• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3809-3813
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• 2013

Background: X-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision repair pathway, as a scaffold protein that brings together proteins of the DNA repair complex. XRCC1 is reported to be a candidate influence on cancer risk. The aim of our present study was to assess the association of rs1799782 (Arg194Trp) and rs25487 (Arg399Gln) XRCC1 gene polymorphisms with breast cancer in the Saudi population. Materials and Methods: The two SNP's were analyzed in breast cancer patients and healthy control subjects. Genotypes were determined by TaqMan SNP genotype analysis technique and data were analyzed using Chi-square or t test and logistic regression analysis by SPSS16.0 software. Results and Conclusions: Results showed that rs1799782 significantly increased susceptibility to breast cancer with Arg/Trp, Arg/Trp+Trp/Trp genotypes and at Trp allele overall study. It also increased risk of breast cancer in older age patients (above 48) and with the ER positive category. XRCC1rs25487 (Arg399Gln) did not showed any significant association. In conclusion the XRCC1rs1799782 polymorphism may be involved in the etiology of breast cancer in the Saudi population. Confirmation of our findings in larger populations of different ethnicities is warranted.

• Korean Institute of Interior Design Journal
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• no.13
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• pp.187-196
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• 1997

A Study on the Characteristics of the Modern Chair Design The features of the modern chair design results from the diverse life style unfolded as per the 20th century social structure and the change of the residential space, and new design has been being developed by the scientists and the artists in various fields through their cooperated work in a way. The field of the scientific or technical study and creation of arts can be developed where they can evoke the sympathy in the circumstances under which the various styles of both arts and science meet across, complement crash together, and grow up. The operation which can control in the network of such pluralistic sphere has been needed for a long period and it has been facing the needs from a time and society. The engineering furniture as the counterplan of the above has brought the value of materials into relief to the forms of human life by making the properties of matter the maximum value or changing it. It can be summarized as following characteristics in its materials and forms along as well as the 3 types (handycrafty, mechanical, and ecological expression) in process through the 20th century. 1. Characteristics in Materials elasticity of the chair as per the changes of the flexibility in the steel pipe development of systematic chair using the plasticity of the plywood, plastic, and wire lightweight due to the materials such as aluminum. 2. Formative characteristics formative simplicity for the increase of the function and the quality improvement such as sociality, productivity, environmental and aesthetic nature emphasis on the structure as per the architectural environment and tecniques pursuit of the forms as a container of the human body seeking for the formative values as the cultural symbols coping with the needs from thepluralistic social structure Furniture is not the makeup for convenience sake but most importantexpression as necessaries of our environments. It should identify itself always as per these kind of needs and also it should be able to used to keep the relation of such mutual division, otherwise the purchase of new furniture should be necessary according to every change of the existing situatiov. Our residence doesn't need the specific style but expresses only the properties of the dwellers.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.7
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• pp.476-482
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• 2017

This study examined the effects of the seat height of a chair on the muscle activity of the erector spinae and rectus abdominis. Thirty healthy subjects were asked to sit on chairs at three different seat heights. The muscle activities of both the erector spinae and rectus abdominis were measured by surface electromyography. The data were analyzed by repeated one way ANOVA and the muscle activity was compared according to the seat height. The alpha level was set to 0.05. The results showed that the muscle activities of the erector spinae were not significantly different among the three seat heights. The muscle activities of the rectus abdominis were significantly different among the three seat heights. Both the rectus abdominis muscle activities were significantly greater in the low seat height than the other seat heights. These results showed that the seat height of the chair affects the muscle activities of the rectus abdominis muscle, leading to musculoskeletal pain, such as low back pain. Therefore, the seat height of a chair with a correct sitting position is important for preventing musculoskeletal pain.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.42 no.4
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• pp.1-7
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• 2019

The customer of massage chair is expanding day by day from middle age to all ages. In 2018, the market size was 700 billion KRW, an increase of 30 times over 10 years. However, most related SMEs suffer from excessive competition by the market monopoly of some major companies. In this situation, in order for a related company to survive, it is necessary to steadily research and develop new products. Founded in 2009, company L produces massage chairs for health and relaxation of customers. L's products use a sound wave vibration module that is favorable for human body, unlike other products that use vibration motor type. However, frequent breakdowns of massage chair due to the vulnerability of plate (leaf) springs, which play an important role in sound wave vibration modules, made sap its competitiveness. In this paper, we propose a method to design desirable plate spring structure by sequentially experimenting with five different plate springs. The results of this study are expected to contribute to improve the quality of plate spring and the reliability of sound wave vibration module. In the future, it is necessary to find a way to use it in the development of foot massage or scalp management device as well as continuous research to find optimal plate spring structure through various analysis.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6469-6474
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• 2012

Background: DNA repair is one of the crucial defense mechanism against mutagenic exposure. Inherited SNPs of DNA repair genes may contribute to variation in DNA repair capacity and susceptibility to cancer. Due to the presence of these variants, inter-individual and ethnic differences in DNA repair capacity have been established in various populations. India harbors enormous genetic and cultural diversity. Materials and Methods: In the present study we aimed to determine the genotypes and allele frequencies of XRCC1 Arg399Gln (rs25487), XRCC3 Thr241Met (rs861539), XPD Lys751Gln (rs13181), and OGG1 Ser326Cys (rs1052133) gene polymorphisms in 186 healthy individuals residing in the Hyderabad region of India and to compare them with HapMap and other populations. Results and Conclusions: The genotype and allele frequency distribution at the four DNA repair gene loci among Hyderabad population of India revealed a characteristic pattern. Comparison of these gene polymorphisms with other populations revealed a distinctiveness of Hyderabad population from the Deccan region of India. To the best of our knowledge, this is the first report of such DNA repair gene polymorphisms in the Deccan Indian population.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1247-1250
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• 2015

Background: Psoriasis, a common cutaneous disorder characterized by inflammation and abnormal epidermal proliferation with a prevalence of 2-3% in the general population, may be linked to certain types of cancer. Several studies have reported an association between interleukin 10 (IL-10) variant polymorphisms and inflammatory diseases such as psoriasis vulgaris although the results vary according to the population studied. No studies have been performed in the Saudi population. The present study concerned novel variants and other genetic polymorphisms of the promoter and exonic regions of the IL10 gene in patients with moderate to severe psoriasis and potential differences in genotype compared to a group of healthy volunteers. Materials and Methods: Patients with moderate to severe psoriasis and healthy controls with no personal or family history of psoriasis were selected from the central region of Saudi Arabia. Polymorphisms of the IL 10 gene of both groups were genotyped. Results: We observed two novel variants in 5'UTR region of the promoter precursor with higher prevalence of the genotype with both wild-type alleles in patients compared to the healthy control group. The differences at positions -377 and -150 were significantly associated with disease, both the variants conferred strong protection against psoriasis in Saudi patients. Conclusions: This observation provides further support for the importance of the part that IL10 plays in the pathophysiology of this disease. Confirmation of our findings in larger populations of different ethnicities would provide evidence for the role of IL-10 in psoriasis.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3051-3056
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• 2013

Background: Genetic aberrations of DNA repair enzymes are known to be common events associated with different cancer entities. The aim of the present study was to analyze genetic associations of rs1805404 (Asp81Asp) and rs1805414 (Ala284Ala) in the PARP1 gene with the risk of breast cancer in Saudi Arabia. Materials and Methods: These two SNP's were analyzed in a primary study group of breast cancer patients and healthy control subjects. Genotypes were determined by TaqMan SNP testing and analyzed using Chi-square or t test and logistic regression analysis with SPSS16.0 software. Results and Conclusions: Results showed that rs1805414 was associated with a significantly increased susceptibility to breast cancer, significant risk being observed for the TC, CC and TC+CC genotypes. In conclusion PARP1 rs1805414 SNP polymorphisms may be involved in the etiology of breast cancer in the Saudi population. In contrast, PARP1 rs1805404 did not show any significant association in overall in breast cancer samples when compared to healthy controls. Confirmation of our findings in larger populations of different ethnicities may provide evidence for a role of the PARP1 gene in breast carcinoma developnment.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.18 no.3
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• pp.219-226
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• 2005

In this study, the problem formulation and solution technique using genetic algorithms for design optimization of laminate composite cylindrical beam section are presented. The hollow cylindrical beams we usually used in the wheel chair. If the weight of wheel chair is reduced, it will lead to huge improvement in passenger's mobility and comfort. In this context, the replacement of steel by high performance and light weight composite material along with optimal design will be a good contribution in the process of weight reduction of a wheel chair. An artificial genetics approach for the design optimization of hollow cylindrical composite beam is presented. On applying the genetic algorithm, the optimal dimensions of hollow cylindrical composite beams which have equivalent rigidities to those of corresponding hollow cylindrical steel beams are obtained. Also structural analysis is conducted on the entire wheel chair structure incorporating Tsai-Wu failure criteria. The maximum Tsai-Wu failure criteria index is $0.192\times10^{-3}$ which is moth less than value of 1.00 indicating no failure is observed under excessive loading condition. It is found that the substitution of steel by composite material could reduce the weight of wheel chair up to 45%.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.29 no.1
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• pp.33-39
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• 2023

Background: Most Pilates programs for older adults have been based on mat Pilates, and there has been limited research on Pilates with mini-balls. Therefore, this study aims to compare the effects of Pilates with mini-balls and mat Pilates interventions on strength, total body endurance, flexibility, and dynamic equilibrium to determine the differences. Methods: The elderly aged 65 or older living in Gyeongsan, Daegu, were divided into two groups, and the experimental group (n=10) conducted a Pilates exercise program using mini balls for 12 weeks, and the control group (n=10) conducted a mat Pilates exercise program for 12 weeks without mini balls. Strength, endurance, flexibility, and dynamic equlibrium were measured as a pre-test, and post-test was performed in the same way after 12 weeks of application. Results: Comparing the mini-ball Pilates group to the mat Pilates group, there was a significant difference (p<.05) in the 'chair sit and reach' after the intervention. In the within-group comparison, there was a significant increase (p<.05) in 'arm curl right', '30-second chair stand', '2-minute walk', 'back scratch', 'chair sit and reach', and '2.44m up and go' in the experimental group using the mini-ball Pilates program. Mat Pilates program significantly increased the within-group comparisons in '30-second chair stand' and 'chair sit and reach' (p<.05). Conclusion: It is suggested that mini-ball Pilates has a positive effect on the senior fitness and will be a good exercise method for using it as an exercise program for the elderly in the future.

• Proceedings of the KIPE Conference
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• 2000.07a
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• pp.628-631
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• 2000

A new control method for precision robust speed control of a PMSM(Permanent Magnet Synchronous Motor) using load torque observer is presented. With this system we can obtain more reliable eye moving singal(nystagmus) Until now rotating chair system which is called 2D-optokinetic stimulator is used to make dizzincess. However an inclined rotating chair system witch is 3D-optokinetic stimulator is needed to obtain the precise dizziness data. This 3D-optokinetic sitimulator include unbalanced load aused by unbalanced center of mass. For this case new compensation method is considered to obtain robust speed control using load torque observer. To reduce the effect of this disturbance we can use dead-beat observer which has high gain. The application of the load torque observer is published in [1] for position control. A problem of using speed information such as amplifying effect of noise is reduce by moving average process. The experimental results are depicted in this paper to show the effect of this proposed algorithm.