• Restorative Dentistry and Endodontics
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• 제27권2호
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• pp.158-174
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• 2002

Filtek$^{TM}$ Z-250(3M Dental Products, St. Paul., MN. USA) 광중합형 복합레진을 대상으로 다양한 광조사 방식이 중합수축, 중합도 및 미세누출에 미치는 영향을 알아보고자 하였다. VIP$^{TM}$(Bisco Dental Products, Schaumburg, IL, USA)를 이용하여 200, 400 및 600mW/$\textrm{cm}^2$의 일정한 광도로 중합시킨 세 군(V2, V4 및 V6군)과 200mW/$\textrm{cm}^2$의 광도로 3초간 중합시키고 5분간 방치 한 후 다시 600mW/$\textrm{cm}^2$의 광도로 중합시키는 pulse-delay 방식을 이용한 군(VPD군) 그리고 Optilux 501$^{TM}$(Demetron/Kerr, Danbury, CT, USA)을 이용하여 C-mode와 R-mode로 중합시킨 두 군(OC군, OR군) 등 모두 6개의 군으로 나누어 실험하였으며, 복합레진의 중합과 누출을 다음의 네 가지 방법으로 측정하였다. 첫째, V2, V4, V6, OC군은 60초간, OR군은 20초간 그리고 VPD군은 두번째 광조사를 60초간 시행하면서 시간에 따른 선형 중합수축을 Linometer(R&B, Daejeon, Korea)로 측정하였다. 둘째, V2, V4, V6, OC군은 각각 5, 10, 20, 40, 60초간 그리고 OR군과 VPD군은 정해진 조건에 따라 중합시킨 2mm 두께 시편의 바닥면에서 시료를 채취한 후 KBr method로 시편을 제작하고, FTIR spectrometer(IFS 120 HR, Broker, Karlsruhe, Germany)로 미반응 잔류단량체의 양을 계측하여 중합도를 측정하였다. 셋째, 두번째 실험과 같은 조건으로 중합시킨 2mm 두께 시편의 광조사면과 바닥면에서 중합 10분 후 미세경도 측정기(FM7, Future-Tech Co., Tokyo, Japan)로 500g의 하중을 10초간 가하여 Knoop Hardness Number(KHN) 값을 측정하였다. 끝으로, 90개의 발거치 치경부에 제5급 와동을 형성하고 V2군은 60초간, V4군은 40초간, V6군은 30초간 그리고 OC, OR, VPD군은 정해진 조건에 따라 중합시킨 후, methylene blue 용액에 침적시키고 종절단하여 법랑질과 상아질 변연의 미세누출 정도를 측정하였다. 중합수축. 중합도 및 미세경도 측정치는 one-way ANO-VA와 Duncan's multiple range test를, 변연누출 정도는 chi-square test를 이용, 통계처리하여 다음의 결과를 얻었다. . 중합수축의 정도는 VIP$^{TM}$(Bisco) 사용군에서 전체 조사광도가 높을수록 큰 경향을 보여 600mW/$\textrm{cm}^2$군에서 가장 크게 나타났고, 그 다음으로 Pulse-delay군, 400mW/$\textrm{cm}^2$군, 200 mW/$\textrm{cm}^2$군 순이었고, Optilux 501$^{TM}$(Demetron/Kerr) 사용군에서는 Continuous 방식이 Ramp 방식 보다 크게 나타났다. . 중합도와 미세경도 값은 공히, 전체 조사광도가 높을수록 높게 나타났으며 , 최종 중합도는 44.77~54.98%의 범위를, 미세경도 값은 34.10~56.30의 범위를 보였다. . 미세누출은 전반적으로 상아질 변연이 법랑질 변연에 비해 많았고, VIP$^{TM}$(Bisco) 사용 군에서는 광도가 높을수록 상아질 변연에서 미세누출이 증가하는 양상을 보였으며, 법랑질 변연에서는 Optilux 501$^{TM}$(Demetron/Kerr)의 Continuous 방식이, 상아질 변연에서는 Ramp 방식이 가장 적은 미세누출을 보였다.

• 한국과학교육학회지
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• 제16권4호
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• pp.376-388
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• 1996

The first and the second "Discussion Contest of Scientific Investigation" was evaluated in this study. This contest was a part of 'Korean Youth Science Festival' held in 1993 and 1994. The evaluation was based on the data collected from the middle school students of final teams, their teachers, a large number of middle school students and college students who were audience of the final competition. Questionnaires, interviews, reports of final teams, and video tape of final competition were used to collect data. The study focussed on three research questions. The first was about the preparation and the research process of students of final teams. The second was about the format and the proceeding of the Contest. The third was whether participating the Contest was useful experience for the students and the teachers of the final teams. The first area, the preparation and the research process of students, were investigated in three aspects. One was the level of cooperation, participation, support and the role of teachers. The second was the information search and experiment, and the third was the report writing. The students of the final teams from both years, had positive opinion about the cooperation, students' active involvement, and support from family and school. Students considered their teachers to be a guide or a counsellor, showing their level of active participation. On the other hand, the interview of 1993 participants showed that there were times that teachers took strong leading role. Therefore one can conclude that students took active roles most of the time while the room for improvement still exists. To search the information they need during the period of the preparation, student visited various places such as libraries, bookstores, universities, and research institutes. Their search was not limited to reading the books, although the books were primary source of information. Students also learned how to organize the information they found and considered leaning of organizing skill useful and fun. Variety of experiments was an important part of preparation and students had positive opinion about it. Understanding related theory was considered most difficult and important, while designing and building proper equipments was considered difficult but not important. This reflects the students' school experience where the equipments were all set in advance and students were asked to confirm the theories presented in the previous class hours. About the reports recording the research process, students recognize the importance and the necessity of the report but had difficulty in writing it. Their reports showed tendency to list everything they did without clear connection to the problem to be solved. Most of the reports did not record the references and some of them confused report writing with story telling. Therefore most of them need training in writing the reports. It is also desirable to describe the process of student learning when theory or mathematics that are beyond the level of middle school curriculum were used because it is part of their investigation. The second area of evaluation was about the format and the proceeding of the Contest, the problems given to students, and the process of student discussion. The format of the Contests, which consisted of four parts, presentation, refutation, debate and review, received good evaluation from students because it made students think more and gave more difficult time but was meaningful and helped to remember longer time according to students. On the other hand, students said the time given to each part of the contest was too short. The problems given to students were short and open ended to stimulate students' imagination and to offer various possible routes to the solution. This type of problem was very unfamiliar and gave a lot of difficulty to students. Student had positive opinion about the research process they experienced but did not recognize the fact that such a process was possible because of the oneness of the task. The level of the problems was rated as too difficult by teachers and college students but as appropriate by the middle school students in audience and participating students. This suggests that it is possible for student to convert the problems to be challengeable and intellectually satisfactory appropriate for their level of understanding even when the problems were difficult for middle school students. During the process of student discussion, a few problems were observed. Some problems were related to the technics of the discussion, such as inappropriate behavior for the role he/she was taking, mismatching answers to the questions. Some problems were related to thinking. For example, students thinking was off balanced toward deductive reasoning, and reasoning based on experimental data was weak. The last area of evaluation was the effect of the Contest. It was measured through the change of the attitude toward science and science classes, and willingness to attend the next Contest. According to the result of the questionnaire, no meaningful change in attitude was observed. However, through the interview several students were observed to have significant positive change in attitude while no student with negative change was observed. Most of the students participated in Contest said they would participate again or recommend their friend to participate. Most of the teachers agreed that the Contest should continue and they would recommend their colleagues or students to participate. As described above, the "Discussion Contest of Scientific Investigation", which was developed and tried as a new science contest, had positive response from participating students and teachers, and the audience. Two among the list of results especially demonstrated that the goal of the Contest, "active and cooperative science learning experience", was reached. One is the fact that students recognized the experience of cooperation, discussion, information search, variety of experiments to be fun and valuable. The other is the fact that the students recognized the format of the contest consisting of presentation, refutation, discussion and review, required more thinking and was challenging, but was more meaningful. Despite a few problems such as, unfamiliarity with the technics of discussion, weakness in inductive and/or experiment based reasoning, and difficulty in report writing, The Contest demonstrated the possibility of new science learning environment and science contest by offering the chance to challenge open tasks by utilizing student science knowledge and ability to inquire and to discuss rationally and critically with other students.

• 대한교통학회:학술대회논문집
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• 대한교통학회 1995년도 제27회 학술발표회
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• pp.101-113
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• 1995

The objective of this research is to test the feasibility of developing a statewide truck traffic forecasting methodology for Wisconsin by using Origin-Destination surveys, traffic counts, classification counts, and other data that are routinely collected by the Wisconsin Department of Transportation (WisDOT). Development of a feasible model will permit estimation of future truck traffic for every major link in the network. This will provide the basis for improved estimation of future pavement deterioration. Pavement damage rises exponentially as axle weight increases, and trucks are responsible for most of the traffic-induced damage to pavement. Consequently, forecasts of truck traffic are critical to pavement management systems. The pavement Management Decision Supporting System (PMDSS) prepared by WisDOT in May 1990 combines pavement inventory and performance data with a knowledge base consisting of rules for evaluation, problem identification and rehabilitation recommendation. Without a r.easonable truck traffic forecasting methodology, PMDSS is not able to project pavement performance trends in order to make assessment and recommendations in the future years. However, none of WisDOT's existing forecasting methodologies has been designed specifically for predicting truck movements on a statewide highway network. For this research, the Origin-Destination survey data avaiiable from WisDOT, including two stateline areas, one county, and five cities, are analyzed and the zone-to'||'&'||'not;zone truck trip tables are developed. The resulting Origin-Destination Trip Length Frequency (00 TLF) distributions by trip type are applied to the Gravity Model (GM) for comparison with comparable TLFs from the GM. The gravity model is calibrated to obtain friction factor curves for the three trip types, Internal-Internal (I-I), Internal-External (I-E), and External-External (E-E). ~oth "macro-scale" calibration and "micro-scale" calibration are performed. The comparison of the statewide GM TLF with the 00 TLF for the macro-scale calibration does not provide suitable results because the available 00 survey data do not represent an unbiased sample of statewide truck trips. For the "micro-scale" calibration, "partial" GM trip tables that correspond to the 00 survey trip tables are extracted from the full statewide GM trip table. These "partial" GM trip tables are then merged and a partial GM TLF is created. The GM friction factor curves are adjusted until the partial GM TLF matches the 00 TLF. Three friction factor curves, one for each trip type, resulting from the micro-scale calibration produce a reasonable GM truck trip model. A key methodological issue for GM. calibration involves the use of multiple friction factor curves versus a single friction factor curve for each trip type in order to estimate truck trips with reasonable accuracy. A single friction factor curve for each of the three trip types was found to reproduce the 00 TLFs from the calibration data base. Given the very limited trip generation data available for this research, additional refinement of the gravity model using multiple mction factor curves for each trip type was not warranted. In the traditional urban transportation planning studies, the zonal trip productions and attractions and region-wide OD TLFs are available. However, for this research, the information available for the development .of the GM model is limited to Ground Counts (GC) and a limited set ofOD TLFs. The GM is calibrated using the limited OD data, but the OD data are not adequate to obtain good estimates of truck trip productions and attractions .. Consequently, zonal productions and attractions are estimated using zonal population as a first approximation. Then, Selected Link based (SELINK) analyses are used to adjust the productions and attractions and possibly recalibrate the GM. The SELINK adjustment process involves identifying the origins and destinations of all truck trips that are assigned to a specified "selected link" as the result of a standard traffic assignment. A link adjustment factor is computed as the ratio of the actual volume for the link (ground count) to the total assigned volume. This link adjustment factor is then applied to all of the origin and destination zones of the trips using that "selected link". Selected link based analyses are conducted by using both 16 selected links and 32 selected links. The result of SELINK analysis by u~ing 32 selected links provides the least %RMSE in the screenline volume analysis. In addition, the stability of the GM truck estimating model is preserved by using 32 selected links with three SELINK adjustments, that is, the GM remains calibrated despite substantial changes in the input productions and attractions. The coverage of zones provided by 32 selected links is satisfactory. Increasing the number of repetitions beyond four is not reasonable because the stability of GM model in reproducing the OD TLF reaches its limits. The total volume of truck traffic captured by 32 selected links is 107% of total trip productions. But more importantly, ~ELINK adjustment factors for all of the zones can be computed. Evaluation of the travel demand model resulting from the SELINK adjustments is conducted by using screenline volume analysis, functional class and route specific volume analysis, area specific volume analysis, production and attraction analysis, and Vehicle Miles of Travel (VMT) analysis. Screenline volume analysis by using four screenlines with 28 check points are used for evaluation of the adequacy of the overall model. The total trucks crossing the screenlines are compared to the ground count totals. L V/GC ratios of 0.958 by using 32 selected links and 1.001 by using 16 selected links are obtained. The %RM:SE for the four screenlines is inversely proportional to the average ground count totals by screenline .. The magnitude of %RM:SE for the four screenlines resulting from the fourth and last GM run by using 32 and 16 selected links is 22% and 31 % respectively. These results are similar to the overall %RMSE achieved for the 32 and 16 selected links themselves of 19% and 33% respectively. This implies that the SELINICanalysis results are reasonable for all sections of the state.Functional class and route specific volume analysis is possible by using the available 154 classification count check points. The truck traffic crossing the Interstate highways (ISH) with 37 check points, the US highways (USH) with 50 check points, and the State highways (STH) with 67 check points is compared to the actual ground count totals. The magnitude of the overall link volume to ground count ratio by route does not provide any specific pattern of over or underestimate. However, the %R11SE for the ISH shows the least value while that for the STH shows the largest value. This pattern is consistent with the screenline analysis and the overall relationship between %RMSE and ground count volume groups. Area specific volume analysis provides another broad statewide measure of the performance of the overall model. The truck traffic in the North area with 26 check points, the West area with 36 check points, the East area with 29 check points, and the South area with 64 check points are compared to the actual ground count totals. The four areas show similar results. No specific patterns in the L V/GC ratio by area are found. In addition, the %RMSE is computed for each of the four areas. The %RMSEs for the North, West, East, and South areas are 92%, 49%, 27%, and 35% respectively, whereas, the average ground counts are 481, 1383, 1532, and 3154 respectively. As for the screenline and volume range analyses, the %RMSE is inversely related to average link volume. 'The SELINK adjustments of productions and attractions resulted in a very substantial reduction in the total in-state zonal productions and attractions. The initial in-state zonal trip generation model can now be revised with a new trip production's trip rate (total adjusted productions/total population) and a new trip attraction's trip rate. Revised zonal production and attraction adjustment factors can then be developed that only reflect the impact of the SELINK adjustments that cause mcreases or , decreases from the revised zonal estimate of productions and attractions. Analysis of the revised production adjustment factors is conducted by plotting the factors on the state map. The east area of the state including the counties of Brown, Outagamie, Shawano, Wmnebago, Fond du Lac, Marathon shows comparatively large values of the revised adjustment factors. Overall, both small and large values of the revised adjustment factors are scattered around Wisconsin. This suggests that more independent variables beyond just 226; population are needed for the development of the heavy truck trip generation model. More independent variables including zonal employment data (office employees and manufacturing employees) by industry type, zonal private trucks 226; owned and zonal income data which are not available currently should be considered. A plot of frequency distribution of the in-state zones as a function of the revised production and attraction adjustment factors shows the overall " adjustment resulting from the SELINK analysis process. Overall, the revised SELINK adjustments show that the productions for many zones are reduced by, a factor of 0.5 to 0.8 while the productions for ~ relatively few zones are increased by factors from 1.1 to 4 with most of the factors in the 3.0 range. No obvious explanation for the frequency distribution could be found. The revised SELINK adjustments overall appear to be reasonable. The heavy truck VMT analysis is conducted by comparing the 1990 heavy truck VMT that is forecasted by the GM truck forecasting model, 2.975 billions, with the WisDOT computed data. This gives an estimate that is 18.3% less than the WisDOT computation of 3.642 billions of VMT. The WisDOT estimates are based on the sampling the link volumes for USH, 8TH, and CTH. This implies potential error in sampling the average link volume. The WisDOT estimate of heavy truck VMT cannot be tabulated by the three trip types, I-I, I-E ('||'&'||'pound;-I), and E-E. In contrast, the GM forecasting model shows that the proportion ofE-E VMT out of total VMT is 21.24%. In addition, tabulation of heavy truck VMT by route functional class shows that the proportion of truck traffic traversing the freeways and expressways is 76.5%. Only 14.1% of total freeway truck traffic is I-I trips, while 80% of total collector truck traffic is I-I trips. This implies that freeways are traversed mainly by I-E and E-E truck traffic while collectors are used mainly by I-I truck traffic. Other tabulations such as average heavy truck speed by trip type, average travel distance by trip type and the VMT distribution by trip type, route functional class and travel speed are useful information for highway planners to understand the characteristics of statewide heavy truck trip patternS. Heavy truck volumes for the target year 2010 are forecasted by using the GM truck forecasting model. Four scenarios are used. Fo~ better forecasting, ground count- based segment adjustment factors are developed and applied. ISH 90 '||'&'||' 94 and USH 41 are used as example routes. The forecasting results by using the ground count-based segment adjustment factors are satisfactory for long range planning purposes, but additional ground counts would be useful for USH 41. Sensitivity analysis provides estimates of the impacts of the alternative growth rates including information about changes in the trip types using key routes. The network'||'&'||'not;based GMcan easily model scenarios with different rates of growth in rural versus . . urban areas, small versus large cities, and in-state zones versus external stations. cities, and in-state zones versus external stations.

• 한국직업건강간호학회지
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• 제6권2호
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• pp.144-155
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• 1997

In December 1990, Occupational Safety and Health Law was amended to reinforce employer's responsibilities on employees' health and safety. Among the amended law it was important to expand the role of an occupational health nurse to the role of an occupational health manager. An occupational health manager should take charge of coordinating periodic health examination and environmental hazard evaluation, providing primary care, monitoring employees' health status, giving the workplace walk-through, selecting safe protection equipment, providing health information, counseling and health education, independently. This position of occupational health nurse is equivalent to the role of doctors or occupational hygienists. In 1991, government made a master plan to prevent occupational disease and injury. Under the plan, Korea Industrial Nursing Association (KINA) was established in 1994 with the purpose of improving health services and upgrading career opportunities for members. Therefore, this study was designed to analyze the transition of occupational health nursing education with the changes of law and policy in Korea between 1991 and 1996. In details, it was to analyze the rate of school providing occupational health nursing practice based lecture, lecture hours, lecture contents in undergraduate curriculum, program contents of graduate school, kinds of continuing education, etc. For this purpose, we conducted survey two times. In February 1991, baseline study was conducted with all nursing programs in Korea (19 BSN programs and 43 nursing departments of junior college). From April to May in 1996, the second survey was conducted with all nursing programs (38 BSN programs and 69 junior colleges). The first response rate was 66.1% and the second was 40.6%. Structured questionnaires were mailed to the deans or the community health nursing faculties. In the case of graduate school, telephone survey was conducted with 10 school of public health or environmental health area. Data from the yearbook of Industrial Safety Training Institute (ISTI), the history of Korea Industrial Health Association, and the journals of KINA were also included in the analysis. As the results, we found that there were remarkable improvement in undergraduate and graduate programs, obligatory as well as voluntary continuing education in terms of occupational health nursing expertise between 1991 and 1996. 1) The number of school providing occupational health nursing practice-based lecture was increased with the rate from 7.3% to 25.6%. The rate of school giving over 15 class-hours was increased from 33.3% to 46.6%. 2) Content areas were composed of introduction of occupational health, occupational epidemiology, industrial hygiene, occupational disease and injury, law and policy, health education, concept of occupational health nursing, role of occupational health nurse, occupational health nursing process, etc. Of content areas, occupational health nursing process was more emphasized with the increased rate from 43.9% to 88.4%. 3) In the case of graduate school, occupational health programs were increased from 4 to 10. One of them has developed occupational health nursing program as an independent course since 1991. 4) The law increased educational hours from 28 hours to 36 hours for introductory course at the time of appointment, and from 14 hours to 24 hours every 2 years for continuing education. Course contents were Occupational safety and health law, introduction of occupational health, health education methodology, planning and evaluation, periodic health exam, occupational disease care, primary care, emergency care, management, industrial environment evaluation, etc. In 1996, Korea Industrial Nursing Association has begun to provide continuing education after Industrial Safety Training Institute. 5) Various educational programs in voluntary base were developed such as monthly seminar, CE articles, annual academic symposium, etc. It was shown that changes of law and policy led rapid growth of occupational health nursing education in various levels. From this trend, it is expected that occupational health nurse expertise be continuously to be enhanced in Korea. Legal and political supports should proceed for the development of occupational health nursing in early stage.

• 대한감각통합치료학회지
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• 제6권1호
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• pp.1-12
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• 2008

서론: 본 연구의 목적은 COMPS를 사용하여 저 학령기 아동의 감각통합 기능 수준을 제시하고 감각통합 기능과 학업성취도와의 관련성을 알아보는 것이다. 연구방법: 연구는 2005년 12월 19일부터 20일까지 김해 지역에 소재하고 있는 56개 초등학교 중에서 무작위로 J초등학교와 S초등학교를 선정하였으며 저학년 중 학업성취도를 위한 지필고사를 실시하지않는 1과 3학년을 제외한 2학년 중에서 무작위로 반을 선정하였다. 연구대상은 2학년에 재학 중인 아동으로 남아가 34명, 여아가 35명으로 총 69명이었다. 평가도구는 감각통합 기능을 평가하기 위한 도구로 COMPS와 학업성취도 평가를 위한 국어, 수학 지필고사를 사용하였다. 결과분석은 SPSS 10.0을 사용하였으며 t-검정과 F-검정 그리고 상관분석을 실시하였다. 결과: 저 학령기 아동의 COMPS 점수와 학업성취도간의 상관관계는 통계적으로 유의한 상관성이 없었으나 산점도 그래프로 볼 때, 전완교환반복운동, 비대칭성 경반사에서는 음의 상관관계를 보였으며, 배와위 굴곡위에서는 양의 상관관계를 나타냈다. 전체, 국어, 수학과목의 학업성취도가 높은군과 낮은 군 사이에서 COMPS 점수는 통계적으로 유의한 차이가 없었다. 그러나 국어과목에서는 학업성취도가 높은 군이 학업성취도가 낮은 군보다 환산점수 총점과 변환환산점수가 높았으며, 하위항목에서도 COMPS 점수가 높았다. 수학과목에서는 배와위 굴곡위를 제외한 나머지 항목에서 학업성취도가 낮은 군이 학업성취도가 높은 군보다 COMPS 점수가 높았다. 일반적 특성 중 나이에 따른 COMPS 점수의 차이에 있어서는 통계적으로 유의하였는데, 슬로모션과 배와위 굴곡위 두 개 항목을 제외하고는 나이가 많을수록 COMPS 점수가 높다는 것으로 나타났다(p<0.05). 결론: 본 연구에서 감각통합기능과 학업성취도의 상관성이 통계적으로 유의하게 나타나지는 않았으나 산점도 그래프 상에서는 상관관계를 가지고 있는 것으로 나타났다. 연구에 제시된 저 학령기 아동에 대한 COMPS 점수는 일반 아동의 감각통합 문제를 판별하여 학습과 관련된 문제의 조기판별 및 조기치료를 통해 학습능력 향상을 위한 기회를 제공하는데 도움이 될 것이다.

• 생물정신의학
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• 제5권1호
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• pp.34-45
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• 1998

단가아민 신경전달물질과 신경펩타이드의 가장 큰 차이점은 합성과정에 있다. 시냅스에서의 활동과 비활성화 과정에서도 양자의 차이는 뚜렷하다. 단가아민 신경전달물질의 작용은 매우 단시간 내에 일어나며, 대개는 재흡수기전을 통해 활동이 정지되고, 일부가 효소반응에 의해 비활성물질로 대사된다. 또한 이들은 단가아민 신경전달물질들과 마찬가지로 presynaptic peptidergic receptor를 갖는다는 사실이 알려져 있으며, 신경펩타이드 분비를 조절하는 자가수용체도 갖고 있다. 신경펩타이드의 시냅스전 세포로의 재흡수기전에 대해서는 아직 밝혀져 있지 않다. 신경펩타이드들도 시냅스 후막의 수용체로 확산되어 이차전령, 삼차전령을 통해 생물학적 반응을 일으킨다는 것은 단가아민 신경전달 물질과 동일하다. 본래 신경세포는 자극에 의해 glycoproteins, enzymes, inorganic ions, metal ions, phospholipids, purines, amines, peptides 등의 물질들을 함께 분비한다. 이들 중에는 신경전달물질의 기준에 부합되는 것도 있으나, 대다수는 기능이 없다. 때로는 수 종류의 신경전달물질들과 신경신경펩타이드들이 한가지 신경전달물질의 분비에 관여하기도 한다. 저자들은 현재 임상연구에서 괄목할 만한 진전을 보이고 있는 두가지 신경펩타이드들에 대해 그 신경생물학적 측면과 임상적 측면을 고찰하였다. 알코올의 신경생리에 있어 가장 흥미있는 것은 아마 강화기전일 것이다. 내인성 opioid계 물질들이 알코올의 강화효과와 관계가 있다는 근거들은 많다. Naltrexone은 수용체 차단을 통해 이러한 강화기전을 차단함으로서 음주욕을 감소시키는 것으로 해석된다. Opioid reinforcement는 변연계의 도파민 활성화를 통해 이루어진다. 이는 알코올의 강화에 도파민이 관여한다는 사실과도 관계된다. 이를 도파민-알코올 강화 가설이라 한다. 기타 세로토닌도 알코올의 강화를 중재하는 신경전달물질로 생각되고 있다. 선택적 세로토닌 재흡수 차단제를 장기간 사용하거나, $5-HT_3$ 수용체 길항제를 사용하면 음주욕이 감소된다고 알려져 있다. 신경전달물질계간에는 중요한 상호작용이 있다. 알코올이 측중격핵에서 도파민의 분비를 촉진시키는 기전에도 여러 신경전달계의 상호작용이 관여된다. 이의 기전에 생리적 수준에서 관여되는 대표적인 물질로는 (1) opiates, (2) serotonin, (3) amino acids, (4) 기타 neuropeptide들을 들 수 있다. Opiate 수용체 길항제들은 측중격핵에서 도파민 분비를 차단하고, $5-HT_3$ 수용체 효현제는 이를 자극한다. 이들을 총체적으로 종합하면, 도파민, 세로토닌, opiate 수용체들을 조절하면 알콜리즘을 치료할 수 있다는 것이다. CCK는 흥분성 신경전달물질로 밝혀지고 있으며, 진통 및 morphine에 대한 내성형성, 포만, 기억 등의 정신병리에 일부 관여하나, 역시 최근 가장 주목을 받는 것은 CCK계가 불안의 병리에 관여한다는 소견이다. 이 분야의 연구에 기폭제가 된 것은 CCK-4가 공황발작을 유발한다는 임상 연구결과로부터 비롯된다. 이에 의한 불안반응은 자연유발된 공황발작과 거의 같으며, 정상인과 공황장애 환자를 구별하는 민감도를 갖고 있다. 이 CCK-4에 의해 유발된 공황발작은 $CCK_B$ 길항제들에 의해 차단된다. 즉 공황불안의 기전에 $CCK_B$ 수용체가 관여할 가능성이 있다. 따라서 공황발작이 $CCK_B$ 수용체의 민감도 결함으로 추정될 수 있다. 또한 이 반응은 imipramine과 benzodiazepine계 약물들에 의해 차단됨이 알려져 있다. 이 공황 불안의 형성 기전에 다른 신경전달계와의 상호작용이 있다. 본고에서는 특히 benzodiazepine계와의 상호작용 및 5-HT계와의 상호작용을 거론하였다. 향후 CCK 길항제들이 항불안제로 개발될 전망이다. 이들은 내성형성, 금단증상, 진정작용 등의 문제가 없으므로 새로운 항불안제로 기대된다.

• 한국유기농업학회지
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• 제24권2호
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• pp.235-251
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• 2016

광역친환경 농업단지 7곳(순천, 산청, 장흥, 영암, 함양, 옥천, 정선)의 농가를 대상으로 2015년에 현장 실사한 결과, 단 1곳(장흥)만이 무항생 가축을 사육하여 나온 친환경 퇴비를 이용하였다. 광역친환경 농업단지 7곳의 0~20 cm 깊이의 토양 pH는 5.3~6.6, EC는 $0.4{\sim}1.2dS\;m^{-1}$, 전질소는 0.03~0.27%, 인산은 $22{\sim}322mg\;kg^{-1}$, 칼륨은 $0.05{\sim}0.29mg\;kg^{-1}$이었고 특히 정선 지역의 농가에서 전체적으로 낮은 수준을 보였다. 순천, 장흥, 옥천의 3농가만을 재배 기간 동안 집중적으로 조사하였을 때 시기별 토양 pH는 6.0 이상을 유지한 옥천 농가에서 높았고 EC는 별다른 차이가 나타나지 않았다. 시기별 토양 전질소 농도는 순천 농가에서 다른 농가 보다 0.1% 이상 높았고 인산과 칼륨은 옥천과 장흥에서 각각 높게 나타났다. 벼의 전질소 농도는 장흥에서 가장 높았고 시기별 전질소, 인산, 칼륨 농도는 감소하는 경향을 보였다. 초장과 분얼수는 옥천 농가에서 가장 높았지만 직경이나 SPAD 수준은 비슷하거나 낮게 관찰되었다. 건물중은 수확 직전에는 주 당 52~63 g으로 별다른 차이가 없었고, 정조중(kg), 정현비율(%), 현미수량(kg), 완전립(%), 싸라기율(%)도 농가 간에 차이가 나타나지 않았다. 연간 조수입은 조생종이면서 고급품종인 '밀키퀸'을 식재한 옥천 농가가 ha당 1,623만원으로 가장 높아 농업소득 증대효과가 기대되었다. 하지만 옥천 농가는 후작물을 재배하는 관계로 비료투입량이 높아서 전질소, 인산, 칼륨 수지가 ha당 200 kg 이상으로 가장 높은 수준을 보였다.

• Journal of Chest Surgery
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• 제38권5호
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• pp.357-365
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• 2005

배경: 관상동맥 질환에 동반된 허혈성 승모판막 폐쇄부전증을 가진 환자들은 장기 생존율이 좋지 않다. 게다가 중등도의 승모판막 폐쇄부전에 대한 치료방법은 아직 확립되어 있지 않은 상태이다. 따라서 본 저자들은 후향적 연구를 통하여 중등도의 허혈성 승모판막 폐쇄부전 환자에서 관상동맥 우회술만을 시행한 군과 승모판막 수술을 함께 시행한 군을 비교하여 승모판막 수술의 유용성을 알아보고자 하였다. 대상 및 방법: 1997년 1월부터 2003년 12월까지 중등도의 허혈성 승모판막 폐쇄부전증으로 진단받은 34명을 대상으로 관상동맥 우회술만을 시행한 군을 I군(n=23), 승모판막 수술을 동시에 시행한 군을 II군(n=11)으로 하였다. 각 군의 평균 추적관찰 기간은 $69.3\pm4.3$개월과 $53.1\pm4.9$개월이었다. 결과: 양 군에서 수술 사망은 없었고, 만기 사망은 I군에서 1명 있었다. II군에서 모든 환자들은 고리(Ring)를 이용한 승모판륜 성형술을 시행받았다. 수술 직후 승모판막 폐쇄부전의 정도는 II군에서 더 만이 감소하였고, 마지막 추적 관찰한 심초음파 검사 상 승모판막 폐쇄부전의 정도를 제외한 나머지 인자들은 양 군간 차이를 보이지 않았다. 양 군의 5년 생존율 또한 차이가 없었다($95.5\%\;vs\;100\%$, p=0.48). 결론: 본 연구 결과에 의하면 중등도의 허혈성 승모판막 폐쇄부전을 가진 선택된 환자에서는 관상동맥 우회술만으로 만족할 만한 결과를 얻을 수 있었으나 수술 전 심박출계수가 낮거나 NYHA class가 낮은 환자들에서는 수술 후 승모판막 폐쇄부전이 지속적으로 남아있는 것을 볼 수 있었다. 따라서 이러한 환자들에서는 승모판막 수술을 시행하는 것이 좋다고 생각된다. 또한, 승모판막 수술을 시행한 환자들에서 좌심실용적과 승모판막 폐쇄부전의 정도가 많이 감소하였는데 심실기능과 장기 생존율에 대한 이러한 인자들의 영향을 알아보기 위해서는 더 많은 환자를 대상으로 한 연구가 필요하다고 생각된다.

• 한국산림과학회지
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• 제17권1호
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• pp.35-42
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• 1973

천연활엽수림(天然闊葉樹林)은 수형(樹型)이 불규칙(不規則)하며 이용가치(利用價値)도 떨어진다. 우리나라에서의 활엽수림(闊葉樹林)은 대체(大體)로 오지(奧地)에 위치(位置)하고 있으며 개발(開發)에 문제점(問題點)이 허다(許多)하겠으나 총축적량(總蓄積量)이 부족(不足)한 현금(現今) 이의 개발이용(開發利用)의 필요성(必要性)이 대두(擡頭)되고 있다. 이러한 시점(時點)에서 본(本) 연구(硏究)는 천연활엽수(天然闊葉樹) 조사(調査)에 알맞은 추출법(抽出法)을 구명(究明)하므로서 조사사업(調査事業)에 이바지할 수 있다고 하겠다. 본(本) 조사(調査)는 1. 10ha되게 3개소(個所)를 선정(選定)하고 이를 대상(對象)으로 4가지 추출법(抽出法)을 적용(適用)하여 0.1ha($20m{\times}50m$) 구형표본점(矩形標本點) 6개(個) 즉(卽) 6%의 추출율(抽出率)로 표본(標本)을 추출(抽出) 조사(調査)하였는데 조사결과(調査結果)는 표(表) 1과 같으며 적용(適用)된 추출법(抽出法)은 (1) 격자법(格子法)에 의(依)한 임의추출법(任意抽出法) (2) 좌표법(座標法)에 의(依)한 임의추출법(任意抽出法) (3) 선표본점법(線標本點法) (4) 부차추출법(副次抽出法)이다. 2. 1:15, 000 항공사진(航空寫眞)을 이용(利用)하여 위 지역(地域)을 포함(包含)하는 지역(地域)에서 150ha 되게 구획(區劃)한 후(後) Mirror Stereoscope로 임상(林相)을 구분(區分)하였다. 경급(經級)과 소밀도(疎密度)를 기준(基準)으로 구분(區分)하였더니 3계급(階級)으로 나눠졌는데 150ha에서 계통적(系統的)으로 7개(個)(추출율(抽出率) 0.46%)의 표본점(標本點)을 배치(配置)하고 현지(現地)에서 0.1ha 원형표본점(圓形標本點)을 조사(調査)하였는데 그 결과(結果)는 표(表) 4와 같다. 3. 추출법(抽出法)에 따른 값과 매목조사결과(每木調査結果)(모평균(母平均))와를 비교(比較)하였더니 유의차(有意差)가 없었다(표(表3)). 4. 이상(以上)의 결과(結果)로 다음과 같은 결론(結論)을 얻었다. 1) 격자법(格子法)과 선표본점법(線標本點法)에 의(依)한 조사(調査)가 타추출법(他抽出法)에 비(比)하여 양호(良好)하다. 2) 원형표본점(圓形標本點)을 사용(使用)했을때는 구형표본점(矩形標本點)을 사용(使用)했을때 보다 과대치(過大値)를 가져온다. 3) 천연활엽수림(天然闊葉樹林)은 임목(林木)이 고르게 서있지 않으므로 표본점(標本點)의 수(數)를 적게 취(取)하면 오차가 커질 위험(危險)이 있다.

• 한국산림과학회지
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• 제90권3호
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• pp.398-412
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• 2001

본 연구는 삼림법(森林法)(1908)에 규정된 지적신고제도(地籍申告制度)가 일제(日帝)의 식민지(植民地) 임지정책(林地政策)에서 어떠한 역할을 수행하였는가를 밝혀보고자 하는데 목적을 두였다. 지적신고제도(地籍申告制度)는 국유림처분정책의 하나인 부분림제도(部分林制度)의 부속물로써 시작되었다. 인간의 기본권에 해당하는 소유권을 정립시키고자 하는 지적신고제도가 한국민의 관습을 무시하고 소유권구분기준도 마련되지 않은 채 우리하게 강행되었다. 한국민은 지적신고에 대해 임야세(林野稅)를 부과하기 위한 전조(前兆)로써 인식하거나 일본인이 한국의 토지를 수탈한다고 보았다. 이 제도에 따라 신고를 했던 계층은 중산층 이상의 지식층에 속하는 자, 나면관경(那面官更)(경원(更員)) 또는 이들의 친척(親戚), 연고자(緣故者)와 측량(測量)을 담당하는 대행업자(代行業者)들로 매우 한정되었다. 특히 임지가치에 비해 측량경비가 훨씬 많이 소요되었기 때문에 원소유자조차 신고할 수 없었다. 3년간의 신고기간동안 약 52만건 220만정보가 신고 되었으며 마지막 5개월 동안 신고가 집중되었다. 그러나 총독부는 신고기간을 연장하라는 한국민의 요구를 묵살한 채 소유권 사정이나 경계 확정과 같은 후속 조치도 없이 일방적으로 종료하였다. 결국 삼림법 제19조에 따라 신고되지 않은 약 1,400만정보의 임지는 국유화되었다. 총독부의 식민지 임지정책은 (1) 총독부 초기에 대규모 국유림을 창출하고, (2) 창출된 국유림을 요존국유림과 불요존국유림으로 구분하여, (3) 불요존국유림을 일본인 중심으로 처분한다는 것이었다. 일본인에게 불요존국유림(不要存國有林)을 안정적으로 처분하기 위해서는 대량 창출된 국유림에 대한 소유권 변화를 막아야 했다. 이를 위해 일본인에게 양여(讓與)하거나 조림대부(造林貸付)해 준 산림에 대해 원소유자가 소유권을 주장할 경우 총독부는 정해진 기한내에 신고하지 않은 원소유자의 태만을 들어 붙요존림 처분을 정당화하였다. 결론적으로 총독부는 "신고주의원칙"을 통치 초기 대규모 국유림의 창출과 일본인을 중심으로 한 불요존림 처분이라는 식민지 임지정책을 강행하기 위한 족쇄로써 이용하였다.