• 한국동물위생학회지
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• 제30권4호
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• pp.497-503
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• 2007

The humoral immune response of chicken vaccinated with fowl and pigeon pox virus vaccines was determined with the protective potentiality of the two vaccines in field condition of Bangladesh. Different aged Fayoumi chicks were subjected for the study. To assess the relationship with better immune response among experimental groups, the average percentage of 'take reaction' was examined and recorded to 97.77% in group A, 93.33% in group B and 100.0% in group C. The level of immune status induced by different vaccinated group was measured by passive hemagglutination (PHA) microplate test method. The mean PHA titer levels after primary vaccination were $33.06{\pm}14.13$ in group A, $32.0{\pm}14.81$ in group B, and $33.0{\pm}13.66$ in group C. Following booster vaccination, the mean PHA titer levels in prior of challenge were increased to $55.46{\pm}14.64$ in groups A and C, and $46.93{\pm}16.52$ in group B. The recorded PHA titer levels of each group at two weeks after challenge were significantly increased to $106.66{\pm}31.22$, $93.86{\pm}33.04$ and $110.93{\pm}29.29$, respectively. The PHA titer levels after vaccination and challenge were significantly increased compared to pre-vaccination titer levels (P<0.01). Although the PHA titer levels among three groups administrated different vaccine combinations in prior of challenge were significantly varied (P<0.01), it was observed that all of the vaccinated chicks were highly protected against challenge infection.

• 경영정보학연구
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• 제8권1호
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• pp.125-139
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• 2006

본 연구는 Csikszentmihalyi(1977)에 의해서 소개되고 Hoffman과 Novak(1996)에 의해서 확장된 플로우 개념을 수용하여 모바일 인터넷 서비스의 사용에 있어 Novak, Hoffman과 Yung(1997)이 이론화한 플로우(flow)개념을 도입하여 모바일 인터넷 환경요인들이 플로우 및 플로우 선행요인에 영향을 미치는지를 확인해 보고 기존 인터넷 환경에서와 같이 모바일 인터넷 환경에서도 플로우 이론이 성립되는가를 구조 방정식분석을 통해 검정해 보았다. 본 연구는 서비스 수용모델과 플로우 개념에 관한 문헌연구, 설문조사, 모바일 인터넷 플로우 모델의 제시, 그리고 가설검정으로 구성되며 그 결과는 다음과 같다. 첫째, 플로우 선행요인인 도전감에 영향을 미치는 요인은 인터넷 환경요인 중 매체 특성, 컨텐츠 특성, 모바일 인터넷 매체의 사용 편의와 정보전송 품질, 컨텐츠의 유일성, 적시성, 간결성으로 나타났다. 둘째, 플로우 선행요인인 숙련도에 영향을 미치는 요인은 컨텐츠특성, 요금특성, 사용특성이며 컨텐츠의 유일성, 적시성, 간결성, 그리고 요금청구의 명확성, 요금제선택의 다양성, 즉시 연결성이 숙련도에 영향을 미치는 것으로 나타났다. 플로우 선행변인인 도전감은 플로우에 정(+)의 유의한 영향을 미치는 것으로 나타났다. 이러한 결과는 소비자들의 모바일 인터넷 사용에 있어 도전적 태도가 플로우 경험에 영향을 미치며 도전감을 증가 시키는 모바일 인터넷 특성을 통해 통찰력 있는 시각을 제시해준다.

• Clinical and Experimental Reproductive Medicine
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• 제23권3호
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• pp.283-292
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• 1996

Objective: To determine the cutoff value of clomiphene citrate challenge test(CCCT) that can predict the normal and abnormal(diminished) ovarian response group and to assess the usefulness of CCCT as a predictor of ovarian reserve. Materials and Methods: From March 1994 to Februry 1996, CCCT was performed to 129 infertile patients and among them, 20 patients whose basal FSH on the third day of menstrual cycle was more than 20 mIU/ml were excluded. At the same time, the same CCCT was performed to the fifteen healthy volunteers with proven fertility to determine the cutoff value of CCCT. Results; 1) A FSH value higher than 23.4 mIU/ml, measured on the 10th day of menstrual cycle, was defined as a abnormal ovarian response. The cutoff value of 23.4 mIU/ml is more than 2 standard deviations(SD) above the mean value of 15 healthy women after CCCT. 2) The abnormal CCCT group, the subpopulation with a FSH value of 23.4 mIU/ml or more, was 7.3%(8/109) and their mean age was higher than the normal CCCT group($36.5{\pm}4.5$ vs. $32.9{\pm}4.8$, P = 0.059). And the percentage of the patients older than 35 years of the abnormal CCCT group was significantly higher than that of the normal CCCT group(62.5% vs. 38.6%, p <0.05). 3) There was no correlation between the hormone values of the third day and the 10th day of menstrual cycle before and after CCCT except between FSH of the third day and the 10th day. Conclusion: The CCCT is a good method to predict the individual ovarian response to COH for ART, especially in the patients who has no other abnormal findings that predict poor prognosis. And it is neccessary to determine the cutoff value of CCCT by the large numbers of randomized study, and combining the previously proven prognostic factors, it can be applicated in many individual centers for evaluate the ovarian response before ART program.

• 한국미생물·생명공학회지
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• 제42권4호
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• pp.386-392
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• 2014

본 연구에서는 감초성분인 glycyrrhizin, liquiritin, liquiritigenin, isoliquiritigenin의 항균활성을 측정하고, 원산지별 감초 추출물에서 항균활성 성분인 isoliquiritigenin과 liquiritigenin을 정량하여 비교평가하였다. 또한 challenge test를 통하여 가장 뛰어난 항균활성을 나타낸 isoliquiritigenin과 합성 방부제인 메틸 파라벤과의 방부력을 비교하였다. 감초 성분의 항균활성을 disc diffusion assay를 통해 측정한 결과, Liquiritigenin과 isoliquiritigenin이 B. subtilis, P. acnes, E. coli, P. aeruginosa에 대해 저해활성을 보였다. 특히 감초성분 중 큰 항균활성을 나타낸 isoliquiritigenin과 합성 방부제로 사용되는 메틸 파라벤과 프로필 파라벤의 최소저해농도를 비교한 결과 isoliquiritigenin이 강력한 항균활성을 나타내는 것을 확인하였다. HPLC를 통해 원산지별 감초 추출물 isoliquiritigenin과 liquiritigenin을 정량한 결과, 이들의 함량은 한국산 감초가 중국산 감초와 우즈베키스탄산 감초보다 높은 것을 확인하였다. 이를 통해 한국산 감초가 우수한 항균력을 나타내는데 isoliquiritigenin, liquiritigenin 함량이 영향을 미치는 것으로 판단된다. Isoliquiritigenin의 B. subtilis, P. acnes, E. coli, P. aeruginosa에 대한 challenge test를 통해 메틸 파라벤 보다 isoliquiritigenin이 뛰어난 방부력을 나타냄을 확인하였다. 이상의 본 연구 결과로부터 감초 성분의 항균활성을 확인하였고, 원산지별 감초(한국, 중국, 우즈베키스탄) 중 한국 감초가 우수한 항균력을 나타내는데 isoliquiritigenin과 liquiritigenin 함량이 영향을 미치는 것으로 사료된다. 또한 감초 성분 중 가장 우수한 항균활성을 나타낸 isoliquiritigenin은 파라벤류를 대체 할 수 있는 천연 보존제로써 이용 가능성이 있다고 판단된다.

• 항공우주시스템공학회지
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• 제10권4호
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• pp.84-89
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• 2016

전자전(EW)은 전자기 영역에서 우위를 차지하고 유지하기 위한 임무분야이다. 이러한 중요 임무를 수행하기 위해 현대 군용기에 적용되는 전자전 장비의 시험평가는 전장 환경의 요구사항을 충족하기 위해 전자전 시스템이 준비되었음을 사용자에게 보여주기 위한 폭넓은 시험 기술과 해석 기법이 요구된다. 본 논문은 전자전 장비, 특히 RWR, CMDS의 시험평가 기술을 소개하고, 초보 엔지니어 뿐 아니라 경험을 보유한 엔지니어 및 사업관리자에게 전자전 장비의 시험평가 절차와 시험 자원에 대한 참조자료로 사용될 것이다.

• 반도체디스플레이기술학회지
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• 제22권3호
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• pp.62-66
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• 2023

With the advancement in technology and rapid increase in the demand for microelectromechanical systems (MEMS) based inertial measurement units (IMUs), high-volume production and test system remain a major challenge for the MEMS industry. To compete with the challenging market of Industry 4.0, here we developed an automatic test system to evaluate the performance of the ovenized IMU sensors as well as analyze the data. The automatic test system was developed by interfacing a commercial MEMS IMU (BMI 088) using LabVIEW. The BMI 088 was tested experimentally for long-term bias stability, ON/OFF bias repeatability, and root mean square (rms) noise. Furthermore, the data was analyzed through the developed test system. The results show that the automatic test system has improved the test time and reduced human effort. The developed automatic test system is a significant approach to MEMS research and development (R&D) to increase and improve the mass production of IMUs.

• Clinical and Experimental Pediatrics
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• 제50권5호
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• pp.422-429
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• 2007

Measurement of lung function is an integral component of respiratory physiology and of clinical assessment of lung diseases in school age children and adults. Pulmonary function test of infants and children under the age of 2 years have now been standardised and are being used both in research and as an adjunct to clinical management. By contrast, until recegntly, children of preschool age, i.e. between 2-6 years represented a major challenge for pulmonary function test assessment, this particular period commonly being referred to as the 'dark ages' of Pediatric Pulmonology. Measurement of lung function in preschool-aged children is now feasible. However, much work remains to be done in standardizing how these tests are performed, and in understanding the most appropriate role for the various tests in the study of growth and development of the respiratory system and in the clinical management of children in this age group. As the field develops and the knowledge of respiratory physiology in this age group expands, investigation of different and more appropriate algorithm use in preschool children, together with development of more appropriate reference data, may result in improved disease discrimination.

• Nuclear Engineering and Technology
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• 제42권4호
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• pp.414-425
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• 2010

In this paper, a procedure is developed for identifying a number of representative solutions manageable for decision-making in a multiobjective optimization problem concerning the test intervals of the components of a safety system of a nuclear power plant. Pareto Front solutions are identified by a genetic algorithm and then clustered by subtractive clustering into "families". On the basis of the decision maker's preferences, each family is then synthetically represented by a "head of the family" solution. This is done by introducing a scoring system that ranks the solutions with respect to the different objectives: a fuzzy preference assignment is employed to this purpose. Level Diagrams are then used to represent, analyze and interpret the Pareto Fronts reduced to the head-of-the-family solutions.

• Biotechnology and Bioprocess Engineering:BBE
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• 제9권6호
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• pp.490-494
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• 2004

An efficacy test of PRP (polyribosylribitol phosphate)-TT (Tetanus toxoid) conjugate vaccines was carried out using BALB/c mice as an animal model by inoculating Haemophilus in­fluenzae type b (Hib) with a virulence enhancement factor (VEF). Three administrations of the conjugate vaccines at 2-week intervals elicited a significantly high level of PRP antibodies (P>0.0001). The protective activity of the PRP immunization was challenged with either Hib with iron dextran (Hib/) or with a combination of mucin and hemoglobin (Hibmh) as a VEF. The me­dium lethal dose $(LD_{50})$ for Hibmh and Hibiwas measured as 10 CFU (Colony Forming Unit) and $2.5{\times}10^{8}$ CFU respectively. Each immunized animal was challenged with five or ten times the $LD_{50}$ level of bacteria with a VEF. A significant difference in mortality between the immunized and control mice (P> 0.01) was observed with the Hibmh challenge inoculation but not with the Hibi challenge inoculation. These results show that a combination of mucin and hemoglobin was able to enhance the virulence of Hib in BALB/c mice to cause a lethal infection, thus suggesting that BALB/c mice introduced to this method can be an effective model animal for testing the protective efficacy of H. influenzae conjugate vaccines.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제24권4호
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• pp.392-402
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• 2021

Purpose: The present study assessed the role of an amino acid-based formula (AAF) in the growth of infants with cow's milk protein allergy (CMPA). Methods: Non-breastfed, term infants aged 0-6 months with symptoms suggestive of CMPA were recruited from 10 pediatric centers in China. After enrollment, infants were started on AAF for two weeks, followed by an open food challenge (OFC) with cow's milk-based formula (CMF). Infants with confirmed CMPA remained on AAF until 9 months of age, in conjunction with a cow's milk protein-free complementary diet. Body weight, length, and head circumference were measured at enrollment and 9 months of age. Measurements were converted to weight-for-age, length-for-age, and head circumference-for-age Z scores (WAZ, LAZ, HCAZ), based on the World Health Organization growth reference. Results: Of 254 infants (median age 16.1 weeks, 50.9% male), 218 (85.8%) were diagnosed with non-IgE-mediated CMPA, 33 (13.0%) tolerated CMF, and 3 (1.2%) did not complete the OFC. The mean WAZ decreased from 0.119 to -0.029 between birth and enrollment (p=0.067), with significant catch-up growth to 0.178 at 9 months of age (p=0.012) while being fed the AAF. There were no significant changes in LAZ (0.400 vs. 0.552; p=0.214) or HCAZ (-0.356 vs. -0.284; p=0.705) from the time of enrollment to age 9 months, suggesting normal linear and head growth velocity. Conclusion: The amino acid-based study formula, in conjunction with a cow's milk proteinfree complementary diet, supported normal growth till 9 months of age in a cohort of Chinese infants with challenge-confirmed non-IgE-mediated CMPA.