• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.4
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• pp.191-197
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• 2019

This study aims to evaluate the effects of the root bark of Morus alba (RMA) on the regulation of the Hippo-YAP pathway. Hippo-YAP signaling is a critical regulator in controlling organ size and tissue homeostasis. Hippo, the serine/threonine kinase phosphorylate the LATS. Phosphorylated LATS then phosphorylates and inactivates the YAP and TAZ, which are two closely related transcriptional co-activator. Here we report RMA activates the Hippo signaling, thereby inhibits the YAP/TAZ activity. First, we examine the cytotoxic effects of RMA by MTT assay. RMA was cytotoxic at concentrations higher than $50{\mu}g/ml$ in HEK293A cells. The reporter gene assay was performed to measure the activity of TEAD, a key transcription factor that controls cell growth and proliferation. RMA significantly suppressed the luciferase activity. By phos-taq gel shift assay, and western blotting, we showed that RMA enhanced the phosphorylation of YAP in wild type cells, but not in LATS1/2 knock out cells, which means RMA activates classical Hippo pathway. RMA induced the cytoplasmic sequestration of YAP. RMA also suppressed the mRNA expression of CTGF and CYR61; the two major YAP dependent genes. Taken together, RMA is considered to be a good candidate for proliferative disease such as cancer, by facilitating cell death through activating the Hippo signaling pathway.

• Journal of Korean Classical Literature and Education
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• no.39
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• pp.5-39
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• 2018

This paper aims to identify the characteristics of literary therapy in relation to literature education. It also intends to clarify its distinctiveness. Literary therapy is not to teach literature. It does not deliver knowledge on agreed analyses, backgrounds and the nature of genres. Literary therapy encourages participants to fully appreciate one's thought and emotions and express them. The end goal is self-knowledge rather than the understanding of texts. Literary therapy focuses on self-knowledge through literatures as opposed to literature education which aims to encourage understandings of literature texts. In literary therapy, literature is media for personal growth facilitating self-expansion. Literature works enable participants to view oneself objectively by the means of one's responses to literature works. Literary therapy has more permissive viewpoints on recipients' response to literature texts than literature education. In addition, the subject of literary therapy is more unique and individualistic.

• (The)Study of the Eastern Classic
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• no.41
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• pp.333-359
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• 2010

Both in the East and the West, the most classical question in classical political philosophy was 'what is truly a human virtue and a good life?' 'Human virtue' and 'Good life', and 'good State' are thus essentially tied together. Platon And Confucianism. We began with Platon and Confucianism's definitions of human virtue & good life, and 'good State'. This Essay attempts to systematically approach to what Confucianism thinks as a human virtue and a good life in contrast with Platon. Confucius asserted that the most humane human life is a civilized life and it means to realize the value of 'benevolence as a human virtue. 'Mencius also concurred that Confucius's explication of the good life was right. Moreover, he argued that to realize this, political practice should follow. Mencius discussed about 'Four Virtues', the essential goodness of human, confirmed by 'Four Clues (四端)' to talk about the possibility of realizing the good life and a good state. On the other hand, he devised Politics of benevolence.)' as a practical tool for it. An classica eastern philosophy(platon and confucianism) consider a human beings as human relationship. Confucianism believe in reality of the human mind & it's nature. Confucian human mind & it's nature is comprised of benevolence, righteousness, propriety and wisdom. Confucianism proposed that we have to approach to other man as benevolence.

• The Journal of Korean Philosophical History
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• no.28
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• pp.331-362
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• 2010

Simjae defined the relationship between Learning of Classics and Learning of the Mind-and-Heart as mutually interdependent. Clarifying "righteousness and principle" lies within the purview of "knowledge" and cultivating the mind-and-heart based on such knowledge lies within the realm of "action." Learning of Classics and Learning of Controlling the Mind-and-Heart thus can be understood as relationship between knowledge and action. If Simjae's theory of knowledge and action is applied to the relationship between Learning of Classics and Learning of the Mind-and-Heart, we can derive the following conclusion. His assertion that "knowledge precedes action" indicates that classical studies to explore the principle of goodness must precede mind-and-heart studies to cultivate the mind. In fact, only when we know what is the right principle can we cultivate our mind based on that principle. However, Simjae attached importance to action in terms of its significance. This means that the Learning of the Mind-and-Heart is "eventually more important" than the Learning of Classics which explores the principle of goodness. Thus, when linked to his theory on knowledge and action, Simjae 's philosophy founded on the twin pillars of classical studies and mind-and-heart studies can be summarized: "One must first delve into the principle of goodness through Confucian classical studies and then rectify one's mind based on knowledge thus gained."

• Journal of the Korean Institute of Landscape Architecture
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• v.41 no.6
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• pp.72-83
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• 2013

This study suggests the necessity of landscaping alternatives for the succession of Takjok(濯足) culture by considering the background and meaning of Takjok's cultural phenomenon shown in old literatures and paintings and its result is as follows. An old idiom, 'Takyoung Takjok(濯纓濯足)' implying a disinterested living attitude from the mundane world and an attitude complying with nature, has been sublimated to 'Takjokjiyu(濯足之遊)' which means living in comfortable retirement through life in seclusion(隱逸). Classical scholars immerse their feet in soft-flowing(柔軟) water for 'Mulailche(物我一體; synchronized with nature)' which is a unified condition with 'Do(道; truth)' and connected to the stage of 'Yu(遊)', a free mental state, and its nature. The cultural phenomenon of Takjok appeared in the inherited landscape paintings in the Joseon dynasty period after the late stage of Koryo. Takjok shown in 'Pal Kyung Shi'(八景詩; poetry singing for the eight scenary) was described as not a transcendent scene, but as a scenery of daily life. Dense forest and water, such as a stream with clean water, rocks, and pine trees shown in Takjok paintings have been symbolized as a seclusion space for classical scholars with higher thinking and their mental states have been more emerged. Mental pleasures called as seclusion and Takjokjiyu have been relatively emphasized in the Takjok paintings of the Joseon Dynasty period contrary to the Chinese Takjok paintings emphasizing Chung Gye(淸溪; clean stream) and Chang Rang(滄浪; high and clean wave) and strongly representing the image of 'Chung Ryu'(淸流; clean flowing water) and the veneration for antiquity. The view of nature described in the Takjok paintings represents the provision of nature as a situation and attitudes of classical scholars and implies a Taoism perspective which describes the 'do' of nature. This view of nature itself remained intact(無爲自然) with the love of mountains and water, showing a side of the zeitgeist and aesthetic consciousness of China and Joseon. The 'Takjokjiyu' of both countries has be interpreted as a symbol of personality development, behavior, life in seclusion, or transcending the mundane world and has also been accepted as a method of summer vacation in the real world. It should be considered that Takjok includes ordinary people's wisdom to resist the hot weather, as well as the classical scholar's ideal and the veneration of antiquity. From this perspective, water space, Takjok rocks, and the use of water based on the environmental supportability should be newly focused as a recreational space and it reminds us that the spirit of Takjok is a classical mental healing method.

• Fashion & Textile Research Journal
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• v.20 no.2
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• pp.143-155
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• 2018

The purpose of this study is elucidate the status and role of fashion house museums including art museums that are affiliated to luxury fashion brands. This study is significant in that it offers profound understanding of the history of luxury brands and the direction of communication these luxury brands are taking through online and offline museums. For research methods in this study, literature review and case studies were combined. Based on the luxury type classification by Sicard, the scope of research was determined to include the French classical luxury brands to modern luxury brands and contemporary luxury brands. Examining the current status of fashion house museums, it was found that Cartier Foundation for Contemporary Art is an art museum operated by the luxury fashion brand, Cartier. Other fashion house museums in operation included $Herm{\grave{e}}s$ Museum, Foundation Louis Vuitton Museum, $Crist{\acute{o}}bal$ Balenciaga Museum, Yves Saint Laurent Museum, Gucci Museum, Christian Dior Museum, Prada Foundation Museum, Ferragamo Museum, Armani Silos, and so on. As for online museums, there was Valentino Garavani Virtual Museum. These luxury fashion brands' museums serves the following roles: provides references to the fashion industry professionals and researchers; differentiates the brand as means of experience marketing; promotes the brand and enhances brand communication through exhibitions of the founder and designers; archive the brand's design and builds the brand's history as a means of storytelling marketing.

• Geomechanics and Engineering
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• v.9 no.4
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• pp.447-464
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• 2015

Millions of scrap tires are discarded annually in Turkey. The bulk of which are currently landfilled or stockpiled. These tires consume valuable landfill space or if improperly disposed, create a fire hazard and provide a prolific breeding ground for rats and mosquitoes. Used tires pose both a serious public and environmental health problem which means that economically feasible alternatives for scrap tire disposal must be found. Some of the current uses of scrap tires are tire-derived fuel, creating barrier reefs and as an asphalt additive in the form of crumb rubber. However, there is a much need for the development of additional uses for scrap tires. One development the creation of shreds from scrap tires that are coarse grained, free draining and have a low compacted density thus offering significant advantages for use as lightweight subgrade fill and backfill material. This paper reports a comprehensive laboratory study that was performed to evaluate the use of a shredded tire-sand mixture as a backfill material in trench conditions. A steel frame test tank with glass walls was created to replicate a classical trench section in field conditions. The results of the test demonstrated that shredded tires mixed with sand have a definite potential to be effectively used as backfill material for buried pipe installations.

• Research in Mathematical Education
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• v.12 no.4
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• pp.283-291
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• 2008

The extension to a wide population of secondary education in many advanced countries seems to have led to a weakening of the mathematics curriculum. In response, many students have been classified as "gifted" so that they can access a stronger program. Apart from the difficulties that might arise in actually determining which students are gifted (Is it always clear what the term means?), there are dangers inherent in programs that might be devised even for those that are truly talented. Sometimes students are moved ahead to more advanced mathematics. Elementary students might be taught algebra or even subjects like trigonometry and vectors, and secondary students might be taught calculus, differential equations and linear algebra. It is my experience over thirty-five years of contact with bright students that acceleration to higher level mathematics is often not a good idea. In this paper, I will articulate some of the factors that have led me to this opinion and suggest alternatives. First, I would like to emphasize that in matters of education, almost every statement that can be made to admit counterexamples; my opinion on acceleration is no exception. Occasionally, a young Gauss or Euler walks in the door, and one has no choice but to offer the maximum encouragement and allow the student to go to the limit of his capabilities. A young genius can demonstrate an incredible amount of mathematical insight, maturity and mastery of technique. A classical example is probably the teen-age Euler, who in the 1720s was allowed regular audiences with Jean Bernoulli, the foremost mathematician of his day.

• Journal of Power Electronics
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• v.16 no.4
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• pp.1438-1454
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• 2016

Because the nonlinear and time-varying characteristics of continuously variable transmission (CVT) systems driven by means of a six-phase copper rotor induction motor (CRIM) are unconscious, the control performance obtained for classical linear controllers is disappointing, when compared to more complex, nonlinear control methods. A blend modified recurrent Gegenbauer orthogonal polynomial neural network (OPNN) control system which has the online learning capability to come back to a nonlinear time-varying system, was complied to overcome difficulty in the design of a linear controller for six-phase CRIM driving CVT systems with lumped nonlinear load disturbances. The blend modified recurrent Gegenbauer OPNN control system can carry out examiner control, modified recurrent Gegenbauer OPNN control, and reimbursed control. Additionally, the adaptation law of the online parameters in the modified recurrent Gegenbauer OPNN is established on the Lyapunov stability theorem. The use of an amended artificial bee colony (ABC) optimization technique brought about two optimal learning rates for the parameters, which helped reform convergence. Finally, a comparison of the experimental results of the present study with those of previous studies demonstrates the high control performance of the proposed control scheme.

• Fashion & Textile Research Journal
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• v.11 no.4
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• pp.515-526
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• 2009

From traditional ceremony to science technology, origami was used as technique for artistic creativity and functionality based on formative characteristics. The purpose of this study is to analyze the expressive characteristics of functionality in fashion design using origami technique. The method of this study was to analyze recent documentaries, fashion books, fashion magazines, internet web site and so forth. The results were as follows: In various fields of design, the category of the expressive characteristics was classified as efficient correspondence of space, compositive convergence of function, variable potentiality of form and human ergonomic optimum. In recent origami fashion based on functionality, the efficient correspondence of space was expressed constructive or decorative pocket design, using on clothing surface and varied design by lifestyle. The compositive convergence of function was expressed innovative connection of fashion items or non-fashion items and deconstructed classical clothing pattern. The variable potentiality of form was expressed control of form by irregular fold, dynamic metamorphosis by organic fold and creation of varied clothing silhouette. The human ergonomic optimum was expressed metamorphosis mechanism from two dimension to three dimension, suitable construction to physical ability and limit and organic form based on articular folding. The functional origami fashion means reflection of nomadic lifestyle, maximum of usability, pursuit of playful sensibility, creation of new body aesthetic and pursuit of technology and humanism. And the result of these study may be used for creative inspiration in fashion design because of unique characteristics.