• The Korean Society of Law and Medicine
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• v.12 no.1
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• pp.257-285
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• 2011

This thesis has studied about the legal characteristic of injection of the trial drug, the position of the pharmaceutical firm as a contractor of the clinical trial, the possibility of compulsory performance of consistent injection of the trial drug, and the damage claim caused in the process of the clinical trial from the viewpoint of protecting the trial subject in the clinical trial. According to court's judgement in the United States, the lawsuit of the trial subject, although the trial subject had expected consistent injections, was dismissed because there was no direct contract between pharmaceutical and trial subject. However, Helsinki Declaration prescribe the medical research as follows. 'All patients who participated in the research should be able to use the best precaution, diagnosis, and treatment proved by the final outcome of the research'. The trial subject is entitled to demand only the pharmaceutical firm which developed and provided the trial drug, and the pharmaceutical firm has the obligation to supply the trial drug to the trial subject. Therefore, it would be not enough to protect the trial subject if the pharmaceutical firm which makes the trial drug is ruled out. In addition, especially, in case the trial drug has a constant effect with the aim of treatment, if the injection of the trial drug is suddenly stopped, the trial subject would not have the benefit of treatment by the trial drug. In this case, the best remedy against the damage is to urge a constant injection of the trial drug. Thus, in certain case, it is reasonable to consider that the pharmaceutical firm has the obligation to supply the trial drug to the trial subject constantly, and it is also necessary to compel it through effective means in case the pharmaceutical firm do not fulfill its obligation to supply the trial drug. However, as an essential prerequisite for the assertion mentioned above, it should be judged under the principle of good faith considering the concrete situation, that is, what roles the pharmaceutical firm has played.

• The Journal of the Korea Contents Association
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• v.13 no.12
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• pp.1036-1047
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• 2013

In this study, we applied the time series analysis to the randomized controlled trial (RCT) researches related to insomnia for finding international trends. The data used in the analysis of 379 of ClinicalTrials, Web of Science was the of 132 by several keyword related with 'Insomnia' and 'Randomized Clinical Trial'. In ClinicalTials, RCT studies for insomnia, drug, cognitive behavioral therapy, depression were the key words make up the main network. In WOS, 'melatonin' key word was added in the main network. In addition to, we found the characteristic that the elderly and female subjects were steady studied.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2000.04a
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• pp.157-162
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• 2000

Discriminant analysis is a method to relate whether the objects have a specific characteristic or not with their 'continuous' attribute values and, for given objects, to estimate whether they have a specific characteristic or not by their values of discriminant scores gotten from their attribute values. The author developed the new 'computational' method of discriminant analysis without specific hypotheses or assumptions and, by this new method, we can find 'feasible' solutions under the conditions required by our actual problems. In this paper, the author tried to apply this new method to the discrimination of logical relations. If this trial could be a success, we can apply this new method of discriminant analysis to the problems about relating the specific characteristic of the objects with their 'discrete' attribute values. The result was successful and the applicability of discriminant analysis could be expanded as a method for constructing the models for "estimating impressions".

• Journal of Radiation Protection and Research
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• v.25 no.2
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• pp.99-107
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• 2000

Through the results of off-gas analysis at 3 sampling points in Plasma Arc Melting vitrification pilot plant, it was evaluated the partitioning of spiked materials in off-gas and the decontamination characteristic of off-gas treatment system. Spiked materials are hazard_us heavy metals(Pb, Cd, Hg), radioactive surrogate(Co, Cs) and radioactive materials($^{60}Co,\;^{137}Cs$). Through the Trial burn tests, Decontamination factor of spiked materials in off-gas treatment system is calculated.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.5
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• pp.706-710
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• 2007

This study was to investigate the caponization effects on bone characteristics in male chickens, and the optimum testosterone implantation dosage on bone characteristics improvement. Healthy Single Comb White Leghorn cockerels were caponized at 12-wk-old and selected at 16-wk-old for a 10-wk feeding experiment. Fifteen intact male and caponized male chickens (capon) respectively were assigned to trial 1. Ten sham-operated chickens and 40 capons (randomly allocated into four treatments) were implanted with cholesterol (1.62 mm i.d., 3.16 mm o.d., $9.24{\pm}0.36$ mg), low (1 mm i.d., 3 mm o.d., $5.88{\pm}0.23$ mg), medium (1.62 mm i.d., 3.16 mm o.d., $9.81{\pm}0.17$ mg) or high dose (2 mm i.d., 4 mm o.d., $16.7{\pm}0.24$ mg) of testosterone in trial 2. The results from trial 1 showed that the tibia length, relative tibia weight, breaking strength, bending moment and stress in intact males were higher than capons (p<0.05). The blood phosphorus concentration in capons was higher than the intact male chickens (p<0.05). Caponization also resulted in more antrums and osteoclasts within periosteum and cortical bone from histological observation. In trial 2, the adverse impact of caponization on the bone breaking strength, bending moment and stress could be alleviated through medium dose testosterone implantation. It appears that caponization reduced androgen secretion hence influenced the biomechanical characteristics of bone (tibia) and these adverse effects could be alleviated through appropriate dose of testosterone implantation.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.2
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• pp.245-251
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• 2006

The aim of this study was to investigate the effects of caponization on the bone characteristics, biomechanical property and histology in Taiwan country chickens fed to market age of 26 wks. Male Taiwan country chickens $D{\times}L_2$ were caponized or sham-operated at 8 wks of age, and selected healthy sham-operated and completely caponized chickens (prominent degenerated comb) were selected at 16 wks old and fed to 26 wks old for the trials. Fifteen intact male chickens (Intact), sham-operated chickens (Sham) and caponized chickens (Capon) were assigned for trial 1, and sixteen Intact and Capon were assigned for trial 2. Results in trial 1 showed that the abdominal fat and relative abdominal fat weights of Capon were significantly heavier than Intact and Sham (p<0.05), while the tibia weight and relative weight were the lightest (p<0.05). The tibia breaking strength, bending moment and stress of Capon were the poorest among groups (p<0.05). The trial 2 produced the similar observation that Capon were significantly lighter than Intact (p<0.05) in the tibia weight, relative tibia weight and their biomechanical properties. On histological determinations, Capon showed a thinner cartilage end and fewer chondrocytes (about 50%) and trabecular, and bigger marrow cavity; while decreased hemopoietic cells number with increased adipocytes than Intact observed by H&E stain and at low magnification. At high magnification, Capon showed a decrease in the chondrocyte size by 33 to 50%, with smaller nucleus located near the cell membrane, and exhibited monocellular form chondrocytes. Capon also showed a less strongly acidic sulfated mucosubstance with weaker dyeing property within cartilage zone, and smaller chondrocytes size by Alcian blue stain.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1430-1434
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• 2003

In this paper, for the fuzzy-reaching law method which has the characteristic of elimination of chattering at sliding mode as well as the characteristic of fast response at the design of variable structure controller with reaching law, optimal solutions for the determination of parameters of fuzzy membership functions by using genetic algorithm are proposed. Generally, the design of fuzzy controller has difficulties in determining the parameters of fuzzy membership functions by using a tedious trial-and-error process. To overcome these difficulties, this paper develops genetic algorithm of an optimal searching method based on genetic operation, and to verify the validity of this proposed method it is simulated through 2 link robot manipulator.

• Journal of the Korea Computer Industry Society
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• v.5 no.1
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• pp.177-182
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• 2004

In sonar sensor design impedance matching design to each sensor affects the whole weighting circuit characteristic very much. But there are many examples that it is made by hands or very simple modeling designs. So these design works make trial and error because it is the limitation of flexible correspondence to the many sensors and follows many errors. This study explains organizations and skills in the sensor modeling package design program with real sonar sensor characteristic measure as the first step in impedance matching design.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1999.10a
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• pp.395-402
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• 1999

This paper discusses the theoretical researches subject to elastic buckling problems of the structures. The purpose is to ensure the characteristic of buckling be true by arc-length method and the finite element method. The difficulties in processes calculating the equilibrium curve after buckling is to get the equilibrium owe near singular point at which the determinant of stiffness matrix is zero. The purpose of the load-displacement curve is to determine the buckling load of the structure, and further to get the information about the characteristic after buckling. Here, this paper expresses the incremental solution at particular point by the linear combination of both homogeneous mode and particular mode, then uses the method which gets the unknown parameter including this function, through trial-and-error method including modified N-R convergence process. Finally, this paper describes the multiple bifurcation of truss dome as the numerical examples according to this algorithm.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.1008-1013
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• 2003

This paper concerns the structural characteristic analysis and evaluation on the hydrostatic guide way and feeding system of a high precision centerless grinder for machining ferrules. In order to realize the required accuracy of ferrules with sub-micron order, the axial stiffness and motion accuracy of feeding system have to become higher level than those of existing centerless grinders. Under these points of view, the physical prototype of feeding system consisted of steel bed, hydrostatic guide way and ballscrew feeding mechanism is designed and manufactured for trial. Experimental results show that the axial and vertical stiffnesses of the physical prototype are very low as compared with those design values. In this paper, to reveal the cause of these stiffness difference, the structural deformations on the virtual prototype of feeding system are analyzed based on the finite element method under experimental conditions. The simulated results illustrate that the deformation of front ballscrew support-bearing bracket is the main cause of reduction in the axial stiffness of feeding system, and the deflection of bed structure and the bending deformation of hydrostatic guide rails are the main causes of reduction in the vertical stiffness of feeding system.