• 대한물리의학회지
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• 제7권4호
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• pp.451-458
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• 2012

PURPOSE: The purpose of present study was to determine effects of circuit class training (CCT) on the synthesis of central serotonin in people with post-stroke depression. METHODS: Forty patients with mild post-stroke depression were participated in current study. All subjects were assigned to two groups of CCT (circuit class training) group and SW (stretching and weight shifting) group. Both groups were performed for 80 minutes. The change of blood f-Trp, BCAAs, f-Trp/BCAAs and serotonin according to period training time were examined and the following results were obtained. RESULTS: In the CCT group, f-Trp, BCAAs, and f-Trp/BCAAs increased according to the time point. However, after 24 hour of circuit class training, all of these were significantly decreased by those before training. The change in blood levels of serotonin was the highest in immediately after the training in the CCT group while it was not changed significantly in the SW group. CONCLUSION: It can be seen that CCT can change the serotonin level and have an effect on the synthesis of central serotonin in people with post-stroke depression.

• 정신신체의학
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• 제15권1호
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• pp.51-55
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• 2007

연구목적 : 비만과 우울증은 모두 심각한 공공 의료 문제이고 특히 주된 심혈관계 질환 위험인자이다. 비만과 우울증 상에 관한 해외 연구는, 일정한 결론은 아니나, 여러 연구에서 연관성 존재를 보고하고 있고 특히 일부 연구는 여성에서 그 연관 정도가 큼을 보고 한 바 있다. 본 연구는 한국 여성에서 있어 비만, 특히 복부비만과 우울증상의 연관성을 분석하고자 한다. 방법: 여성 연구 대상자 4,609명을 대상으로 Beck 우울 척도 및 체계측을 시행한 결과를 이용 우울증상과 비만과의 연관성을 분석하였다. 비만도는 체질량지수로 정하였으며 체질량지수 $25kg/m^2$ 이상을 비만으로 하였고 복부비만은 허리둘레 85cm 이상으로 정의하였다. 임상적으로 우울증을 의심할 수 있는 Beck 우울척도 분할점은 16점으로 하였다. 결과: 정상 체중군에 비해 비만 여성군에서 우울 여성의 비율이 유의미하게 높았고(27.6% VS. 23.2%, p<0.01), 복부 비만 여성에서도 우울 여성군의 비율이 통계적으로 유의하게 높았고(26.9% VS. 22.7%, p<0.01), 비만 여성군 중 우울 여성에서 복부 비만 가진 비율이 통계적으로 유의미하게 높았다(93.2% VS. 86.9%, p<0.01). 결론 : 본 연구의 결과는 한국 여성에서 비만, 특히 복부비만과 우울증간 연관성이 존재함을 보였고 향후 전향적 연구를 통한 비만과 우울증간 상호 역할에 대한 적극적 이해가 필요함을 시사한다.

• 셀메드
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• 제9권2호
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• pp.2.1-2.1
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• 2019

Depression is common psychiatric diseases characterized by diverse physical and emotional symptoms including low mood, loss of interest in pleasurable activities, and feelings of worthlessness. Depression causes of death and disability. The first antidepressant was created by the idea that central serotonin mechanism. Selective serotonin reuptake inhibitor, fluoxetine is the first-line drug in the treatment of depressive disorder and their few side effects as opposed to tricyclic antidepressants. Not all people with depression respond adequately to standard treatments. Korean music playing/listening actions appear to be a reliable approach to developing recovery from depression.

• The Korean Journal of Pain
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• 제37권2호
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• pp.91-106
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• 2024

The mechanisms of the chronic pain and depression comorbidity have gained significant attention in recent years. The complement system, widely involved in central nervous system diseases and mediating non-specific immune mechanisms in the body, remains incompletely understood in its involvement in the comorbidity mechanisms of chronic pain and depression. This review aims to consolidate the findings from recent studies on the complement system in chronic pain and depression, proposing that it may serve as a promising shared therapeutic target for both conditions. Complement proteins C1q, C3, C5, as well as their cleavage products C3a and C5a, along with the associated receptors C3aR, CR3, and C5aR, are believed to have significant implications in the comorbid mechanism. The primary potential mechanisms encompass the involvement of the complement cascade C1q/C3-CR3 in the activation of microglia and synaptic pruning in the amygdala and hippocampus, the role of complement cascade C3/C3a-C3aR in the interaction between astrocytes and microglia, leading to synaptic pruning, and the C3a-C3aR axis and C5a-C5aR axis to trigger inflammation within the central nervous system. We focus on studies on the role of the complement system in the comorbid mechanisms of chronic pain and depression.

• 대한불안의학회지
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• 제4권2호
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• pp.91-98
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• 2008

Depression and anxiety disorders are common psychiatric illnesses whose etiology remains partially understood. The etiology of depression and anxiety disorders is multi-factorial, and abnormalities in neurotransmitter, neuroendocrine system, and brain activation have been implicated in those conditions. However, the pathophysiology of depression and anxiety disorder is certainly not well understood, and some patients with depression or anxiety disorders do not respond to antidepressant therapy. Recently, immunological factors such as cytokines are known to be closely related to central nervous system as well as depression and anxiety disorders. This review highlights recent progress in understanding the function of cytokines in depression and anxiety disorders.

• Journal of Dental Anesthesia and Pain Medicine
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• 제19권4호
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• pp.235-238
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• 2019

Corticobasal degeneration (CBD) is a rare neurodegenerative disease characterized by dystonia, cognitive deficits, and an asymmetric akinetic-rigid syndrome. Little information is available regarding anesthetic management for CBD patients. Our patient was a 55-year-old man with CBD complicated by central sleep apnea (CSA). Due to the risk of perioperative breathing instability associated with anesthetic use, a laryngeal mask airway was used during anesthesia with propofol. Spontaneous respiration was stable under general anesthesia. However, respiratory depression occurred following surgery, necessitating insertion of a nasopharyngeal airway. Since no respiratory depression had occurred during maintenance of the airway using the laryngeal mask, we suspected an upper airway obstruction caused by displacement of the tongue due to residual propofol. Residual anesthetics may cause postoperative respiratory depression in patients with CBD. Therefore, continuous postoperative monitoring of $SpO_2$ and preparations to support postoperative ventilation are necessary.

• 한국산림과학회지
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• 제96권2호
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• pp.203-207
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• 2007

Restorative effect of forest settings is an emerging issue in the field of forestry. It is also the central question facing those currently engaged in the psychotherapeutic interventions is which treatments work. This study was performed to investigate the efficacy of forest experience on alcoholics' depression. Among 531 participants in forest healing camps, 47 alcoholics who participated all three sessions of the camps were selected for this study. Using pre-test and post-test group design with Beck Depression Inventory (BDI), mean changes in alcoholics' depression by completion of the camp was measured. The result of this study indicated that the 3-session of forest camp played significant role in reducing participants depression levels (i.e., positive changes in depression scores).

• 대한한방내과학회지
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• 제41권6호
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• pp.1300-1306
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• 2020

Background: The aim of this study was to determine the clinical effects of complex Korean medicine therapy for tinnitus associated with ear fullness, depression, and anxiety. Case Report: A 52-year-old female patient suffering from tinnitus with ear fullness, depression, and anxiety was treated with acupuncture, pharmacopuncture, and herbal medicine. We used the Tinnitus Handicap Inventory (THI), Beck Depression Inventory (BDI-II), Beck Anxiety Inventory (BAI), and a Verbal Numerical Rating Score (VNRS) to assess the patient's symptoms. The administration of the acupuncture, pharmacopuncture, and herbal medicine improved the ear fullness, depression and anxiety symptoms. No side effects were observed during the treatment. Conclusion: The study findings suggest that complex Korean medicine therapy, such as acupuncture, pharmacopuncture, and herbal medicine, may be effective for the treatment of tinnitus associated with ear fullness, depression, and anxiety.

• Asian-Australasian Journal of Animal Sciences
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• 제18권10호
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• pp.1363-1367
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• 2005

A pedigree file of 4,738 records of a purebred flock of Muzaffarnagari sheep, maintained at Central Institute for Research on Goats (CIRG), Makhdoom, for a period of 24 years (1978 to 2001) was used to calculate inbreeding coefficients. The lambtraits studied were birth, 3, 6, 9 and 12 months weights as well as 6 and 12 months fleece yields. The lambs' and ewes' inbreeding coefficients ranged from 0 to 26.4% and 0 to 25%, respectively. The average inbreeding coefficient of lambs was higher than that of ewes in all periods as expected in a closed flock. Fluctuations in lamb and ewe inbreeding were observed in the periods under study. The percentages of animals in the higher inbred categories varied somewhat but generally were relatively constant. The mean rate of inbreeding was 0.63% per generation. The effective population size of the flock was 79.1. On average, an increase of 1% individual inbreeding significantly (p<0.05) reduced weights at birth by 0.010 kg, at 3 month by 0.048 kg, at 6 month by 0.075 kg, at 9 month by 0.129 kg and at 12 month by 0.112 kg. Ewes' inbreeding had non-significant effects on body weight at all ages. Effects of both lambs' and ewes' inbreeding had negative but non-significant effects on fleece weights at 6 and 12 months of age. Thus, inbreeding depression in lambs significantly reduced body weights from birth to 12 months of age but had a negligible effect on fleece yields.

• 대한수의학회지
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• 제33권1호
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• pp.71-80
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• 1993

The central nervous system depressant effect of xylazine and xylazine-ketamine was studied in chicken and mice. Intraperitoneal injection of xylazine(1~30 mg/kg) and xylazine(1~30 mg/kg)-ketamine(100 mg/kg) induced a loss of the righting reflex in chicken and mice, respectively. These effects of xylazine were dose-dependent. The results obtained were as follows; 1. The effect of xylazine-induced depression was antagonized by adrenergic antagonists having ${\alpha}_2$-blocking activity(yohimbine, tolazoline, piperoxan and phentolamine). 2. Yohimbine was most effective in the reduction of the CNS depression by xylazine. 3. Phenoxybenzamine and prazosin did not reduced CNS depression by xylazine in both species. 4. Labetalol (${\alpha}_1$, ${\beta}_1$-adrenergic antagonist) and propranolol(${\beta}$-adrenergic blocking agent) were not effective in reducing xylazine induced depression. 5. Cholinergic blocking agents (atropine and mecamylamine), a dopaminergic antagonist (Haloperidol), a histamine $H_1$-antagonist(chlorpheniramine), a histamine $H_2$-antagonist(cimetidine), a serotonergic-histamine $H_1$ antagonist(cyproheptadine) were not effective in reducing xylazine-induced depression. 6. Xylazine-induced depression is mediated by ${\alpha}_2$-adrenergic receptors and appears not to be involved in cholinergic, dopaminergic, serotonergic or histaminergic pathways.