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http://dx.doi.org/10.7314/APJCP.2014.15.4.1879

Influence of Adipocytokines and Periprostatic Adiposity Measurement Parameters on Prostate Cancer Aggressiveness  

Zhang, Qiang (Department of Urology, The Affiliated Hospital of Qingdao University Medical College)
Sun, Li-Jiang (Department of Urology, The Affiliated Hospital of Qingdao University Medical College)
Qi, Jun (Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)
Yang, Zhi-Gang (Department of Urology, Baotou City Central Hospital)
Huang, Tao (Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.4, 2014 , pp. 1879-1883 More about this Journal
Abstract
Background: The relationship between obesity and prostate cancer aggressiveness is controversial in recent studies, partly because BMI is the only generally applied marker of obesity. Our study aimed at evaluating the correlation of periprostatic fat (PF) on magnatic resonance imaging (MRI) and adipocytokines with prostate cancer aggressiveness. Patients and method: A total of 184 patients who underwent radical retropubic prostatectomy (RRP) were analyzed retrospectively; different fat measurements on MRI slices and levels of adipocytokines were compared with the clinical and pathologic factors using SSPS ver.13.0. Result: The PF rates showed a statistically significant variation (p=0.019, 0.025) among groups, that is to say, more adipose tissue was distributed in periprostatic areas of high risk patients. Logistic regression analysis adjusted for age revealed a statistically association between the PF, the ratio and the risk of having high-risk disease (p=0.031, 0.024). The levels of IL-6, leptin and c-reactive protein (CRP) significantly increased with the aggressiveness of prostate cancer, and also with PF and its ratio. The strongest correlation was seen between IL-6 and PF (Pearson r coefficient=0.67, P<0.001). No association was observed between adipocytokines and BMI. Conclusion: Periprostatic adiposity not only affects prostate cancer aggressiveness, but also influences the secretion of adipocytokines. IL-6, PF and CRP have promoting effects on progression of prostate cancer.
Keywords
Prostate cancer; periprostatic adiposity; body mass index (BMI); tumor aggressiveness; adipocytokine;
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1 Rodrigues C, Freedland SJ, Deka A, et al (2007). Body mass index, weight change, and risk of prostate cancer in the cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev, 16, 63-9.   DOI   ScienceOn
2 Saglam K, Aydur E, Yilmaz M, et al (2003). Leptin influences cellular differentiation and progression in prostate cancer. J Urol, 169, 1308-11.   DOI   ScienceOn
3 Stark JR, Li H, Kraft P, et al (2009). Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortality. Int J Cancer, 124, 2683-9.   DOI   ScienceOn
4 Tewari R, Rajender S, Natu SM, et al (2013). Significance of obesity markers and adipocytokines in high grad and high stage prostate cancer in North Indian men-A cross-sectional study. Cytokine, 63, 130-4.   DOI   ScienceOn
5 Tobias P, Ute N, Heiner B (2008). Obesity and cancer. Proc Nutr Soc, 67, 128-45.   DOI   ScienceOn
6 McGrowder DA, Jackson LA, Crawford TV (2012). Prostate cancer and metabolic syndrome: is there a link? Asian Pac J Cancer Prev, 13, 1-13.   DOI   ScienceOn
7 Mallah KN, DiBlasio CJ, Rhee AC, et al (2005). Body mass index is weakly associated with, and not a helpful predictor of, disease progression in men with clinically localized prostate carcinoma treated with radical prostatectomy. Cancer, 103, 2030-4.   DOI   ScienceOn
8 Amling CL, Riffenburgh RH, Sun L, et al (2004). Pathologic variables and recurrence rates as related to obesity and race in men with prostate cancer undergoing radical prostatectomy. J Clin Oncol, 22, 439-45.   DOI
9 Ann W, Lori C, Steamson C (2007). Obesity, metabolic syndrome, and prostate cancer. Am J Clin Nutr, 86, 843-57.   DOI
10 Merrick GS, Galbreath RW, Butler WM, et al (2007). Obesity is not predictive of overall survival following permanent prostate brachytherapy. Am J Clin Oncol, 30, 588-96.   DOI   ScienceOn
11 Mistry T, Digby JE, Desai KM, et al (2007). Obesity and prostate cancer: a role for adipokines. Eur Urol, 52, 46-53.   DOI   ScienceOn
12 Mucksavage P, Mitchell C, Kutikov A, et al (2012). Anthropometric difference in obese men with biochemical failure after radical retropubic prostatectomy. Urol Oncol, 30, 590-5.   DOI   ScienceOn
13 Ouchi N, Kihara S, Funahashi T, et al (2003). Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation, 107, 671-4.   DOI   ScienceOn
14 Prins RC, Rademacher BL, Mongoue-Tchokote S, et al (2012). C-reaction protein as an adverse prognosis marker for men with castration-resistant prostate cancer (CRPC): confirmatory results. Urol Oncol, 30, 33-7.   DOI   ScienceOn
15 Freedland SJ, Sun L, Kane CJ, et al (2008). Obesity and oncologic outcome after radical prostatectomy: Impact of prostate-specific antigen-based prostate cancer screening: Results from the Shared Equal Access Regional Cancer Hospital and Duke Prostate Center Databases. BJU International, 102, 969-74.   DOI   ScienceOn
16 Baillargeon J, Rose DP (2006). Obesity, adipokines, and prostate cancer. Int J Oncol, 28, 737-45.
17 Buschemeyer WC, Freedland SJ (2007). Obesity and prostate cancer: Epidemiology and clinical implications. Eur Urol, 52, 331-43.   DOI   ScienceOn
18 Carroll PR (2003). Nomograms are superior to staging and risk grouping systems for identifying high-risk patients: preoperative application in prostate cancer. Urol Oncol, 21, 484-5.
19 Van Roermund JG, Hinnen KA, Tolman CJ, et al (2011). Periprostatic fat correlates with tumour aggressiveness in prostate cancer patients. BJUI Int, 107, 1775-9.   DOI   ScienceOn
20 Von HP, Pina F, Perez A, et al (2004). Visceral fat accumulation as a risk factor for prostate cancer. Obes Res, 12, 1930-5.   DOI
21 Van Romermund JG, Bol GH, Witjes JA, et al (2010). Periprostatic fat measured on computed tomography as a marker for prostate cancer aggressiveness. World J Urol, 28, 699-704.   DOI   ScienceOn
22 Vol Hafe P, Pina F, Perez A, et al (2004). Visceral fat accumulation as a risk factor for prostate cancer. Obes Res, 12, 1930-5.   DOI
23 Tang Z-L, Bai J, Gu L-N (2013). A systematic review: epidemic status of prostate Cancer and Breast Cancer from 2000 to 2010 in China. China Cancer, 4, 260-5.
24 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin , 61, 69-90.   DOI
25 Gallina A, Karakiewicz PI, Hutterer GC, et al (2007). Obesity does not predispose to more aggressive prostate cancer either at biopsy or radical prostatectomy in Europen men. Int J Cancer, 121, 791-5.   DOI   ScienceOn
26 Guo YZ, Pan L, Du CJ, et al (2013). Association between C-reactive protein and risk of cancer: a meta-analysis of prospective cohort studies. Asian Pac J Cancer Prev, 14, 243-8.   DOI   ScienceOn
27 Hsing AW, Sakoda LC, Chua S Jr (2007). Obesity, metabolic syndrome, and prostate cancer. Am J Clin Nutr, 86, 843-57.   DOI
28 Kane CJ, Bassett WW, Sadetsky N, et al (2005). Obesity and prostate cancer clinical risk factors at presentation: data from CaPSURE. J Urol, 173, 732-6.   DOI   ScienceOn
29 Loeb S, YU X, Nadler RB, et al (2007). Does body mass index affect preoperative prostate specific antigen velocity or pathological outcomes after radical prostatectomy? J Urol, 177, 102-6.   DOI   ScienceOn
30 Azevedo A, Cunha V, Teixeira AL, et al (2011). IL-6/IL-6R as a potential key signaling pathway in prostate cancer development. World J Clin Oncol, 2, 384-96.   DOI   ScienceOn
31 Van Roermund JG, Hinnen KA, Battermann JJ, et al (2009). Kiemeney LA. Body mass index is not a prognostic marker for prostate specific antigen failure and survival in Dutch men treated with brachytherapy. BJU Int, 105, 42-8.