• 부모자녀건강학회지
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• 제11권1호
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• pp.15-24
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• 2008

Maternal depression is known to have important negative effects on mother, child and mother-child relationship. To review current research evidence of association between maternal depression and their children's health and development, relevant studies were identified using Medline and Kiss(Korean studies Information Service System). The majority of research has reported that children of mother with depression are at risk for impaired physical functioning, growth and developmental delays, and behavioral problems compared to general population. From these studies, it is suggested that these kinds of studies are necessary in this country to examine the relation between maternal depression and children's health and development. Recommendations are included for future research and screening programs for maternal depression.

• Clinical and Experimental Pediatrics
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• 제58권1호
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• pp.8-14
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• 2015

In patients with a language developmental delay, it is necessary to make a differential diagnosis for autism spectrum disorders (ASDs), specific language impairment, and mental retardation. It is important that pediatricians recognize the signs and symptoms of ASDs, as many patients with language developmental delays are ultimately diagnosed with ASDs. Pediatricians play an important role in the early recognition of ASDs, because they are usually the first point of contact for children with ASDs. A revision of the diagnostic criteria of ASDs was proposed in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) that was released in May 2013. The autism spectrum describes a range of conditions classified as neurodevelopmental disorders in the fifth edition of the DSM. The new diagnostic criteria encompasses previous elements from the diagnosis of autistic disorder, Asperger disorder, childhood disintegrative disorder, and pervasive developmental disorder-not otherwise specified. An additional change to the DSM includes synthesizing the section on social and communication deficits into one domain. In ASD patients, the appropriate behavioral therapies and rehabilitation treatments significantly affect the prognosis. Therefore, this makes early diagnosis and treatment very important. In conclusion, pediatricians need to be able to recognize the signs and symptoms of ASDs and be attentive to them in order to make an early diagnosis and provide treatment.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2016년도 춘계 종합학술대회 논문집
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• pp.391-392
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• 2016

In Japan, the children with problem behavior have been called the difficult children. However, the definitions of the difficult children in the medical, health, childcare and education are different. As a result, it is difficult to support for the needs of children. In addition, the difficult children have been influenced by the subjectivity of the teachers. IN-Child (Inclusive Needs Child) is defined by the result of this study. IN-Child means "Child in need of inclusive education by a team, including experts. It does not depend on intellectual and developmental delays due to physical, mental, home environment." We developed the IN-Child record that enables the educational diagnosis of IN-Child. IN-Child record was made to organize and analyze of the items by experts including 3 researchers and 2 teachers. As a result, it was classified into two domains of "cause" and "effect". The domain of "cause" is classified by two domains of "physical" and "mental". The domain of effect is classified by two domains of "daily living" and "learning".

• 대한감각통합치료학회지
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• 제21권3호
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• pp.1-12
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• 2023

목적 : 본 연구의 목적은 발달지연아동 부모와 일반아동 부모의 감각처리 특성이 양육스트레스에 미치는 영향을 비교하는 것이다. 연구방법 : 2022년 7월부터 8월까지 소아과의원과 아동발달센터에서 작업치료 서비스를 이용하는 7세 이하 발달지연아동의 부모 61명과 일반아동 부모 64명을 대상으로 양육스트레스와 감각프로파일을 평가하였다. 결과 : 양육스트레스 총점에 대한 감각처리 특성의 영향을 분석한 다중회귀분석에서 발달지연아동 부모는 촉각처리(β=0.353, p=0.001), 성별(β=0.438, p=0.000), 월수입(β=-0.261, p=0.014)이 유의하게 양육스트레스에 대한 영향 요인으로 파악되었다. 일반아동 부모에서는 촉각처리(β=0.376, p=0.002), 성별(β=-0.264, p=0.024)이 유의하게 양육스트레스에 영향을 주는 것으로 나타났다. 결론 : 발달지연아동과 일반아동 부모의 성별과 촉각처리 특성은 양육스트레스에 대한 유의한 영향 요인이다.

• 대한유전성대사질환학회지
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• 제23권2호
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• pp.31-38
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• 2023

Maple syrup urine disease (MSUD) is an autosomal recessive metabolic disorder caused by a deficiency in branched chain α-keto acid dehydrogenase (BCKAD). Between 1997, when Korea's MSUD case was first reported, and 2023, 14 cases were reported in the literature. 29% of the cases experienced developmental delay, and 29% expired. The prevalence of MSUD in Korea was estimated to be 1 in 230,000. Of 21 MSUD patients currently being treated at the Korea Genetics Research Center, 19 were detected through newborn screening program, and 2 were diagnosed by the symptoms. 14 MSUD patients had confirmed genetic mutations; 6 (43%) were BCKDHA and 8 (57%) were BCKDHB. In one case, a large deletion was observed. 4 patients had leucine levels above 2,000 (umo/L), and post-dialysis diet therapy was initiated in the newborn period. No patient required further dialysis as diet therapy and regular monitoring proved highly effective. Most MSUD patients were growing normally; weight and height growth were above the 50th percentile in 76% of the cases while BMI values were higher than normal in 71% of cases. Developmental delays were observed only in 2 cases (10%) and anticonvulsant use in 3 cases (14%). With newborn screening available to all Korean infants, early diagnosis and intervention should allow most patients to remain asymptomatic. However, ongoing surveillance, dietary management and continued patient compliance as well as rapid correction of acute metabolic decompensations remain critical to a favorable long-term prognosis.

• 대한감각통합치료학회지
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• 제7권2호
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• pp.13-22
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• 2009

목적: 본 연구는 그룹 감각통합치료가 학령전기 발달지연 아동의 감각운동 및 행동 변화에 미치는 효과에 대하여 알아보았다. 연구방법: 연구대상은 만 3~5세의 발달지연 아동 5명이었고, 실험기간은 2009년 6월에서 11월까지이었다. 그룹 감각통합치료는 주 1회(매 70분), 총 26회기를 실시하였다. 그룹 감각통합치료의 효과를 알아보기 위해 단일집단 사전-사후 설계(one group pretest-posttest design)를 사용하였다. 그룹감각통합치료 사전/사후의 임상관찰, Behavior during testing의 차이는 윌콕슨 순위검정(Wilcoxon matched-pairs signed ranks test)을 사용하여 분석하였다. 결과: 그룹 감각통합치료 전과후의 임상관찰(Z=-2.023, p=.043) 점수는 소폭 상승하였으나 통계적으로 유의하지 않았다. 행동 변화를 보기 위한 하위 카테고리인 사회성(Z=-2.121, p=.034), 주의집중(Z=-2.032, p=.042)과총B점ehavior during testing (Z=-2.032, p=.042)에서 통계적으로 유의한 차이를 보였다. 결론: 본 연구는 그룹 감각통합치료가 감각운동 발달에 긍정적인 영향을 미치나 확실한 근거를 제시하기 에는 미흡하며, 사회성 및 주의집중과같은 행동 변화에는 효과가 있음을 제시하였다. 이는 개별적인 감각통합치료에 대한 연구는 많으나 그룹 감각통합치료의 효과에 대한 연구는 거의 없는 실정이므로 그룹치료에 대한 근거를 제시하였다는 것에 의의가 있다. 그러나 연구대상자의 수가 적고, 다양한 내적 환경적 요소에 의해 영향을 받을 수 있으므로 연구결과를 일반화하기에는 어려움이 있다. 따라서 향후 연구에서는 대상 아동의 수를 고려하고, 외적변인을 제한하며, 보다 객관적인 자료 수집 방법을 사용해야 할 것으로 사료된다.

• Clinical and Experimental Pediatrics
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• 제56권8호
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• pp.351-354
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• 2013

Isovaleric aciduria (IVA) is caused by an autosomal recessive deficiency of isovaleryl-CoA dehydrogenase (IVD). IVA presents either in the neonatal period as an acute episode of fulminant metabolic acidosis, which may lead to coma or death, or later as a "chronic intermittent form" that is associated with developmental delays, with or without recurrent acidotic episodes during periods of stress, such as infections. Here, we report the case of a 2-year old boy with IVA who presented with the chronic intermittent form. He was admitted to Asan Medical Center Children's Hospital with recurrent vomiting. Metabolic acidosis, hyperammonemia, elevated serum lactate and isovalerylcarnitine levels, and markedly increased urine isovalerylglycine concentration were noted. Sequence analysis of the IVD gene in the patient revealed the novel compound mutations-a missense mutation, c.986T>C (p.Met329Thr) and a frameshift mutation, c.1083del (p.Ile361fs$^*11$). Following stabilization during the acute phase, the patient has remained in a stable condition on a low-leucine diet.

• Clinical and Experimental Pediatrics
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• 제65권3호
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• pp.142-149
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• 2022

Background: Individuals with Down syndrome present with several impairments such as hypotonia, ligament laxity, decreased muscle strength, insufficient muscular cocontraction, inadequate postural control, and disturbed proprioception. These factors are responsible for the developmental challenges faced by children with Down syndrome. These individuals also present with balance dysfunctions. Purpose: This systematic review aims to describe the motor dysfunction and balance impairments in children and adolescents with Down syndrome. Methods: We searched the Scopus, ScienceDirect, MEDLINE, Wiley, and EBSCO databases for observational studies evaluating the motor abilities and balance performance in individuals with Down syndrome. The review was registered on PROSPERO. Results: A total of 1,096 articles were retrieved; after careful screening and scrutinizing against the inclusion and exclusion criteria, 10 articles were included in the review. Overall, the children and adolescents with Down syndrome showed delays and dysfunction in performing various activities such as sitting, pulling to stand, standing, and walking. They also presented with compensatory mechanisms to maintain their equilibrium in static and dynamic activities. Conclusion: The motor development of children with Down syndrome is significantly delayed due to structural differences in the brain. These individuals have inefficient compensatory strategies like increasing step width, increasing frequency of mediolateral center of pressure displacement, decreasing anteroposterior displacement, increasing trunk stiffness, and increasing posterior trunk displacement to maintain equilibrium. Down syndrome presents with interindividual variations; therefore, a thorough evaluation is required before a structured intervention is developed to improve motor and balance dysfunction.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제33권2호
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• pp.35-40
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• 2022

Objectives: Restricted and repetitive behaviors (RRBs) are a core symptom in the diagnosis of autism spectrum disorder (ASD). The complexity of behavioral patterns has called for the creation of phenotypically homogeneous subgroups among individuals with ASD. The purpose of this study was 1) to investigate the different types of RRBs and 2) to explore whether subgroups created by RRBs would show unique levels of functioning in toddlers and young children with ASD. Methods: A total of 313 children with ASD, aged 12-42 months were included in the analysis. The Autism Diagnostic Interview-Revised was used to obtain information on the different types of RRBs by grouping 15 items into six categories. The Vineland Adaptive Behaviors Scale, a parent-reported questionnaire, was used to measure adaptive functioning. A portion of the children were analyzed separately for verbal-related RRBs based on their expressive language level. Two-step cluster analysis using RRB groups as features was used to create subgroups. Analysis of covariance while covarying for age and language was performed to explore the clinical characteristics of each cluster group. Results: Sensory-related RRBs were the most prevalent, followed by circumscribed interests, interest in objects, resistance to change, and repetitive body movements. A subset of the children was analyzed separately to explore verbal-related RRBs. Four cluster groups were created based on reported RRBs, with multiple RRBs demonstrating significant delays in adaptive functioning. Conclusion: Heterogeneity of RRBs emerges at a young age. The different patterns of RRBs can be used as valuable information to determine developmental trajectories with better implications for treatment approaches.

• 대한감각통합치료학회지
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• 제15권2호
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• pp.66-79
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• 2017

목적 : 본 연구는 발달지연 아동에게 청지각 훈련과 병행한 감각통합 치료를 시행하여 감각처리, 시지각 발달, 주의집중에 미치는 영향을 알아보고자 한다. 연구방법 : 발달지연 및 의심소견을 보이는 아동 만 4~7세 아동 3명을 대상으로 2016년 11월부터 2017년 1월 까지 총 9주간 청지각 훈련과 감각통합치료를 병행하여 실시하고 평가 하였다. 개별실험연구방법(single subject research design)중 ABA' 설계를 사용하였으며, 기초선 1기간(A) 4회, 치료 1기간(B)15회, 기초선2 기간(A')4회로 총 23회기를 적용하였다. 시지각 능력은 기초선 A와 A'기간에 Korean Developmental Test Visual Perception-2(K-DTVP-2)를 통하여 측정하였고 감각처리능력은 감각프로파일(Sensory Profile)로 평가하였다. 주의집중 행동의 유지시간은 기초선 기간에 중재가 없는 상태에서 측정하였으며 중재 기간에는 매 중재 후 10분간 마무리 활동시 소근육 과제를 제공하여 비디오로 촬영하였고 등간기록법(interval recording)의 전간기록법을 사용하여 30초 간격으로 주의집중 발생을 평가하였다. 결과 : 청지각 훈련과 감각통합치료를 실시하기 전보다 후에 시지각 기능과 감각처리의 점수의 수치상 향상은 있었고, 주의집중에서는 A아동에게서 통계적으로 유의한 차이가 있었으나 B, C 아동은 통계적으로 유의한 차이가 없었다. 결론 : 청지각 훈련을 병행한 감각통합 치료가 발달지연 아동의 시지각 기능과 주의집중에 긍정적인 영향을 미친다고 결론짓기에는 한계가 있다. 그러나 일부 발달지연 아동에게서 주의집중의 유의미한 증진이 있었고 점수의 향상이 있었다. 향후 발달지연 아동에게 연구기간, 표준데이터를 제시할 수 있는 평가도구를 적용한다면 명확한 결과가 나타날 수 있을 것이다. 또한 주의집중 유도와 학습을 준비하기 위한 치료방법으로 청지각 훈련의 연구가 추가적으로 시행되어야 한다.