• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.8
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• pp.786-792
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• 2009

Topology optimization is to find the optimal material distribution of the specified design domain minimizing the objective function while satisfying the design constraints. Since the genetic algorithm (GA) has its advantage of locating global optimum with high probability, it has been applied to the topology optimization. To guarantee the structural connectivity, the concept of compliance pattern is proposed and to improve the convergence rate, small number of population size and variable probability in genetic operators are incorporated into GA. The rank sum weight method is applied to formulate the fitness function consisting of compliance, volume, connectivity and checkerboard pattern. To substantiate the proposed method design examples in the previous works are compared with respect to the number of function evaluation and objective function value. The comparative study shows that the compliance pattern based GA results in the reduction of computational cost to obtain the reasonable structural topology.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.16 no.1
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• pp.47-52
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• 2007

A material mixing method to obtain an optimal topology for a structure in a thermal environment was suggested. This method is based on Evolutionary Structural Optimization(ESO). The proposed material mixing method extends the ESO method to a mixing several materials for a structure in the multicriteria optimization of thermal flux and thermal stress. To do this, the multiobjective optimization technique was implemented. The overall efficiency of material usage was measured in terms of the combination of thermal stress levels and heat flux densities by using a combination strategy with weighting factors. Also, a smoothing scheme was implemented to suppress the checkerboard pattern in the procedure of topology optimization. It is concluded that ESO method with a smoothing scheme is effectively applied to topology optimization. Optimal topologies having multiple thermal criteria for a printed circuit board(PCB) substrate were presented to illustrate validity of the suggested material mixing method. It was found that the suggested method works very well for the multicriteria topology optimization.

• Journal of Mechanical Science and Technology
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• v.16 no.5
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• pp.683-695
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• 2002

The objective of the present study is to analyze the fluid flow with moving boundary using a finite element method. The algorithm uses a fractional step approach that can be used to solve low-speed flow with large density changes due to intense temperature gradients. The explicit Lax-Wendroff scheme is applied to nonlinear convective terms in the momentum equations to prevent checkerboard pressure oscillations. The ALE (Arbitrary Lagrangian Eulerian) method is adopted for moving grids. The numerical algorithm in the present study is validated for two-dimensional unsteady flow in a driven cavity and a natural convection problem. To extend the present numerical method to engine simulations, a piston-driven intake flow with moving boundary is also simulated. The density, temperature and axial velocity profiles are calculated for the three-dimensional unsteady piston-driven intake flow with density changes due to high inlet fluid temperatures using the present algorithm. The calculated results are in good agreement with other numerical and experimental ones.

• Proceedings of the KSME Conference
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• 2000.04a
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• pp.900-907
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• 2000

The three-dimensional turbulent flow in curved pipes susceptible to flow-accelerated corrosion has been analyzed numerically to predict the pressure and shear stress distributions on the inner surface of the pipes. The analysis employs the body-fitted non-orthogonal curvilinear coordinate system and a standard $ {\kappa}-{\varepsilon}$ turbulence model with wall function method. The finite volume method is used to discretize the governing equations. The convection term is approximated by a high-resolution and bounded discretization scheme. The cell-centered, non-staggered grid arrangement is adopted and the resulting checkerboard pressure oscillation is prevented by the application of a modified version of momentum interpolation scheme. The SIMPLE algorithm is employed for the pressure and velocity coupling. The numerical calculations have been performed for two curved pipes with different bend angles and curvature radii, and discussions have been made on the distributions of the primary and secondary flow velocities, pressure and shear stress on the inner surface of the pipe to examine applicability of the present analysis method. As the result it is seen that the method is effective to predict the susceptible systems or their local areas where the fluid velocity or local turbulence is so high that the structural integrity can be threatened by wall thinning degradation due to flow-accelerated corrosion.

• Toxicological Research
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• v.13 no.1_2
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• pp.111-116
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• 1997

In the present study, we investigated the neutralization activity of various antimicrobials against lipopolysaccharide (LPS) as well as interaction between two antimicrobials (enrofioxacin and coilstin) using checkerboard method. The neutralization activity of antimicrobials used in the test was assayed by means of LAL chromogenic test after reaction of LPS with colistin, enorfioxacin, ampicillin, polymyxin B, oxytetracycline, streptomycin, and erythromycin. As the results, the neutralization activity of coltstin and polymixin B had a more stronger than that of tested other antimicrobials. In bacterial culture broth, the best neutralization activity of the antibiotics was also shown to coltstin and polymixin B. Meanwhile, It was shown to have synergism between enorfloxacin and coltstin on the basts of FIC (fractional inhibition concentration). The FIC of enorfioxacin-colistin combinations was 0.50-1.03 to Staphylococcus aureus R-209, 1.03-1.06 to Salmonella typhimurium, 0.75-1.25 to Bordetella Bronchtseptica and 1.02-1.25 to E. coli K88ab. On the basts of the above results, the present study may be of clinical usefulness in the choice of an antibiotic therapy for severe sepsts in animals.

• YAKHAK HOEJI
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• v.43 no.2
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• pp.221-227
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• 1999

The fungistatic and fungicidal activities of amphotericin B, fluconazole, miconazole, econazole, and 5-fluorocytosine against Saccharomyces cerevisiae were estimated in the presence of 1/2 minimum inhibitory concentration (MIC) and 1/2 minimum fungicidal concentration (MFC) of polygodial, respectively. Among them, the antifungal activities of miconazoles by polygodial was still shown against several yeast-like fungi including Candida albicans, Candida utilis, Cryptococcus neoformans, except for Candida krusei. The combination of polygodial with imidazole drugs against Saccharomyces cerevisiae was further examined using the macrobroth dilution checkerboard method. The fractional inhibitory concentration (FIC) and the fractional fungicidal concentration (FFC) index between polygodial and miconazole were 0.16 and 0.19, while the combination of polygodial with econazole exhibited the FIC index of 0.19 and the FFC of 0.25, respectively. These results suggest that polygodial and the imidazoles on the fungistatic and fungicidal action are highly synergistic.

• YAKHAK HOEJI
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• v.43 no.2
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• pp.228-232
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• 1999

The combination effect of anethole with amphotericin B, fluconazole, miconazole, or 5-fluorocytosine was investigated against Saccharomyces cerevisiae. When combined with $\frac{1}{2}$ minimum inhibitory concentration (MIC) or $\frac{1}{2}$ minimum fungicidal concentration (MFC) of anethole, the antifungal activities of fluconazole and 5-fluorocytosine were not changed, but the fungistatic and the fungicidal activities of miconazole were increased 64-fold, respectively. In the case of amphotericin B, the fungistatic activity was increased 2-fold, while the fungicidal activity was decreased 2-fold. The combination effect of anethole with miconazole or amphotericin B was also investigated at the various concentrations using the macrobroth dilution checkerboard method. The fractional inhibitory concentration (FIC) and the fractional fungicidal concentration (FFC) index between B exhibited the FIC index of 8.25 and the FFC of 32.06, respectively. Thus, it is analyzed that the combination of anethole with miconazole or amphotericin B on the antifungal action shows synergism and antagonism, respectively.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.572-577
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• 2007

The paper presents design optimization of an automobile body for dynamic stiffness improvement. The thicknesses of plates making-up the monocoque body of an automobile were employed as design variables for optimization and the objective was to increase the first torsional and bending natural frequencies. By allotting one design variable to each plate of the body, compared to previous works based on element-wise design variables, design space of optimization was reduced to a large extent and numerical instabilities such as checkerboard pattern was efficiently evaded. The method resulted to a considerable amount of increase in the automobile body's torsional and bending natural frequencies. Considering manufacturability of the optimized result, the converged values of plate thicknesses were approximated to commercially-available values by appropriately reflecting their design sensitivities.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.467-472
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• 2007

A modern MEMS resonator is a micro-scale structure operated over a high frequency range. In order to predict its resonant behavior in a design process, High-frequency response analysis (Hi-FRA) is demanded. Algebraic substructuring (AS) is known as a fast numerical technique to construct an eigenspace for FR and frequency sweep (FS) algorithm efficiently solves the frequency response system projected on the eigenspace. However, the existing FS algorithm using AS is developed for low-FRA, say over the range 1Hz-2KHz. In this work, we extend the FS algorithm using AS for FRA over an arbitrary frequency range. Therefore, it can be efficiently applied to systems operated at a high frequency, say over the range 230MHz-250MHz. The success of the proposed method is demonstrated by Hi-FRA of a checkerboard resonator.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05b
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• pp.173-178
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• 1996

A three-dimensional thermo-hydraulic computer code is developed for simulation of incompressible flows in complex geometries. The computer code employs a body-fitted, nonorthogonal grid system in order to efficiently handle the complex geometries encountered in many engineering applications. The finite volume method is used to discretize the governing equations and the convection term is treated by higher-order bounded schemes. The cell-centered, nonstaggered grid arrangement is adopted and the resulting checkerboard pressure oscillation is avoided by use of momentum interpolation practice. The computer code employs the SIMPLE algorithm for pressure and velocity coupling and the k-$\varepsilon$ turbulence for turbulent calculation. The computer code has been tested through application to a variety of test problems and some results are presented in this paper