no significant difference between the two groups in most cognitive domains including speed of processing, attention and vigilance, working memory, verbal learning, visual learning and reasoning and problem solving domain. However, patients treated with paliperidone palmitate showed better improvement in social cognition domain than those taking oral paliperidone. The standardized values of social cognition domain scores had significantly improved over time in patients under paliperidone palmitate, demonstrating a significant time-by-group interaction. Conclusion : Our results show that long-acting injectable paliperidone could be helpful in some aspects of improving cognitive function in schizophrenia spectrum and other psychotic disorders. Further studies with other antipsychotics are necessary to generalize the results.

• 한국초등과학교육학회지:초등과학교육
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• 제19권1호
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• pp.41-56
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• 2000

The purpose of this study was to investigate the change of elementary school students' conception on the movement of the moon, after teaching a lesson about the lunar phase which focused on concrete activities. The 396 subjects in this study consisted of intact groups of second, third, fourth, fifth, and sixth grade students. Pre-test and post-test instrument concerning on the conception in the movement of the moon were developed after reviewing the related literature and curriculum. Prevailing conceptions were identified by frequency of each conception. Then, the pattern of change and consistency of each conception were analyzed in comparison pre-test with post-test. To figure out the effect of teaching, the GEFT and the GALT instrument were administered to analyze it by gender, cognition mode and level. SPSS/WIN programs were used to process the data. The result showed that teaching 'movement of the moon' was the most effective in fourth grade. The effect of teaching 'changes in shape of the moon' was effective regardless of their sexes. Teaching 'changes in shapes of the moon' was more effective for the students whose cognitive modes were field-independent, than those filed-dependent. But the improvement by the teaching was not significantly different. The pre-score by cognitive level was significantly high in the order of the formal operational, transitional stage and the concrete operational stage. But the improvement of conception after teaching was high in the order of the concrete operational, transitional stage and the formal operational stage. That is to say, teaching was more effective as the cognitive level lowered.

• 인간행동과 음악연구
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• 제8권2호
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• pp.65-75
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• 2011

본 연구는 성악과 기악 배경음악이 단어 암기 과제에 미치는 영향을 알아보고자 하는데 목적이 있다. 30명의 대학생과 대학원생이 참여하여 두 그룹으로 무작위로 나뉘어 졌다. 단어 암기 과제를 하는 동안 배경음악이 삽입 되었다. 그룹 A에 있는 참가자들은 성악곡을 감상했고 그룹 B에 있는 참가자들은 동일 음악이지만 첼로로 연주되는 기악 음악을 감상 했다. 모든 참가들은 배경 음악이 있는 단어 암기 과제 후 암기력을 측정하기 위해 사후 검사가 실시되었다. T test를 통해 두 그룹의 차이를 보고자 하였다. 그룹 A의 평균(8.93)이 그룹 B(7.46) 보다 높았지만 두 그룹간의 유의미한 차이는 없었다(t(28) = 1.38, p < .05). 이는 가사가 단어 암기 과제에 방해되지 않는다는 것을 제시하였으며 배경음악이 인지 능력에 직접적인 영향을 미치지 않는다는 것을 시사한다.

• 치위생과학회지
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• 제22권2호
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• pp.67-74
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• 2022

Background: Depression and cognitive function have a positive effect on the improvement of quality of life and extension of lifespan in the elderly. In addition, it appears as a major factor influencing oral health status. Therefore, this study looked at the relationship between the Geriatric Oral Health Assessment Index (GOHAI), depression, and cognitive function in the elderly using the Korea Longitudinal Study of Aging. Methods: In this study, 4,535 elderly people aged 65 years and over were targeted using the 7th data of the 2018 Korea Longitudinal Study of Aging. A t-test and ANOVA analysis were performed to compare GOHAI, depression, and cognitive function by group. In addition, hierarchical multiple linear regression was performed to understand the effect of the elderly's perceived depression scale and cognitive ability on GOHAI. Results: As a result of adding the depression scale and cognitive function variables to Model 2, the explanatory power was 22%. Educational level, marital status, private health insurance subscription, average monthly allowance, subjective health status, use of dentures, smoking status, economic activity, depression scale, and cognitive function were found to have significant influence (p<0.05). In addition, when controlled and viewed with all factors, depression and cognitive function were found to have an effect on oral health-related quality of life. Conclusion: The findings indicate that depression and cognitive function are associated with oral health-related quality of life in the Korean elderly. As the age increases, the quality of life declines due to depression and cognitive function problems, in addition to oral discomfort, eating disorders, and physical discomfort.

• The Journal of Korean Physical Therapy
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• 제27권5호
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• pp.364-368
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• 2015

Purpose: Walking in the dual-task condition is a critical skill for hemiplegic patients to live in real-life situations. The purpose of this study was to compare the effect of dual-task gait training and general gait training on gait parameters and cognitive function in patients with chronic stroke during dual-task walking. Methods: The study included 23 patients with chronic hemiparetic stroke who were randomly divided into experimental (dual-task gait training) and control (general walking training) groups. The 11 subjects in the experimental group and nine subjects in the control group received dual-task gait training (walking while handling a ball, crossing obstacles, picking up various objects, and problem solving simple cognitive tasks and general over-ground gait training, respectively, for 30 minutes per day 5 days per week for 4 weeks. Spatiotemporal parameters and cognitive tasks in the dual-task gait condition were measured. Statistical analysis of the changes between the pre- and post-intervention measurement variables was performed using ANCOVA. Results: In the gait condition under cognitive tasks, the changes pre- and post-intervention in gait velocity, stride length, double support limb, and step symmetry were significantly greater in the dual-task gait training group; however, the dual-task gait training group showed no significant improvement compared to the general gait training group in terms of the assessment of cognitive tasks. Conclusion: The findings suggest that dual-task gait training may be beneficial for walking ability in dual-task walking condition.

• 한국실내디자인학회논문집
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• 제23호
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• pp.124-131
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• 2000

In the nowadays years our city's housing environment which progresses rapidly social-economical development is posited the role in the nowadays multi-family housing brings about the individualism of the nowadays city, and makes muddy neighborhood meaning, and the quality of the nowadays city dwelling house environment becoming worse. This study was started with the cognition of the need of intermediate-space, in the our life in the neighborhood city. Intermediate-spaces, has same meaning to come into the action of consciousness of the neighborhood. For the improvement of the quality of city housing, we should cleary recognized the individual territory after we set the proper in intermediate-zone in the multi-family housing. Therefore, this study inquires ito the meaning of intermediate-zone, and catches the formation technique of intermediate-zone and the method of plan through the investigation of the use cases of the multi-family housing which is established intermediate-territory. and then I analyze the role of the formative space by this method. By this method, I grope for the effect of the use through the alternative plan of the design method of the intermediate-zone. If the methods of play use the role in the nowadays multi-family housing, high quality will build up.

• The Journal of Korean Physical Therapy
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• 제19권4호
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• pp.25-32
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• 2007

Purpose: The purpose of this study was to evaluate the effect of computerized neurocognitive function program on cognitive function about memory and attention with stroke. Methods: 24subjects with stroke were recruited. Twelve of subjects received conventional therapy including physical therapy, occupational therapy and language therapy. Another subjects received additional computer assisted cognitive training using Computer-aided Cognitive rehabilitation training system(COMCOG, MaxMedica Inc., 2004). All patients were assessed their cognitive function of memory and attention using Computerized Neurocognitive Function Test(CNT, MaxMedica Inc., 2004) before treatment and 6 weeks after treatment. Results: Before the treatment, two groups showed no difference in cognitive function(p>0.05). After 6 weeks, two groups showed significantly difference in digit span (forward, backward), verbal learning(A5, $A1{\sim}A5$), auditory CPT(n), visual CPT(n)(p<0.05). After treatment, the experimental group showed a significant improvement of digit span(forward, backward), verbal learning(A5, $A1{\sim}A5$), visual span (forward, backward), auditory CPT(n, sec), visual CPT(n, sec), and trail-making (A, B)(p<0.05). Conclusion: Computerized neurocognitive function program would be improved cognitive function of memory and attention in patients with stoke.

• International Journal of Advanced Culture Technology
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• 제9권2호
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• pp.18-31
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• 2021

The purpose of the present study was to present evidence for driving interventions for the elderly by conducting programs that can improve visual perception and cognitive function in a driving simulator for elderly drivers and analyse their effects. Three elderly subjects who were 65 years or older, did not have physical and cognitive impairments, and were able to drive themselves participated in the present study. A total of 12 intervention sessions, of which subjects participated in 10 sessions of nine different visual perception and cognitive function programs available in a driving simulator, were conducted and pre- and post-program assessments were conducted (two assessments in total). The assessments included the evaluation of visual perception, frontal lobe function, concentration, safe driving behaviour, and self-efficacy. The results showed positive effects of the driving simulator program on the visual perception, frontal lobe function, concentration, safe driving behaviour, and self-efficacy of all subjects. Changes in the simulator results showed remarkable improvement in the response evaluation, judgment evaluation, and predictive power evaluation, but showed difficulties in interference tasks and depth perception in common. The results showed positive effects of driving simulator training on the driving ability of the elderly, and consistent provision of such training is expected to improve the quality of life of the elderly by securing the safety of driving and actively supporting social participation.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 춘계학술대회
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• pp.394-395
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• 2022

Exergames are playing an important role in healthcare/rehabilitation. It has also been used to improve motivation among patients with reduced cognition. The purpose of this pilot study was to evaluate the feasibility of using augmented reality (AR) with game-based cognitive-motor training programs for executive function, restricted and repetitive behaviors (RRBs) in children with autism spectrum disorder. Sixteen children aged 6 -16 years were randomly allocated to the experimental group and control group. Outcome measures were performed before and after the intervention and included executive function, restricted and repetitive behavior. A satisfactory survey was conducted post-intervention. A statistically significant improvement was observed in working memory and cognitive flexibility in the experimental group (P<0.05). However, despite no statistical improvements in cognitive inhibition and four subscales of RRBs, promising changes were observed in all the subscales of the executive function and the behavioral outcomes. Parents appreciated the program and children enjoyed the interaction with the AR game-based training. The findings of this preliminary feasibility study showed that AR using Kinect v2 motion with a cognitive-motor game content can be used for children with autism. However, there is a need for conducting a large-scale study to evaluate his effectiveness on executive function and restricted and repetitive behaviors.

• 대한의생명과학회지
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• 제21권2호
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• pp.92-102
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• 2015

This work aimed to study whether rice bran extract fermented with Lactobacillus plantarum (LW) promotes functional recovery and reduces cognitive impairment after ischemic brain injury. Ischemic brain injury was induced by middle cerebral artery occlusion (MCAO) in rats. Four groups were studied, namely the (1) sham, (2) vehicle, (3) donepezil, and (4) LW groups. Animals were injected with LW once a day for 7 days after middle cerebral artery occlusion. LW group showed significantly improved neurological function as compared to the vehicle group, as well as enhanced learning and memory in the Morris water maze. The LW group showed the greatest functional recovery. Moreover, the LW group showed an enhanced more survival cells anti-apoptotic effect in the cortex and neural cell densities in the hippocampal DG and CA1. In addition, this group showed enhanced expression of neurotrophic factors, antioxidant genes, and the acetylcholine receptor gene, as well as synaptophysin (SYP), Fox-3 (NeuN), doublecortin (DCX), and choline acetyltransferase (ChAT) proteins. Our findings indicate that LW treatment showed the largest effects in functional recovery and cognitive improvement after ischemic brain injury through stimulation of the acetylcholine receptor, antioxidant genes, neurotrophic factors, and expression of NeuN, SYP, DCX, and ChAT.