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A Case of Hemophilia A Diagnosed in a Premature Infant  

Oh, Ki-Won (Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine)
Lee, Kyung-Yeon (Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine)
Kim, Ja-Hyeong (Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine)
Rhee, Kang-Won (Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine)
Jeong, Jin-Young (Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine)
Park, Sang-Kyu (Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine)
Publication Information
Neonatal Medicine / v.17, no.1, 2010 , pp. 132-135 More about this Journal
Abstract
Although the majority of abnormal bleeding during the neonatal period results from acquired coagulation disorders, inherited coagulation disorders can also manifest at this time. Hemophilia is the most common of inherited coagulation disorder. Although 40-70% of cases with hemophilia are diagnosed in the neonatal period, few cases have been reported in premature infants. We report a case of a premature infant born at 31 weeks of gestation, diagnosed with hemophilia A by blood coagulation test, coagulation factor assay and study of the F8 gene. The baby was treated with recombinant factor VIII (Recombinate$^{(R)}$, USA) because of repeated seizures and intramuscular hematoma.
Keywords
Hemophilia A; Preterm; Infant; Recombinant factor VIII;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Gelbart B, Barnes C. Severe haemophilia and extreme prematurity-a case report. Haemophilia 2009;15:352-4.   DOI   ScienceOn
2 Chalmers EA. Neonatal coagulation problems. Arch Dis Child Fetal Neonatal Ed 2004;89:F475-8.   DOI
3 Park YS. Recent advance of pharmacotherapy in hemophilia. J Korean Med Assoc 2009;52:1201-6.   DOI
4 Kulkarni R, Lusher J. Perinatal management of newborns with haemophilia. Br J Haematol 2001;112:264-74.   DOI   ScienceOn
5 Kraft KE, Verlaak R, van Heijst AF, Novakova I, Brons PP. Management of haemophilia in three premature infants. Haemophilia 2008;14:378-80.   DOI   ScienceOn
6 Yoo KY. Hemophilia. Korean J Pediatr 2006;49:821-9.   DOI   ScienceOn
7 Baehner RL, Strauss HS. Hemophilia in the first year of life. N Engl J Med 1966;275:524-8.   DOI   ScienceOn
8 Chalmers EA. Haemophilia and the newborn. Blood Rev 2004;18:85-92.   DOI   ScienceOn
9 Kulkarni R, Lusher JM, Henry RC, Kallen DJ. Current practices regarding newborn intracranial haemorrhage and obstetrical care and mode of delivery of pregnant haemophilia carriers: a survey of obstetricians, neonatologists and haematologists in the United States, on behalf of the National Hemophilia Foundation's Medical and Scientific Advisory Council. Haemophilia 1999;5:410-5.   DOI   ScienceOn
10 Gale RF, Hird MF, Colvin BT. Management of a premature infant with moderate haemophilia A using recombinant factor VIII. Haemophilia 1998;4:850-3.   DOI   ScienceOn
11 Bidlingmaier C, Bergmann F, Kurnik K. Haemophilia A in two premature infants. Eur J Pediatr 2005;164:70-2.   DOI   ScienceOn
12 Lorenzo JI, Lopez A, Altisent C, Aznar JA. Incidence of factor VIII inhibitors in severe haemophilia: the importance of patient age. Br J Haematol 2001;113:600-3.   DOI   ScienceOn
13 van der Bom JG, Mauser-Bunschoten EP, Fischer K, van den Berg HM. Age at first treatment and immune tolerance to factor VIII in severe hemophilia. Thromb Haemost 2003;89:475-9.   DOI
14 Gouw SC, van der Bom JG, Marijke van den Berg H. Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study. Blood 2007;109:4648-54.   DOI   ScienceOn
15 Mancuso ME, Graca L, Auerswald G, Santagostino E. Haemophilia care in children-benefits of early prophylaxis for inhibitor prevention. Haemophilia 2009;15 Suppl 1:8-14.   DOI