• Journal of the Korea Society for Simulation
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• v.19 no.2
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• pp.157-164
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• 2010

While both functional verification and performance evaluation of a system are necessary for the development of effective and reliable communication systems, they have been usually performed individually through functional modeling with formal language tools and performance modeling with professional network performance evaluation tools, respectively. However, separate and duplicated modeling of a system may cause increase of the cost and inconsistency between the models. In order to overcome this problem, this paper proposes an integrated design technique that estimates the performance of a communication protocol designed in SDL with SDL-OPNET co-simulation. The proposed technique presents how to design a co-simulation system with the environment functions of Tau and the external system module of OPNET. InRes protocol was used as an example to show the applicability and usefulness of the proposed technique.

• Journal of Nutrition and Health
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• v.46 no.3
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• pp.226-238
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• 2013

Omega-3 polyunsaturated fatty acids are essential fatty acids because humans cannot synthesize them de novo and must obtain them in their diet. Fish and fish oil are rich sources of omega-3 fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Significant evidence of the beneficial role of dietary intake of omega-3 fatty acids in blood flow has been reported and putative mechanisms for improvement of blood flow include anti-thrombotic effects, lowered blood pressure, improved endothelial function, and anti-atherogenic effects. Edible oils containing omega-3 fatty acids were registered as functional ingredients in the Korea Health Functional Food Code. Although omega-3 fatty acids have been evaluated by the Korea Food and Drug Administration (KFDA) based on scientific evidence, periodic re-evaluation may be needed because emerging data related to omega-3 fatty acids have accumulated. Therefore, in this study, we re-evaluated scientific evidence for the effect of omega-3 fatty acids as a functional ingredient in health functional food on improvement of blood flow. A comprehensive literature search was conducted for collection of relevant human studies using the Medline and Cochrane, KISS, and IBIDS databases for the years 1955-2012. Search keywords were used by combination of terms related to omega-3 fatty acids and blood flow. The search was limited to human studies published in Korean, English, and Japanese. Using the KFDA's evidence based evaluation system for scientific evaluation of health claims, 112 human studies were identified and reviewed in order to evaluate the strength of the evidence supporting a relation between omega-3 fatty acids and blood flow. Among 112 studies, significant effects on improvement of blood flow were reported in 84 studies and the daily intake amount was ranged from 0.1 to 15 g. According to this methodology of systematic review, we concluded that there was possible evidence to support a relation between omega-3 fatty acid intake and blood flow. However, because inconsistent results have recently been reported, future studies should be monitored.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.2
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• pp.293-299
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• 2014

Although the functional ingredient has been evaluated based on scientific evidence by the Ministry of Food and Drug Safety (MFDS), the levels of scientific evidence and consistency of the results might vary according to the emerging data. Therefore, a periodic re-evaluation may be needed in some functional ingredients. In this study, we re-evaluated the scientific evidence for the joint health of glucosamine as a functional ingredient in health functional food. Literature searches were conducted using Pubmed, Cochrane, KISS, and IBIDS databases with the search term of glucosamine in combination with osteoarthritis. The search was limited to human studies published in English, Korean and Japanese. Using the MFDS's evidence based evaluation system for scientific evaluation of health claims, 34 human studies were identified and reviewed in order to evaluate the strength of the evidence supporting the relation between glucosamine and joint health. Among the 34 studies, significant effects for joint health were reported in 28 studies, and their daily intake amount was 1.5 to 2 g. Eleven out of 34 studies were identified, excluding severe radiographic osteoarthritis, and ten from those eleven studies reported significant effects for joint health. Based on this systematic review, we concluded that there was possible evidence to support a relation between glucosamine intake and joint health.

• Journal of Internet Computing and Services
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• v.18 no.4
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• pp.7-17
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• 2017

Despite various types of online social networks having different topological and functional characteristics, the kinds of online social networks considered in social recommendations are highly restricted. The pervasiveness of social networks has brought scholarly attention to expanding the scope of social recommendations into more diverse and less explored types of online social networks. As a preliminary attempt, this study examined the information-sharing patterns of a new type of online social network - unilateral (directed) network - and assessed the feasibility of the network as a useful information source. Specifically, this study mainly focused on the presence of shared interests in unilateral networks, because the shared information is the inevitable condition for utilizing the networks as a feasible source of personalized recommendations. As the results, we discovered that user pairs with direct and distant links shared significantly more similar information than the other non-connected pairs. Individual users' social properties were also significantly correlated with the degree of their information similarity with social connections. We also found the substitutability of online social networks for the top cohorts anonymously chosen by the collaborative filtering algorithm.

• Journal of Information Technology Applications and Management
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• v.16 no.3
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• pp.87-100
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• 2009

The purpose of this study is to investigate the evolution of regional tourism resources from the perspective of business ecosystem network. A regional tourism structure changes due to various factors such as natural resources, facilities, festivals and events, public resources, and etc. An exploratory analysis was conducted to examine the interaction between resource characteristics and alliance complexity in the regional tourism industry. In the process, the duality of technology provides an insight into the interaction among several players within an alliance network which include regional attractions and tourism industry. As a result. we identified four types of tourism alliance network: functional, organizational, resource-oriented, and artificially-allied. The managerial implications are also discussed.

• IMMUNE NETWORK
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• v.21 no.5
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• pp.32.1-32.14
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• 2021

Over two hundred twenty-eight million cases of coronavirus disease 2019 (COVID-19) in the world have been reported until the 21^st of September 2021 after the first rise in December 2019. The virus caused the disease called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 4 million deaths blame COVID-19 during the last one year and 8 months in the world. Currently, four SARS-CoV-2 variants of concern are mainly focused by pandemic studies with limited experiments to translate the infectivity and pathogenicity of each variant. The SARS-CoV-2 α, β, γ, and δ variant of concern was originated from United Kingdom, South Africa, Brazil/Japan, and India, respectively. The classification of SARS-CoV-2 variant is based on the mutation in spike (S) gene on the envelop of SARS-CoV-2. This review describes four SARS-CoV-2 α, β, γ, and δ variants of concern including SARS-CoV-2 ε, ζ, η, ι, κ, and B.1.617.3 variants of interest and alert. Recently, SARS-CoV-2 δ variant prevails over different countries that have 3 unique mutation sites: E156del/R158G in the N-terminal domain and T478K in a crucial receptor binding domain. A particular mutation in the functional domain of the S gene is probably associated with the infectivity and pathogenesis of the SARS-CoV-2 variant.

• Journal of Acupuncture Research
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• v.37 no.2
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• pp.128-135
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• 2020

Background: Classical acupuncture is being used in the treatment of rheumatoid arthritis (RA). To explore the biological response to acupuncture, a network-based analysis was performed on gene expression data collected from an animal model of RA treated with acupuncture. Methods: Gene expression data were obtained from published microarray studies on blood samples from rats with collagen induced arthritis (CIA) and non-CIA rats, both treated with manual acupuncture. The weighted gene co-expression network analysis was performed to identify gene clusters expressed in association with acupuncture treatment time and RA status. Gene ontology and pathway analyses were applied for functional annotation and network visualization. Results: A cluster of 347 genes were identified that differentially downregulated expression in association with acupuncture treatment over time; specifically in rats with CIA with module-RA correlation at 1 hour after acupuncture (-0.27; p < 0.001) and at 34 days after acupuncture (-0.33; p < 0.001). Functional annotation showed highly significant enrichment of porphyrin-containing compound biosynthetic processes (p < 0.001). The network-based analysis also identified a module of 140 genes differentially expressed between CIA and non-CIA in rats (p < 0.001). This cluster of genes was enriched for antigen processing and presentation of exogenous peptide antigen (p < 0.001). Other functional gene clusters previously reported in earlier studies were also observed. Conclusion: The identified gene expression networks and their hub-genes could help with the understanding of mechanisms involved in the pathogenesis of RA, as well understanding the effects of acupuncture treatment of RA.

• International Journal of Advanced Culture Technology
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• v.5 no.1
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• pp.64-69
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• 2017

The rapid growth of algae occurs can induce the algae bloom when nutrients are supplied from anthropogenic sources such as fertilizer, animal waste or sewage in runoff the water currents or upwelling naturally. The algae blooms creates the human health problem in the environment as well as in the water resource managers including hypoxic dead zones and harmful toxins and pose challenges to water treatment systems. The algal blooms in the source water in water treatment systems affects the drinking water taste & odor while clogging or damaging filtration systems and putting a strain on the systems designed to remove algal toxins from the source water. This paper propose the emerging In-Situ self-diagnosable smart algae sensing device with wireless connectivity for smart remote monitoring and control. In this research, we developed the In-Site Algae diagnosable sensing device with wireless sensor network (WSN) connectivity with Optical Biological Sensor and environmental sensor to monitor the water treatment systems. The proposed system emulated in real-time on the water treatment plant and functional evaluation parameters are presented as part of the conceptual proof to the proposed research.

• International Journal of Internet, Broadcasting and Communication
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• v.8 no.1
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• pp.64-68
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• 2016

These fields are integrated to visualize and finalize the proposed development, in simulation environment. SCADA (supervisory control and data acquisition) systems and distributed control systems (DCSs) are widely deployed in all over the world, which are designed to control the industrial infrastructures, in real ways. To supervise and control the various parts of designed systems; trends to require a deep knowledge to understand the overall functional needs of industries, which could be a big challenge. Industrial field devices (or network sensors) are usually distributed in many locations and are controlled from centralized site (or main control center); the communication provides various signs of security issues. To handle these issues, the research contribution will twofold: a method using cryptography is deployed in critical systems for security purposes and overall transmission is controlled from main controller site. At controller site, multimedia components are employed to control the overall transmission graphically, such as system communication, bytes flows, security embedded parameters and others, by the means of multimedia technology.

• Journal of Advanced Navigation Technology
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• v.19 no.5
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• pp.423-432
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• 2015

This paper shows that design, manufacture and the performance of FC-NIC (fibre channel network interface card) for network unit configuration which is based on one of the 5 main configuration items of the common functional module for IMA (integrated modular Avionics) architecture. Especially, FC-NIC uses zynq SoC (system on chip) for host load reductions. The host merely transmit FC destination address, source memory location and size information to the FC-NIC. After then the FC-NIC read the host memory via DMA (direct memory access). FC upper layer protocol and sequence process at local processor and programmable logic of FC-NIC zynq SoC. It enables to free from host load for external communication. The performance of FC-NIC shows average 5.47 us low end-to-end latency at 2.125 Gbps line speed. It represent that FC-NIC is one of good candidate network for IMA.