• 한국생산제조학회지
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• 제24권2호
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• pp.186-191
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• 2015

Presently, rapidly changing and unstable global economic environments demand engineers. Products should be designed to increase profits by lowering costs and provide distinguished performance compared with competitors. This study aims to optimize the design of the power-transmission drive shaft. The mass is reduced as an objective function, and the stress is constrained under a constant value. To reduce the number of experiments, CCD (central composite design) and D-Optimal are used for the experimental design. RSM (response surface methodology) is employed to construct a regression model for the objective functions and constraint function. In this problem, there is only one objective function for the mass. The other objective function gives 1; thus, NSGA-II is used.

• 한국물환경학회지
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• 제26권1호
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• pp.35-43
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• 2010

This experimental design and response surface methodology (RSM) have been applied to the investigation of the electrocoagulation/flotation of dye wastewater. The electrocoagulation/flotation reactions were mathematically described as a function of parameters current (A), NaCl concentration (B), initial RhB concentration (C) and time (D) being modeled by use of the central composite design (CCD). The application of RSM using the CCD yielded the following regression equation, which is an empirical relationship between the RhB removal (%) and test variables in RhB removal (%) = $-300.42+129.21{\cdot}Current+46.99{\cdot}NaCl-0.11{\cdot}RhB-+43.71{\cdot}Time-5.67{\cdot}Current{\cdot}NaCl-3.18{\cdot}Current{\cdot}Time-2.41{\cdot}NaCl{\cdot}Time-19.79{\cdot}Current^2-2.27{\cdot}NaCl^2-1.59{\cdot}Time^2$. the model predictions agreed well with the experimentally observed result ($R^{2}=0.9728$). The estimated ridge of maximum response and optimal conditions for RhB removal (%) using canonical analysis was 99.4% (A: 1,77 A, NaCl concentration: 2.23 g/L, RhB concentration: 56.12 mg/L, Time: 9.98 min). To confirm this optimum condition, three additional experiments were performed and RhB removal (%) were within range of 86.87% (95% PI low)~111.93% (95% PI high) obtained.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2010년도 춘계학술대회 논문집
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• pp.207-208
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• 2010

• Journal of Microbiology and Biotechnology
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• 제15권5호
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• pp.930-937
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• 2005

The Plackett-Burman design and the response surface method (RSM) with a central composite design (CCD) were employed to develop a culture medium for ansamitocin P-3 production using Actinosynnema pretiosum ATCC 31565. Among the 11 nutrients tested using the Plackett-Burman design, two carbon sources, sucrose and dextrin, and two nitrogen sources, polypeptone and yeast extract, were selected. Optimization of the concentrations of the selected nutrients was then performed using RSM with CCD. After two rounds of RSM, the optimum concentrations ($\%w/v$) of sucrose, dextrin, polypeptone, and yeast extract were identified as 4.5, 4.5, 0.16, and 0.89, respectively. The maximum ansamitocin P-3 titer was 45.2 mg/l with the optimized medium, which was about 6 times higher than that (7.315 mg/l) obtained with an $R_{2}YE$ medium before optimization.

• 한국정밀공학회지
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• 제32권9호
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• pp.815-824
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• 2015

In this study, we conducted the approximate multi-objective optimization of gap sizes of pressurized-water reactor (PWR) annular fuels. To determine the contacting tendency of the inner-outer gaps between the annular fuel pellets and cladding, thermoelastic-plastic-creep (TEPC)analysis of PWR annular fuels was performed, using in-house FE code. For the efficient heat transfer at certain levels of stress, we investigated the tensile, compressive hoop stress and temperature, and optimized the gap sizes using the non-dominant sorting genetic algorithm (NSGA-II). For this, response surface models of objective and constraint functions were generated, using central composite (CCD) and D-optimal design. The accuracy of approximate models was evaluated through $R^2$ value. The obtained optimal solutions by NSGA-II were verified through the TEPC analysis, and we compared the obtained optimum solutions and generated errors from the CCD and D-optimal design. We observed that optimum solutions differ, according to design of experiments (DOE) method.

• Journal of Microbiology and Biotechnology
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• 제18권12호
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• pp.1919-1926
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• 2008

Statistical experimental designs; involving (i) a fractional factorial design (FFD) and (ii) a central composite design (CCD) were applied to optimize the culture medium constituents for production of a unique antifreeze protein by the Antartic micro algae Chaetoceros neogracile. The results of the FFD suggested that NaCl, KCl, $MgCl_2$, and ${Na}_{2}{SiO}_{3}$ were significant variables that highly influenced the growth rate and biomass production. The optimum culture medium for the production of an antifreeze protein from C. neogracile was found to be Kalle's artificial seawater, pH of $7.0{\pm}0.5$, consisting of 28.566 g/l of NaCl, 3.887 g/l of $MgCl_2$, 1.787 g/l of $MgSO_4$, 1.308 g/l of $CaSO_4$, 0.832 g/l of ${K_2}{SO_4}$, 0.124 g/l of $CaCO_3$, 0.103 g/l of KBr, 0.0288 g/l of $SrSO_4$, and 0.0282 g/l of ${H_3}{BO_3}$. The antifreeze activity significantly increased after cells were treated with cold shock (at $-5^{\circ}C$) for 14 h. To the best of our knowledge, this is the first report demonstrating an antifreeze-like protein of C. neogracile.

• Food Science and Biotechnology
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• 제17권5호
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• pp.904-911
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• 2008

Covalent cross-links between a number of proteins and peptides explain why transglutaminase may be widely used by food processing industries. The objective of this work was optimization of the fermentation process to produce transglutaminase from a new microbial source, the Streptomyces sp. P20. The strategy adopted to modify the usual literature media was: (1) fractional factorial design (FFD) to elucidate the key medium ingredients, (2) central composite design (CCD) to optimise the concentration of the key components. Optimization of the medium resulted in not only an 86% increase in microbial transglutaminase activity as compared to the media cited in the literature, but also a reduction in the production cost. Optimal fermentation conditions - namely temperature and agitation rate - were also studied, using CCD methodology. Usual conditions of $30^{\circ}C$ and 100 rpm were within the optimal area. All other parameters for enzyme production were experimentally proven to be optimum fermentation conditions.

• 한국생산제조학회지
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• 제21권6호
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• pp.954-960
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• 2012

Nowadays, rapidly changing and unstable global economic environments request a lot of roles to engineers. In this situation, product should be designed to make more profit by cost down and to satisfy distinguished performance comparing to other competitive ones. In this research, the optimization design of the industrial robot casting will be done. The weight and deflection have to be reduced as objective functions and stress has to be constrained under some constant value. To reduce time cost, CCD (Central Composite Design) will be used to make experimental design. And RSM (Response Surface Methodology) will be taken to make regression model for objective functions and constraint function. Finally, optimization will be done with Genetic Algorithm. In this problem, the objective functions are multiple, so NSGA-II which is brilliant and efficient for such a problem will be used. For the solution quality check, the diversity between Pareto solutions will be also checked.

• 한국기계가공학회지
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• 제14권3호
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• pp.85-91
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• 2015

The press-fit shaft is an important part used in automobiles, vessels, and trains. This study proposes an optimized design method to reduce damage that may occur in the press-fitted shaft by modifying the shape of the boss step of the press-fitted shaft. To reduce the time and cost of running the optimized design method, an approximate design optimization is applied and an optimized algorithm is generated using a genetic algorithm that is widely used in engineering fields and an approximate model using a response surface method. The planned experiments for the data that are needed to generate the approximate model use a central composite design (CCD) and Latin hypercube sampling (LHS), and the results of the approximate optimization using the above two design of experiments are to be compared.

• 공업화학
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• 제32권5호
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• pp.562-568
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• 2021

천연 밀배아유와 복합 sugar ester를 이용하여 밀배아유 원료 O/W (oil in water) 유화액을 제조하였다. HLB 값, 유화제의 첨가량 및 유화시간이 O/W wheat germ oil 유화액의 평균 입자크기, 유화점도 및 ESI에 미치는 영향을 조사하였으며, 반응표면분석방법인 중심합성계획모델에 의해 제조된 유화과정의 파라미터를 모의하고 최적화하였다. O/W wheat germ oil 유화액의 제조를 위한 최적의 공정조건은 HLB 값(hydrophile-lipophile balance value)은 8.4, 유화제의 첨가량은 6.4 wt%, 유화시간은 25.4 min이며, 최적조건에서 중심합성계획(central composite design, CCD-RSM) 모델을 통한 예측 반응치는 7일 후의 유화액을 기준으로 MDS (mean droplet size)= 206 nm, 점도 = 8125 cP, ESI 98.2%이었다. 또한 실제 실험을 통해 얻어진 유화액의 MDS, 점도 및 ESI는 각각 209 nm, 7974 cP 및 98.7%로 나타났다. 따라서 중심합성계획 모델을 통해 밀배아유 원료 유화액의 안정성을 평가하는 최적화 과정을 설계할 수 있었다.