• Nutritional Sciences
• /
• 제1권1호
• /
• pp.61-69
• /
• 1998

Five hundred and seventy-eight healthy subjects (351 men and 227 women) with a mean age of 44.8 years (45.2 for men, 44.3 for women) participated in this study. The serum concentrations of $\alpha$-tocopherol, \beta$-carotene, $\alpha$-carotene, zeaxanthin + lutein, cryptoxanthin, lycopene and retinol of normal Koreans were measured, and their relation to gender, age, BMI, alcohol consumption, cigarette smoking, and menopausal status were evaluated. The concentrations of $\alpha$-tocopherol, carotenoids and retinol in serum were measured simultaneously by reverse phase HPLC (multi-wavelength, gradient and computerized automatic system). Average serum levels of $\alpha$-tocopherol, \beta$-carotene and retinol were 10.1$\pm$0.41\mu$g/dl, 33.1$\pm$1.24\mu$g/dl, and 82.0$\pm$1.63\mu$g/dl for men and 11.1$\pm$0.74\mu$g/ml, 48.1$\pm$1.60\mu$g/dl and 64.5$\pm$1.96\mu$g/dl for women, respectively, Serum concentrations of $\alpha$-tocopheol \beta$-carotene, $\alpha$-carotene, cryptoxanthin and lycopene appeared to be higher in women than in men. The serum concentrations of zeaxanthin + lutein increased with the increase in age of men and those of $\alpha$-carotene and \beta$-carotene increased with the increase in age of women. For men, current smokers showed significantly lower serum concentrations of \beta$-carotene and $\alpha$-carotene than ex-smokers (p <0.05) . Current drinkers also showed significantly lower serum \beta$-carotene and zeaxanthin + lutein concentrations than ex-drinkers. For women, current smokers showed significantly love. serum concentrations of zeaxanthin+lutein and cryptoxanthin than ex-smokes (p<0.05). Men with BMI$\geq$24 showed significantly lower serum concentrations of \beta$-carotene, $\alpha$-carotene, lycopene and cryptoxanthin than men with BMI < 20. The mean concentrations of $\alpha$-tocopherol, \beta$-carotene, $\alpha$-carotene and lycopene far postmenopausal women were higher than those for premenopausal women (p<0.05). In conclusion, there were obvious differences in serum $\alpha$-tocopherol and carotenoids levels depending on gender, age, cigarette-smoking habits, alcohol consumption, BMI and menopausal status. further studies are required to establish the normal levels of these vitamins for children and the elderly and to elucidate their roles in different disease states.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권6호
• /
• pp.2675-2680
• /
• 2014

Background: To investigate differentiated thyroid cancer risk factors in natives of French Polynesia is of interest because of the very high incidence of this cancer in the archipelago. Materials and Methods: To assess the role of various potential risk factors of thyroid cancer in the natives of French Polynesia we performed a case-control study. The study included almost all the French Polynesians diagnosed with differentiated thyroid carcinoma between 1981 and 2003 (n=229) and 373 French Polynesian control individuals from the general population without cancer. Results: Thyroid radiation dose received from nuclear fallout before the age of 15, a personal history of neck or/and head medical irradiation, obesity, tallness, large number of children, an artificial menopause, a familial history of thyroid cancer, a low dietary iodine intake, and having a spring as the main source of drinking water were found to be significant risk factors. No roles of smoking habits, alcohol consumption, iodine containing drugs, and exposure to pesticides were evidenced. Conclusions: Except for smoking, differentiated thyroid carcinoma risk factors in natives of French Polynesia are similar to those in other populations. Our finding on the role of having a spring as a drinking water origin is coherent with some other studies and could be due to geological factors.

• 산업융합연구
• /
• 제19권1호
• /
• pp.109-116
• /
• 2021

본 연구의 목적은 청소년의 천식과 알레르기 비염, 아토피 피부염, 고강도 운동량이 우울 증상과 자살사고에 미치는 영향을 확인하기 위함이다. 제15차(2019) 청소년 정신건강행태조사를 활용한 이차 자료분석연구이다. 자료 분석은 SPSS 22.0을 이용하여 복합표본 교차분석과 로지스틱 회귀분석을 시행하였다. 그 결과 우울 증상과 자살사고 모두 알레르기 질환과 고강도 운동, 흡연 경험, 음주 경험이 차이가 있었다. 흡연 경험과 음주 경험을 보정한 후 천식과 알레르기 비염, 아토피 피부염에 의해서는 우울 증상(OR:1.16, 95% CI:1.07-1.26; OR:1.16, 95% CI: 1.11-1.21; OR:1.17, 95% CI:1.11-1.23)과 자살사고(OR:1.32, 95% CI:1.20-1.47; OR:1.22, 95% CI:1.15-1.29; OR:1.21, 95% CI:1.14-1.29)가 증가하였으나 고강도 운동에 의해서는 우울 증상과 자살사고를 느끼는 정도가 감소하였다(OR:0.90, 95% CI:0.86-0.94; OR:0.85, 95% CI:0.80-0.90). 본 연구 결과로 청소년의 알레르기 질환과 고강도 운동량은 정신건강에 많은 영향을 미치는 것을 알 수 있었고 청소년의 정신건강 관련 예방과 연구에 기초자료로 삼고자 한다.

• 한국산학기술학회논문지
• /
• 제21권12호
• /
• pp.440-448
• /
• 2020

본 연구는 제7기 3차년도(2018) 국민건강영양조사 통계 자료 중 건강 설문 조사 결과를 토대로 인구사회학적 특성 및 건강관련 특성이 성인 여성의 모유수유에 미치는 영향요인을 파악하고자 시행되었다. 자료는 가중치를 적용하여 SPSS Win 22.0 프로그램의 복합표본 분석방법을 이용하여 분석하였다. 성인 여성의 모유수유에 영향을 미치는 요인을 알아보기 위하여 복합표본 다중 로지스틱 회귀분석을 한 결과, 연령, 교육 수준, 흡연이 모유수유에 영향을 미치는 것으로 나타났다. 30-39세 연령군인 경우 19-29세 연령군인 경우보다 3.06배, 초등학교 이하의 학력인 경우가 대학 이상의 학력인 경우보다 4.70배, 비흡연자가 흡연자에 비해 2.51배 모유수유율이 높았다. 따라서 30세 미만의 연령의 경우 모유 수유에 대한 교육을 더욱 강화하고 40세 이상의 연령의 경우 모유생산량을 높이고 돌봄 제공서비스를 제공해야 한다. 또한 학력이 높은 경우에는 직장생활 등의 제한된 환경에서의 효율적인 모유수유 방법을 익히고 수유부를 배려하는 사회적 분위기 조성이 필요할 것이다. 뿐만 아니라 여성 흡연자의 금연프로그램에는 임신 및 수유와 관련된 교육이 포함되어야 할 것이다.

• 한국산학기술학회논문지
• /
• 제21권12호
• /
• pp.246-252
• /
• 2020

본 연구는 제15차(2019년) 청소년 건강행태 조사의 원시자료를 이용하여, 우리나라 다문화 청소년들의 건강 위험 행동들이 주관적인 구강 증상에 미치는 위험요인을 조사하였다. 다문화 가족 범위는 한국인 여성과 결혼한 이주 남성 가족, 한국인 남성과 결혼한 이주 여성 가족의 자녀로 한정 지었으며, 572명을 연구 대상자로 최종 선정하였다. 연구 도구는 사회경제학적 변수로는 성별, 학년, 경제 수준, 학교 성적이 조사되었으며, 건강위험 행태로는 음주, 흡연, 약물 복용, 스트레스, 수면 만족, 자살 생각, 우울 경험, 취침 전 잇솔질 여부가 조사되었고 구강 증상으로는 치아 통증, 잇몸 통증, 입 냄새 여부가 조사되었다. 연구 결과, 치아 통증은 음주, 취침 전 잇솔질, 스트레스, 수면시간, 자살 생각, 우울 경험 여부와 관련성을 나타냈으며, 잇몸 통증은 약물복용, 수면, 자살 생각, 우울 경험에서 관련성을 나타냈다. 그리고, 구취는 약물복용, 취침 전 잇솔질, 스트레스, 자살 생각, 우울 요인과 관련성을 보였다. 건강위험 요인이 구강 증상에 미치는 요인으로는 치아 통증은 음주, 스트레스, 수면시간이 위험요인으로 나타났다. 잇몸 통증은 흡연, 수면, 자살이 위험요인으로 나타났다. 구취는 취침 전 잇솔질 여부와 스트레스가 위험요인으로 나타났다. 결론적으로 청소년들의 구강 건강 증진을 위해 국가 차원의 방과 후 활동이나, 동아리 활동 등의 시간에 구강보건교육 프로그램을 지원하는 정책 제도 마련이 필요하다.

• Clinical and Experimental Pediatrics
• /
• 제49권4호
• /
• pp.410-416
• /
• 2006

목 적 : 호흡기계 섬모 이상은 점막 섬모의 청소 기능에 장애를 초래하므로 반복적 혹은 지속적인 호흡기 계통의 질환 즉, 부비동염, 기관지염, 기관지확장증, 비염 또는 중이염 등을 동반한다. 이 질환은 주로 선천적으로 발생하지만, 드물게는 후천성 혹은 일과성으로 발생되기도 한다. 본 연구에서는 자주 재발하거나 지속되는 호흡기 질환의 증상을 가진 환아들을 대상으로 호흡기계 섬모 이상이 선행하는지를 알아보고자 하였다. 방 법 : 2000년 8월부터 2003년 7월까지 한양대학교병원 소아과에 입원하였거나 외래에 내원한 3개월 이상 지속되는 만성 또는 재발하는 호흡기 질환 환아들 중 17례에서 비강 내 점막 조직생검을 시행한 후 전자현미경을 이용하여 섬모의 상태를 검사하였다. 결 과 : 대상 환아 중 남아가 7례였고 여아가 10례였으며, 연령분포는 2세에서 10세 사이였다. 대상 환아 17례 중 만성 부비동염이 12례, 만성 기침이 9례, 잦은 상기도 감염이 9례에서 관찰되었으며 그 다음으로는 재발성 중이염(7례), 재발성 폐렴(4례), 기관지 천식(4례) 순으로 관찰되었다. 조직검사를 시행한 17례 중 4례가 병적인 소견을 나타냈는데 1례에서는 inner dynein arm 결손이 있었고 1례는 microtubular transposition, 1례는 supernumerous tubules, 1례는 singlet을 가지고 있었다. 결 론 : 자주 재발하거나 지속되는 호흡기 질환의 증상을 가진 환아에서 면역 결핍증 등이 배제된 경우 기도 섬모의 상태를 반영하는 것으로 사료되는 비강 내 점막 생검 실시를 통한 섬모의 미세구조 이상을 확인함으로써 선천적 또는 후천적 원인의 감별 및 효과적인 치료 방법을 결정하는데 도움이 될 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권9호
• /
• pp.4517-4525
• /
• 2016

Background: Sperm DNA damage is underlying aetiology of poor implantation and pregnancy rates but also affects health of offspring and may also result in denovo mutations in germ line and post fertilization. This may result in complex diseases, polygenic disorders and childhood cancers. Childhood cancer like retinoblastoma (RB) is more prevalent in developing countries and the incidence of RB has increased more than three fold in India in the last decade. Recent studies have documented increased incidence of cancers in children born to fathers who consume alcohol in excess and tobacco or who were conceived by assisted conception. The aetiology of childhood cancer and increased disease burden in these children is lin ked to oxidative stress (OS) and oxidative DNA damage( ODD) in sperm of their fathers. Though several antioxidants are in use to combat oxidative stress, the effect of majority of these formulations on DNA is not known. Yoga and meditation cause significant decline in OS and ODD and aid in regulating OS levels such that reactive oxygen speues meditated signal transduction, gene expression and several other physiological functions are not disrupted. Thus, this study aimed to analyze sperm ODD as a possible etiological factor in childhood cancer and role of simple life style interventions like yoga and meditation in significantly decreasing seminal oxidative stress and oxidative DNA damage and thereby decreasing incidence of childhood cancers. Materials and Methods: A total of 131 fathers of children with RB (non-familial sporadic heritable) and 50 controls (fathers of healthy children) were recruited at a tertiary center in India. Sperm parameters as per WHO 2010 guidelines and reactive oxygen species (ROS), DNA fragmentation index (DFI), 8-hydroxy-2'-deoxy guanosine (8-OHdG) and telomere length were estimated at day 0, and after 3 and 6 months of intervention. We also examined the compliance with yoga and meditation practice and smoking status at each follow-up. Results: The seminal mean ROS levels (p<0.05), sperm DFI (p<0.001), 8-OHdG (p<0.01) levels were significantly higher in fathers of children with RB, as compared to controls and the relative mean telomere length in the sperm was shorter. Levels of ROS were significantly reduced in tobacco users (p<0.05) as well as in alcoholics (p<0.05) after intervention. DFI reduced significantly (p<0.05) after 6 months of yoga and meditation practice in all groups. The levels of oxidative DNA damage marker 8-OHdG were reduced significantly after 3 months (p<0.05) and 6 months (p<0.05) of practice. Conclusions: Our results suggest that OS and ODD DNA may contribute to the development of childhood cancer. This may be due to accumulation of oxidized mutagenic base 8OHdG, and elevated MDA levels which results in MDA dimers which are also mutagenic, aberrant methylation pattern, altered gene expression which affect cell proliferation and survival through activation of transcription factors. Increased mt DNA mutations and aberrant repair of mt and nuclear DNA due to highly truncatred DNA repair mechanisms all contribute to sperm genome hypermutability and persistant oxidative DNA damage. Oxidative stress is also associated with genome wide hypomethylation, telomere shortening and mitochondrial dysfunction leading to genome hypermutability and instability. To the best of our knowledge, this is the first study to report decline in OS and ODD and improvement in sperm DNA integrity following adoption of meditation and yoga based life style modification.This may reduce disease burden in next generation and reduce incidence of childhood cancers.

• 대한지역사회영양학회지
• /
• 제6권3호
• /
• pp.516-526
• /
• 2001

Working towards the compression of morbidity, we attempted to find the way to contribute to desirable aging and/or healthy old age. By looking into the factors affecting nutrient intake in middle-aged adults, we sought to find ways to improve their health status, Two hundred and fifty middle-aged adults from 40 to 60 years of age residing in Seoul and its vicinity were recruited for the survey. Subjects were interviewed for general characteristics, dietary habits lifestyle, status and food intake by a trained interviewer. Two -day food record was included in addition to the 1 -day 24 hr recall. Date were analyzed for the relationship among nutrient intake, health status, socio-economic status dietary habits and lifestyle using a statistical program (SAS) Although the mean energy intake of the subjects did not reach the recommenced dietary allowances(RDA), mean protein intake was well above the RAD for both sex groups(111.2% and 129.1% for men and women, respectively) The caloric contribution of fat was 15 to 20 % of total energy intake among different groups. Riboflavin was the most deficient nutrient and its mean intake reached only 71.0% of RDA for mean This seemed to be due to the lower intake of milk and dairy products among middle-aged Koreans who are more accustomed to traditional meals. Income and exercise habit were the most important factors influencing the nutrient intake of middle-age adults. Also, BMI, smoking habit, level of education regularity of meal, and hours of sleeping influenced the nutrient intake, In conclusion, middle-age adults appeared to have similar problems with the elderly in terms of nutrient intake and this age group should to included when considering nutritionally vulnerable groups in addition to the elderly and young children. The improvement in the nutrition status of middle-age adults is even more important because that could lead into the better health the elderly.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권12호
• /
• pp.4815-4821
• /
• 2014

Background: This study aimed to examine the relationship between respiratory health of Malaysian adolescents with secondhand smoke (SHS) exposure and smoke-free legislation (SFL) implementation. Materials and Methods: A total of 898 students from 21 schools across comprehensive- and partial-SFL states were recruited. SHS exposures and respiratory symptoms were assessed via questionnaire. Prenatal and postnatal SHS exposure information was obtained from parental-completed questionnaire. Results: The prevalence of respiratory symptoms was: 11.9% ever wheeze, 5.6% current wheeze, 22.3% exercise-induced wheeze, 12.4% nocturnal cough, and 13.1% self-reported asthma. SHS exposure was most frequently reported in restaurants. Hierarchical logistic regression indicates living in a comprehensive-SFL state was not associated with a lower risk of reporting asthma symptoms. SHS exposure in public transport was linked to increased risk for wheeze (Adjusted Odds Ratio (AOR) 16.6; 95%confidence interval (CI), 2.69-101.7) and current wheezing (AOR 24.6; 95%CI, 3.53-171.8). Conclusions: Adolescents continue to be exposed to SHS in a range of public venues in both comprehensive- and partial-SFL states. Respiratory symptoms are common among those reporting SHS exposure on public transportation. Non-compliance with SFL appears to be frequent in many venues across Malaysia and enforcement should be given priority in order to reduce exposure.

• Journal of Preventive Medicine and Public Health
• /
• 제42권5호
• /
• pp.323-330
• /
• 2009

Objectives : The aim of this study was to investigate whether working married women in different occupational classes affected diverse health outcomes. Methods : We used data for married women aged 25-59 (N=2,273) from the 2005 National Health and Nutritional Examination Survey. Outcome measures included physical/mental and subjective/objective indicators (selfrated poor health, chronic diseases, depression, and suicidal ideation from reported results; metabolic syndrome dyslipidemia from health examination results). Agestandardized prevalence and logistic regression were employed to assess health status according to three types working groups (housewives, married women in manual jobs, married women in non-manual jobs). Sociodemographic factors (age, numbers of children under 7, education, household income) and health behaviors (health examination, sleep, rest, exercise, smoking, drinking) and a psychological factor (stress) were considered as covariates. Results : Non-manual married female workers in Korea showed better health status in all five health outcomes than housewives. The positive health effect for the non-manual group persisted in absolute (age-adjusted prevalence) and relative (odds ratio) measures, but multivariate analyses showed an insignificant association of the non-manual group with dyslipidemia. Manual female workers showed significantly higher age-adjusted prevalence of almost all health outcomes than housewives except chronic disease, but the associations disappeared after further adjustment for covariates regarding sleep, rest, and stress. Conclusions : Our results suggest that examining the health impact of work on married women requires the consideration of occupational class.