• Molecules and Cells
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• 제37권4호
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• pp.275-285
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• 2014

Macrophages, found in circulating blood as well as integrated into several tissues and organs throughout the body, represent an important first line of defense against disease and a necessary component of healthy tissue homeostasis. Additionally, macrophages that arise from the differentiation of monocytes recruited from the blood to inflamed tissues play a central role in regulating local inflammation. Studies of macrophage activation in the last decade or so have revealed that these cells adopt a staggering range of phenotypes that are finely tuned responses to a variety of different stimuli, and that the resulting subsets of activated macrophages play critical roles in both progression and resolution of disease. This review summarizes the current understanding of the contributions of differentially polarized macrophages to various infectious and inflammatory diseases and the ongoing effort to develop novel therapies that target this key aspect of macrophage biology.

• IMMUNE NETWORK
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• 제16권3호
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• pp.147-158
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• 2016

The liver lies at the intersection of multiple metabolic pathways and consequently plays a central role in lipid metabolism. Pathological disturbances in hepatic lipid metabolism are characteristic of chronic metabolic diseases, such as obesity-mediated insulin resistance, which can result in nonalcoholic fatty liver disease (NAFLD). Tissue damage induced in NAFLD activates and recruits liver-resident and non-resident immune cells, resulting in nonalcoholic steatohepatitis (NASH). Importantly, NASH is associated with an increased risk of significant clinical sequelae such as cirrhosis, cardiovascular diseases, and malignancies. In this review, we describe the immunopathogenesis of NASH by defining the known functions of immune cells in the progression and resolution of disease.

• Clinical and Experimental Pediatrics
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• 제46권4호
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• pp.326-334
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• 2003

목 적 : 이번 연구의 목적은 다양한 비만지표를 이용하여 인천지역 중고등학교의 비만 유병율을 알아보았으며, 비만지표와 비만의 합병증인 고혈압과 고지혈증의 연관성을 알아보고 중심성 비만을 평가하기 위해 허리둘레 측정치와 WHR의 유효성을 알아보았다. 방 법 : 2000년 4, 5월 인천지역의 3개의 중학교, 5개의 고등학교를 선별하여 11세에서 18세까지의 총 1,382명(남 : 여=690 : 692)을 대상으로 신체계측과 혈청지질농도, 혈압을 측정하였다. 결 과 : 1) 비만의 유병율은 BMI를 기준으로 분류할 때 남자 6.7%, 여자 6.9%이었고, 허리둘레 측정치를 기준시 남자 5.4%, 여자 5.0%이었고, WHR 기준시 남자 7.0%, 여자 5.8%이었다. 2) 남녀 모두에서 BMI, 허리둘레, WHR은 수축기 혈압과 확장기 혈압 모두 양의 유의한 상관관계가 있었다. 3) 남자에서 중성지방은 BMI(r=0.13, P<0.05), 허리둘레 측정치(r=0.34, P<0.05)와 양의 유의한 상관관계가 있었다. 여자에서는 지질농도와 유의한 상관관계가 없었다. 4) 남자에서 BMI는 비만도(r=0.98, P<0.05), 허리둘레 측정치(r=0.89, p<0.05), 체지방(r=0.85, P<0.05)과 높은 상관관계가 있었다. 여자에서 BMI는 비만도(r=0.98, P<0.05), 허리둘레 측정치(r=0.82), 체지방(r=0.89, P<0.05)과 높은 상관관계가 있었다. 결 론 : 이번의 결과는 고혈압의 유병율이 정상체중군에 비해서 남녀 모두 비만할수록 증가하였고 비만지표와 상관관계가 있었다. 소아비만과 관련된 고혈압은 성인 혈압의 가장 뛰어난 예측인자이고 성인 비만으로의 지속과 무관하게 고혈압을 유발시키므로 청소년의 비만을 예방하고 치료하는 것이 필요하다.

• 대한간호학회지
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• 제45권4호
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• pp.483-494
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• 2015

Purpose: This study identified effects of dietary and physical activity interventions including dietary interventions or physical activity interventions alone or combined dietary-physical activity interventions to improve symptoms in metabolic syndrome including abdominal obesity, high triglycerides, low high density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose through meta-analysis. Methods: Articles on metabolic syndrome X published from 1988 to 2013 were searched through electronic databases, Google Scholar, and reference reviews. Methodological quality was assessed by the checklist, SIGN (Scottish Intercollegiate Guidelines Network). Results: In the meta-analysis, there were 9 articles reporting 13 interventions with 736 participants. Using random effect models, the dietary and/or physical activity interventions showed a lower mean difference in waist circumference ( - 1.30 cm, 95% CI: - 2.44~ - 0.15, p=.027). The combined dietary-physical activity interventions showed a lower mean difference in waist circumference ( - 2.77 cm, 95% CI: - 4.77~ - 0.76, p=.007) and systolic blood pressure ( - 5.44 mmHg, 95% CI: - 10.76~ - 0.12, p=.044). Additionally, interventions of over 24 weeks yielded a lower mean difference in waist circumference ( - 2.78 cm, 95% CI: - 4.69~ - 0.87, p=.004) and diastolic blood pressure ( - 1.93 mmHg, 95% CI: - 3.63~ - 0.22, p=.026). Conclusion: The findings indicate that dietary and/or physical activity interventions for metabolic syndrome reduce central obesity with no adverse effects. This finding provides objective evidences for dietary and physical activity management on metabolic syndrome as an efficient intervention.

• 대한한방부인과학회지
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• 제27권2호
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• pp.71-82
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• 2014

Objectives: The purpose of this systematic review was to overview and evaluate the efficacy of acupuncture treatment for women with polycystic ovary syndrome (PCOS). Methods: Relevant randomized controlled studies (RCTs) were identified by database searches in MEDLINE, EMBASE, and CENTRAL, up to Dec 2013, and by additional hand searches. Data were extracted regarding anovulation, hyperandrogenism, obesity indices. Meta-analyses were separatedly conducted for the symptoms of PCOS. The risk of bias was assessed. Results: Three studies which were included for analysis, but they showed severly heterogeneity therefore meta-analysis could not be performed. Outcomes for evaluating the efficacy of acupuncture treatment for PCOS were anovulation index (menstrual frequency), hyperandrogenism index (free testosterone) and obesity index (body-mass index). For menstrual frequency, acupuncture treatment consistently suggested an interventional benefit. Although other outcomes did not suggest any enough relevant evidence to interventional benefit for acupuncture treatment. Conclusions: Acupuncture treatment appeared to improve menstrual frequency in PCOS patients. Since a limited number of RCTs were available in the current literature and those studies were also clinically heterogeneous, further research is needed to gather evidence to support acupuncture therapy in PCOS.

• Interdisciplinary Bio Central
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• 제4권2호
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• pp.4.1-4.4
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• 2012

Background: Serum concentration of cystatin C, a marker of glomerular filtration has been associated with cardiovascular disease (CVD). The aim of this study was to evaluate cystatin C as a marker of obese patients without chronic kidney disease (CKD). Materials and Methods: The study population consisted of 36 subjects with metabolic syndrome and 32 subjects free of metabolic syndrome (the control group). HDL-C, LDL-C, blood urea, triglycerides, glucose, HbA1c, serum cystatin C and serum creatinine were measured in both groups. GFR was calculated in both groups using Cockroft-Gault equation. Results: Obese patients showed higher cystatin C levels than normal samples ($1.28{\pm}0.29$, P < 0.05). In the binary logistic regression, obese patients were significantly associated with elevated cystatin C levels. Conclusion: Our results suggest that cystatin C may be a marker for obese patients and may identify a certain degree of renal dysfunction even when serum creatinine does not exceed the normal level. In this study, we demonstrated that serum creatinineand GFR did not differ significantly between the diabetic and the control groups. Serum concentration of cystatin C was significantly higher in the diabetic group compared with the control group. The strengths of this study are the evaluation of reliability and sensivity in comparison with a 'routine test of GFR'. The methodology used allows an appropriate statistical comparison of reliability in contrast to most other previous evaluations of GFR.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1879-1883
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• 2014

Background: The relationship between obesity and prostate cancer aggressiveness is controversial in recent studies, partly because BMI is the only generally applied marker of obesity. Our study aimed at evaluating the correlation of periprostatic fat (PF) on magnatic resonance imaging (MRI) and adipocytokines with prostate cancer aggressiveness. Patients and method: A total of 184 patients who underwent radical retropubic prostatectomy (RRP) were analyzed retrospectively; different fat measurements on MRI slices and levels of adipocytokines were compared with the clinical and pathologic factors using SSPS ver.13.0. Result: The PF rates showed a statistically significant variation (p=0.019, 0.025) among groups, that is to say, more adipose tissue was distributed in periprostatic areas of high risk patients. Logistic regression analysis adjusted for age revealed a statistically association between the PF, the ratio and the risk of having high-risk disease (p=0.031, 0.024). The levels of IL-6, leptin and c-reactive protein (CRP) significantly increased with the aggressiveness of prostate cancer, and also with PF and its ratio. The strongest correlation was seen between IL-6 and PF (Pearson r coefficient=0.67, P<0.001). No association was observed between adipocytokines and BMI. Conclusion: Periprostatic adiposity not only affects prostate cancer aggressiveness, but also influences the secretion of adipocytokines. IL-6, PF and CRP have promoting effects on progression of prostate cancer.

• 보건교육건강증진학회지
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• 제33권5호
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• pp.83-91
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• 2016

Objectives: This study was aimed to investigate utilization of health promotion indices of the 3rd National Health Plan 2011-2020 (HP2020) in the 6th Korean Community Health Plan. Methods: Health promotion indices were defined as a set of indicators on smoking, alcohol drinking, physical activity, nutrition and obesity used in HP2020. This indices were categorized into essential indicator, accessory indicators and others. Based on chi-square test, we analyzed utilization of health promotion indices in 186 Community Health Plans by regional classifications: four large influence areas (SudoGangwon, Chungcheong, Gyeongsang and HonamJeju) and four regional classification (metropolitan district, city, urban-rural area and rural area) Results: Among total 186 plans, indicator utilization rate were 97.8% in smoking, 71.0% in alcohol drinking, 91.9% in physical activity, 99.5% in nutrition and 72.0% in obesity. Utilization rates of alcohol drinking indicators and essential indicators in alcohol drinking show significantly difference by four large influence areas (p<0.01) and four regional classification (p<0.01). Essential indicators in physical activity show significantly difference by four large influence areas (p<0.01). Conclusions: Central government must provide technical assistance and educate personnel in community health centers and provincial health department about meaning and usefulness of Health Plan 2020 indicators.

• 대한한의학방제학회지
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• 제31권2호
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• pp.81-98
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• 2023

Objectives : This study aimed to analyze the trends in research and development projects related to herbal medicine and natural products in the field of traditional Korean medicine (TKM) over the past 20 years. Methods : Research projects were identified using "Korean medicine" as the subject heading in the National Science and Technology Information Service. The included projects investigated Korean medicine, natural products, or were related to the TKM industry. Data pre-processing and network analysis were performed using Python and Networkx package, and the network was visualized using the ForceAtlas2 visualization algorithm. Results : 1. Over the study period, 4,020 projects were conducted with a research budget of KRW 835.2 billion. Seven institutions performed over 100 projects each, accounting for 2.4% of all participating institutions, and the top 10 institutions accounted for 58.9% of total projects. 2. Obesity was the most frequently mentioned disease-related keyword. Chronic or age-related diseases such as diabetes, osteoporosis, dementia, parkinson's disease, cancer, inflammation, and asthma were also frequent research topics. Clinical research, safety, and standardization were also frequently mentioned. 3. Centrality analysis found that obesity was the only disease-related keyword identified, alongside TKM-related keywords. Standardization, safety, and clinical trials were identified as central keywords. Conclusions : The study found that research projects in TKM have focused on standardizing and ensuring the safety of herbal medicine, as well as on chronic and age-related diseases. Clinical studies aimed at verifying the effectiveness of herbal medicine were also frequent. These findings can guide future research and development in herbal medicine.

• 대한임상검사과학회지
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• 제54권2호
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• pp.149-156
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• 2022

본 연구는 지질 축적 지수(lipid accumulation product, LAP)는 중심 지질 축적을 반영하는 새로운 지표로서, 심혈관 위험이나 당뇨병의 강력한 위험인자로 알려져 있다. 본 연구의 목적은 대한민국 20 성인에서 비만의 유무에 따른 지질 축적 지수와 인슐린저항성(homeostasis model assessment of insulin resistance, HOMA-IR)의 관련성에 대하여 조사하였다. 본 연구는 2019년도 국민건강영양조사 자료(2019 Korean National Health and Nutrition Examination Survey, KNHANES V-3)를 이용하여 20세 이상의 대한민국 성인 6,090명을 대상으로 실시하였다. 본 연구결과에서 중요한 결과는 다음과 같다. 첫째, 연령, 성별, 음주습관, 흡연습관, 운동습관, 수축기 및 이완기혈압, 혈중 요소 질소 및 크레아티닌을 보정한 후의 결과에서, 전체인구(P<0.001), 비만이 아닌 군(P<0.001) 및 비만군(P<0.001)에서 LAP의 사분위수가 증가함에 따라 HOMA-IR 평균값(M±SE, 95% confidence interval)이 증가하였다. 둘째, 전체인구, 비만이 아닌 군 및 비만군에서, 공복혈당(모든 그룹, P<0.001), 인슐린(모든 그룹, P<0.001) 및 대사증후군 점수(모든 그룹, P<0.001)의 평균값(M±SE, 95% CI)은 LAP의 사분위수가 증가함에 따라 증가하였다. 결론적으로, 대한민국 성인 중 비만군과 비만이 아닌 군 모두에서 지질 축적 지수가 증가함에 따라 인슐린저항성이 증가하였다.