• Archives of Plastic Surgery
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• 제39권2호
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• pp.150-153
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• 2012

Hemophilia B is a rare blood coagulation disorder. Complications such as bleeding and hematoma can cause necrosis of flaps, wound disruption, and the disturbance of wound healing. In particular, guidelines for flap operations in hemophilia B patients have still not been defined, and case reports are rare. We reconstructed the heel of a 41-year-old male hemophilia B patient using a reverse sural artery flap operation. The patient presented with mild hemophilia, having 27% of the normal value of coagulation factor IX. Coagulation and the changing value of the coagulation factor were regularly measured, and 70% of the normal value of coagulation factor IX was maintained through the injection of recombinant coagulation factors and antihemorrhagics. Hematoma developed twice (postoperative day [POD] 5 and POD 7) and in each case the hematoma was removed. Injections of recombinant coagulation factors and antihemorrhagics were continuously administered until postoperative week 2. When the coagulation factors were within normal ranges. In this article, a hemophilia B patient underwent reverse sural artery flap surgery and the healing progress was analyzed. We conclude that higher than baseline levels of coagulation factors are needed for successful healing in reverse sural artery flap surgery.

• 한국동물위생학회지
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• 제46권2호
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• pp.107-113
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• 2023

Tenebrio molitor, rich in protein, is used as an alternative protein source. Many studies have evaluated Tenebrio molitor larvae (TML) for anti-obesity effects, fatty liver relief, antithrombosis, and antioxidant effects. In this study, we prepared an experimental diet by adding Tenebrio molitor larvae oil (TMLO) to feed and administered it to adult male ICR mice for six weeks. The study assessed the weight gain of mice, prothrombin time (PT), activated partial thromboplastin time (aPTT), blood coagulation time, and the activities of coagulation factor VII and coagulation factor XII. The weight gain of mice was suppressed in the groups fed with TMLO, indicating a potential anti-obesity effect. The blood coagulation time was delayed in the TMLO-fed groups, as evidenced by amplified PT and aPTT values. Furthermore, the activities of coagulation factor VII and coagulation factor XII were diminished in the TMLO-treated groups, indicating a potential thrombosis relieving effect. The concentrations of thromboxane B2 and serotonin declined in the TMLO-fed groups, signifying potential blood circulation effects. Finally, blood triglyceride and LDL-cholesterol concentrations were reduced in the TMLO-fed groups. In summary, TMLO supplementation may have an inhibitory effect on liver damage and blood clot formation caused by obesity.

• Neonatal Medicine
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• 제18권1호
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• pp.1-5
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• 2011

Coagulation involves the regulated sequence of proteolytic activation of a series of proteins to achieve appropriate and timely hemostasis in an injured vessel. In the non-pathological state, the inciting event involves exposure of circulating factor VIIa to extravascularly expressed tissue factor, which brings into motion the series of steps which results in cell based model of coagulation. In the new concepts of coagulation system, initiation, amplification and propagation steps are involved to converse of fibrinogen to fibrin. The precisely synchronized cascade of events is counter-balanced by a system of anticoagulant mechanisms. Developmental hemostasis refers to the age-related changes in the coagulation system that are most marked during neonate and childhood. An understanding of these changes in crucial to the accurate diagnosis of hemostatic abnormalities in neonate and children. This review aims to elucidate the main events within the coagulation cascade as it is currently understood to operate in vivo, and also a short review of the anticoagulants as they relate to this model. Also this paper describes the common pitfalls observed in the clinical data related to the coagulation system in neonate to children.

• Bulletin of the Korean Chemical Society
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• 제34권4호
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• pp.1212-1220
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• 2013

The human coagulation factor XI (FXI) is a serine protease that plays a significant role in blocking of the blood coagulation cascade as an attractive antithrombotic target. Selective inhibition of FXIa (an activated form of factor XI) disrupts the intrinsic coagulation pathway without affecting the extrinsic pathway or other coagulation factors such as FXa, FIIa, FVIIa. Furthermore, targeting the FXIa might significantly reduce the bleeding side effects and improve the safety index. This paper reports on a docking-based three dimensional quantitative structure activity relationship (3D-QSAR) study of the potent FXIa inhibitors, the chloro-phenyl tetrazole scaffold series, using comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) methods. Due to the characterization of FXIa binding site, we classified the alignment of the known FXIa inhibitors into two groups according to the docked pose: S1-S2-S4 and S1-S1'-S2'. Consequently, highly predictive 3D-QSAR models of our result will provide insight for designing new potent FXIa inhibitors.

• Animal cells and systems
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• 제7권3호
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• pp.255-259
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• 2003

Mutations in the factor Ⅴ gene are major risk markers for venous thrombosis. Several factors for blood coagulation have been related with cardiovascular disease. Ⅰ investigated genotype distribution for three mutations (G1691 A, A2379G and G2391 A) of the factor Ⅴ gene in the Korean population. Genotype frequencies were examined by polymerase chain reaction in 135 patients with coronary artery disease (CAD) and 116 healthy subjects. For the G1691A mutation (factor Ⅴ

• Neonatal Medicine
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• 제17권1호
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• pp.132-135
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• 2010

미숙아에서 비정상적인 출혈의 대부분은 감염과 관련되어 발생하는 후천성 응고 장애가 원인인 경우가 많으므로 혈우병과 같은 유전응고장애질환은 간과되기 쉽다. 저자들은 반복되는 출혈 경향을 보인 재태 기간 31주 1일, 1,880 g으로 출생한 미숙아에서 혈우병 A를 진단하고 VIII인자 보충을 통해 치료하였기에 보고하는 바이다.

• 한국환경보건학회지
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• 제29권2호
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• pp.1-6
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• 2003

This paper reports on a pilot scale comparison of PACS coagulation with and without pH preadjustment. The pH of the water was adjusted with carbon dioxide and sulfuric acid. Process performance was assessed on the basis of total organic carbon(TOC), UV absorbance, turbidity and disinfection by-product(DBP) precursors. Coagulation pH appeared to be a determining factor for maximum NOM removal. The optimum coagulation pH in order to decrease TOC and turbidity were pH 7. Preadjustment of pH 7 increased TOC removal to as much as 43, 47 percent with sulfuric acid and carbon dioxide. Moreover, coagulation at pH 7 caused a reduction in UV$_{254}$, THMFP and HAAFP compared to the baseline coagulation. For preadjustment of pH 7 with carbon dioxide, the percentage of TOC, UV$_{254}$, THMFP and HAAFP shows the reduction rate of 3.8, 0.5, 4.8, 9.4％ comparing to the coagulation rendition using sulfuric acid. Acid addition to depress pH during coagulation decrease Langelier Saturation Index(LSI), potentially causing increase corrosion in water distribution systems. LSI for carbon dioxide and sulfuric acid at pH 6 was -2.3, -3.3. Therefore, carbon dioxide was more effective at controlling corrosion than sulfuric acid.

• 한국환경보건학회지
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• 제38권2호
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• pp.128-135
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• 2012

Objectives: This study was aimed at determining the optimum coagulation dosage in a high turbid kaolin water sample using streaming current detection (SCD) as an alternative to the jar test. Methods: SCD is able to optimize coagulant dosing by titration of negatively charged particles. Kaolin particles were used to mimic highly turbid water ranging from 50 to 600 NTU, and polyaluminum chloride (PAC, 17%) was applied as a titrant and coagulant. The coagulation consisted of rapid stirring (5 min at 140 rpm), reduced stirring (20 min at 70 rpm), and settling (60 min). To confirm the coagulation effect, a jar test was also compared with the SCD titration results. Results: SCD titration of kaolin water samples showed that the dose of PAC increased as the pH rose. However, supernatant turbidity less than 1 NTU after coagulation was not achieved for high turbid water by SCD titration. Instead, a conversion factor was used to calculate the optimum PAC dosage for high turbid water by correlating a jar test result with that from an SCD titration. Using this approach, we were able to successfully achieve less than 1 NTU in treated water. Conclusions: For high turbid water influent in a water treatment plant, particularly during summer, the application of SCD control by applying a conversion factor can be more useful than a jar test due to the rapid calculation of coagulation dosage. Also, the interpolation of converted PAC dose could successfully achieve turbidity in the treated water of less than 1 NTU. This result indicates that an SCD system can be effectively used in a water treatment plant even for high turbid water during the rainy season.

• 대한임상검사과학회지
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• 제47권4호
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• pp.237-242
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• 2015

aPTT 참고치의 정상범위 내에서 하한 측 10% (29.1~30.9 sec)와 상한 측 10% (38.0~41.9 sec)에 포함된 정상성인의 혈액응고인자 활성도를 분석하여 하한 측과 상한 측간에 혈액응고인자의 종류와 각각의 활성도가 성별, 연령 및 ABO 혈액형 등에 통계학적으로 유의한 차이를 보이는지 알아보고자 하였다. 성별에 따른 혈액응고인자들의 활성도 차이를 분석한 결과 하한 측에서 IX (p=0.0088)만 남성이 여성보다 높았으며, 상한 측에서 IX (p<0.0001)와 X (p=0.0013)은 남성이 여성보다 높았다. 연령군간 혈액응고인자들의 활성도 차이 검정은 하한 측에서 VIII (p<0.0001), IX (p=0.0050)는 60세 이상이 60세 미만보다 높았으며, XII (p=0.0285)는 60세 이상보다 60세 미만이 높았다. 상한 측에서 V (p=0.0219), VIII (p=0.0005), IX (p=0.0014)는 60세 이상이 60세 미만보다 높았다. O형과 non-O형의 혈액형 구분에 의한 혈액응고인자들의 활성도 차이는 VIII (p<0.001)은 양쪽 그룹에서 non-O형이 O형보다 높았으며, XII (p=0.016)는 상한 측에서 non-O형이 O형보다 낮았다.

• 한국물환경학회지
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• 제21권4호
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• pp.379-384
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• 2005

In this research, coagulation was employed as the pretreatment for membrane process. The effective coagulation conditions were decided after the discussion of different coagulant doses and mixing conditions, etc. Raw water was taken from Nakdong River. The best operation occurred when G value was $230s^{-1}$ and the slow mixing lasted around 5 minutes at G value was $23s^{-1}$. To investigate the optimum coagulant dosage, the optimum organics removal was target as organic removal reduces membrane fouling effectively than particle removal. This result indicated that organics are more important causes than turbidity for membrane fouling. However, turbidity becomes an important factor after certain amount of organic matters is removed.