• Bulletin of the Korean Chemical Society
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• 제29권1호
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• pp.111-116
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• 2008

A piperazinylalkylisoxazole library containing 86 compounds was constructed and evaluated for the binding affinities to dopamine (D3) and serotonin (5-HT2A/2C) receptor to develop antipsychotics. Dopamine antagonists (DA) showing selectivity for D3 receptor over the D2 receptor, serotonin antagonists (SA), and serotonin-dopamine dual antagonists (SDA) were identified based on their binding affinity and selectivity. The analogues were divided into three groups of 7 DAs (D3), 33 SAs (5-HT2A/2C), and 46 SDAs (D3 and 5-HT2A/2C). A classification model was generated for identifying structural characteristics of those antagonists with different affinity profiles. On the basis of the results from our previous study, we conducted the generation of the decision trees by the recursive-partitioning (RP) method using Cerius2 2D descriptors, and identified and interpreted the descriptors that discriminate in-house antipsychotic compounds.

• International Journal of Fuzzy Logic and Intelligent Systems
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• 제16권1호
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• pp.27-35
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• 2016

Black-box classifiers, such as artificial neural network and support vector machine, are a popular classifier because of its remarkable performance. They are applied in various fields such as inductive inferences, classifications, or regressions. However, by its characteristics, they cannot provide appropriate explanations how the classification results are derived. Therefore, there are plenty of actively discussed researches about interpreting trained black-box classifiers. In this paper, we propose a method to make a fuzzy logic-based classifier using extracted rules from the artificial neural network and support vector machine in order to interpret internal structures. As an object of classification, an anomalous propagation echo is selected which occurs frequently in radar data and becomes the problem in a precipitation estimation process. After applying a clustering method, learning dataset is generated from clusters. Using the learning dataset, artificial neural network and support vector machine are implemented. After that, decision trees for each classifier are generated. And they are used to implement simplified fuzzy logic-based classifiers by rule extraction and input selection. Finally, we can verify and compare performances. With actual occurrence cased of the anomalous propagation echo, we can determine the inner structures of the black-box classifiers.

• 혜화의학회지
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• 제9권2호
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• pp.159-171
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• 2001

In the result of investigating the drugs for replenishing Qi in many herbal books, we could get consistent relation in their immunopharmacologic effects as follows: 1. The effects of drugs for replenishing Qi was shown in the Shen Nong's Herbal, but its classification was natural such as trees and plants, insects and beasts, fruits, vegetables, and we think that trial about classification of drugs for replenishing Qi was accomplished in the ben-cao-jiu-zhen(本草求眞). 2. Main drugs for replenishing Qi was Gingseng Radix, Codonopsis pilosulae Radix, Astragali Radix, Atractylodis macrocephalae Rhizoma, Dioscoreae Rhizoma, Glycyrrhizae Radix. 3. Drugs for replenishing Qi commonly contain polysaccharides as much, and it was thought that they have also immunopharmacolologic effects by means of activating T and B cells, secreting cytokines, making lymphocytes, activating NK cells, increasing abilities of voracity and generating antibodies. 4. Drugs for replenishing Qi mainly replenish lung-Qi and Wei-Qi so that they have also effects of activating T and B cells, secreting cytokines, making lymphocytes, activating NK cells, increasing abilities of voracity and generating antibodies. 5. Drugs for replenishing Qi modulate content of cAMP and inhibit Na(+)-K(+) ATPase, so that they have effects of treating indistinctive pulse from Qi deficiency by means of inhibition delivery of chemical substances, activating lymphocytes. promoting contraction of myocardium.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권2호
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• pp.536-564
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• 2019

Soft faults are inherent in wireless sensor networks (WSNs) due to external and internal errors. The failure of processes in a protocol stack are caused by errors on various layers. In this work, impact of errors and channel misbehavior on process execution is investigated to provide an error classification mechanism. Considering implementation of WSN protocol stack, inter-process correlations of stacked and peer layer processes are modeled. The proposed model is realized through local and global decision trees for fault diagnosis. A hybrid framework is proposed to implement local decision tree on sensor nodes and global decision tree on diagnostic cluster head. Local decision tree is employed to diagnose critical failures due to errors in stacked processes at node level. Global decision tree, diagnoses critical failures due to errors in peer layer processes at network level. The proposed model has been analyzed using fault tree analysis. The framework implementation has been done in Castalia. Simulation results validate the inter-process correlation model-based fault diagnosis. The hybrid framework distributes processing load on sensor nodes and diagnostic cluster head in a decentralized way, reducing communication overhead.

• 국제학술발표논문집
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• The 9th International Conference on Construction Engineering and Project Management
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• pp.728-735
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• 2022

Roofers get exposed to increased risk of knee musculoskeletal disorders (MSDs) at different phases of a sloped shingle installation task. As different phases are associated with different risk levels, this study explored the application of machine learning for automated classification of seven phases in a shingle installation task using knee kinematics and roof slope information. An optical motion capture system was used to collect knee kinematics data from nine subjects who mimicked shingle installation on a slope-adjustable wooden platform. Four features were used in building a phase classification model. They were three knee joint rotation angles (i.e., flexion, abduction-adduction, and internal-external rotation) of the subjects, and the roof slope at which they operated. Three ensemble machine learning algorithms (i.e., random forests, decision trees, and k-nearest neighbors) were used for training and prediction. The simulations indicate that the k-nearest neighbor classifier provided the best performance, with an overall accuracy of 92.62%, demonstrating the considerable potential of machine learning methods in detecting shingle installation phases from workers knee joint rotation and roof slope information. This knowledge, with further investigation, may facilitate knee MSD risk identification among roofers and intervention development.

• Nuclear Engineering and Technology
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• 제56권2호
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• pp.558-567
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• 2024

Diagnostic support systems are being researched to assist operators in identifying and responding to abnormal events in a nuclear power plant. Most studies to date have considered single abnormal events only, for which it is relatively straightforward to obtain data to train the deep learning model of the diagnostic support system. However, cases in which multiple abnormal events occur must also be considered, for which obtaining training data becomes difficult due to the large number of combinations of possible abnormal events. This study proposes an approach to maintain diagnostic performance for multiple abnormal events by training a deep learning model with data on single abnormal events only. The proposed approach is applied to an existing algorithm that can perform feature selection and multi-label classification. We choose an extremely randomized trees classifier to select dedicated monitoring parameters for target abnormal events. In diagnosing each event occurrence independently, two-channel convolutional neural networks are employed as sub-models. The algorithm was tested in a case study with various scenarios, including single and multiple abnormal events. Results demonstrated that the proposed approach maintained diagnostic performance for 15 single abnormal events and significantly improved performance for 105 multiple abnormal events compared to the base model.

• 대한교통학회지
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• 제24권1호
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• pp.39-52
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• 2006

본 연구는 대형 교통사고의 발생지점들을 특성별로 유형화하기 위하여 군집분석(Cluster hnalysis)을 행하고, 아울러 충돌 형태에 미치는 영향요인에 대한 영향 정도를 판별할 수 있도록 하기 위하여 수량화 이론 II류(Quantification II)와 C&RT(Classification and Regression Trees) 방법에 의해 분석을 실시하여 이에 대한 적합성을 평가함으로써, 정량적 척도의 간략화를 도모하고자 하였다. 그 결과, 발생 지점별 유형화에 따른 4개 집단의 판별 및 분류분석의 충돌 형태별 제반 영향요인들 특성은 집단별로 명확한 차이를 보이는 것으로 나타나, 교통사고에 대해 우선 시행되어져야 할 대책과 보완 대책들을 집단별로 체계적으로 제시할 수 있었다. 하지만 상당수 변수들에 결측치가 많아, 막대한 정보 손실이 초래되어 보다 심층적인 분석을 하기 어려웠는바, 이러한 문제점을 해결하기 위해서는 대형 교통사고 조사. 분석 시 표준화된 원 자료 시트의 작성을 의무화할 필요가 있는 것으로 나타났다.

• 대한공간정보학회지
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• 제19권3호
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• pp.41-47
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• 2011

원시 LiDAR 데이터는 벡터 구조이기 때문에 직접 활용 시 처리과정이 복잡해지지만, LiDAR 데이터를 필터링을 통해 정규 가상 격자 형태로 변환하면 데이터 용량이 감소되고 처리 속도가 빠르기 때문에 저가의 장비에서도 처리가 가능하다. 특히 Quadtree와 같은 영상 압축 처리 기법을 적용할 경우, 평활화를 통하여 비지면 요소인 자동차, 수목등이 제거되어 모델링에 유리하다는 장점이 있다. 따라서 본 연구에서는 대용량의 LiDAR 데이터로부터 Quadtree와 영역확장법을 활용하여 지면점을 자동 추출할 수 있는 알고리즘을 제시하였으며, 오차분류기법을 활용하여 정확도를 분석하였다. 그 결과, 지면점 분류 정확도는 98%이상으로 나타나, 지면점 추출에 유리함을 알 수 있었다. 또한 Quadtree와 영역확장법을 활용시 자동차, 수목등의 비지면 요소들을 효과적으로 제거할 수 있었다.

• 한국음향학회:학술대회논문집
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• 한국음향학회 2000년도 하계학술발표대회 논문집 제19권 1호
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• pp.83-86
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• 2000

본 논문에서는 비정형 단위를 사용한 음성 합성 시스템의 합성음에 대한 자연성을 향상시키기 위한 휴지 구간 추출 및 휴지 지속시간 예측 모델을 제안한다. 제안된 휴지 지속시간 예측 모델은 트리 기반 모델링 기법 중 하나인 CART (Classification And Regression Trees)방법을 이용하였다. 이를 위해 남성 단일 화자가 발성한 6,220개의 어절경계 포함하는 총 400문장의 문 음성 데이터베이스를 구축하였고, 이 데이터베이스로부터 V-fold Cross-Validation 방법에 의해 최적의 트리를 결정하였다. 이 모델을 평가한 결과, 휴지 구간 추출 정확율은 $81\%$로 휴지 구간 존재 추출 정확율은 $83\%, 휴지 구간 비존재 추출 정확율은 $80\%이었고, 실 휴지지속시간과 예측 휴지지속시간과의 다중상관 계수는 0.84로, 오차 범위 20ms 이내에서 의 정 확율은 $88\%$ 이었다. 또한, 휴지지속시간을 예측하여 적용한 합성음을 청취 실험한 결과 자연 음성과 대체적으로 유사하게 나타났다.

• Communications for Statistical Applications and Methods
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• 제9권3호
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• pp.809-824
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• 2002

we propose two methods which separate the variable selection step and the split-point selection step. We call these two algorithms as CHITES method and F&CHITES method. They adapted some of the best characteristics of CART, CHAID, and QUEST. In the first step the variable, which is most significant to predict the target class values, is selected. In the second step, the exhaustive search method is applied to find the splitting point based on the selected variable in the first step. We compared the proposed methods, CART, and QUEST in terms of variable selection bias and power, error rates, and training times. The proposed methods are not only unbiased in the null case, but also powerful for selecting correct variables in non-null cases.