• Journal of Pharmaceutical Investigation
• /
• v.10 no.3
• /
• pp.5-13
• /
• 1980

A study on the diuretic action of Siegesbeckiae herba in dogs was made using a clearance technique with ethanol extract. Siegesbeckiae herba ethanol extract (SGEE) administered intravenously in doses 6.0 and 60.0mg/kg elicited diuresis and an increase in sodium and potassium excretion, and it simultaneously produced a decrease in the reabsorption rate of sodium and potassium in renal tubules. Neither renal plasma flow nor glomerular filtration rate changed significantly. SGEE, when infused directly into a renal artery in doses of 0.5 and 1.5mg/kg min, exhibited identical results to the intravenous responses confined only to the infused kidney. The above observations lead to the suggestion that SGEE elicits diuresis in dogs by decreasing the reabsorption rates of sodium and potassium in renal tubles.

• Journal of the Korean Society for Precision Engineering
• /
• v.16 no.1 s.94
• /
• pp.174-181
• /
• 1999

In this paper the technique to predict tool wear theoretically in shearing process is suggested. The tool wear in the process affects the tolerances of final pans, metal flows and costs of processes. In order to predict the tool wear the deformation of workpiece during the process is analyzed by using non-isothermal finite element program. The ductile fracture criterion and the element kill method are also used to estimate if and where a fracture will occur and to investigate the features of the sheared surface in shearing process. Results obtained from finite element simulation, such as nodal velocities and nodal forces, are transformed into sliding velocity and normal pressure on tool monitoring points respectively. The monitoring points are automatically generated and the wear rates on these points are accumulated during the process. It is assumed that the wear depth on the tool surface is linear function of the lot sizes based upon the known experimental results. The influence of clearance between die and punch upon tool wear is also discussed.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.12 no.3
• /
• pp.27-36
• /
• 2004

A Numerical analysis has been used to predict the performance in the automotive water pump with double discharge single suction. The influence of parameters such as coolant flow rate, rotational speed, ratio of blade height and clearance has been investigated. Also, the prediction of hydraulic performances such as static pressure rise, shaft power, hydraulic power and pump efficiency is carried out on the water pump including an impeller and a volute casing. A full size water pump test bench has been developed to validate the CFD flow model. Discharge flow rate, suction pressure, discharge pressure, rotational speed and torque measurements are provided. Coolant temperature is 8$0^{\circ}C$, water tank pressure is 1 kgf/$\textrm{cm}^2$ and flow rates vary.

• Journal of information and communication convergence engineering
• /
• v.17 no.4
• /
• pp.267-273
• /
• 2019

South Korea has allowed parallel importation since 1995. Parallel importation causes competition among importers in the logistics process allowing, consumers to purchase foreign brand products at low prices. Most parallel importers base product pricing on subjective judgements. Fashion products in particular, have different sales rates depending on trends and seasons, so sales performance varies greatly depending on selling price timing and policy. The merchandiser (MD) set the price on parallel importation products by aggregating information on imported products and pricing goods. However, this customized process is very time consuming for the MD. This is because the logistics process of parallel importation's customs clearance procedures and repair works is complicated and takes a significant amount of time. In this paper, we propose an improved parallel importation logistics process based on big data, which automatically sets the price of parallel importation products.

• Tuberculosis and Respiratory Diseases
• /
• v.86 no.3
• /
• pp.183-195
• /
• 2023

Bronchiectasis, which is characterized by irreversibly damaged and dilated bronchi, causes significant symptoms, poor quality of life, and increased economic burden and mortality rates. Despite its increasing prevalence and clinical significance, bronchiectasis was previously regarded as an orphan disease, and ideal treatment of this disease has been poorly understood. The European Respiratory Society and British Thoracic Society have recently published guidelines to assist physicians in the clinical field. Guidelines and reports suggest comprehensive management that includes both non-pharmacological and pharmacological treatment. Physiotherapy and pulmonary rehabilitation are two of the most important non-pharmacologic therapies in bronchiectasis patients; long-term inhaled antibiotics and macrolide therapy have gained significant evidence in reducing exacerbation risk in frequent exacerbators. In this review, we summarize recent updates on bronchiectasis treatment to prevent exacerbation and manage clinical deterioration.

• Journal of the Korean Society for Precision Engineering
• /
• v.23 no.10
• /
• pp.103-112
• /
• 2006

This paper describes a theoretical analysis and experimental verification on the performances of a vacuum-compatible air bearing, which is designed with a cascaded exhaust scheme to minimize the air leakage in a vacuum environment. The design of the vacuum-compatible air bearing equipped with the differential exhaust system requires great care because several design parameters, such as the number of exhaust stages, diameter of exhaust tube, pumping speed of a vacuum pump, and bearing clearance greatly influence the air leakage and thus degree of vacuum. In this study, a performance analysis method was proposed to estimate the performances of the air bearing, such as load capacity, stiffness, and air leakage. Results indicate that the load capacity and stiffness of the air bearing was improved as its boundary pressure, which was determined by the $1^{st}$ exhaust method, was lowered, and the dominant factors on the chamber's degree of vacuum were the number of exhaust stages, exhaust tube diameter and bearing clearance. A vacuum chamber and air bearing stage using porous pad were fabricated to verify the theoretical analysis. The results demonstrate that chamber pressure up to an order of $10^{-3}$ Pa was achieved with the air bearing stage operating inside the chamber, and this analysis method was valid by comparing predicted values with experimental data, for the mass flow rates from the porous pad, and pressures at each exhaust port and chamber, respectively.

• Journal of Korean Society on Water Environment
• /
• v.26 no.3
• /
• pp.518-524
• /
• 2010

Continuous removal of organic matters (CROM) using freshwater bivalve Anodonta woodiana was operated to evaluate the effect of water current on the water quality improvement (clearance) of eutrophic lake. The CROM system comprised three treatment steps such as flow control, treatment and analysis, and operated at the two different currents ($24L\;h^{-1}$ and $48L\;h^{-1}$) with mussels at density of $312.5indiv.\;m^{-2}$ for 12 consecutive days. Water quality including suspended solids (SS) and chlorophyll-a (Chl-a) was daily measured at the same time. Results indicate that although both the system strongly decreased the concentration of SS and chl-a, a slow CROM system was more effective to diminish the SS contents than a fast CROM system; 82% and 66%, respectively (ANOVA, P<0.0001). Clearance rates, based on chl-a, were also significantly higher in a slow system than a fast system (ANOVA, P<0.0001), although the mussel mortality was conversely. In both systems, there showed a remarkable excretion of dissolved inorganic nutrients (i.e. $NH_3-N$ and $PO_4-P$), while a slow CROM system was higher than a fast system, significantly (ANOVA, P<0.0001). Therefore, it may suggest that a slow current CROM system is more suitable to maximize the efficacy of water quality improvement, but further study is needed to diminish the mortality of mussel and to reuse the nutrient released during the operation.

• The Korean Journal of Malacology
• /
• v.28 no.4
• /
• pp.349-359
• /
• 2012

The purpose of this study is to compare the clearance rate (CR) and intake rate (IR) of juvenile purple clam, Saxidomus purpuratus when feeding on different unialgal diet of red tide dinoflagellates (RTDs), and to know what is the most important cell characteristic of RTDs to cause the differences in feeding parameters. Experiments were performed to measure the CR and IR of juvenile S. purpuratus as a function of algal concentration when food was either the standard food, Isochrysis galbana or one of 9 RTDs. Patterns of CR with increasing algal concentration were similar among different RTDs. The highest $C_{max}$ was observed when S. purpuratus was feeding on A. affine, while the lowest on C. polykrikoides. The patterns of IR with increasing algal concentration were also similar among different RTDs. However, there were great differences in the maximum value of IR ($I_{max}$) among different RTDs. The highest $I_{max}$ was observed when S. purpuratus was feeding on A. carterae, while the lowest on G. catenatum. Some RTDs similar in size showed different $C_{max}$. Other RTDs different in size showed similar $I_{max}$. Life form of each RTD affected significantly the $I_{max}$, which was higher for single-celled RTDs than chain-forming RTDs. There were no significant differences in feeding parameters between toxic and nontoxic RTDs. Moreover, a toxic dinoflagellate, A. carterae recorded the highest $I_{max}$ among RTDs. The most important characteristic of RTD as a factor affecting the feeding rate of S. purpuratus was life form, not size or toxicity of RTD species.

• Journal of Oriental Neuropsychiatry
• /
• v.7 no.1
• /
• pp.49-63
• /
• 1996

After applying the gravity acceleration stress to a mice, the effect on organ index was examined, and the Con A stimulating proliferation rate of splenocytes, expression of IL-2 receptor and T cell subsets of thymocytes were analyzed and also clearance of C. neoformans was measured. The results were as follows :1. Form finding the organ index after 4 days stress, the indexes of the spleen and thymus were reduced in the res group exposed to the gravity acceleration.2. From finding the proliferation rate by stimulating the splenocytes with Con 4 after 7 days stress, the proliferation rates were all reduced in the stress group, the Yangsimtang group, and the stress and Yangsimtang group. 3. The expression of IL-2 receptor in resting stage was reduced, comparing to the test group, both in the stress group and the Yangsimtang group, however, comparing to the stress group, it was somewhat recovered in the stress and Yangsimtang group.4. To see the IL-2 receptor driven-out after being stimulated by Con-A, the expression of IL-2 receptor was all reduced in the stress group, the Yangsimtang group, and the stress and Yangsimtang group.5. To the rate of T cell subsets of thymus, there's no difference, comparing to the test group, in the Yangsimtang group, however, the rate of $CD4^+CD8^-,\;CD4^-CD8^+,\;and\;CD4^-CD8^-$ cell was significantly reduced in the stress group. And, the $CD4^+CD8^+$ which had been reduced by stress was somewhat recovered in the stress and Yangsimtang group.6. To the effect on the clearance of C, neoformans infection, the numbers of fungi detected at the spleen was, comparing to the test group, increased by 12.6 tines in the Yangsimtang group.

• YAKHAK HOEJI
• /
• v.41 no.4
• /
• pp.498-511
• /
• 1997

The effects of UK 14,304, an ${\alpha}_2$-adrenergic agonist, on renal function were investigated in dogs. UK 14,304, when given intravenousely($15.0{\mu}g/kg,\;50{\mu}g/kg$), produced the increase of urine flow accompanied with the marked augmentation of free water clearance ($C_{H_2O}$) and reabsorption rates of sodium in renal tubules ($R_{Na}$), and the remarkable decrease of osmolar clearance ($C_{osm}$) and the amounts of sodium excreted in urine ($E_{Na}$). UK 14,304 given into a renal artery($1.5{\mu}g/kg,\;5.0{\mu}g/kg$) elicited the increase of urine flow with the augmentation of $C_{H_2O}$ in both kidney. UK 14,304, when administered into carotid artery($3.0{\mu}g/kg,\;10.0{\mu}g/kg$). exhibited the same aspect as shown in intravenous UK 14.304 at smaller dose than the intravenous dose. Diuretic action of intravenous UK 14,304 were produced together with increase of $C_{H_2O}$ in situation of water diuresis too, changes of renal function in this state were the increase of $C_{osm},\;E_{Na},\;and\;E_K$ (excreted amounts of potassium in urine), and the decrease of $R_{Na}\;and\;R_K$, these were different appearances from situation of saline diuresis. Diuretic action of intravenous UK 14,304 were blocked completely by post or pretreatment of yohim-bine, ${\alpha}_2$-adrenergic blocking agents, and inhibited by pretreatment of vasopressin, antidiuretic hormone. Above results suggest that UK 14,304 produces the diuretic action by the inhibition of vasopressin secretion and suppression of electrolytes reabsorption of electrolytes in renal tubules mediated with central ${\alpha}_2$-adrenoceptor in dog.