• 한국농림기상학회지
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• 제22권4호
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• pp.340-345
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• 2020

본 연구에서는 첨단 옥외환경조절시설인 SPAR 시스템의 작물 및 환경 관측 자료의 품질 관리와 보증 방법을 최초로 제시하였다. 특히 실시간 군락 CO2플럭스의 경우에는 수집되는 자료의 특성을 고려하여 이상치의 제거와 보정이 병행되어야 함을 확인하였다. 본 연구를 통해 구축된 자료 처리 방법들은 향후 SPAR 자료를 통한 작물 생육 모형 개선에 매우 중요하게 활용될 수 있을 것으로 보인다. SPAR 내 작물과 환경 관련 10분 평균 자료는 국립식량과학원 내 작물 연구 통합 정보시스템(Crop Research Information System, CRIS) 웹사이트(www2.nics.go.kr/cris)에서 이용 가능하다.

• 한국수산경영학회:학술대회논문집
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• 한국수산경영학회 2004년도 심포지움 발표 초록
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• pp.57-74
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• 2004

• 한국식품저장유통학회지
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• 제6권4호
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• pp.380-385
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• 1999

CA저장에 적합한 떫은감 품종을 선발하기 위해 청도반시, 사곡시, 고종시, 봉옥시 4품종을 공시하여 $CO_2$농도를 12, 16%로 하였으며 $O_2$농도는 같이 3%로 하여서 약 160일간 저장하여 품질변화를 조사한 결과는 다음과 같다. 가용성 고형분 함량은 저장기간이 경과함에 따라 거의 변화가 없거나 감소하였으며, 청도반시, 사곡시, 고종시는 $CO_2$12%, $CO_2$16% 모두 일반 저온저장고와 비슷한 수준이었으나, 봉옥시는 고농도의 $CO_2$로 가용성 고형분의 감소가 현저하였다. 경도변화에서 청도반시, 사곡시 및 고종시는 고농도의 $CO_2$에 의한 CA저장에서 일반 저온저장보다 경도 유지가 좋았고 봉옥시는 CA저장과 일반 저온저장간에 큰 차이가 없었다. 장기저장시 청도반시의 중량감소가 가장 적었고, 고종시의 중량감소가 가장 컸다. 장기저장에 따른 부패과 발생은 $CO_2$농도가 높을수록 억제효과가 높았으며 청도반시, 사곡시에서 발생율이 현저히 낮아서 CA효과가 있는 것으로 보였다. 색도변화에서 CA저장으로 Hunter값이 약간 증가하거나 비슷한 수준이었다. 청도반시, 사곡시, 고종시는 일반 저온저장, CA저장에서 저장기간이 오래 경과해도 tannin 지수가 높아서 추후 탈삽처리가 필요할 것으로 생각되며, 봉옥시는 고농도 $CO_2$로 탈삽이 진행되었으나 과육이 검게 변하는 갈변화 현상을 보였다.

• 보건행정학회지
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• 제18권2호
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• pp.86-106
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• 2008

This research analyzed. knowledge structure and its effect factor by analysis of co-author and keyword network in Korea's health policy and administration sector. The data was extracted from 339 articles listed in the Korean Journal of Health Policy and Administration, and was transformed into a co-author and keyword matrix. In this matrix the existence of a link was defined by impact factors which were calculated by the weight value of what the role was and the rate of how many authors contributed. We demonstrated that the research achievement was dependent on the author's status and network index. Analysis methods were neighborhood degree, correspondence analysis, multiple regression and the difference of weight distribution by research fields. Co-author networks were developed as closeness centrality as well as degree centrality by a few high productivity researchers. In particular, power law distribution was discovered in impact factor and research productivity. The effect of the author's role was significant in both the impact factor calculated by the participatory rate and the number of listed articles. Especially, this journal shared its major researchers who had a licensed physician with the Journal of Preventive Medicine and Public Health. Therefore, social scientists were likely to be small co-author network differently from natural scientists. It was so called 'two cultures' phenomenon. This study showed how can we verified academic research structure existed in the unit of journal like as citation networks. The co-author networks in the field of health policy and administration had more differentiated and clustered than preventive medicine and epidemiology fields.

• 대한한의학회지
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• 제41권4호
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• pp.1-11
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• 2020

Objectives: Objectives: The object of this study was to elucidate the possible effects on the pharmacokinetics of tamoxifen after single oral co-administration of Gamisoyo-san (GMSYS) with 2.5 hr-intervals combination therapy of tamoxifen with GMSYS. Methods: After 2.5 hr of 50 mg/kg of tamoxifen treatment, GMSYS 100 mg/kg was administered. The plasma was collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of GMSYS treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen were analysis as compared with tamoxifen single administered rats. Results: Although single co-administration with GMSYS with 2.5 hr-interval induced increased trends of plasma tamoxifen concentrations, there are no significant changes on the plasma concentrations of tamoxifen were demonstrated in tamoxifen and GMSYS 100 mg/kg co-administrated rats with 2.5 hr-intervals as compared to those of tamoxifen single 50 mg/kg treated rats, and also GMSYS co-administrated rats did not showed any significant changes on the all pharmacokinetic parameters as compared to those of tamoxifen single formula treated rats. Conclusions: According to the this study, single co-administration of GMSYS with 2.5 hr-intervals did not critically influenced on the oral bioavailability of tamoxifen, suggesting GMSYS did not critically influenced on the absorption and excretion of tamoxifen, the oral bioavailability, when they were co-administered with 2.5 hr-intervals, at the dose levels of tamoxifen 50 mg/kg and GMSYS 100 mg/kg.

• Journal of Pharmaceutical Investigation
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• 제31권2호
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• pp.89-94
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• 2001

The pharmacokinetics of recombinant human granulocyte colony stimulating factor (rhG-CSF) following intravenous (i.v.), intramuscular (i.m.) and subcutaneous (s.c.) administration of HM1041l-lyo and HM10411-liq (lyophilized and liquid formulations of rhG-CSF, recently under development by Hanmi Pharmaceutical Company) were studied in rats, and compared with that of Filgrastim (conventional formulation of rhG-CSF on market). The plasma concentration of rhG-CSF was quantified using a specific ELISA. The pharmacokinetic parameters of rhG-CSF, after i.v., i.m. and s.c. administration of Filgrastim, HM1041l-lyo and HM1041l-liq to rats at a rhG-CSF dose of $10\;{\mu}g/kg$, were almost identical among the three formulations. No dose-dependency was observed in the pharmacokinetic parameters of rhG-CSF following i.v. administration in the dose range of $5{\sim}100\;{\mu}g/kg$. rhG-CSF, after i.v. administration of the three preparations at a dose of $10\;{\mu}g/kg$ to rats, was detected at low levels in all of the body tissues with highest tissue/plasma ratio of $0.46{\sim}0.51$ for the kidney at 30 min after the administration. The pharmacokinetics of rhG-CSF, after i.v. administration to mice at a dose of $10\;{\mu}g/kg$, were comparable among the three formulations. In conclusion, HM10411-lyo and HM10411-liq exhibited similar pharmacokinetics for rhG-CSF with Filgrastim regandless of animal species. Considering the fact that HM10411 series, contrary to Filgrastim, are proteins lacking a methionine residue, the methionine moiety in rhG-CSF molecule does not appear to influence the pharmacokinetics of the protein significantly.

• Archives of Pharmacal Research
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• 제28권4호
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• pp.476-482
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• 2005

We investigated the pharmacokinetics of 11-hydroxyaclacinomycin X (ID-6105), a novel anthracycline, after intravenous (i.v.) bolus administration at a multiple dose every 24 h for 5 days in rats. To analyze ID-6105 levels in biological samples, we used an HPLC-based method which was validated in a pharmacokinetic study by suitable criteria. The concentrations of ID-6105 after the multiple administration for 5 days were not significantly different from the results after the single administration. The $t_{1/2\alpha}, t_{l/2\beta}, V_{dss}, and CL_{t}$ after the multiple administration were not significantly different from the values after the single administration. Moreover, the concentrations of ID-6105 1 min at day 1-5 after i.v. bolus multiple administration did not show the significant difference. Of the various tissues, ID-6105 mainly distributed to the kidney, lung, spleen, adrenal gland, and liver after i.v. bolus multiple administration. ID-6105 concentrations in the kidney or lung 2 h after i.v. bolus administration were comparable to the plasma concentration shortly after i.v. bolus administration. However, the ID-6105 concentrations in various tissues 48 h after i.v. bolus administration decreased to low levels. ID-6105 was excreted largely in the bile after i.v. bolus multiple administration at the dose of 3 mg/kg. The amounts of ID-6105 found in the bile by 12 h or in the urine by 48 h after the administration were calculated to be $14.1\% or 4.55\%$ of the initial dose, respectively, indicating that ID-6105 is mostly excreted in the bile. In conclusion, ID-6105 was rapidly cleared from the blood and transferred to tissues, suggesting that ID-6105 might not be accumulated in the blood following i.v. bolus multiple dosages of 3 mg/kg every 24 h for 5 days. By 48 h after i.v. bolus administration, ID-6105 concentrations in various tissues had decreased to very low levels. The majority of ID-6105 appears to be excreted in the bile.

• Journal of Microbiology and Biotechnology
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• 제22권11호
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• pp.1575-1579
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• 2012

Paenibacillus polymyxa is known to be a plant-growth-promoting rhizobacterium. The present study describes a quantitative polymerase chain reaction (qPCR) assay for the specific detection and quantitation of P. polymyxa using a primer pair based on the sequence of a membrane-fusion protein for the amplification of a 268 bp DNA fragment. This study reports that the qPCR-based method is applicable for the rapid and sensitive detection of P. polymyxa and can be used as an alternative method for agricultural soil monitoring.

• 대한예방한의학회지
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• 제18권2호
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• pp.89-100
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• 2014

Objective : The co-administration effects of Gongjindan (GJD) on the pharmacokinetics (PK) of sorafenib were observed as a process of the comprehensive and integrative medicine. Methods : After sorafenib treatment, GJD was administered within 5 min. The plasma were collected at 30min before administration, 30min, 1, 2, 3, 4, 6, 8 and 24hrs after end of GJD treatment, and plasma concentrations of sorafenib were analyzed using LC-MS/MS methods. PK parameters of sorafenib ($T_{max}$, $C_{max}$, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with sorafenib single administered rats. Results : The absorption of sorafenib were significantly increased at 30min, 1, 6 and 6hrs after co-administration with GJD as compared with sorafenib single treated rats. Accordingly, the $AUC_{0-t}$ (47.20%) of sorafenib was significantly increased but $t_{1/2}$ (-30.63%) and $MRT_{inf}$ (-34.11%) in co-administered rats were non-significantly decreased. These findings are considered as direct evidences that GJD increased the oral bioavailability of sorafenib through increase of the absorption, when they co-administered within 5min. Conclusion : Based on the results, co-administration of GJD increased the oral bioavailability of sorafenib through increase of the gastrointestinal absorption. It is considered that the more detail pharmacokinetic studies should be tested to conclude the effects of GJD on the pharmacokinetics of sorafenib, when they were co-administered, like the effects after co-administration with reasonable intervals considering the $T_{max}$ of sorafenib (about 3.5hr-intervals) and after repeated co-administrations.Hence, concomitant uses of GJD with sorafenib may require close monitoring for potential drug interactions.

• Biomolecules & Therapeutics
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• 제5권3호
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• pp.278-283
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• 1997

DW-166HC ($^{166}$ Holmium ($^{166}$ Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumoriginec spectrum, especially against human fepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous and intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I ($^{165}$ Ho-Chitosan complex cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC ($^{166}$ Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr and 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative control group but there was significant difference this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.