• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1184-1189
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• 2002

Allii sativi Bulbus(garlic) have been shown to possess medicinal value, in particular, antimicrobial activity. In this study, we compared the efficacy on some pathogenic bacteria and fungus among several different extracts(water, hexane, ethyl acetate, methanol, chloroform) of Allii sativi Bulbus. Animal pathogenic bacteria and fungus(S. gallinarium: KCTC 2441, S. flexneri: KCTC 2361, E. cloacae: KCTC 2006, K. pneumonia: KCTC 2208, C. albicans: KCTC 1940) were used to test by measurement of minimum inhibitory concentrations(MIC) and disc diffusion. Allii sativi Bulbus were cut and mixed with water at 37℃ about 24 h and filtered, and several different solvents(hexane, chloroform, ethyl acetate, methanol) were respectively added to separate the fraction of each solvent. The antimicrobial(bacteriocidal) and antifungal effect were apparently shown from water extract, hexane and ethyl acetate extract against using strains(Staphylococcus gallinarium, Shigella flexneri, Enterobacter doacae, Klebsiella pneumonia, Candida albicans). Especially, the water extract showed the superior efficacy. And the clear zone size of water extract (11～27 mm) was greater than that of gentamycin, hexane extract and ethyl acetate extract against S. gallinarium. S. flexneri, K. pneumonia and C. albicans. Minimum inhibitory concentrations(MIC) of water extract appeared to around 2.0～7.5 ㎎/㎖ against S. gallinarium, S. flexneri, E. cloacae and K. pneumonia. The greater activity was shown by water extract because the MIC of water extract for C. albicans observed in very low concentration(<1.0 ㎎/㎖) compared to hexane(5.0 ㎎/㎖) and ethyl acetate(10.0 ㎎/㎖). Therefore, these results exhibited that water extract of Allii sativi Bulbus have stronger antimicrobial activity than hexane and ethyl acetate extract, and may be useful as topical medicine of superficial infections causing C. albicans as well as antifungal agents.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05b
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• pp.20-45
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• 2002

In this study, we demonstrated the in vitro and in vivo formation of carcinogen-lipid adduct and its correlation with DNA or protein adducts. The lipids from serum or hepatocyte membranes of Spragu-Dawley rats. human serum, and standard major lipids were in vitro reacted with benzo[a]pyrene(BP) and BP metabolites. 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]-pyrene(BPDE-I), an ultimate carcinogenic form of BP, was covalently bound to triglyceride(TG). BPDE-I-TG adducts isolated by thin-layer chromatography (TLC) were further detected by high performance liquid chromatography(HPLC). TGs, including triolein, tripalmitin and tristearin, showed positive reactions with BPDE-I. However, cholesterol, phospholipids(Phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidyl-inositol and sphingomyelin) and nonesterified fatty acids(palmitic acid, oleic acid, linoleic acid and stearic acid) did not react with BPDE-I. In addition, other BP metabolites (BP-phenols and -diols) did not react with TG, which TG appeared to be the most reactive lipid yet studied with respect to its ability to form an adduct with BPDE-I. There was a clear-cut dose-respect to its ability to form an adduct with BPDE-I-lipid adduct in vitro between TG and [1,3-3H]BPDE-I. In an animal study, BPDE-I-TG was also formed in the serum of rats orally treated with BP(25 mg/rat). Also, obvious correlations between [3H]BP related-biomolecule adducts (DNA, protein) or lipid damage and the BPDE-I-TG adduct were obtained in various tissues of mice i.p. treated with [3H]BP. These data suggest that TG can form an adduct with BPDE-I, as do other macromolecules (DNA, RNA, and protein). Therefore, a carcinogen-lipid adduct would be a useful biomarker for chemical carcinogenesis research and cancer risk assessment.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.5
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• pp.728-733
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• 2005

The frequency and distribution of lymphoma caused by bovine leukemia virus (BLV) infection in various organs were investigated. Lymphoma samples were obtained from slaughtered cattle or from cattle submitted to the National Veterinary Research and Quarantine Service, Korea. Thirty female Holstein-Friesian dairy cattle aged over three years with the BLV-associated lymphoma were studied. None of the Korean native cattle (Hanwoo) had lymphoma in this study however. Lymphoma tissues were gray to pink in color, soft in consistency, and bulged from the cut surface. In advanced lymphoma tissues, there was great variety in the appearance of involved structures due to hemorrhage, necrosis, and/or calcification. Neoplastic tissues were observed in lymph nodes in all lymphoma cases. Intestine (96.4%), heart (88.9%), stomach (73.1%), and diaphragm (62.5%) were frequently involved with lymphoma. However, there was no lymphoma detected in liver. Large neoplastic masses, sometimes reaching the size of over 20 cm, were found in the abdominal cavities. It is suggested that metastasis of lymphomas occurs mainly via lymph based on gross observations; neoplasia may have been initiated in the serosal surface of the lung, heart, peritoneum, and numerous hollow organs in the abdominal cavity. Also many organs in the abdominal and thoracic cavity were affected by neoplastic tissues simultaneously. Characteristics observed in this study could be used as criteria to differentiate BLV-associated lymphoma from other nodular lesions in the slaughterhouse and as fundamental data to make clear the mechanism of metastasis or pathogenesis of EBL.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4847-4851
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• 2013

Objectives: To evaluate accuracy of FDG-PET CT in prediction of persistent disease in head and neck cancer cases and to determine prognostic value of metabolic tumor response. Materials and Methods: Between 2009 and 2011, 46 patients with squamous cell carcinoma of head and neck receiving PET-CT were treated with definitive radiotherapy, with or without chemotherapy. There were 29 nasopharyngeal, 11 hypopharyngeal, 3 oropharyngeal and 3 laryngeal cancer patients, with a median age of 50.5 years (range 16-84), 32 males and 14 females. All patients were evaluated with PET-CT median 3-5 months (2.4-9.4) after completion of radiotherapy. Results: After a median 20 months of follow up, complete metabolic response was observed in 63% of patients. Suspicious residual uptake was present in 10.9% and residual metabolic uptake in 26.0% of patients. The overall sensitivity, specificity, positive predictive value and negative predictive value of FDG-PET-CT for detection of residual disease was 91% and 81%, 64% and 96% respectively. Two year LRC was 95% in complete responders while it was 34% in non-complete responders. Conclusions: FDG PET CT is a valuable tool for assessment of treatment response, especially in patients at high risk of local recurrence, and also as an indicator of prognosis. Definitely more precise criteria are required for assessment of response, there being no clear cut uptake value indicating residual disease. Futhermore, repair processes of normal tissue may consume glucose which appear as increased uptake in control FDG PET CT.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.12
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• pp.5247-5250
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• 2016

Objective: Endometriosis, one of the most common estrogen dependent gynecological disorders, can present as both benign and malignant disease. The prevalence of tumoral transformation is 0.7-1.6% and the most common tumors are clear cell and endometrioid carcinomas. Unfortunately, the pathogenesis of transformation is unknown. For this purpose, we examined molecular alterations in ovarian endometriosis and endometriosis-associated tumors. Methods: Using the data bank of Alzahra hospital pathology department and paraffin blocks from appropriate cases were identified. Sections were cut and stained for 3 markers: estrogen receptor, P53 and bcl2. Correlations between findings were investigated. Results: Nineteen cases of endometriosis-associated tumor and 19 cases of endometriosis were identified. Staining for bcl2 was documented in 14 of 19 (73.7%) of endometriosis-associated tumor cases and also 7 of 19 (36.8%) endometriosis cases (P=0.02). Only 3 of the 19 (15.8%) endometriosis-associated tumors exhibited positive staining for estrogen receptors, compared with 14 of 19 (73.7%) endometriosis cases (P<0.001). Positive staining for P53 was noted in 5 of 19 (31.6%) endometriosis-associated ovarian tumor samples but was absent in endometriosis samples (0%), (P =0.008). Conclusions: Endometriosis-associated tumors appear to be associated with overexpression of bcl2 and P53 and reduced expression of Estrogen receptor. These finding may help to diagnose tumoral transformation with a background of endometriosis.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3601-3604
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• 2016

Background: The monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemoattractant for natural killer cells, monocytes, and memory T lymphocytes. However, any role in the genesis of salivary gland tumors (SGT) is unknown. To assess the diagnostic relevance of chemokines in SGT, MCP-1 levels in the serum of patients were investigated in association with tumor progression and clinical aggressiveness. Materials and Methods: Using an ELISA kit, we assessed and compared the circulating levels of MCP-1 in blood serum of 70 SGT patients with 44 healthy control samples. Results: The results of this study showed that the concentration of MCP-1 was significantly lower in patients with benign ($463.8{\pm}158.5pg/ml$, P=0.033) and malignant ($454.8{\pm}190.4pg/ml$, P=0.007) SGT than in healthy subjects ($645.7{\pm}338.9$). No significant difference in mean serum levels of MCP-1 was observed between the benign and malignant group (p=0.9). While MCP-1 levels were lower in patients with an advanced clinical stage, advanced tumor size, higher tumor grade, or lymph node involvement, but the mean MCP-1 level between groups showed no statistically significant difference (p>0.05). Conclusions: MCP-1 levels in the serum of patients with SGT were decreased, indicating that this might a good marker for discriminating patients with SGT from healthy people. However, no clear-cut relationship was detected between MCP-1 levels and clinicopathologic factors, and MCP-1 is not a good marker for evaluating tumor dissemination.

• Korean Business Review
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• v.16
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• pp.123-144
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• 2003

The transfer of R&D performance is the technology transfer in a narrow sense. This study aimed at fanning the effective managerial systems of the transfer of the academic entrepreneur's R&D performance. For this purpose, this study analysed the characteristics and success factors of R&D performance transfer based on the theory of project life cycle. This research classified the life cycle of academic entrepreneurs' R&D projects into six stages. And the risks associated with the transfer process was categorized using the case study about the establishing processes the mineral-related small finns. Especially, the risk of the technology transfer was investigated by the R&D project implementation stages. Based on this results, this paper suggested the strategic system such as the marketing-oriented thinking, the clear-cut statement of the role among the stake-holders of the R&D and commercialization processes, the dynamic system of the academic entrepreneurs' leadership, the formation of the transfer management system, and the usage of project risk management techniques.

• Journal of the Korean Society of Costume
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• v.65 no.4
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• pp.109-123
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• 2015

The object of this research is to take a bilateral look into cultural exchanges of the Netherlands and Japan through the East India Company and thereby improve the general understanding in regards to the exchanges of costume cultures between the East and the West. The study conducted qualitative analyses on features of contemporary costumes of the Netherlands and Japan from 1602 to 1799 by investigating the secondary sources, such as the histories of costumes, arts, and literature. The results are as follows; the traditional sleeves of the Japanese Kimono were basically cut out in a straight line. However due to the growing popularity of the kimono home gown in Europe, the producers of the kimono in India as well as several other European countries modified them into western-style sleeves. Regarding the costumes of the Netherlands, which were introduced to Japan, the study found that Japan imported Dutch fabrics, instead of specific clothing items. In Japan, costume controls and anti-conspicuous consumption regulations among social classes including a closed-door policy had negative effects on both developments and exchanges of costumes of the country. However, when it comes to the Jinbaori, a costume for ruling classes, Japan was open to using fabrics, patterns and designs of the West. In light of what have been discussed so far, the study confirmed that the costume exchanges between the two countries started long after their first business of the general cultural exchanges. Though it is clear that the advancements in the natural sciences that the Japanese made can be attributed to the West, Japan was one of the nations that impacted the costume cultures in Europe.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.3C
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• pp.279-287
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• 2009

In this paper, a hierarchical stereo matching with color information is proposed. To generate an initial disparity map, feature based stereo matching is carried out and to generate a final disparity map, hierarchical stereo matching is carried out. The boundary (edge) region is obtained by segmenting a given image into R, G, B and White components. From the obtained boundary, disparity is extracted. The initial disparity map is generated when the extracted disparity is spread to the surrounding regions by evaluating autocorrelation from each color region. The initial disparity map is used as an initial value for generating the final disparity map. The final disparity map is generated from each color region by changing the size of a block and the search range. 4 test images that are provided by Middlebury stereo vision are used to evaluate the performance of the proposed algorithm objectively. The experiment results show better performance compared to the Graph-cuts and Dynamic Programming methods. In the final disparity map, about 11% of the disparities for the entire image were inaccurate. It was verified that the boundary for the non-contiguous point was clear in the disparity map.

• Speech Sciences
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• v.5 no.2
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• pp.77-91
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• 1999

The purpose of this paper is to investigate the phonetic characteristics of the 'focus' phrases associated with the particle '-man' in Korean. The particle '-man' is a bound morpheme which, like other postpositions such as the subject marker '-ka' and the object marker '-lil', the so-called 'case markers' in Korean, typically attaches to a noun (phrase). The semantics of '-man' roughly corresponds to that of only, its counterpart in English, and is thus classified as a 'delimiter' (Yang 1973). It is assumed in this paper that '-man', like only in English, should have a 'focus' associated with it (von Stechow 1991, Rooth 1992). In general, '-man' attached phrases get the focus, but sometimes the association is not clear-cut, especially in the cases of emphatic use of '-man' or when the context strongly favors other phrase as the focus (Choe 1996). In this paper, we compare the phonetic characteristics of the '-man' marked phrases with those to which '-ka'/'-lil' is attached, and conclude that the focused '-man' phrases show higher fundamental frequencies than their equally focused 'case' -marked counterparts. However, when the context clearly forces the focus to fall on phrases other than the '-man' or '-ka'/'-lil' attached ones, there is no meaningful difference in fundamental frequency between the '-man' and '-ka'/'-lil' attached phrases. We also compare the phonetic characteristics of the regular use of '-man' with those of the emphatic '-man'. According to our experiments, the emphatic '-man' does not bring forth its phonetic effects, namely, higher fundamental frequencies, on the' -man' attached words or phrases but rather in various other ways such as higher fundamental frequencies in '-man', lengthening of the following word-initial syllable, or the inclusion of the following word in the same accentual phrase. Finally, it is claimed that '-man' associated focus phenomena, especially the emphatic use of '-man', show some typical acoustic characteristics of the other well-known focus phenomena, namely, wh-interrogatives.