• Bulletin of the Korean Chemical Society
• /
• 제28권6호
• /
• pp.941-946
• /
• 2007

Bacillus halodurans O-methyltransferase (BhOMT) is a S-adenosylmethionine (SAM or AdoMet) dependent methyltransferase. Three dimensional structure of the BhOMT bound to S-adenosyl-L-homocysteine (SAH or AdoHcy) has been determined by comparative homology modeling. BhOMT has 40% sequence identity with caffeoyl-CoA 3-O-methyltransferase (CCoAOMT) from alfalfa. Based on x-ray structure of CCoAOMT, three dimensional structure of BhOMT was determined using MODELLER. The substrate binding sites of these two proteins showed slight differences, but these differences were important to characterize the substrate of BhOMT. Automated docking study showed that four flavonoids, quercetin, fisetin, myricetin, and luteolin which have two hydroxyl groups simultaneously at 3'- and 4'-position in the B-ring and structural rigidity of Cring resulting from the double bond characters between C2 and C3, were well docked as ligands of BhOMT. These flavonoids form stable hydrogen bondings with K211, R170, and hydroxyl group at 3'-position in the Bring has stable electrostatic interaction with Ca2+ ion in BhOMT. This study will be helpful to understand the biochemical function of BhOMT as an O-methyltransferase for flavonoids.

• 한국기계가공학회지
• /
• 제19권1호
• /
• pp.100-107
• /
• 2020

As demand for high value-added products with hard materials increases, the line center is used for producing high value-added products in many industries such as aerospace, automobile fields. The line center is a key device for smart factory automation that can improve the production efficiency and the productivity. Therefore, the development of a mill-turn line center is necessary to produce high value-added products with complex shapes flexibly. In the mill-turn process, a milling process and a turning process are combined. In particular, the turning process needs to increase the rigidity of the spindle. The purpose of this study is to analyze the thermal-structural stability through thermo-structural coupled analysis for a mill-turn spindle with a curvic coupling. The maximum temperature and thermal stability of the spindle were analyzed by thermal distribution. In addition, the thermal deformation and thermal-structural stability of the spindle were analyzed through thermo-structural coupled analysis.

• Bulletin of the Korean Chemical Society
• /
• 제25권3호
• /
• pp.357-360
• /
• 2004

We developed in the present study molecular imprinted polymers (MIPs), using single templates (pentoxifylline, caffeine and theophylline) and mixed-templates (pentoxifylline-caffeine, pentoxifylline-theophylline and caffeine-theophylline). The MIPs were prepared with methacrylic acid (MAA) as the monomer, ethylene glycol dimetharylate (EGDMA) as the crosslinker and 2,2'-azobis(isobutyronitrile) (AIBN) as the initiator. The obtained polymer particles (particle size after grinding was about 25-35 ${\mu}$m) were packed into a HPLC column (3.9 mm i.d. ${\times}$ 150 mm). The selectivity and chromatographic characteristics of the MIPs were studied using acetonitrile as the mobile phase at a flow rate of 0.8 mL/min. UV detector wavelength was set at 270 nm. Different single template MIPs showed different molecular recognitions to the templates and the structurally analogues, according to the rigidity and steric hindrance of the compounds. Recognition was improved on the mixed-template MIPs as a result of the cooperation or sum effect of the templates, whereas on the pentoxifylline-theophylline imprinted polymer, the highest selectivity and affinity were obtained. Separations of the test compounds on different polymers were also investigated.

• Journal of the Korean Wood Science and Technology
• /
• 제45권1호
• /
• pp.53-61
• /
• 2017

본 연구에서는 고강성, 고인성의 경량화된 목질접합부를 제작하기 위하여 슬릿 가공된 기둥부재 중앙에 강판 대용인 목질접합물을 삽입하고 기둥부재와 목질접합물만 결합된 시험편들을 제작하였다. 시험편들은 강판을 사용한 대조군 시험편과 모멘트 저항성능을 비교분석하였다. GFRP보강목질적층판과 핀으로 제작된 시험편들은 강판삽입형 시험편 보다 평균 24% 저하된 최대모멘트가 측정되었으나 양호한 인성이 관찰되었다. 파괴형상은 기둥부재의 연단부분에서 연륜을 따라 파괴되었다. 집성재와 목질적층판을 접착제로 일체화한 강절형 시험편은 대조군 시험편보다 초기강성이 2.8배 향상되었고, 최대모멘트도 평균 40% 향상된 경향을 보였다. 강절형 시험편들은 접착층 주위에서 파단되었다.

• 한국전산구조공학회논문집
• /
• 제26권1호
• /
• pp.19-28
• /
• 2013

전단벽-골조 구조시스템의 구조적인 거동은 휨거동하는 전단벽과 전단거동하는 골조의 상호작용에 의하여 결정된다. 이러한 전단벽-골조 구조물의 거동특성을 효과적으로 고려하기 위하여 선행 연구에서는 2차원 T형 강체를 사용한 단순 해석모델을 제안하였다. 본 논문에서는 이를 바탕으로 편심코어를 가진 전단벽-골조 구조물에 대한 효율적인 해석모델을 제안한다. 2차원 등가모델을 3차원으로 확장하여 비틀림 거동을 고려할 수 있도록 하였고, 그 결과 제안하는 등가모델이 편심코어를 가지는 전단벽-골조 구조물에도 적용가능 하도록 하였다.

• Korean Journal of Radiology
• /
• 제22권11호
• /
• pp.1841-1849
• /
• 2021

Objective: To prospectively investigate the feasibility of shear wave elastography (SWE) as a new quantitative and objective method for evaluating the stiffness of the gastrocnemius medialis (GM) muscle during passive stretching in patients with Parkinson's disease (PD). Materials and Methods: SWE of the GM muscle was performed in 28 patients with PD [13 female and 15 male; mean age ± standard deviation (SD): 63.0 ± 8.5 years] and 12 healthy controls (5 female and 7 male; mean age ± SD: 59.3 ± 6.4 years) during passive ankle rotation. A Young's modulus-ankle angle curve was constructed. The GM slack angle and baseline Young's modulus (E₀) were compared between the markedly symptomatic and mildly symptomatic sides of patients with PD, and healthy controls. Additionally, the correlation between the GM slack angle and the severity of rigidity, and the observer reproducibility of SWE in determining the GM slack angle were evaluated. Results: The GM slack angle was smaller on both the markedly and mildly symptomatic sides in patients with PD than in healthy controls (mean ± SD of -29.13° ± 3.79° and -25.65° ± 3.39°, respectively, vs. -21.22° ± 3.52°; p < 0.001 and p = 0.006, respectively). Additionally, in patients with PD, the GM slack angle on the markedly symptomatic side was smaller than that on the mildly symptomatic side (p = 0.003). The E0 value was lower on both the markedly and mildly symptomatic sides in patients with PD than in healthy controls (mean ± SD of 10.11 ± 2.85 kPa and 10.08 ± 1.88 kPa, respectively, vs. 12.23 ± 1.02 kPa; p = 0.012 and p < 0.001, respectively). However, no significant difference was found between the markedly and mildly symptomatic sides in patients with PD (p = 0.634). A negative linear relationship was observed between the GM slack angle and lower limb rigidity score on the markedly symptomatic side in patients with PD (r = -0.719; p < 0.001). The intraclass correlation coefficients for observer reproducibility of SWE ranged from 0.880 to 0.951. Conclusion: The slack angle determined by SWE may be a useful quantitative and reproducible method for evaluating muscle stiffness in patients with PD.

• 한국철도학회논문집
• /
• 제15권5호
• /
• pp.485-497
• /
• 2012

최근 철도의 소음, 진동에 대한 사회적 관심이 증가하면서, 철도 진동을 효과적으로 줄일 수 있는 플로팅 슬래브 궤도의 적용이 활발히 이루어 지고 있다. 본 연구에서는 플로팅 슬래브 궤도의 동적 거동을 보다 정확히 이해하기 위하여 실모형 실내 실험을 통해 정적 거동과 시스템 고유 진동수 부근의 저주파 대역에서 플로팅 슬래브 궤도의 동적 거동을 분석함으로써 플로팅 슬래브 궤도의 설계의 적정성과 설계에 적용되는 해석모델의 유효성을 입증하고자 하였다. 실험 및 유한요소 해석 결과에 따르면 플로팅 슬래브 궤도는 강체 모드 고유진동수보다 휨모드 고유 진동수에 가까운 대역에서 탁월 주파수가 나타나며 변형 형상도 휨모드가 가장 지배적인 모드가 되므로, 플로팅 슬래브 궤도의 설계 시에는 슬래브의 휨강성과 조인트 및 단부의 경계조건 등을 고려해야 한다. 또한 Kelvin-Voigt 모델을 사용한 2차원 유한요소 해석모델에 의한 해석 결과는 정적 및 동적 처짐, 하중 전달율 등 실험결과와 매우 잘 일치하는 것으로 나타나 플로팅 슬래브 궤도의 설계에 활용하기에 충분한 신뢰성을 가지고 있는 것으로 나타났다.

• Structural Engineering and Mechanics
• /
• 제46권4호
• /
• pp.519-531
• /
• 2013

To have a better understanding of the torsional mechanism and influencing factors of PC composite box-girder with corrugated steel webs, ultimate torsional strength of four specimens under pure torsion were analyzed with Model Test Method. Monotonic pure torsion acts on specimens by eccentric concentrated loading. The experimental results show that cracks form at an angle of $45^{\circ}$ to the member's longitudinal axis in the top and bottom concrete slabs. Longitudinal reinforcement located in the center of cross section contributes little to torsional capacity of the specimens. Torsional rigidity is proportional to shape parameter ${\eta}$ of corrugation and there is an increase in yielding torque and ultimate torque of specimens as the thickness of corrugated steel webs increases.

• Journal of the Korean Wood Science and Technology
• /
• 제35권5호
• /
• pp.76-86
• /
• 2007

This study was conducted to investigate the effects of formaldehyde to urea (F/U) mole ratio on thermomechanical curing of UF resin adhesives with different F/U mole ratios. Thermomechanical curing of these UF resin adhesives was characterized using parameters of dynamic mechanical analysis (DMA) such as the gel temperature, maximum storage modulus, and peak temperatures of storage and loss modulus. As the F/U mole ratio decreased, the gel temperature of UF resin adhesives increased. The maximum storage modulus as an indicator of the rigidity of UF resin adhesives decreased with decreasing F/U mole ratio. The peak temperature of tan $\delta$ increased with decreasing F/U mole ratio, indicating that the vitrification occurred faster for high F/U mole ratio of UF resin adhesives than for the one of lower F/U mole ratio. These results partially explained the reason why UF resin adhesives with lower F/U mole ratio resulted in relatively poor adhesion performance when they were applied.

• 대한조선학회지
• /
• 제23권4호
• /
• pp.1-10
• /
• 1986

A container ship, due to wide hatch openings, has characteristics of poor torsional rigidity, strong coupling of horizontal-torsional modes and significant discontinuity in the longitudinal variation of hull sections. In the mathematical formulation of the problem the hull is modeled as a beam and the transfer matrix method is utilized. The cross decks between cargo hatch opening are separated from the main hull and regarded as equivalent springs restraining torsion of hull. The effect of shear deformation of ship-side plating on torsion is taken into account in addition to St. Venant's and bending torsional rigidities. Compatibility requirements at cross section discontinuity are approximately considered. Developing the practical calculation procedure and the computer programs for application to an actual ship, some parametric studies on modeling methods of the cross deck, the compatibility condition, added-mass center etc. are out for the purpose of comparison.