• IMMUNE NETWORK
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• 제22권1호
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• pp.6.1-6.19
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• 2022

Chimeric antigen receptor (CAR) T cells, which express a synthetic receptor engineered to target specific antigens, have demonstrated remarkable potential to treat haematological malignancies. However, their transition beyond haematological malignancy has so far been unsatisfactory. Here, we discuss recent challenges and improvements for CAR T cell therapy against solid tumors: Antigen heterogeneity which provides an effective escape mechanism against conventional mono-antigen-specific CAR T cells; and the immunosuppressive tumor microenvironment which provides physical and molecular barriers that respectively prevent T cell infiltration and drive T cell dysfunction and hypoproliferation. Further, we discuss the application of CAR T cells in infectious disease and autoimmunity.

• Journal of Hospice and Palliative Care
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• 제27권3호
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• pp.103-106
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• 2024

Palliative care is a comprehensive approach aimed at improving the quality of life for patients and their families. The symptom burden and care needs of patients with end-stage, non-malignant diseases are similar to those experienced by patients with advanced cancer. Therefore, the World Health Organization (WHO) has recommended the expansion of palliative care to encompass a broad spectrum of diseases. However, in Korea, the adoption of palliative care for non-malignant conditions remains markedly low, presenting numerous challenges that differ from those associated with cancer. Key barriers to implementing hospice care for non-malignant diseases include the difficulty in predicting end-of-life and a general lack of awareness about hospice palliative care among healthcare providers, patients, and their families. Additionally, there is a risk that suggesting palliative care to patients with non-malignant diseases might be misinterpreted as an endorsement by healthcare providers to cease treatment or abandon the patient. This article explores strategies to broaden the scope of hospice and palliative care for patients with non-malignant diseases.

• 통상정보연구
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• 제6권3호
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• pp.245-268
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• 2004

The application of Internet-technologies to support inter-business transactions and relationships (also termed business-to-business, B2B, electronic commerce) has recently received tremendous attention. Recognizing the importance of the Internet as a powerful business tool, many companies including public organization such as KEPCO(Korea Electronic Power Corporation) have moved quickly to take advantage of electronic commerce. This study explores the impact of Internet-based technology on the procurement function, howe-procurement is helping organizations to enhance their competitiveness and the challenges to its adoption. The study also presents the findings from a survey conducted to gain insight into the adoption of e-procurement by KEPCO. Specifically, it seeks to uncover the prevalence of and extent to which public organization is adopting e-procurement, the benefits reaped and the barriers encountered in the course of implementation.

• Genomics & Informatics
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• 제7권1호
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• pp.46-48
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• 2009

Finishing is the most time-consuming step in sequencing, and many genome projects are left unfinished due to complex repeat regions. Here, we have developed BACContigEditor, a prototype shotgun sequence finishing tool. It is essentially an editor that visualizes assemblies of shotgun sequence fragment reads as gapped multiple alignments. The program offers some flexibility that is needed to rapidly resolve complex regions within a working session. The sole purpose of the release is to promote collaborative creation of extensible software for fragment assembly editors, foster collaborative development, and reduce barriers to initial tool development effort. We describe our software architecture and identify current challenges. The program is available under an Open Source license.

• Korean Membrane Journal
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• 제5권1호
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• pp.1-9
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• 2003

Due to the increasing intelligence, the increasing connectivity, and always-on characteristics energy needs for the portable electronics cannot be managed by the state-of-art battery technology. Micro fuel cell fuelled by aqueous methanol is gaining lots of interest from the new energy storage developers since it has the potential to offer the longer operation time to the portable electronic devices. Although the technical barriers to the commercialization exit, it is expected that the micro fuel cell technology bring huge benefits to the current energy storage market once it matures. In the article, benefits, challenges and market players of the direct methanol fuel cell arena is briefly reviewed.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2013년도 춘계학술발표대회
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• pp.175-178
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• 2013

Mobile Virtual Desktop Infrastructures (mVDI) are gaining popularity in cloud computing by allowing mobile devices to execute their mobile applications in a cloud server instead of relying on physical mobile devices. Consolidating many users into mVDI environment can significantly lower IT management expenses and enables new features such as "available-anywhere" desktops. However, there are many barriers to broad adoption including the slow performance of virtualized I/O, CPU scheduling interference problems. In this paper, we will discuss about mVDI with the current issues, the corresponding solutions and challenges.

• 한국수학교육학회지시리즈A:수학교육
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• 제63권1호
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• pp.1-18
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• 2024

본 연구는 고등학교 1학년 노력형 학생들이 (1) 수학 서술형 평가에서 보이는 어려움에 대한 분석과 (2) 이를 극복하기 위한 쓰기 활동 지도 방안을 탐구하고자 하였다. 이를 위해 서술형 문항으로 이루어진 검사를 수행한 후 검사 결과를 바탕으로 학생들과 면담을 진행하고, 15회에 걸쳐 수학 노트 쓰기 활동을 지도하였다. 연구 결과에 따르면 학생들은 서술형 평가에서 20가지의 어려움을 보였다. 이를 '수학적 어려움'과 '서술형 어려움' 등 2가지 범주로 분류한 결과 수학이라는 과목 특성에서 보이는 어려움은 수학 개념과 원리의 이해 부족, 수학 기호 사용의 어려움, 문장제 문항에 대한 어려움, 수학에 대한 고정관념에서 오는 어려움이 있었다. 서술형 문항이라는 특성에서 보이는 학생의 어려움은 객관식 문항과는 다른 평가 방법에서 오는 어려움, 서술형 문항의 풀이 과정 기술의 어려움, 기타 심리적인 어려움이 있었다. 노력형 학생들이 서술형 평가에서 보이는 어려움을 극복할 수 있는 학습전략의 일환으로 개별 수학 노트 쓰기 활동을 지도하였고 (1) 수학적 개념의 내면화, (2) 관계적 이해를 통한 정당화, (3) 다양한 풀이 시도, (4) 수학적 기호 사용, (5) 반성적 사고, (6) 심리적 방해 요소 극복으로 범주화하고 지도 과정 및 효과에 대하여 정리하였다.

• 자원ㆍ환경경제연구
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• 제11권2호
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• pp.211-231
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• 2002

This paper summarizes the results of a study that assess how a demand side management (DSM) system addresses key economic and environmental challenges facing in the Korean natural gas sector considering; ${\bullet}$ high discrepancies of seasonal consumption volume and of load factor in unmatured domestic LNG market, ${\bullet}$ unfavorable and volatile international LNG market, imposing with the contestable "take-or-pay" contract terms, ${\bullet}$ low profile of LNG and existence of market barriers against an optimal fuel mix status in the industrial energy sector. A particular focus of this study is to establish an 'extended' DSM system in the unmatured gas market, especially in industry sector, that could play a key role to assure an optimum fuel mix scheme. Under the concept of 'extended' DSM, a system dynamics modeling approach has been introduced to explore the option to maximize economic benefits in terms of the national energy system optimization, entailing different ways of commitments accounting for different DSM measures and time delay scenarios. The study concludes that policy options exist that can reduce inefficiencies in gas industry and end-use system at no net costs to national economy. The most scenarios find that, by the year 2015, it is possible to develop a substantial potential of increased industrial gas end-uses under more reliable and stable load patterns. Assessment of sensitivity analysis suggests that time delay factor, in formulating DSM scenarios, plays a key role to overcome various market barriers in domestic LNG market and provides a strong justification for the policy portfolios 'just in time' (time accurateness), which eventually contribute to establish an optimum fuel mix strategy. The study indicates also the needs of advanced studies based on SD approach to articulate uncertainty in unmatured energy market analysis, including gas.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.4961-4964
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• 2013

Greater use of mobile phone devices seems inevitable because the health industry and cancer care are facing challenges such as resource constraints, rising care costs, the need for immediate access to healthcare data of types such as audio video texts for early detection and treatment of patients and increasing remote aids in telemedicine. Physicians, in order to study the causes of cancer, detect cancer earlier, act in prevention measures, determine the effectiveness of treatment and specify the reasons for the treatment ineffectiveness, need to access accurate, comprehensive and timely cancer data. Mobile devices provide opportunities and can play an important role in consulting, diagnosis, treatment, and quick access to health information. There easy carriage make them perfect tools for healthcare providers in cancer care management. Key factors in cancer care management systems through a mobile phone health approach must be considered such as human resources, confidentiality and privacy, legal and ethical issues, appropriate ICT and provider infrastructure and costs in general aspects and interoperability, human relationships, types of mobile devices and telecommunication related points in specific aspects. The successful implementation of mobile-based systems in cancer care management will constantly face many challenges. Hence, in applying mobile cancer care, involvement of users and considering their needs in all phases of project, providing adequate bandwidth, preparation of standard tools that provide maximum mobility and flexibility for users, decreasing obstacles to interrupt network communications, and using suitable communication protocols are essential. It is obvious that identifying and reducing barriers and strengthening the positive points will have a significant role in appropriate planning and promoting the achievements of mobile cancer care systems. The aim of this article is to explain key points which should be considered in designing appropriate mobile health systems in cancer care as an approach for improving cancer care management.

• International Journal of Computer Science & Network Security
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• 제21권4호
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• pp.255-263
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• 2021

Smart grid is a fully-automated, bi-directional, power transmission network based on the physical grid system, which combines sensor measurement, computer, information communication, and automatic control technology. Blockchain technology, with its security features, can be integrated with Smart Grids to provide secure and efficient power management and transmission. This paper dicusses the deployment of Blockchain technology in Smart Grid. It presents application areas and protocols in which blockchain can be applied to in securing smart grid. One application of each area is explored in detail, such as efficient peer-to-peer transaction, lower platform costs, faster processes, greater flexibility in power generation to transmission, distribution and power consumption in different energy storage systems, current barriers obstructing the implementation of blockchain applications with some level of maturity in financial services but concepts only in energy and other sectors. Wide range of energy applications suggesting a suitable blockchain architecture in smart grid operations, a sample block structure and the potential blockchain technicalities employed in it. Also, added with efficient data aggregation schemes based on the blockchain technology to overcome the challenges related to privacy and security in the smart grid. Later on, consensus algorithms and protocols are discussed. Monitoring of the usage and statistics of energy distribution systems that can also be used to remotely control energy flow to a particular area. Further, the discussion on the blockchain-based frameworks that helps in the diagnosis and maintenance of smart grid equipment. We have also discussed several commercial implementations of blockchain in the smart grid. Finally, various challenges have been discussed for integrating these technologies. Overall, it can be said at the present point in time that blockchain technology certainly shows a lot of potentials from a customer perspective too and should be further developed by market participants. The approaches seen thus far may have a disruptive effect in the future and might require additional regulatory intervention in an already tightly regulated energy market. If blockchains are to deliver benefits for consumers (whether as consumers or prosumers of energy), a strong focus on consumer issues will be needed.