• Journal of Pharmaceutical Investigation
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• v.32 no.1
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• pp.21-26
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• 2002

The primary culture of human nasal epithelial cell monolayer was performed on a Transwell. The effect of various factors on the tight junction formation was observed in order to develop an in vitro experimental system for nasal transport studies. Human nasal epithelial cells, collected from human normal inferior turbinates, were plated onto diverse inserts. After 4 days, media of the apical surface was removed for air-liquid interface (ALI) culture. Morphological characteristics was observed by transmission electron microscopy (TEM). A polyester membrane of $0.4\;{\mu}m$ pore size was determined as the most effective insert based on the change in the transepithelial electric resistance (TEER) value as well as the $^{14}C-mannitol$ transport study. The ALI method was effective in developing the tight junction as observed in the further increase in the TEER value and reduction in the permeability coefficient $(P_{app})$ of $^{14}C-mannitol$ transport. Results of the transport study of a model drug, budesonide, showed that the primary culture system developed in this study could be further developed and applied for in vitro nasal transport studies.

• Journal of Navigation and Port Research
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• v.34 no.1
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• pp.33-37
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• 2010

It is very important to prevent the electromagnetic interference and to prevent malfunction of electronic equipments mounted on ships. To solve these problems, in this paper, the EMC filter was designed, fabricated, and tested. The Ni-Zn ferrite beads with high permeability were used to make large inductance as the inductor and the feed-through capacitors without any resonance points. As a result, excellent attenuation characteristics of 25~70 dB were obtained from the 0 kHz~1.5 GHz band. In addition, when the Electric Fast Transient (EFT) of 4 kV in the level 4 of IEC 61000-4-4 was induced the EFT reduced to 600 V. Therefore, it was clearly shown that the developed EMC felter can be used for suppressing the electromagnetic interference on-board electronic devices and equipments.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2009.06a
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• pp.183-184
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• 2009

In this paper the internal or external of the ships mounted electronic devices due to the propagation of electromagnetic interference and to prevent malfunction EMC filter was designed and fabricated. It was designed and fabricated with Ni-Zn ferrite beads of high permeability to make large inductance as the inductor and Feed-through capacitors, which did not have any resonance point, to restraint resonance effectively, and the characteristics was evaluated. The results from the 0 kHz$\sim$1.5 GHz bandwidth of $25{\sim}70$ dB were able to obtain excellent attenuation characteristics. And, when the Electric Fast Transient (EFT) of 4 kV in the level 4 of IEC 61000-4-4 was induced, it was soon attenuated more than 1/6 to 600 V. Therefore, it was confirmed that the developed EMC filter can be used for suppressing ships mounted electromagnetic interference between electronic devices.

• Geomechanics and Engineering
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• v.21 no.4
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• pp.357-369
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• 2020

Different from the conventional planar fracture and simplified Newton model, for power-law slurries with a lower water-cement ratio commonly used in grouting engineering, flow model in geological rough fractures is built based on ten standard profiles from Barton (1977) in this study. The numerical algorithm is validated by experimental results. The flow mechanism, grout superiority, and water plugging of pseudo plastic slurry are revealed. The representations of hydraulic grouting properties for JRCs are obtained. The results show that effective plugging is based on the mechanical mechanisms of the fluctuant structural surface and higher viscosity at the middle of the fissure. The formulas of grouting parameters are always variable with the roughness and shear movement, which play a key role in grouting. The roughness can only be neglected after reaching a threshold. Grouting pressure increases with increasing roughness and has variable responses for different apertures within standard profiles. The whole process can be divided into three stationary zones and three transition zones, and there is a mutation region (10 < JRCs < 14) in smaller geological fractures. The fitting equations of different JRCs are obtained of power-law models satisfying the condition of -2 < coefficient < 0. The effects of small apertures and moderate to larger roughness (JRCs > 10.8) on the permeability of surfaces cannot be underestimated. The determination of grouting parameters depends on the slurry groutability in terms of its weakest link with discontinuous streamlines. For grouting water plugging, the water-cement ratio, grouting pressure and grouting additives should be determined by combining the flow conditions and the apparent widths of the main fracture and rough surface. This study provides a calculation method of grouting parameters for variable cement-based slurries. And the findings can help for better understanding of fluid flow and diffusion in geological fractures.

• Journal of The Korean Society of Agricultural Engineers
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• v.61 no.6
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• pp.67-72
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• 2019

This study compared the theory of a culvert spacing and analytical results of the seepage flow for the subsurface drainage. i) If culvert spacing (Sc) is within 5 m, the unit drainage (q) is very larger; in contrast, if Sc is 5 m or more, there is very little drainage in the middle between drains. Therefore, the drain spacing should be within 5 m to ensure high drainage efficiency. ii) Since the planned culvert drainage increases linearly with the soil's permeability coefficient (k), k must be taken into account when determining the drain diameter by the planned culvert drainage. iii) As a result of analyzing the drainage performance of the absorbing culvert, the drainage performance is sufficient with the diameter of the corrugated drain pipe Dc = 50 mm at the length of the drain Lc = 100 m. iv) Therefore, if the drain spacing (Sc) is less than 5 m using the low-cost non-excavated drainage pipe method (${\Phi}50mm$ the corrugated drain pipe and fiber mat) rather than the conventional trench drain method (Sc > 10 m, Dc > 100 mm), uniform and high drainage efficiency can be ensured as well as low construction cost. v) The sub-irrigation+drainage culvert requires narrower drain spacing (Sc < 2-3 m) for irrigation. As a result of examining the condition of 35 mm in diameter (Dc) and 2~3 m in drain spacing, it is possible to apply the non-excavated drainage pipe method to the sub-irrigation+drainage culvert because drainage performance is sufficient at the drain length Lc = 50 m.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.228-228
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• 2018

강변여과는 지하수 인공함양 방식 중 유도함양(induced recharge) 또는 간접함양 방식에 속한다. 이는 하천 및 강변 부근에 집수시설을 설치한 후, 미고결층 대수층(unconsolidated aquifer)의 자연 오염 저감능을 이용하여 지표수를 간접 취수하는 방식으로 수질이 불량한 지표수가 대수층을 관류하면서 희석, 화학적 이온 교환 및 반응, 흡착, 생물막(biofilm; 미생물에 의한 자연저감), 여과 등을 통하여 수질이 개선된다. 강변여과수내의 용존 농도가 높은 철과 망간은 수처리 비용증가, 용수관정 및 시설물의 수명단축을 초래한다. 따라서 강변여과 지역의 미고결 대수층에서 효과적인 철과 망간 동시 제거(vyredox)를 위해 에어서징(air surging)과 블록 서징(block surging)을 실시하기 위해서 실내 물탱크 모델(water tank model)에서 에어서징에 따른 공기 순환 우물시스템을 관찰하였으며, 이를 바탕으로 현장시험(Test bed)에 적용하였다. 미고결 대층수층에서의 철 망간은 음용수 기준치(각각 0.3 mg/L)를 초과하고 있으며, 강변여과 취수 개발 및 이용을 제한하는 요인이 되고 있다. 본 연구에서 사용된 에어서징과 블록서지 기술은 자갈층 및 미고결 대수층에 충진된 슬라임 및 폐색(clogging)을 제거함과 동시에 관정 주변의 대수층의 투수성 개선과 산화환경으로 치환되며, 대수층에 잔존하는 철/망간의 산화물들을 관정내로 빼낼 수 있는 방법이다. 따라서 서징에 따른 폐색 제거효율을 검토한 결과에서 철 망간 이온농도 저감효과와 관정 주변의 수리전도도(hydraulic conductivity) 및 저류계수(coefficient of storage)가 증가한 것으로 나타났다. 이와 같이 강변여과에 의한 폐색은 미고결층내 공기주입 및 블록서지를 통하여 철/망간 이온농도 저감 및 수리특성 개선 효과에 유용한 것으로 평가된다.

• Journal of the Korean Geotechnical Society
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• v.35 no.4
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• pp.37-42
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• 2019

Hydrate dissociation is required to produce methane, which generates both water and methane. Thus, multiphase fluid flow and desalination are expected during methane production, which causes the fine migration and clogging in pores. The goal of this study is to explore the effects of both multiphase fluid flow and desalination on the migration and clogging of kaolin particles as typical fines. The results are as follows : (1) the larger the pore size is, the more mounting the critical clogging concentration is, (2) kaolin particles are more easily clustering and clogging in deionized water than salty water, and (3) the critical clogging concentration of kaolin in multiphase fluid flow is lower than in singlephase fluid flow. Therefore, clustering and clogging of kaolin within pore occur easily due to desalination and multiphase fluid flow when methane is produced from hydrates, and the efficiency of methane production is expected to decrease due to the degradation of permeability coefficient.

• Journal of Yeungnam Medical Science
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• v.36 no.3
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• pp.231-240
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• 2019

Background: We sought to determine the value of combining diffusion-weighted (DW) and perfusion-weighted (PW) sequences with a conventional magnetic resonance (MR) sequence to assess solid components of borderline ovarian tumors (BOTs) and stage I carcinomas. Methods: Conventional, DW, and PW sequences in the tumor imaging studies of 70 patients (BOTs, n=38; stage I carcinomas, n=32) who underwent surgery with pathologic correlation were assessed. Two independent radiologists calculated the parameters apparent diffusion coefficient (ADC), $K^{trans}$ (vessel permeability), and $V_e$ (cell density) for the solid components. The distribution on conventional MR sequence and mean, standard deviation, and 95% confidence interval of each DW and PW parameter were calculated. The inter-observer agreement among the two radiologists was assessed. Area under the receiver operating characteristic curve (AUC) and multivariate logistic regression were performed to compare the effectiveness of DW and PW sequences for average values and to characterize the diagnostic performance of combined DW and PW sequences. Results: There were excellent agreements for DW and PW parameters between radiologists. The distributions of ADC, $K^{trans}$, and $V_e$ values were significantly different between BOTs and stage I carcinomas, yielding AUCs of 0.58 and 0.68, 0.78 and 0.82, and 0.70 and 0.72, respectively, with ADC yielding the lowest diagnostic performance. The AUCs of the DW, PW, and combined PW and DW sequences were $0.71{\pm}0.05$, $0.80{\pm}0.05$, and $0.85{\pm}0.05$, respectively. Conclusion: Combining PW and DW sequences to a conventional sequence potentially improves the diagnostic accuracy in the differentiation of BOTs and stage I carcinomas.

• Geomechanics and Engineering
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• v.27 no.6
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• pp.605-614
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• 2021

Water inrush from fault is one of the most severe hazards during tunnel excavation. However, the traditional evaluation methods are deficient in both quantitative evaluation and uncertainty handling. In this paper, a comprehensive methodology method combined intuitionistic fuzzy AHP with a Bayesian network for the risk assessment of water inrush from fault in the subsea tunnel was proposed. Through the intuitionistic fuzzy analytic hierarchy process to replace the traditional expert scoring method to determine the prior probability of the node in the Bayesian network. After the field data is normalized, it is classified according to the data range. Then, using obtained results into the Bayesian network, conduct a risk assessment with field data which have processed of water inrush disaster on the tunnel. Simultaneously, a sensitivity analysis technique was utilized to investigate each factor's contribution rate to determine the most critical factor affecting tunnel water inrush risk. Taking Qingdao Kiaochow Bay Tunnel as an example, by predictive analysis of fifteen fault zones, thirteen of them are consistent with the actual situation which shows that the IFAHP-Bayesian Network method is feasible and applicable. Through sensitivity analysis, it is shown that the Fissure development and Apparent resistivity are more critical comparing than other factor especially the Permeability coefficient and Fault dip. The method can provide planners and engineers with adequate decision-making support, which is vital to prevent and control tunnel water inrush.

• Journal of the Korean Geotechnical Society
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• v.26 no.7
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• pp.107-115
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• 2010

In this paper, the applicability of cement grout bas been studied as an alternative to bentontite grout to backfill ground heat exchangers. To provide an optimal mixture design, the groutabilty and thermal conductivity of cement grouts with various mixture ratios were experimentally evaluated and compared. The unconfined compression strength of cement grout specimen was measured, which was exposed to cyclic temperature variation ranging from $50^{\circ}C$ to $-5^{\circ}C$. In addition, the integrity of the interface between circulating HDPE pipes and cement grout was evaluated by performing equivalent hydraulic conductivity tests, on the specimen. in which a pipe locates at the center of the specimen.