• Archives of Pharmacal Research
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• v.26 no.12
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• pp.1042-1046
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• 2003

This study was undertaken to observe the effects of the blend of partially purified Yucca schidigera and Quillaja saponaria extracts on cholesterol levels in the human's blood and gastrointestinal functions, and to determine if a new cholesterol-lowering drug can be developed by the further purification of the extracts. Ultrafiltration and sequential diafiltration increased the amounts of steroidal saponin in aqueous yucca extract and terpenoid saponin in aqueous qullaja extract from 9.3% and 21.4% to 17.2% and 61.8%, respectively. Taking 0.9 mg of the blend (6:4, v:v) of the resulting filtrates a day for 4 weeks resulted in the decreases in total and LDL cholesterol levels in blood plasma of hyper-cholestrolemic patients with enhancement in gastrointestinal symptoms of patients.

• Clinical and Experimental Reproductive Medicine
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• v.50 no.3
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• pp.177-184
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• 2023

Objective: Reconstructed oocytes after polar body genome transfer constitute a potential therapeutic option for patients with a history of embryo fragmentation and advanced maternal age. However, the rescue of genetic material from the first polar body (PB1) through introduction into the donor cytoplasm is not yet ready for clinical application. Methods: Eighty-five oocytes were obtained following in vitro maturation (IVM) and divided into two groups: PB1 nuclear transfer (PB1NT; n=54) and control (n=31). Following enucleation and PB1 genomic transfer, PB1 fusion was assessed. Subsequently, all fused oocytes underwent intracytoplasmic sperm injection (ICSI) and were cultured in an incubator under a time-lapse monitoring system to evaluate fertilization, embryonic morphokinetic parameters, and cleavage patterns. Results: Following enucleation and fusion, 77.14% of oocytes survived, and 92.59% of polar bodies (PBs) fused. However, the normal fertilization rate was lower in the PB1NT group than in the control group (56.41% vs. 92%, p=0.002). No significant differences were observed in embryo kinetics between the groups, but a significant difference was detected in embryo developmental arrest after the four-cell stage, along with abnormal cleavage division in the PB1NT group. This was followed by significant between-group differences in the implantation potential rate and euploidy status. Most embryos in the PB1NT group had at least one abnormal cleavage division (93.3%, p=0.001). Conclusion: Fresh PB1NT oocytes successfully produced normal zygotes following PB fusion and ICSI in IVM oocytes. However, this was accompanied by low efficiency in developing into cleavage embryos, along with an increase in abnormal cleavage patterns.

• Korean Journal of Pharmacognosy
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• v.51 no.1
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• pp.1-29
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• 2020

Diabetes mellitus, commonly known as diabetes, is a group of metabolic disorders characterized by high blood sugar levels over a prolonged period. Diabetes has been found to show many acute complications such as cardiovascular disease, stroke, chronic kidney disease, foot ulcer and damage to eyes. Korean ginseng (Panax ginseng) has been traditionally known to normalize the functional deficiencies of the lung, spleen and stomach, and thus improve the secretion of body fluids, thereby quenching thirst, suggesting it to be effective in the treatment of diabetes. Experimental studies (in vitro and in vivo) have recently shown that Korean ginseng and its extracts exhibit antidiabetic effects, and also insulin secretion and sensitizing effects related to blood glucose control. Moreover, clinical trials on antidiabetic effects of Korean ginseng have been reported to show blood glucose control, improvement of insulin resistance, reduction of postprandial blood glucose level and improvement of serum lipids (TG, TC, LDL-C). These will be critically examined by means of in vitro studies, cell experiment, animal models and human trials with a focus on understanding of molecular mechanisms.

• Proceedings of the IEEK Conference
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• 2002.07c
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• pp.1788-1791
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• 2002

In the post-genome era. it is one of important research subject to Investigate the roles of the proteins in human body based on decoded genome information during Human Genome Project. In order to clarify them. it is necessary to analyze the structure of the protein crystals and their function. ' Crystallization is the beginning stage of protein structure determination process. There are some methods for structural analysis of the proteins, and general one is X-ray structural analysis method. In order to utilize this method for analyzing the protein crystal's structure, artificial protein crystallization is required. However, since artificial crystallizing work takes much time and manpower. the performance against its cost is still low. Therefore. we started to discuss to develop a supporting system for improving efficiency of the crystallization distinction procedure. In this paper, we examine to realize such supporting system for crystallization distinction using image-processing technique and report about our experimental result with many real protein solution images.

• Proceedings of the Korea Information Processing Society Conference
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• 2000.10a
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• pp.179-182
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• 2000

본 논문은 특별한 마커를 사용하지 않고 연속되는 영상들에서 사람의 2 차원 움직임 정보를 추출하는 알고리즘을 제안한다. 사람의 움직임 정보를 추출하기 위해 색상, 움직임, 그리고 윤곽선 정보를 이용한다. 뿐만 아니라 사용자의 신체적인 차이와 특징점의 일관성을 위해 사람 몸통 모델을 사용한다. 본 논문의 알고리즘은 마커를 사용할 수 없는 HCI 응용분야에 될 수 있다.

• Molecules and Cells
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• v.40 no.6
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• pp.401-409
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• 2017

The primary cilium is a non-motile microtubule-based organelle that protrudes from the surface of most human cells and works as a cellular antenna to accept extracellular signals. Primary cilia assemble from the basal body during the resting stage ($G_0$ phase) and simultaneously disassemble with cell cycle re-entry. Defective control of assembly or disassembly causes diverse human diseases including ciliopathy and cancer. To identify the effective compounds for studying primary cilium disassembly, we have screened 297 natural compounds and identified 18 and 17 primary cilium assembly and disassembly inhibitors, respectively. Among them, the application of KY-0120, identified as Brefeldin A, disturbed Dvl2-Plk1-mediated cilium disassembly via repression of the interaction of $CK1{\varepsilon}-Dvl2$ and the expression of Plk1 mRNA. Therefore, our study may suggest useful compounds for studying the cellular mechanism of primary cilium disassembly to prevent ciliopathy and cancer.

• Korean Journal of Digital Imaging in Medicine
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• v.16 no.1
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• pp.7-11
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• 2014

The body to achieve an interaction that are connected to each other. Foot of which plays an important role in motor activity. Insole that has been recently used, have a dynamic functional elements. In particular, support of Arch plays a very important role in terms of a motor function of the human body as a whole. It is possible to predict the proper support Arch with insole, the overall structure of the body there can affect the balance. In this study, by applying the insole which supports the Longitudinal arch and Transverse arch, you are trying to assess the interaction of balance and the body's ability. To target the 20 there is no problem in the sense of balance, college student, and changes were observed by measuring the Center of Position area and distance through the Biorescue device worn before and after led by Arch support. As a result, I showed improved results significantly discount rate after wearing in the Center of Position area and distance to assess the balance ability. Therefore, the correction insole function is to support the Longitudinal arch and Transverse arch to an important role in the foot. It may be that it has a functional element for improving the balance of the function of preventing collapse of the arch during walking, to disperse the weight of the entire foot, us reduce fatigue in the end.

• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.357-366
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• 2015

Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviolet (UV) B exposure in human HaCaT keratinocytes. Isorhamnetin eliminated UVB-induced intracellular reactive oxygen species (ROS) and attenuated the oxidative modification of DNA, lipids, and proteins in response to UVB radiation. Moreover, isorhamnetin repressed UVB-facilitated programmed cell death in the keratinocytes, as evidenced by a reduction in apoptotic body formation, and nuclear fragmentation. Additionally, isorhamnetin suppressed the ability of UVB light to trigger mitochondrial dysfunction. Taken together, these results indicate that isorhamnetin has the potential to protect human keratinocytes against UVB-induced cell damage and death.

• Science of Emotion and Sensibility
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• v.14 no.4
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• pp.531-536
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• 2011

The precise measurement of human emotion is of pivotal importance in the field of emotion science. Based on the perspective of psychoneuroimmunoendocrinology, human emotion is now considered to be measurable by body fluid. The biological molecule cortisol, which is known for the stress hormone, has been widely investigated to help researchers to estimate the stress loaded on human body. Until now, several measurement techniques such as High Performance Liquid Chromatography (HPLC), fluorometric assay, and reverse phase chromatography have been developed. However, since these measurements are expensive, take relatively long time for an operation, and they are not portable, they are not appropriate for POCT (point of care testing). In this paper we demonstrate the performance of a miniaturized-microwave resonant device in the measurement of cortisol. Our method has many advantages in that it requires a small volume of sample, has fast response time, is easy to operate and needs no labeling process. Besides, it will shed a light on the measurement techniques for emotion science.

• Journal of Fashion Business
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• v.15 no.6
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• pp.85-100
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• 2011

The objective of this study was to analyze body measurements, BMI and body type according to age in the male and female groups based on 3D scan body measurement data of adult men and women in their 20's~30's and to provide basic information usable in the clothing and fashion industry. For this purpose, we analyzed 3D scan body measurement data of 848 adults measured in the 6th Size Korea project and the results were as follows. First, there were differences in 3D scan body measurements according to age in the male and female groups, and in general the measurements of the height items were larger in younger adults and the measurements of the circumference, breadth and depth items were larger in older ones. Second, there were differences in 3D scan body measurements according to BMI in the male and female groups, and in general body measurements were largest in the obesity group and lowest in the underweight group. Third, BMI was different according to gender and in general BMI was higher in men and obesity and overweight were more frequent in men than in women. Moreover, BMI was significantly different according to age and was higher in the 30's than in the 20's. Fourth, the mean difference in the drop and lower drop values according to age in the male and female groups was significant, and the drop and lower drop values were lower in the 30's than in the 20's. These results are considered meaningful as data for the development of clothing size systems, patterns and grading in the areas of clothing and fashion targeting consumers in their 20's~30's.