• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.303-308
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• 2013

Background: Medical students' views may provide some direction for future policy considerations. Aim: The aim of this study was to assess gender differences in future doctors' receptiveness to currently implemented anti-smoking messages and the effectiveness of those messages. Materials and Methods: We administered a questionnaire to all students at a medical university in Malaysia, asking how frequently they noted anti-smoking policies, anti-smoking campaigns, and anti-smoking messages in schools. In addition, the questionnaire investigated most effective methods to convey these messages. Results: A total of 522 (59.7%) students responded. Students were least likely to approve of total bans on cigarettes and increasing the price of cigarettes, and most likely to approve of bans on use of cigarettes in public places and sales to individuals less than 16 years old. Approval of total bans on cigarettes was more common in female students than in males OR=0.39 (95%CI: 0.18-0.86). Furthermore, compared to the female students, the male students thought that printed media; OR=2.32 (95%CI: 1.31-4.10), radio; OR=1.93 (95%CI: 1.15-3.22) and the internet; OR=1.96 (95%CI: 1.15-3.33) were very effective at delivering anti-smoking messages. Conclusions: Gender differences existed in the future doctors' perception of the effectiveness of anti-smoking initiatives. Taking this gender difference into account may increase the receipt of anti-smoking messages in adolescents.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1919-1923
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• 2013

Background: Smoking is known as a major risk factor for different types of cancer, as well as cardiovascular disease. Its prevalence is increasing in developing countries. The aims of this study were to determine the prevalence of smoking and its associated factors among the population aged 40-64 years in the city of Shahroud which is a representative urban population in Iran. Materials and Methods: A cross-sectional population-based study with stratified random cluster sampling was conducted in 2009 as the first phase of Shahroud Eye Cohort Study. Of 6,311 people, 5,190 participated (82.2%). Information about smoking habit was obtained by face-to-face interview. Results: The overall prevalence of current tobacco smoking was 11.3% (95%CI: 10.5-12.3). It was significantly higher among males than females (25.7% and 0.71%, P<0.001). The prevalence of current cigarette smoking was 10.8% and 1.75% were past smokers. The smoking rate of water-pipe was 0.67%. Unemployed people smoked more than employed (OR=2.66, 95%CI: 1.38-5.14). Conclusions: The prevalence of smoking is low in Shahroud compared with other parts of Iran and other countries. Age, sex, job and marital status were associated with smoking. The low smoking rate among women may be attributed to cultural and social reasons.

• 농업과학연구
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• 제16권1호
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• pp.111-117
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• 1989

시판(市販)되고 있는 국산(國産)담배와 외산(外産)담배 각각(各各) 3종(種)을 대상(對相)으로 담배각초(刻草)의 평형수분(平衡水分), 전당(全糖) 및 수추출물(水抽出物)등을 분석(分析)하여 측정(測定)하여 얻은 결과(結果)를 요약(要約)하면 다음과 같다. 1. 담배의 평형수분(平衡水分)은 국산(國産)담배가 외산(外産)담배에 비하여 높다. RH80%에서 24시간(時間) 보존(保存) 후(後)에 함수분(含水分)은 SOL은 Y.S.L보다 3.3%, EUNHASU는 Marlboro(L) 보다 2.4%가 높았다. 2. 제조(製造)담배의 온습도별 함수분(含水分) 변화(變化)의 경우(境遇), 국내외산(國內外産) 제조(製造)담배의 흡습속도(吸濕速度)는 국산(國産)담배가 외산(外産)담배에 비(比)하여 빨랐다. 3. 담배 각초(刻草)의 수추출물(水抽出物)에 따른 상대습도별(相對濕度別) 평형수분(平衡水分)은 국산(國産)담배는 외산(外産)담배에 비(比)하여 높았다. 4. 담배 각초(刻草)의 전당함량(全糖含量)이 상대습도(相對濕度)에 따른 담배 평형수분(平衡水分)은 국산(國産)담배가 외산(外産)담배에 비(比)하여 높았다. 이와 같은 국산(國産)담배가 평형수분(平衡水分)이 높고, 흡습속도(吸濕速度)가 빠른 것은 국산(國産)담배가 황색종(黃色種)이 많이 배합(配合)되어 있는 반면(反面) 외산(外産)담배는 버어리엽(葉)이 다량배합(多量配合)되어 있는 결과(結果)라고 추정(推定)된다.

• 한국연초학회지
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• 제22권2호
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• pp.176-183
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• 2000

This study was conducted to compare the volatile components of lamina(cutter group) and midrib of flue-cured tobacco leaves by two analytical methods, Curie-Point pyrolysis and Purge & Trap headspace technique. The pyrolysis of lamina and midrib part of tobacco leaves was performed at the temperature of $330^{\circ}C$, $650^{\circ}C$, and $920^{\circ}C$ by Curie-Point Pyrolyzer, and 33 compounds were identified in the pyrolyzates by GC/MSD. The composition of the components identified showed a quite difference between lamina and midrib. However, the amount of the pyrolyzed products from the both of lamina and midrib was increased with temperature increase except that of acetic acid, furfural, and nicotine. The content of phenolic compounds including phenol, 4-methyl phenol, and 3-methyl phenol was higher in midrib than in lamina, while that of furan compounds such as 2,3-dihydrobenzofuran, 5-hydroxymethyl furfural, was high in lamina. Interestingly, acetamide, 2-propenamide and 3-acetoxy pyridine were not defected in the pyrolyzates of lamina. By Purge & Trap headspace technique, 28 volatile components were identified in both lamina and midrib. The composition of the identified compounds and their chromatograpic patterns also showed the complete difference between the two. The content of solanone, $\beta$-damascone, $\beta$-damascenone, and megastigmatrienones, key components of tobacco aroma, was much higher in lamina than in midrib. The results indicate that lamina contains much more carbonyl compounds known to enhance the smoke taste of cigarette, whereas midrib takes nitrogenous and phenolic compounds, which are known to cause a deteriorate effect of smoke such as irritation.

• 보건교육건강증진학회지
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• 제11권2호
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• pp.125-145
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• 1994

The objectives of this study were to characterize the health status, the requirement of home nursing care, and dependency of daily life of the elderly so that the result could be used to provide basic data necessary for establishing home nursing care practices. The study subjects were 249 elders over 65 years old who resided at home in low income areas of three districts in Pusan. The field survey was conducted from December 27, 1993 through January 27, 1994, with a structured questionnaire. Statistical analysis was done by X²-test and Student's T-test using SPSS/PC/sup +/ program. The result were as follows; 1. Alcohol drinking rate was 50.0% for men and 27.7% for women, and cigarette smoking rate was 77.8% for men and 27.1% for women. 92.9% of elders aged 65-75 exercised regularly as compared to 81.9% of elders aged 75 and over(p<0.05). 2. 63.9% of male and 85.9% of female elders had chronic diseases showing singnificant differences(p<0.01), and both sexes had 1.7 kinds of chronic diseases in average; musculoskeletal diseases were the most common in 25.7%, while 6.8% of the elderly had cardiovascular diseases. 3. Partially movable elderly was 6.9% for men and 6.8% for woman, showing 47.1% of causes being cerebrovascular accidents. 4. The home nursing requirement was the highest for medication(66.3%), intramuscular injection(53.8%), and measurement of blood pressure·body·temperature·pulse rate(47.0%). 5. Among Physical Activities of Daily Life, bathing(10.4%) and movement(4.0%) showed high dependency rates, and among Instrumental Activities of Daily Life, phone calling(25.3%), shopping(24.5%), going out by bus(22.5%) showed high dependency rates. 6. For five categories of home nursing showing high requirements such as physical health examination, blood pressure·temperature·pulas rate measurements, medication, and intravascular injection, the requirements were different by age groups, education, and marital status(p<0.05).

• Tuberculosis and Respiratory Diseases
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• 제78권3호
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• pp.239-245
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• 2015

Background: Chronic obstructive pulmonary disease is characterized by emphysema, chronic bronchitis, and small airway remodeling. The alveolar destruction associated with emphysema cannot be repaired by current clinical practices. Stem cell therapy has been successfully used in animal models of cigarette smoke- and elastase-induced emphysema. However, the optimal dose of mesenchymal stem cells (MSCs) for the most effective therapy has not yet been determined. It is vital to determine the optimal dose of MSCs for clinical application in emphysema cases. Methods: In the present study, we evaluated the therapeutic effects of various doses of MSCs on elastase-induced emphysema in mice. When 3 different doses of MSCs were intravenously injected into mice treated with elastase, only $5{\times}10^4$ MSCs showed a significant effect on the emphysematous mouse lung. We also identified action mechanisms of MSCs based on apoptosis, lung regeneration, and protease/antiprotease imbalance. Results: The MSCs were not related with caspase-3/7 dependent apoptosis. But activity of matrix metalloproteinase 9 increased by emphysematous lung was decreased by intravenously injected MSCs. Vascular endothelial growth factor were also increased in lung from MSC injected mice, as compared to un-injected mice. Conclusion: This is the first study on the optimal dose of MSCs as a therapeutic candidate. This data may provide important basic data for determining dosage in clinical application of MSCs in emphysema patients.

• Tuberculosis and Respiratory Diseases
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• 제70권6호
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• pp.462-473
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• 2011

Background: Smoking is a risk factor for idiopathic pulmonary fibrosis (IPF), but the mechanism of the association remains obscure. There is evidence demonstrating that plasminogen activator inhibitor-1 (PAI-1) is involved in the progression of pulmonary fibrosis. This study was to determine whether the administration of small interfering RNA (siRNA) targeting PAI-1 or PAI-1 inhibitor to the cigarette smoking extract (CSE)-exposed rat alveolar type II epithelial cells (ATII cells) limits the epithelial-mesenchymal transition (EMT). Methods: ATII cells were isolated from lung of SD-rat using percoll gradient method and cultured with 5% CSE. The EMT was determined from the ATII cells by measuring the real-time RT PCR and western blotting after the PAI-1 siRNA transfection to the cells and after administration of tiplaxtinin, an inhibitor of PAI-1. The effect of PAI-1 inhibitor was also evaluated in the bleomycin-induced rats. Results: PAI-1 was overexpressed in the smoking exposed ATII cells and was directly associated with EMT. The EMT from the ATII cells was suppressed by PAI-1 siRNA transfection or administration of tiplaxtinin. Signaling pathways for EMT by smoking extract were through the phosphorylation of SMAD2 and ERK1/2, and finally Snail expression. Tiplaxtinin also suppressed the pulmonary fibrosis and PAI-1 expression in the bleomycin-induced rats. Conclusion: Our data shows that CSE induces rat ATII cells to undergo EMT by PAI-1 via SMAD2-ERK1/2-Snail activation. This suppression of EMT by PAI-1 siRNA transfection or PAI-1 inhibitor in primary type II alveolar epithelial cells might be involved in the attenuation of bleomycin-induced pulmonary fibrosis in rats.

• 보건교육건강증진학회지
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• 제22권1호
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• pp.135-146
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• 2005

A total of 448 male students(220 college-bound students, 228 vocational students) were surveyed through a self-administered questionnaire in Daegu from November to December 2003. This study aimed to identify the pattern in cigarette smoking according to personality type and related factors to smoking. Among respondents, $30.8\%$ of college-bound students and $69.3\%$ of vocational students have ever smoked. The rate of current smoking was $9.2\%$ in the college-bound students and $56.6\%$ in the vocational students. Smoking experience and current smoking status was significantly associated in psychotic personality in the college-bound students and in extroversive and psychotic personality in the vocational student group. The logistic regression analysis revealed that smoking of parents, siblings, and friends were significant variables on the current smoking in the college-bound students, and smoking of friends and extroversive and psychotic personality in the vocational students. As a results, this study suggest that those students who have the factors identified in this study regarded as having the potential to start smoking, and they can be subject to anti-smoking programs to help them quell their desire for smoking or delay.

• 지역사회간호학회지
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• 제19권4호
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• pp.636-648
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• 2008

Purpose: The smoking rates among teenagers in Korea grow gradually since 1980s despite of the numerous programs for youth smoking prevention and cessation have been developed and implemented. The purpose of this study was to explore and describe the processes of habituating to smoking among teenagers using the grounded theory methodology. Method: Qualitative data was collected via six focus group interviews. A total of 38 people, twelve teachers and 24 middle school students participated in this study. All focus group interviews were tape-recorded. transcribed. and analyzed according to the grounded theory methodology. Results: The overriding theme of the elicited grounded theory was "stepping into a quagmire by a merest chance". The student participants began smoking by a simple chance. The contingent factors to starting smoking were "discord within the family", "family member's smoking", "schoolwork stresses". or "a rebellious spirit". The conditions of smoking included accessibility. going around in group, and the lack of discipline. "Stigmatizing", "involved in mob violence", and "making a poor academic record" coexisted as the covariance of the smoking habituation. Conclusion: The findings of this study illustrated the comprehensive and insightful picture of the phenomena under investigation. Nursing implications and further directions for research were discussed.

• 생물정신의학
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• 제18권2호
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• pp.90-94
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• 2011

Objectives It is well-known that tobacco smoking is related to various disease entities including chronic obstructive pulmonary disease, inflammation, cardiovascular disease, and neoplasms. The prohibition of smoking is important for the protection of these health problems. Regarding leptin, ghrelin, glucagon-like peptide 1 (GLP-1), and nerve growth factor (NGF) levels, correlations with the smoking are suggested but the reports on the effects after smoking cessation are not sufficient. Method The changes of plasma levels of leptin, ghrelin, GLP-1, and NGF levels were analyzed after quitting smoking in Korean adults. Eleven participants succeeding in quitting smoking among 37 male smokers were included in the final analysis. The plasma levels of NGF, leptin, ghrelin, and GLP-1 were measured before and after 8-weeks period of smoking cessation. Results The plasma level of leptin increased after 4 weeks of smoking cessation. In addition, the plasma level of NGF increased after 8 weeks of smoking cessation (p < 0.05). Conclusion Our results suggested that smoking cessation induces increases in leptin and the NGF level after smoking cessation. Many toxic materials including nicotine in the cigarette may be related to these changes of plasma level of leptin and NGF, playing a key role in neurogenesis and synaptic plasticity.