• Journal of Veterinary Clinics
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• 제7권1호
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• pp.391-402
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• 1990

To examine the effects of vaccination against Babesia gibsoni infection in dogs, 15 normal mixed-breed dogs(5 month to 1 year old) divided into 3 groups with 5 dogs in a group. One of them was selected as control group(group A) and others were selected as experimental groups(group B and C). The group B was vaccinated with sonicated antigens and the group C was vaccinated with 0.2% of formalin treated antigens. The results obtained in the examination were summarized as follows : 1. In the western blot, the lane A revealed specific two bands on the regions of 54kd and 100kd, respectively. 2. After the first vaccination, the antibody titers of group B and C were higher 5 times(1 ： 200) than those of control group(1：40). After the second vaccination, the antibody titers of group B and C have not changed. When challenged with the protozoa(Babesia gibsoni), the antibody titers(1 : 5,000) were elevated in all groups. But these were not exceeded over 1 ： 5,000 for 4 weeks. 3. After challenge, the peak time of increased numbers of the protozoa was the 15th day (12-18 days) in all groups. During these days, the rate of parasitized erythrocytes in control group was 55.0${\pm}$5.4%. But those of group B and group C were 26.0${\pm}$6.4%, and 15.6${\pm}$7.8％, respectively. 4. After challenge, all of the values of PCV, Hb, RBC were shown to decrease in all of the control and experimental groups. 5. The total leukocytes counts are shown a tendency of reduction in all groups after challenge. 6. In all groups, there were increase in lymphocytes and monocytes after challenge.

• The Journal of the Korea Contents Association
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• 제11권5호
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• pp.291-301
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• 2011

This research describes the comparison broker's role and its effectiveness measurement framework of comparison shopping. We verified seller-led comparison challenge method provide comparison information of products to buyers more efficiently. Buyer's satisfaction of purchase (S) can be defined as an interactive function between seller's competitiveness vector (P) of products that supplied to the market, and buyer's informed level vector (B) of products that is known from a lot of sources. Then the buyer's informed level can be changed through the information analysis among products by transformation process using comparison matrix (C). So the role of comparison shopping is to construct a comparison matrix and to serve it to the buyers, and to change the buyer's informed level. The changed informed level influences a buyer's satisfaction, that improved satisfaction of purchase is defined as the effectiveness of comparison shopping. As a perfect construction and usage of comparison matrix is impossible, a more efficient method for improving the comparison effectiveness is the comparison challenge. This research shows that comparison shopping makes 9.32% and comparison challenge makes 19.11% enhancement of comparison effectiveness through television market data experiments.

• Journal of Korea Game Society
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• 제15권4호
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• pp.169-178
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• 2015

Providing various levels of difficulty of game play is one of important considerations in game development. In this paper, we propose a method for obtaining the challenges that will be placed on the track of an one-player car driving game. Herein challenges denote obstacles on the track, and the level of difficulty is represented by an estimated time needed for driving one lap of the track. In the proposed method, the problem for finding challenge placement is modeled as an IP(Integer Programming) one, and then LP relaxation and Simultaneous Annealing are employed to find a solution. To the experiment with the proposed method, we can obtain challenge placements to approximately meet given target driving times. Also, after practically driving on the track where those obtained challenges are being placed, it is seen that the average driving times approximate the target driving times of those challenge placements. Our method can allow game play with various levels of difficulty so that the users' interest and the level of immerse are expected to be raised.

• Journal of the Korean Society of Food Science and Nutrition
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• 제29권1호
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• pp.140-146
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• 2000

Even though coix (Coix lachryma-jobi L. var. ma-yuen) has many physiological effects, since it has been known to cause sterility, farmers avoid using coix bran as a forage for their livestock. Therefore, as the consumption of coix increases, coix bran, which is a by product of pounding process, becomes a serious issue of environmental problem. Present study examined the physiological effects of coix bran in normal and diabetic rats for its possible use as a functional material. The effects of coix bran supplementation on plasma and hepatic lipid profile were evaluated in rats fed one of the following diet for 12 weeks : chow diet ; chow-bran diet (chow diet＋25% coix bran), high fat diet and high fat-bran diet (high fat diet＋25% coix bran). Additionally, glucose challenge and lipid metabolism in streptozotocin-diabetic rats were also examined. In normal rats, consumption of coix bran remarkably reduced body weight gain in chow or high fat diet fed rats. Additionally, consumption of coix branreduced blood TG, TC and atherogenic index (26%, 24% and 72%, respectively) in chow diet fed rats. Liver TG and cholesterol concentrations were reduced (43% and 49%, respectively) in high fat fed rats by coix bran supplementation. In diabetic rats, fasting blood glucose level was reduced about 25% by coix bran consumption. Also, glucose challenge pattern was improved and resembled normal pattern : it reaches to peak 15~30 minutes after glucose administration and get back to fasting blood glucose level after 90 minutes. Plasma concentrations of TG were elevated in diabetic rats and were reduced to normal level by coix bran supplementation. Liver TG and cholesterol concentrations were also elevated in diabetic rats and reduced to normal level by consumption of coix bran. These results suggest that coix bran may have beneficial effects on blood lipid and glucose level in normal and diabetic rats.

• Journal of Animal Science and Technology
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• 제63권3호
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• pp.501-509
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• 2021

The aim of this was evaluate the efficacy of lysozyme on growth performance, nutrient digestibility, excreta microflora population, and blood profiles of weanling pigs under Escherichia coli (E. coli) challenge. A total of 30 piglets weaned at 25 days, 7.46 kg body weight, were assigned to three dietary treatments, composed of five replications, two piglets per replication, for 7 days. The dietary treatment groups were negative control (NC; without antibiotics and lysozyme), positive control (PC; NC + antibiotics), lysozyme (NC + 0.1% lysozyme). All piglets were challenged orally with 6 ml suspension, containing E. coli K88 (2 × 10⁹ CFU/mL). Dietary supplementation with lysozyme and PC resulted in no significant differences in average daily gain and gain to feed efficiency. Weanling pigs fed with E. coli challenge with lysozyme and PC treatments had significantly enhanced nutrient retentions of dry matter and energy (p < 0.05); however, there was a tendency to increase nitrogen digestibility. Furthermore, dietary inclusion of lysozyme and antibiotics treatment groups had a beneficial effect on excreta, ileal, and cecal of the fecal microbial population as decreased E. coli (p < 0.05) counts, without effects on lactobacillus counts. A significant effect were observed on a white blood cells, epinephrine and cortisol concentrations were reduced in piglets fed diets containing E. coli challenge with lysozyme and antibiotics supplementation comparison with the NC group. Therefore, the present data indicate that lysozyme in diet could ameliorate the experimental stress response induced by E. coli in piglets by decreasing intestinal E. coli, white blood cells and stress hormones and improving nutrient digestibility.

• The Journal of the Korea Contents Association
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• 제19권3호
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• pp.466-474
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• 2019

The purpose of this study was to investigate the enhancing creative competency and changes in academic challenge for the pre-service teachers. For this purpose, 94 pre-service teachers participated in project learning through the preparation of the convergence instruction and the class demonstration during one semester. The pre and post questionnaire survey was conducted the measurement of creative leader competence and K-NSSE for academic challenge. Analysis of data was performed using the IBM SPSS 18.0 program for the corresponding sample t test. The creative competency included 'higher mental thinking', 'problem solving', 'curiosity', 'sensitivity' 'task commitment', 'the pursuit of social value', and 'co-operations and considerations'. This results was significant(p< .05). Academic challenge, high-order learning domain and learning strategies domain were significant(p< .05). Based on this, in order to generalize the convergence education and convergence lesson, it is necessary to design various convergence lessons and practice study to make a plan and practice it. In addition, the implications for the necessity of correcting and supplementing the effects after repeated convergence lessons were discussed.

• International Journal of Advanced Culture Technology
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• 제6권4호
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• pp.275-283
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• 2018

Cancer show distinct pattern of gene expression when it is compared to normal. This difference results malignant characteristic of cancer. Many cancer drugs are targeting this difference so that it can selectively kill cancer cells. One of the recent demand for personalized treating cancer is retrieving normal tissue from a patient so that the gene expression difference between cancer and normal be assessed. However, in most clinical situation it is hard to retrieve normal tissue from a patient. This is because biopsy of normal tissues may cause damage to the organ function or a risk of infection or side effect what a patient to take. Thus, there is a challenge to estimate normal cell's gene expression where cancers are originated from without taking additional biopsy. In this paper, we propose in-silico based prediction of normal cell's gene expression from gene expression data of a tumor sample. We call this challenge as reverting the cancer into normal. We divided this challenge into two parts. The first part is making a generator that is able to fool a pretrained discriminator. Pretrained discriminator is from the training of public data (9,601 cancers, 7,240 normals) which shows 0.997 of accuracy to discriminate if a given gene expression pattern is cancer or normal. Deceiving this pretrained discriminator means our method is capable of generating very normal-like gene expression data. The second part of the challenge is to address whether generated normal is similar to true reverse form of the input cancer data. We used, cycle-consistent adversarial networks to approach our challenges, since this network is capable of translating one domain to the other while maintaining original domain's feature and at the same time adding the new domain's feature. We evaluated that, if we put cancer data into a cycle-consistent adversarial network, it could retain most of the information from the input (cancer) and at the same time change the data into normal. We also evaluated if this generated gene expression of normal tissue would be the biological reverse form of the gene expression of cancer used as an input.

• Journal of The Korean Association of Information Education
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• 제23권1호
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• pp.65-72
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• 2019

As the importance of SW education grows, researches are actively being conducted to improve students' thinking skills. We conducted the group III tasks, which are experiencing and challenging in Beaver Challenge 2018, on 55 students of 5th grade in elementary school. Based on the result, we analyzed their average scores and defined whether each test has a correlation with possession of smartphone, computer familiarity, patience, concentration, and academic ability. The result indicated challenging task boosted the average score, the percentage of correct answers, and the percentage of correct answers for each level of difficulty. Moreover, the challenge task scores were higher as they higher computer familiarity, patience and concentration level. However, possession of smartphones and academic ability did not affect the score. Lastly, the scores were affected by different factors in different level of difficulty that patience factor in advanced level, computer familiarity factor in intermediate level, and concentration factor in beginner level. Thus, further researches are necessary to be conducted to expand the scope of the analysis through the diversification of test subject group and expansion of an evaluation area.

• KSCE Journal of Civil and Environmental Engineering Research
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• 제39권2호
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• pp.345-349
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• 2019

The National Aeronautics and Space Administration (NASA) has long been studying the essential elements of manned planetary exploration and has held several international challenges to encourage the research works related to it. One of them was the NASA Centennial Challenge Programs which started in 2015. Following the second in 2017, the third is currently going on in 2019. Participating "3D-Printed Habitat Challenge", one of the challenges in the second program, this research team designed and developed the 3D printer extruding module for the Lunar Simulant (Korea Hanyang Lunar Simulant-1; KOHLS-1) and the polymer. For optimizing the modul, a cylindrical specimen of ${\varnothing}150{\times}300mm^3$ volume and a specimen of $200{\times}100{\times}650mm^3$ volume were manufactured and their compressive and flexural strengths were tested. The findings can help automatize the space construction in the future.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제20권6호
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• pp.48-54
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• 2019

This study was based on Job Demand-Resource Model and tried to understand the causes of presenteeism that work but have decreased productivity in spite of health problems. In order to examine the psychological causes of presenteeism, we reinterpreted job resources as psychological capital, which is a psychological resource of personal dimension, and examined the positive and negative aspects of job demands by classifying job demands into challenge and hindrance stressors. Data analysis was conducted using SPSS 21.0 and AMOS 20.0 statistical programs. Data were gathered from 329 employee in Korea. The results of this study are as follows: Hindrance and challenge stressor and psychological capital were fully mediated in the influence of presenteeism through job engagement, and hindrance stressor and psychological capital were fully mediated in the influence of presenteeism though job burnout. Based on the results.