• The Journal of Korean Medical History
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• v.22 no.2
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• pp.63-66
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• 2009

Since the prehistoric age, chinese medicine has been a fusion of diverse medical contents from different regions. In "黃帝內經", the origin of the medicine is explained : acupuncture is from the East, moxibustion is from the South and North, massage is from middle region. These medical characteristics from different regions fuse into one and constitute the chinese medicine of today.

• Journal of Ginseng Research
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• v.48 no.2
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• pp.236-244
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• 2024

Background: Fusarium oxysporum (F. oxysporum) is the primary pathogenic fungus that causes Panax notoginseng (P. notoginseng) root rot disease. To control the disease, safe and efficient antifungal pesticides must currently be developed. Methods: In this study, we prepared and characterized a nanoemulsion of Foeniculum vulgare essential oil (Ne-FvEO) using ultrasonic technology and evaluated its stability. Traditional Foeniculum vulgare essential oil (T-FvEO) was prepared simultaneously with 1/1000 Tween-80 and 20/1000 dimethyl sulfoxide (DMSO). The effects and inhibitory mechanism of Ne-FvEO and T-FvEO in F. oxysporum were investigated through combined transcriptome and metabolome analyses. Results: Results showed that the minimum inhibitory concentration (MIC) of Ne-FvEO decreased from 3.65 mg/mL to 0.35 mg/mL, and its bioavailability increased by 10-fold. The results of gas chromatography/mass spectrometry (GC/MS) showed that T-FvEO did not contain a high content of estragole compared to Foeniculum vulgare essential oil (FvEO) and Ne-FvEO. Combined metabolome and transcriptome analysis showed that both emulsions inhibited the growth and development of F. oxysporum through the synthesis of the cell wall and cell membrane, energy metabolism, and genetic information of F. oxysporum mycelium. Ne-FvEO also inhibited the expression of 2-oxoglutarate dehydrogenase and isocitrate dehydrogenase and reduced the content of 2-oxoglutarate, which inhibited the germination of spores. Conclusion: Our findings suggest that Ne-FvEO effectively inhibited the growth of F. oxysporum in P. notoginseng in vivo. The findings contribute to our comprehension of the antifungal mechanism of essential oils (EOs) and lay the groundwork for the creation of plant-derived antifungal medicines.

• The Journal of Korean Medicine
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• v.32 no.1
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• pp.36-55
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• 2011

Objective: This study was performed to compare knowledge of and expectations for traditional medicine between Korean, Chinese and Taiwanese, to figure out whether these factors influence the intention to use traditional medical treatment in the future. Methods: One-hundred ninety-nine Korean, eighty-five Chinese, and one-hundred seventy-four Taiwanese subjects responded to the survey. A one-way ANOVA was performed to compare experiences of traditional medical treatment, knowledge of both traditional medicine and western medicine, expectations for traditional medicine, and future intention to use traditional medical treatment. Multiple regression analyses were also performed to evaluate a possible correlation between the other factors and the intention to use traditional medical treatment in the future. Results: The experiences of traditional medical treatment were in the order of Taiwanese, Korean, and Chinese, from more frequent to less frequent. Chinese had more knowledge of traditional medicine compared to Taiwanese and Koreans, and the expectations for traditional medicine were in the order of Chinese, Korean and Taiwanese, from higher to lower. The intentions to use traditional medical treatment in the future were in the order of Korean, Chinese and Taiwanese, from more to less. Multiple regression analyses showed that experiences of traditional medical treatment, knowledge of traditional medicine, and expectations for traditional medicine were associated with the intention to use traditional medicine in the future in Korean and Taiwanese, but not in Chinese. Only the expectations for traditional medicine were associated with the future intentions to use traditional medical treatment in Chinese. Conclusions: These findings suggest that Korean and Taiwanese may need to improve their knowledge of traditional medicine whereas Chinese need to link their knowledge of traditional medicine with the intention to use it in the future. Understanding the characteristics of traditional medicine would probably contribute to enhancing the intentions to use it more.

• Journal of Ginseng Research
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• v.17 no.2
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• pp.159-183
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• 1993

• Journal of Sasang Constitutional Medicine
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• v.28 no.1
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• pp.11-18
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• 2016

Objectives The body shape was a key information for diagnosing the Sasang constitution (SC) in Sasang constitutional medicine. The aim of this study was to compare the body shapes and mainly focusing on the Korean and Chinese-KoreanMethods We calculated the propensity score for each SC type in males and females separately, and compared body shape including 8 circumference and 5 width between Korean and Chinese-Korean according to the sex and SC.Results Koreans have larger trunk and hip area compared to Chinese-Koreans, while Chinese-Koreans have larger abdomen compared with Koreans. Most variables were significantly different among SC types, for both Korean and Chinese-Korean. Especially, the Taeumin (TE) type has the largest body shape compared with the other SC types, it was similar between Korean and Chinese-Korean.Conclusions This study showed that the TE type has the largest body shape, followed by Soyangin (SY) and Soeumin (SE) in order, for both Korean and Chinese-Korean respectively. These results suggests that the body shape of Chinese-Korean is similar with Korean based on SC type.

• Journal of Ginseng Research
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• v.44 no.3
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• pp.461-474
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• 2020

Background: Ginseng effectively reduces fatigue in both animal models and clinical trials. However, the mechanism of action is not completely understood, and its molecular targets remain largely unknown. Methods: By screening for proteins that interact with the primary components of ginseng (ginsenosides) in an affinity chromatography assay, we have identified muscle-type creatine kinase (CK-MM) as a potential target in skeletal muscle tissues. Results: Biolayer interferometry analysis showed that ginsenoside metabolites, instead of parent ginsenosides, had direct interaction with recombinant human CK-MM. Subsequently, 20(S)-protopanaxadiol (PPD), which is a ginsenoside metabolite and displayed the strongest interaction with CK-MM in the study, was selected as a representative to confirm direct binding and its biological importance. Biolayer interferometry kinetics analysis and isothermal titration calorimetry assay demonstrated that PPD specifically bound to human CK-MM. Moreover, the mutation of key amino acids predicted by molecular docking decreased the affinity between PPD and CK-MM. The direct binding activated CK-MM activity in vitro and in vivo, which increased the levels of tissue phosphocreatine and strengthened the function of the creatine kinase/phosphocreatine system in skeletal muscle, thus buffering cellular ATP, delaying exercise-induced lactate accumulation, and improving exercise performance in mice. Conclusion: Our results suggest a cellular target and an initiating molecular event by which ginseng reduces fatigue. All these findings indicate PPD as a small molecular activator of CK-MM, which can help in further developing better CK-MM activators based on the dammarane-type triterpenoid structure.

• Korean Journal of Radiology
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• v.23 no.10
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• pp.986-997
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• 2022

Objective: Whether metabolic redistribution occurs in patients with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is unknown. This study aimed 1) to propose a measure of the brain metabolic network for an individual patient and preliminarily apply it to identify impaired metabolic networks in patients with WMHs, and 2) to explore the clinical and imaging features of metabolic redistribution in patients with WMHs. Materials and Methods: This study included 50 patients with WMHs and 70 healthy controls (HCs) who underwent ¹⁸F-fluorodeoxyglucose-positron emission tomography/MRI. Various global property parameters according to graph theory and an individual parameter of brain metabolic network called "individual contribution index" were obtained. Parameter values were compared between the WMH and HC groups. The performance of the parameters in discriminating between the two groups was assessed using the area under the receiver operating characteristic curve (AUC). The correlation between the individual contribution index and Fazekas score was assessed, and the interaction between age and individual contribution index was determined. A generalized linear model was fitted with the individual contribution index as the dependent variable and the mean standardized uptake value (SUV_mean) of nodes in the whole-brain network or seven classic functional networks as independent variables to determine their association. Results: The means ± standard deviations of the individual contribution index were (0.697 ± 10.9) × 10^-3 and (0.0967 ± 0.0545) × 10^-3 in the WMH and HC groups, respectively (p < 0.001). The AUC of the individual contribution index was 0.864 (95% confidence interval, 0.785-0.943). A positive correlation was identified between the individual contribution index and the Fazekas scores in patients with WMHs (r = 0.57, p < 0.001). Age and individual contribution index demonstrated a significant interaction effect on the Fazekas score. A significant direct association was observed between the individual contribution index and the SUV_mean of the limbic network (p < 0.001). Conclusion: The individual contribution index may demonstrate the redistribution of the brain metabolic network in patients with WMHs.

• Journal of Ginseng Research
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• v.45 no.4
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• pp.465-472
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• 2021

Background: Ginseng can help regulate brain excitability, promote learning and memory, and resist cerebral ischemia in the central nervous system. Ginsenosides are the major effective compounds of Ginseng, but their protein targets in the brain have not been determined. Methods: We screened proteins that interact with the main components of ginseng (ginsenosides) by affinity chromatography and identified the 14-3-3 ζ protein as a potential target of ginsenosides in brain tissues. Results: Biolayer interferometry (BLI) analysis showed that 20(S)-protopanaxadiol (PPD), a ginseng saponin metabolite, exhibited the highest direct interaction to the 14-3-3 ζ protein. Subsequently, BLI kinetics analysis and isothermal titration calorimetry (ITC) assay showed that PPD specifically bound to the 14-3-3 ζ protein. The cocrystal structure of the 14-3-3 ζ protein-PPD complex showed that the main interactions occurred between the residues R56, R127, and Y128 of the 14-3-3 ζ protein and a portion of PPD. Moreover, mutating any of the above residues resulted in a significant decrease of affinity between PPD and the 14-3-3 ζ protein. Conclusion: Our results indicate the 14-3-3 ζ protein is the target of PPD, a ginsenoside metabolite. Crystallographic and mutagenesis studies suggest a direct interaction between PPD and the 14-3-3 ζ protein. This finding can help in the development of small-molecular compounds that bind to the 14-3-3 ζ protein on the basis of the structure of dammarane-type triterpenoid.

• Journal of Society of Preventive Korean Medicine
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• v.22 no.1
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• pp.69-80
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• 2018

Objectives : This paper examines the effects of Particulate Matter on human bodies and the possibility of treating them with Chinese or Korean medicines. Methods : This paper categorizes the diseases caused by Particulate Matter, as well as the causes, pathology, prevention methods, and effectiveness of treatments by Chinese and Korean medicines. Based on these results, it analyzes whether such diseases can be managed by Chinese and Korean medicine. Results : Particulate Matter is known to affect respiratory organs, skin, circulatory system, nervous system, gestational diabetes, and other parts of the human body. While studies show evidence that treatments by Chinese and Korean medicines can reduce symptoms of some diseases and improve bodily functions that are damaged by Particulate Matter, there is no statistically significant evidence that they can provide fundamental treatments nor treat irreversible damages. Conclusion : Currently, there is no definite evidence that Chinese and Korean medicine can treat symptoms and diseases caused by Particulate Matter. Therefore, some Korean medicine doctors' arguments that Korean medicine is effective in treating such diseases are problematic, and thus, there is a need for much research in this field.

• The Journal of Korean Medicine
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• v.28 no.1 s.69
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• pp.117-125
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• 2007

Objectives : This study was to assess the Traditional chinese medicine forecast subjects that had been expected to be accomplished over 20 year (1990-2010). The result will help Korea medical society to compare the status of Korean Medicine with that of Traditional Chinese Medicine and to plan for polices and studies on Korean Traditional Medicine. Methods : Assessed targets were the subjects selected by the China Academy of Chinese Medical Sciences, which are classified into 6 fields. These were assigned by the quantity of related theses. Reference source is CAJ（China academic Journal) of CNKI (China National Knowledge infrastructure). Results : 1) Forecast subject ratio by field was basic theory 31% / clinical research 17% / Chinese herbal drug 17% / acupuncture and moxa 17% / Tui-na(推拿) and Qi-gong(氣功) 9% / medical information, literature history 6%. 2) Accomplishment percentage (full accomplishment) by field was medical information, literature, history 60% / basic theory 50% / acupuncture and moxa 46% Tui-na(推拿) and Qi-gong(氣功) 38% / chinese herbal drug 25% / clinical research 23%. Conclusions : 78% of all forecast subjects were accomplished or partially accomplished. According to 'accomplishment percentage by field', while those in the medical information, literature, history field were most realized of all, those in the clinical research field were least realized.