• Title/Summary/Keyword: cheju

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Induction of Antioxidant Enzymes in Phloroglucinol Treated Cells

  • Kang Kyoung Ah;Lee Kyoung Hwa;Chae Sungwook;Ahzang Rui;Jung Myung Sun;Ham Young Min;Baik Jong Seok;Lee Nam Ho;Hyun Jin Won
    • Environmental Mutagens and Carcinogens
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    • v.25 no.4
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    • pp.129-133
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    • 2005

  • We investigated the cytoprotective effect of phloroglucinol, which was isolated from Ecklonia cava (brown seaweed), against oxidative stress induced cell damage in Chinese hamster lung fibroblast(V79-4) cells. Phloroglucinol was found to scavenge intracellular reactive oxygen species (ROS) generated by $\gamma-ray$ radiation. In addition, Phloroglucinol inhibited cell damage induced by radiation through scavenging ROS. Phloroglucinol increased the superoxide dismutase and glutathione peroxidase activity, Taken together, the results suggest that phloroglucinol protectes V79-4 cells against oxidative damage by enhancing the cellular antioxidant enzymes activity.

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The Cytotoxicity of Eutigosides from Eurya emarginata Against HL-60 Promyelocytic Leukemia Cells

  • Park Soo Yeong;Yang Hong Chul;Moon Ji Young;Lee Nam Ho;Kim Se Jae;Kang Ji Hoon;Lee Young Ki;Park Deok Bae;Yoo Eun Sook;Kang Hee Kyoung
    • Archives of Pharmacal Research
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    • v.28 no.9
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    • pp.1047-1052
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    • 2005

  • Two phenolic glucosides, eutigoside Band eutigoside C were isolated from the fresh leaves of Eurya emarginata. These two phenolic glucosides exerted a significant inhibitory effect on the growth of HL-60 promyelocytic leukemia cells. Furthermore, when the HL-60 cells were treated with eutigoside C, several apoptotic characteristics such as DNA fragmentation, morphologic changes, and increase of the population of sub-G1 hypodiploid cells were observed. In order to understand the mechanism of apoptosis induction by eutigoside C, we examined the changes of Bcl-2 and Bax expression levels. The eutigoside C reduced BcI-2 protein and mRNA levels, but slightly increased Bax protein and mRNA levels in a time-dependent manner. When we examined the activation of caspase-3, an effector of apoptosis, the eutigoside C increased the expression of active form (19-kDa) of caspase-3 and the increase of their activities was demonstrated by the cleavage of poly (ADP-ribose) polymerase, a substrate of caspase-3, to 85-kDa. The results suggest that the inhibitory effect of eutigoside C from E. emarginata on the growth of HL-60 appears to arise from the induction of apoptosis via the down-regulation of BcI-2 and the activation of caspase.

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Water Mass Distribution and Seasonal Circulation Northwest of Cheju Island in 1994

  • PANG Ig-Chan;RHO Hong-Kil;LEE Jae-Hak;LIE Heung-Jae
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.29 no.6
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    • pp.862-875
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    • 1996

  • The CTD data observed in the sea northwest of Cheju Island have been analyzed to figure out the seasonal circulation around Cheju Island. Warm and saline waters flow into the Yellow Sea through the middle region of the Yellow Sea in winter and along the west coast of Korean Peninsula in summer. On the other hand, cold and less saline waters flow out of the Yellow Sea through the middle region in summer and along the west coast of Korean Peninsula in winter. These flows make the seasonal circulation around Cheju Island. As dynamics, the monsoon wind and the variation of Kuroshio transport have been suggested. Comparing the observational result, the circulation driven by the variation of Kuroshio transport is strengthened by monsoon winds in the numerical model.

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