• Journal of Korean Neurosurgical Society
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• v.61 no.3
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• pp.333-342
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• 2018

Intracranial germ cell tumors (iGCTs) are a heterogeneous group of tumors with peculiar characteristics clearly distinguished from other brain tumors of neuroepithelial origin. Diverse histology, similarity to gonadal GCT, predilection to one sex, and geographic difference in incidence all present enigmas and fascinating challenges. The treatment of iGCT has advanced for germinoma to date; thus, clinical attention has shifted from survival to long-term quality of life. However, for non-germinomatous GCT, current protocols provide only modest improvement and more innovative therapies are needed. Recently, next-generation sequencing studies have revealed the genomic landscape of iGCT. Novel mutations in the KIT-RAS-MAPK and AKT-MTOR pathways were identified. More importantly, methylation profiling revealed a new method to assess the pathogenesis of iGCT. Molecular research will unleash new knowledge on the origin of iGCT and solve the many mysteries that have lingered on this peculiar neoplasm for a long time.

• Journal of the Korean Home Economics Association
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• v.37 no.12 s.142
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• pp.153-168
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• 1999

With rapid changes in modern societies, abrupt increases in knowledges and fast conversions in technologies have caused serious generation gaps among members of the family. This have generated problems for housewives who is generally in charge of maintaining and coordinating a family with limited life experiences and knowledges earned only through several years of school education, to resolve every problems evoked in their families. This has made us to realize the needs for the education related to the family life. Especially for middle-aged housewives, this type of education is absolutely required to maintain ideal family relationships, and this can be accomplished by improving their abilities and potentials. The 8-step program to improve the relationship between middle-aged housewives and their children was developed. Overall, this program improved the self-respect and psychological well-being of middle-aged housewives. Also, the relationship with their children was greatly improved through better understanding and communication. This was solely reflected on the quantitative evaluations through pre-and post-tests, so that all the participants scored higher in the post-test.

• Journal of The Korean Association For Science Education
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• v.28 no.3
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• pp.197-210
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• 2008

The purpose of this study is to explore the cases and features of the abductive inference used by young children when trying to explain natural phenomena in everyday life. From observing a 5-year-old's daily activities with his family, and analyzing the data according to the criterion extracted from the form of abductive inference described by C. S. Peirce, a few cases where the child used abductive inferences to explain natural phenomena were found. The abductive inferences in the cases were conducted: (a) based on figural resemblance and behavioral resemblance (b) under the influence by individual belief and communal belief, then (c) resulted in new categorization accompanied by over generalization. Such features of the abductive inference showed the 'double faces'; sometimes encourages and sometimes discourages children's generating better scientific hypotheses and explanations. These results suggest that even young children use abductive inference to explain doubtful natural phenomena in everyday life, although we need to consider carefully with the double aspects of the features of abductive inference for the practical applications to the fields of science education. Finally, several suggestions and following studies for science education are proposed.

• Journal of Genetic Medicine
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• v.16 no.2
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• pp.62-66
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• 2019

Harlequin ichthyosis (HI, OMIM #242500) is one of the most severe skin diseases among the autosomal recessive congenital ichthyoses, with high morbidity and mortality, particularly in newborns. Clinically, it is characterized by a typical appearance of generalized, thick, yellowish, hyperkeratotic plates with deep erythematous fissures on the skin. Herein, we present the case of a newborn girl with HI that was genetically confirmed by targeted gene panel analysis. The premature baby was encased in an opaque white membrane with erosion covering the skin of the entire body except the lips, with her hands and feet restricted by the membrane. Humidification, emollient, and retinoic acid treatment were started; the thick ichthyosis gradually peeled off and the underlying skin was only covered with thin scales. Targeted gene panel analysis using next-generation sequencing and validation with Sanger sequencing and quantitative polymerase chain reaction analyses confirmed compound heterozygous mutations of the ABCA12 gene (p.N1380S and a partial gene deletion encompassing exon 9). The parents were carriers for each of the identified mutations. Early recognition of the genetic etiology of congenital ichthyosis can, thus, facilitate genetic counseling for patients and their families.

• Korean Journal of Adult Nursing
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• v.17 no.5
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• pp.719-731
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• 2005

Purpose: This research was conducted to explore the experience of middle-aged women parting with their children and to develop a grounded theory. Method: The participants were 11 women in their 50's who had experienced parting with their children due to schooling, military service and marriage. The grounded theory methodology based on symbolic interactionism was used. Results: 106 concepts, 30 subcategories and 14 categories were derived from the analysis through processes of open coding, axial coding and selective coding. The central phenomenon was 'happy but sad' and the core category was a process of 'independence that is sorrowful yet delightful'. Four types were identified; the independent-type; submissive -type; family-reliant-type ; and fragile-type; based on the attachment to the child, state of mind, satisfaction of the situation, family support system and self-achievement. Conclusion: This research identified that the modern Korean middle-aged women who are considered to be the 'sandwich generation' since they have experienced a turbulent history and the change from a confucian parent-child lifestyle to a couple-oriented one, moved away from an attitude dependent on children in parting with them and started preparing for an independent late life. Based on the results, the verification research is advised on the variables that affect the experience of parting with children.

• Journal of Digital Contents Society
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• v.19 no.5
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• pp.845-852
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• 2018

This study has developed a preventive launcher from smartphone addiction for the digital generation and the contents recommendation based on machine learning which used multiple and collective intelligence. This could provide convenient digital nurturing experience for the parents who fear their children's over use of digital devices and also suggest individually adaptive digital learning methods that enhance the learning efficiency and pleasurable and safe learning environment for the children. Suggested application is a kind of gamification launcher that protects children from harmful contents and from smartphone addiction with time limit settings. For parents who find difficulty choosing from various kinds of contents and applications for education, this suggested system could provide a learning analytic report based on big data after collecting and analyzing the data of their children's learning and activities and recommend contents necessary for their kids using recommended algorithm by collective intelligence.

• The Journal of the Convergence on Culture Technology
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• v.2 no.2
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• pp.1-8
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• 2016

This study was designed to analyze the perceptions of 4 and 5 years old children on the elderly, and how different the perceptions were according to the experience of living with grandparents. The subjects of the study were 54 children, 4 and 5 years old K kindergarten in H city. In the procedure of study, the children were asked to draw pictures of the elderly images, and individual interviews. The findings as follows. firstly, that the most positive perception of the children on the elderly was family-relationship and the most negative perception was physical feature. Secondly, Images for the elderly did not differ according to the experience of living with a grandparent. Based on these results, this study provides the basis for the research on understanding culture and communication between generations and gives useful information on developing of a generation program.

• Research in Community and Public Health Nursing
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• v.9 no.2
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• pp.324-335
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• 1998

This study describes the extent of recognition of problems to the aged in a future society, the recognition and necessity of day care facilities, and the service contents and patterns preferred as a method of mediation for nursing the aged and increasing their quality of life. It also tries to certify the relations between those subjects. The result of the study is as follows: 1. Concerning problems of the aged of social significance the aged of the next generation consider the difficulties in nursing the aged to be the most important at 63.6%. 2. Concerning the nursing of parents, 49.4% of those answered 'children should take care of their parents and live together', while 46.7% answered that 'it is enough for children to provide an economic support, not necessarily living together. 3. Concerning information of day care facilities, 66.9% answered that they have no information. 4. Concerning the use of day care facilities, 54.6% answered that 'they would under certain circumstances', and 21.0% that 'they had better use them in the future'. 5. Concerning the feelings of the aged using day care facilities, 46.6% say 'they do not look poor', and 33.4% said that 'they look a little poor'. 6. Concerning the reasons for using day care facilities, 56.1% answered' because children do not proride care', and 48.5% answered 'because their economic ability is not sufficient'. 7. Concerning the programs potentially needed, food supply, medical services and physical therapy were ranked in that order. 8. Concerning social facilities necessary for the aged, centers that specialize in dementia, free day care facilities, home care services, and fee - based day care centers were ranked in that order. 9. Concerning institutions providing day care, welfare centers for the aged, those centers auxiliary to hospitals, asylums, and individuals were ranked in that order. 10. Concerning the responsibity running day care facilities, social workers, doctors/nursing assistants, nurses, and entrusted visitors were ranked in that order. Based on the results of this study, the study proposes that the study of applied cases of therapy in day care facilities for the aged continue.

• BMB Reports
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• v.37 no.6
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• pp.635-641
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• 2004

Interferons regulate a number of biological functions including control of cell proliferation, generation of antiviral activities and immumodulation in human cells. Studies by several investigators have identified a number of cellular signaling cascades that are activated during engagement of interferon receptors. The activation of multiple signaling cascades by the interferon receptors appears to be critical for the generation of interferon mediated biological functions and immune surveillance. The present review summarizes the existing knowledge on the multiple signaling cascades activated by Type I interferons. Recent developments in this research area are emphasized and the implications of these new discoveries on our understanding of interferon actions are discussed.

• Journal of Families and Better Life
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• v.17 no.1
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• pp.103-120
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• 1999

The purpose of this study was to investigate the characteristics and caregiving behavior in families who awarded on filial piety. Using the qualitative method 137 families and social supports to them were analyzed,. The major findings can be summarized as follows (1) Most of caregivers were daughter-in -law over 40 years in 3-generation or 2-generation family. Elderly can be characterized as oldest-old dependent long-term care for more than 10 years. (2) These families showed very high family solidarity with strong collectivity. (3) Their economic emotional and service cares were family-centered with helps from their extended family. These families were supported emotional helps rather than instrumental helps from social network. It was concluded that to help family elder care social support program for the frail elder caregiving families should be complemented in their children support program family life enrichment program for the inter-generational relationship medical care program other social network program and religion program etc. And more concrete and qualified study for the adaptation of filial piety families should be followed.