• Title/Summary/Keyword: cnb-1

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The Role of Ultrasound Guided Core Needle Biopsy in Thyroid Nodule (갑상선 결절에서 초음파 유도하 중심생검의 역할)

  • Ryu, Yoon-Jong;Ahn, Soon-Hyun
    • Korean Journal of Head & Neck Oncology
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    • v.31 no.1
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    • pp.1-4
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    • 2015
  • Fine needle aspiration cytology(FNAC) holds a main role in assessing thyroid nodules. But nonnegligible rate of thyroid cytology is reported as uncertain, indeterminate or inadequate for diagnosis. Recently, the microhistologic evaluation by core needle biopsy(CNB) under ultrasound sonographical guidance has been reported to show high accuracy for the diagnose of thyroid nodules. Aim of this review was to furnish the state of the art of this topic by summarizing previous published data about indication, diagnostic performance, and complication of CNB in thyroid lesions compared with FNAC

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Identification and spectral analysis of the CIBER/LRS detected stars

  • Kim, MinGyu;Matsumoto, T.;Lee, Hyung Mok;Arai, T.;Battle, J.;Bock, J.;Brown, S.;Cooray, A.;Hristov, V.;Keating, B.;Korngut, P.;Lee, Dae-Hee;Levenson, L.R.;Lykke, K.;Mason, P.;Matsuura, S.;Nam, U.W.;Renbarger, T.;Smith, A.;Sullivan, I.;Wada, T.;Jeong, Woong-Seob;Zemcov, M.
    • The Bulletin of The Korean Astronomical Society
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    • v.37 no.2
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    • pp.141.1-141.1
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    • 2012
  • CIBER (Cosmic Infrared Background ExpeRiment) is a sounding-rocket borne experiment which is designed to find the evidence of the First stars (Pop.III stars) in the universe. They are expected to be formed between the recombination era at z ~ 1100 and the most distant quasar (z ~ 8). They have never been directly detected due to its faintness so far, but can be observed as a background radiation at around $1{\mu}m$ which is called the Cosmic Near-Infrared Background (CNB). The CIBER is successfully launched on July 10, 2010 at White Sands Missile Range, New Mexico, USA. It consists of three kinds of instruments. One of them is a LRS (Low Resolution Spectrometer) which is a refractive telescope of 5.5 cm aperture with spectral resolution of 20 ~ 30 and wavelength coverage of 0.7 to $2.0{\mu}m$ to measure the spectrum of the CNB. Since LRS detects not only CNB but also stellar components, we can study their spectral features with the broad band advantage especially at around $1{\mu}m$ which is difficult at ground observations because of the atmospheric absorption by water vapor. I identified around 300 stars from observed six fields. If we can classify their spectral types with SED fitting, we can study their physical conditions of the stellar atmosphere as well as making a stellar catalogue of continuous stellar spectrum.

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MR Findings of Papillary Neoplasms of the Breast (유두 종양의 자기공명 영상소견)

  • Jo, Yeseul;Kim, Sung Hun;Kang, Bong Joo;Choi, Byung Gil
    • Investigative Magnetic Resonance Imaging
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    • v.18 no.1
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    • pp.43-51
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    • 2014
  • Purpose : To review MR imaging finding of papillary lesion identified as additional suspicious lesion on MR image in women with biopsy-proven breast cancer and to evaluate upgrading rates after subsequent surgical histopathological diagnosis. Materials and Methods: Among 1729 preoperative MR image of women with biopsy proven breast cancer, US-guided CNB-proven 22 papillary lesions from 21 patients, which showed additional suspicious contrast enhancement other than index cancer on MR image, were subjected to the study. Some of these lesions underwent surgery, thus the comparisons between the histopathologic results were able to be compared to the results of US-guided CNB. Also retrospective analysis was done for MR findings of these lesions by BI-RADS MRI lexicon. Results: On MR imaging, 8 mass lesions, 7 non-mass lesions, 7 focus lesions were detected. All of the focus lesion (100%, 7/7) was diagnosed as benign lesion and showed plateau and washout pattern in dynamic MR image. After excisional biopsy, one of 9 benign papilloma (11.1%), 3 of 3 papillary neoplasm with atypia component (100%), 3 of 5 papillary neoplasm (60%) were upgraded to malignancy such as ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC), invasive lobular carcinoma (ILC). Conclusion: The MR images of papillary lesions diagnosed by US-guided CNB exhibit no significant differences between malignancy and benign lesion. Also 41.2% of the lesion (7/17) was upgraded after subsequent surgery. Thus all of the papillary lesions require excisional biopsy for definite diagnosis and the MR imaging, it's just not enough by itself.

Observation of the Cosmic Near-Infrared Background with the CIBER rocket

  • Kim, Min-Gyu;Matsumoto, T.;Lee, Hyung-Mok;Arai, T.;Battle, J.;Bock, J.;Brown, S.;Cooray, A.;Hristov, V.;Keating, B.;Korngut, P.;Lee, Dae-Hee;Levenson, L.R.;Lykke, K.;Mason, P.;Matsuura, S.;Nam, U.W.;Renbarger, T.;Smith, A.;Sullivan, I.;Wada, T.;Zemcov, M.
    • The Bulletin of The Korean Astronomical Society
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    • v.37 no.1
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    • pp.42-42
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    • 2012
  • The First stars (Pop.III stars) in the universe are expected to be formed between the recombination era at z - 1100 and the most distant quasar (z - 8). They have never been directly detected due to its faintness so far, but can be observed as a background radiation at around 1${\mu}m$ which is called the Cosmic Near-Infrared Background (CNB). Main part of the CNB is thought to be redshifted Lyman-alpha from gas clouds surrounding the Pop.III stars. Until now, the COBE (COsmic Background Explorer) and the IRTS (Infrared Telescope in Space) observed excess emission over the background due to galaxies. To confirm the COBE and the IRTS results and pursue more observational evidences, we carried out the sounding rocket experiment named the Cosmic Infrared Background ExpeRiment (CIBER). The CIBER is successfully launched on July 10, 2010 at White Sands Missile Range, New Mexico, USA. It consists of three kinds of instruments. We report the results obtained by LRS (Low Resolution Spectrometer) which is developed to fill the uncovered spectrum around 1${\mu}m$. LRS is a refractive telescope of 5.5 cm aperture with spectral resolution of 20 - 30 and wavelength coverage of 0.7 to 2.0${\mu}m$. After subtracting foreground components (zodiacal light, integrated star light and diffuse galactic light) from the sky brightness of observed five fields, there remained significant residual emission (even for the lower limit case) consistent with the IRTS and the COBE results. In addition, there exists a clear gap at 0.7 - 0.8${\mu}m$ in the CNB spectrum over the background due to galaxies according to recent results (Matsuoka et al. 2011; Mattila et al. 2011). The origin of the excess emission could be ascribed to the Pop.III stars with its active era of z = 7 - 10.

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A Novel Calcineurin-interacting Protein, CNP-3, Modulates Calcineurin Deficient Phenotypes in Caenorhabditis elegans

  • Kim, Yun Hee;Song, Hyun-Ok;Ko, Kyung Min;Singaravelu, Gunasekaran;Jee, Changhoon;Kang, Junsu;Ahnn, Joohong
    • Molecules and Cells
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    • v.25 no.4
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    • pp.566-571
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    • 2008
  • Calcineurin (Cn) is a calcium/calmodulin-dependent serine/threonine protein phosphatase that has diverse functions in different cell types and organisms. We screened proteins interacting with the C. elegans CnA homolog, TAX-6, by the yeast two-hybrid system. CNP-3 (Calcineurin interacting protein-3) is a novel protein that physically interacts with the catalytic domain of TAX-6. It is strongly expressed in the nuclei of intestine, hypodermis, dorsal uterine regions and spermatheca. Expression begins around the 60-cell stage and proceeds during all larval stages and the adult. To elucidate the biological function of cnp-3 we isolated a cnp-3 deletion mutant. Since CNP-3 binds CnA, we looked at factors associated with calcineurin loss-of-function mutants, such as brood size, body size, serotonin- and levamisole-mediated egg-laying behavior. The cnp-3(jh145) single mutant had no gross defects compared to wild-type animal. However, the phenotypes of the double mutants, tax-6(p675);cnp-3(jh145) and cnb-1(jh103);cnp-3(jh145), were more severe in terms of brood size, body size and serotonin-mediated egg-laying defects than tax-6(p675) and cnb-1(jh103), respectively. These results suggest that dysfunction of cnp-3 enhances certain calcineurin loss-of-function phenotypes in C. elegans.

Antioxidant Activity and Physicochemical Properties of ABC Healthy Juice Replaced with Berry Fruits (베리류를 첨가한 ABC 건강주스의 항산화 활성 및 이화학적 품질 특성)

  • Yeop Jung;Si Hyun Park;So Young Park;Eun Sun Yeom;Seon Young Kim;Hyo-Nam Song
    • The Korean Journal of Food And Nutrition
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    • v.36 no.1
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    • pp.25-32
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    • 2023
  • To increase antioxidant activity and physicochemical quality characteristics, four kinds of berries (blueberry (BEB), blackberry (BKB), cranberry (CNB), raspberry (RSB)) with antioxidant activities were used to replace beet (B) in existing ABC juice. In the experimental group, the pH was decreased while the content of soluble solids was increased significantly. Total polyphenol content was significantly increased in all experimental groups compared to that in the control group. The control group had the lowest polyphenol content at 14.723 ㎍ GAE/g, whereas the blackberry replacement group had the highest polyphenol content at 67.12 ㎍ GAE/g. The total flavonoid content was the lowest in the control group at 8.98 ㎍ QE/g but the highest in the blackberry group at 50.47 ㎍ QE/g. All experimental groups showed significantly higher antioxidant activities than the control group. DPPH & ABTS radical scavenging activities were the lowest in the control group at 15.69% and 19.55%, respectively, but the highest in the blackberry group at 48.24% and 59.43%, respectively. SOD-like activity was also the lowest in the control group at 14.12%, but the highest in the blackberry group at 48.18%. When comparing experimental groups, antioxidant activities (DPPH, ABTS, SOD) and antioxidant components (total polyphenols and total flavonoids) were in the order of BKB > CNB > RSB > BEB > Control. In conclusion, the new ABC juice containing four types of berries is enriched in antioxidants with significantly improved antioxidant activities and physicochemical quality characteristics.

Comparison of Machine Learning Techniques for Cyberbullying Detection on YouTube Arabic Comments

  • Alsubait, Tahani;Alfageh, Danyah
    • International Journal of Computer Science & Network Security
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    • v.21 no.1
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    • pp.1-5
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    • 2021
  • Cyberbullying is a problem that is faced in many cultures. Due to their popularity and interactive nature, social media platforms have also been affected by cyberbullying. Social media users from Arab countries have also reported being a target of cyberbullying. Machine learning techniques have been a prominent approach used by scientists to detect and battle this phenomenon. In this paper, we compare different machine learning algorithms for their performance in cyberbullying detection based on a labeled dataset of Arabic YouTube comments. Three machine learning models are considered, namely: Multinomial Naïve Bayes (MNB), Complement Naïve Bayes (CNB), and Linear Regression (LR). In addition, we experiment with two feature extraction methods, namely: Count Vectorizer and Tfidf Vectorizer. Our results show that, using count vectroizer feature extraction, the Logistic Regression model can outperform both Multinomial and Complement Naïve Bayes models. However, when using Tfidf vectorizer feature extraction, Complement Naive Bayes model can outperform the other two models.